scholarly journals Bisphosphonate-induced osteonecrosis of the jaws: a literature review

2021 ◽  
Vol 1 (4) ◽  
pp. 190-198
Author(s):  
Nayane de Andrade Teófilo ◽  
Caio Denardin ◽  
Thiago Quirino Mota Da Silva ◽  
Túlio Garcia Margute ◽  
Andrei Rabenschlag Rossato ◽  
...  
Keyword(s):  
Literature Review ◽  
Adverse Effects ◽  
Digital Library ◽  
Research Problem ◽  
Osteonecrosis Of The Jaw ◽  
Exclusion Criteria ◽  
Osteonecrosis Of The Jaws ◽  
The Subject ◽  
Library Websites

Bisphosphonates are widely used, whether in osteoporosis or malignant bone disorders. Therefore, it is necessary that there is sufficient knowledge about the adverse effects of this drug, especially in relation to Osteonecrosis of the Jaws Developed by Bisphosphonates, which is a pathology generated in the gnathic bones. So, the following question was asked in the research problem: What is the current situation regarding the use of bisphosphonates and the onset of osteonecrosis of the jaw? Searches were carried out on digital library websites in search of articles and research in books by renowned authors. Inclusion and exclusion criteria for articles found were defined. The verification of each article was carried out so that it could have perspective and follow-up on the subject discussed. The following databases were used: PUBMED, BIREME and LILACS, and SCIELO between the years 2007 to 2019. It was concluded then that Bisphosphonates play a very important role as a cause of osteonecrosis of the jaws, where the prognosis will be worse if the patient is treated with intravenous rather than oral types.

scholarly journals Impact of Antiresorptive Agents on Maxillary Bones: a Narrative Literature Review

2021 ◽  
Vol 23 (4) ◽  
pp. 268-276
Author(s):  
Maria Luiza da Silva Matos ◽  
Pedro Henrique Bastos de OIiveira ◽  
Ana Carla Barletta Sanches ◽  
Tila Fortuna Costa Freire ◽  
Juliana Borges de Lima Dantas ◽  
...  
Keyword(s):  
Literature Review ◽  
Adverse Effects ◽  
Osteonecrosis Of The Jaw ◽  
Drug Holiday ◽  
Osteonecrosis Of The Jaws ◽  
Antiresorptive Agents ◽  
Antiresorptive Drugs ◽  
Bibliographic Search ◽  
Narrative Literature ◽  
Narrative Literature Review

AbstractAntiresorptive drugs operate in the bone metabolism modulation and are widely used in the treatment of bone metastases and bone losses related to hormonal deficiency. Although this therapy shows satisfactory results, there are adverse effects associated with its use, such as osteonecrosis of the jaws. Medication-related osteonecrosis of the jaws (MRONJ) is, therefore, a serious and challenging condition with important implications in dentistry. The aim was to conduct a narrative literature review on anti-resorptive drugs and their latest repercussions on the maxillary bones. The review was carried out through a bibliographic search using Decs/Mesh descriptors of interest, in Portuguese and English, in the PubMed, Virtual Health Library (VHL) and Scielo databases. After applying the inclusion and exclusion criteria, a total of 33 studies were selected for analysis. It can be noticed that therapy with anti-resorptive agents is complex, especially in dental practice, since MRONJ is a complication that is difficult to manage. Regarding the therapeutic options, these are divided into conservative, surgical or adjuvant therapy, however, there are no protocols in the literature, and there is no consistency regarding the indication of the suspension of the drug administration - "Drug Holiday". Thus, it is important that the multidisciplinary team seeks strategies that minimize complications and promote control over the use of these drugs. In addition, there is a need for investigations that contribute with guidelines for the management and control of adverse effects resulting from therapy with antiresorptive drugs. Keywords: Bone Density Conservation Agents. Diphosphonates. Denosumab. Bisphosphonate-Associated Osteonecrosis of the Jaw. ResumoAs drogas antirreabsortivas atuam na modulação do metabolismo ósseo e são indicadas para o tratamento de metástases ósseas e perdas ósseas relacionadas à deficiência hormonal. Ainda que esta terapia apresente resultados satisfatórios, observam-se efeitos adversos associados ao seu uso, como a osteonecrose dos maxilares. A osteonecrose dos maxilares associada ao uso de medicamentos (OMAM) é, portanto, uma condição séria e desafiadora com implicações importantes na Odontologia. O objetivo foi realizar uma revisão narrativa de literatura sobre as drogas antirreabsortivas e suas respectivas repercussões nos ossos maxilares. A revisão foi realizada através de busca bibliográfica utilizando descritores Decs/Mesh de interesse, em português e inglês, nas bases de dados PubMed, Biblioteca Virtual de Saúde (BVS) e Scielo. Após aplicação dos critérios de inclusão e exclusão, um total de 33 trabalhos foram selecionados para análise. Pode-se constatar que a terapia com agentes antirreabsortivos é complexa, sobretudo na prática odontológica, visto que a OMAM é uma complicação de difícil manejo. Em relação às condutas terapêuticas para esta condição, divide-se em terapia conservadora, cirúrgica ou adjuvante, todavia, não existem protocolos validados na literatura, bem como não há consistência quanto à indicação do intervalo de suspensão da administração da droga - “Drug Holiday”. Desse modo, é importante que a equipe multidisciplinar busque estratégias que minimizem as complicações e promovam o controle no uso dessas drogas. Além disso, nota-se a necessidade de realizar investigações que contribuam com diretrizes para o manejo e controle dos efeitos adversos decorrentes da terapia com medicamentos antirreabsortivos. Palavras-chave: Conservadores da Densidade Óssea. Bisfosfonatos. Denosumabe. Osteonecrose Associada a Bisfosfonatos.  

scholarly journals Cuidado de enfermagem ao recém-nascido em fototerapia, o que as evidências revelam: revisão integrativa

2020 ◽  
Vol 10 (32) ◽  
pp. 259-268
Author(s):  
Karla Brandão de Araújo ◽  
Erika Oliveira Abinader ◽  
Anete Leda de Oliveira Martins ◽  
Gláucia Alvarenga de Araújo ◽  
Karem De Souza Brandão ◽  
...  
Keyword(s):  
Literature Review ◽  
Nursing Care ◽  
Clinical Condition ◽  
Search Strategy ◽  
Scientific Evidence ◽  
Neonatal Hyperbilirubinemia ◽  
Exclusion Criteria ◽  
Specific Care

A Hiperbilirrubinemia neonatal é uma condição clínica caraterizada pelo acúmulo de bilirrubina no organismo do neonato podendo acarretar graves sequelas quando não tratada. Um dos meios terapêuticos consiste fototerapia, um tratamento que demanda cuidados específicos para prevenir iatrogenias. A enfermagem desempenha relevante papel nesses cuidados, pois permanece 24 horas no seguimento dos casos prevenindo complicações e contribuindo para a eficácia da terapêutica. Portanto, nesse estudo o objetivo foi investigar, através de revisão integrativa da literatura, as evidências científicas sobre os cuidados de enfermagem ao recém nascido em fototerapia. Para tal, foram pesquisadas as bases de dados: BDENF, LILACS, MEDLINE e SCIELO. Na formulação da estratégia de busca foram utilizados os descritores em saúde combinados entre si através dos operadores booleanos AND e OR. Foram encontrados quarenta artigos que após uso de critérios de inclusão e exclusão pré-definidos, permaneceram quatro que compuseram a amostra. A revisão revelou que os cuidados de enfermagem influenciam positivamente na adesão e resultado do tratamento.Descritores: Assistência de Enfermagem, Hiperbilirrubinemia Neonatal, Fototerapia. Nursing care for newborn in phototherapy, what the evidence reveals: integrative reviewAbstract: Neonatal hyperbilirubinemia is a clinical condition characterized by the accumulation of bilirubin in the neonate's organism and can cause serious sequelae when not treated. One of the therapeutic means consists of phototherapy, a treatment that requires specific care to prevent iatrogenesis. Nursing plays an important role in this care, as it remains 24 hours in the follow-up of cases, preventing complications and contributing to the effectiveness of therapy. Therefore, in this study the objective was to investigate, through an integrative literature review, the scientific evidence on nursing care for newborns undergoing phototherapy. For this, the databases were searched: BDENF, LILACS, MEDLINE and SCIELO. In the formulation of the search strategy, health descriptors combined with each other through the Boolean operators AND and OR were used. Forty articles were found that, after using pre-defined inclusion and exclusion criteria, four remained in the sample. The review revealed that nursing care positively influences adherence and treatment results.Descriptors: Nursing Care, Neonatal Hyperbilirubinemia, Phototherapy. Cuidado de enfermería para lo recién nacida en fototerapia, lo que revelan la evidencia: revisión integrativaResumen: La hiperbilirrubinemia neonatal es una condición clínica caracterizada por la acumulación de bilirrubina en el organismo del recién nacido y puede causar secuelas graves cuando no se trata. Uno de los medios terapéuticos consiste en la fototerapia, un tratamiento que requiere atención específica para prevenir la iatrogénesis. La enfermería desempeña un papel importante en esta atención, ya que permanece 24 horas en el seguimiento de los casos, previniendo complicaciones y contribuyendo a la efectividad de la terapia. Por lo tanto, en este estudio el objetivo fue investigar, a través de una revisión bibliográfica integradora, la evidencia científica sobre el cuidado de enfermería para los recién nacidos sometidos a fototerapia. Para esto, se realizaron búsquedas en las bases de datos: BDENF, LILACS, MEDLINE y SCIELO. En la formulación de la estrategia de búsqueda, se utilizaron descriptores de salud combinados entre sí a través de los operadores booleanos AND y OR. Cuarenta artículos se encontraron que, después de utilizar criterios de inclusión y exclusión predefinidos, cuatro permanecieron en la muestra. La revisión reveló que la atención de enfermería influye positivamente en la adherencia y los resultados del tratamiento.Descriptores: Cuidados de Enfermería, Hiperbilirrubinemia Neonatal, Fototerapia.

scholarly journals Riedel’s Thyroiditis: Report of Two Cases and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Victor Manuel Blanco ◽  
Camilo Andrés Páez ◽  
Angela María Victoria ◽  
Luis Guillermo Arango ◽  
Ana María Arrunategui ◽  
...  
Keyword(s):  
Literature Review ◽  
Immunoglobulin G ◽  
Rare Entity ◽  
Diagnostic Challenge ◽  
Riedel’S Thyroiditis ◽  
Fibrotic Process ◽  
The Subject ◽  
Fibrotic Disorders ◽  
Riedel's Thyroiditis

Riedel’s thyroiditis is a rare entity consisting of a fibrotic process of the thyroid which can generate gland destruction, infiltration of cervical structures and even airway obstruction. It has been associated with systemic fibrotic disorders, autoimmune diseases, and more recently with spectrum of diseases related to excess of Immunoglobulin G type 4 (IgG4). Two cases of Riedel’s thyroiditis by IgG4, confirmed by immunohistochemistry and was managed surgically with favorable results during the follow-up time, are presented. These case descriptions highlight the diagnostic challenge of this disease, describe the response with surgical management, and make a brief update on the subject.

scholarly journals Singular therapeutic project in mental health: an integrative review

2020 ◽  
Vol 73 (2) ◽  
Author(s):  
Juliana Ávila Baptista ◽  
Marcio Wagner Camatta ◽  
Paula Gonçalves Filippon ◽  
Jacó Fernando Schneider
Keyword(s):  
Mental Health ◽  
Health Care ◽  
Psychological Distress ◽  
Health Services ◽  
Literature Review ◽  
Multidisciplinary Team ◽  
Exclusion Criteria ◽  
The Subject ◽  
Review Study ◽  
Specialized Mental Health

ABSTRACT Objectives: to analyze the Singular Therapeutic Projects’ characteristics in mental health care used to assist the subject with psychological distress. Methods: it is an Integrative Literature Review study conducted in July 2017. The following databases used to collect the data were LILACS, MEDLINE and BDENF. After applying the inclusion and exclusion criteria, 12 articles were selected. Results: there was divergence between what was recommended by the Ministry of Health for PTS elaboration with that described in the studies analyzed. Emphasis is placed on the low participation and co-responsibility between team/user in PTS elaboration, excessive referrals to specialized mental health services, fragmentation of knowledge within the multidisciplinary team, and difficulty sharing and discussing information about cases. Final considerations: it is pointed out the need to adapt PTS elaboration, and its respective steps, to the needs of each individual.

Mind Wandering (Internal Distractibility) in ADHD: A Literature Review

2019 ◽  
pp. 108705471986578 ◽  
Author(s):  
Jane Lanier ◽  
Elizabeth Noyes ◽  
Joseph Biederman
Keyword(s):  
Literature Review ◽  
Literature Search ◽  
Statistical Evaluation ◽  
Case Reports ◽  
A Priori ◽  
Mind Wandering ◽  
Functional Impairments ◽  
Exclusion Criteria ◽  
The Subject ◽  
Adequate Sample Size

Objective: Mind wandering, the unintended shifting of attention from a task, has been previously associated with symptoms of ADHD. To this end, we conducted a literature search to investigate the association between mind wandering and ADHD. Method: We conducted a systematic search of the literature of relevant articles assessing mind wandering and ADHD in PubMed, PsycINFO/OVID, and Medline. Included were original articles in English that had operationalized definitions of ADHD and mind wandering, adequate sample size, and reliance on statistical evaluation of findings. Excluded were reviews, opinions, and case reports. Results: Only nine studies met our a priori inclusion and exclusion criteria ( N = 8 in adults; N = 1 in pediatrics). Findings suggest that ADHD is frequently associated with spontaneous mind wandering and when present heralds more functional impairments. Conclusion: The limited research on mind wandering in ADHD indicates that it is prevalent and morbid supporting further research on the subject.

scholarly journals Health disorders and teachers' voices: a workers' health issue

2009 ◽  
Vol 17 (4) ◽  
pp. 566-572 ◽  
Author(s):  
Liliana Amorim Alves ◽  
Maria Lúcia do Carmo Cruz Robazzi ◽  
Maria Helena Palucci Marziale ◽  
Ana Clara Naufel de Felippe ◽  
Cristiane da Conceição Romano
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Voice Disorders ◽  
Basic Knowledge ◽  
Exclusion Criteria ◽  
Lead Teachers ◽  
The Subject ◽  
Occupational Disorders ◽  
Health Disorders ◽  
The Voice

Environmental and/or work risk factors, lack of basic knowledge related to voice, its incorrect use, and a defective vocal model can lead teachers to develop occupational dysphonia. This study aimed to analyze studies focusing on occupational vocal disorders through a literature review. Articles published over a period of 11 years in periodicals indexed in the ScieLO library were searched according to predetermined inclusion and exclusion criteria. Twenty articles related to teachers' vocal occupational disorders were found. We argue that intense vocal use should not harm professionals; the voice has to be pleasant to the speaker and correctly produced. The conclusion is that there is a scarcity of articles available at the studied library relating to teachers' voice disorders. Further studies need to be developed and disseminated so as to increase knowledge in the subject.

scholarly journals Clinical considerations for medication-related osteonecrosis of the jaw: a comprehensive literature review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mampei Kawahara ◽  
Shinichiro Kuroshima ◽  
Takashi Sawase
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Dental Treatment ◽  
Treatment Strategies ◽  
Osteonecrosis Of The Jaw ◽  
High Dose ◽  
Exclusion Criteria ◽  
Clinical Recommendations ◽  
Pubmed Database ◽  
Clinical Considerations

Abstract Background Medication-related osteonecrosis of the jaw (MRONJ), which was first reported as bisphosphonate-related osteonecrosis of the jaw (BRONJ) in bisphosphonate users, is a rare but severe soft and hard tissue disease induced by several types of medications. There has been a deluge of information about MRONJ, such as epidemiology, risk factors, clinical recommendations for dental treatment to prevent it, and treatment strategies in medication-prescribed users. The aim of this study was to comprehensively review recent articles and provide the current scientific information about MRONJ, especially clinical considerations or recommendations for dental treatment to prevent its occurrence. Materials and methods The current literature review was mainly based on 14 systematic reviews with or without meta-analysis, 4 position papers, 1 consensus statement, 1 clinical guideline, and 2 clinical reviews regarding MRONJ after a PubMed database and manual searches according to inclusion and exclusion criteria. Moreover, 53 articles were selected by manual search in regard to all references from selected articles and other articles identified on the PubMed search, irrespective of publication date, and inclusion and exclusion criteria. Results The incidence and prevalence of MRONJ are relatively low, although they are clearly higher in cancer patients receiving high-dose antiresorptive agents or angiogenesis inhibitors rather than osteoporosis patients receiving oral bisphosphonates or denosumab. There are many types of local, systemic, and other risk factors for the development of MRONJ. Clinical recommendations are provided for each clinical situation of patients to prevent MRONJ. There are also treatment strategies for MRONJ in each stage. Conclusions General dentists should perform appropriate dental treatment to prevent MRONJ in the patients prior to or when receiving medications that could induce MRONJ. Moreover, there are treatment strategies for MRONJ in each stage that oral surgeons could follow. Adequate and updated clinical information regarding MRONJ based on scientific data is required whenever possible.

scholarly journals Medication-Related Osteonecrosis of the Jaws: Considerations on a New Antiresorptive Therapy (Denosumab) and Treatment Outcome after a 13-Year Experience

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Gianfranco Favia ◽  
Angela Tempesta ◽  
Luisa Limongelli ◽  
Vito Crincoli ◽  
Eugenio Maiorano
Keyword(s):  
Staging System ◽  
Osteonecrosis Of The Jaw ◽  
Clinicopathological Features ◽  
Antiresorptive Therapy ◽  
Osteonecrosis Of The Jaws ◽  
Current Series ◽  
Antiresorptive Drugs ◽  
Radiological Healing ◽  
Invasive Surgical Approach

Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients receiving antiresorptive therapies for bone neoplastic localizations and osteoporosis. The aim of this study was to evaluate the clinicopathological features of MRONJ in a cohort of patients treated by new antiresorptive drugs (denosumab) and the corresponding outcome after 13-year maximum follow-up. Overall, 244 patients affected by MRONJ were treated from 2003 to 2015. After clinical and radiological examinations, all lesions were staged according to a dimensional staging system and then surgically treated. All the denosumab-related lesions were classified as stage II or III, thus requiring a more or less invasive surgical approach, despite the results of many recent studies, which suggested a conservative medical approach with early resolution for MRONJ in patients on denosumab. In the current series, 86.9% of treated lesions showed complete clinical and radiological healing, while 13.1% recurred; all recurrences were detected in patients who could not interrupt chemotherapy, steroids, and/or antiresorptive drugs administration due to their general conditions. In conclusion, all oral specialists should be aware of the MRONJ risk among patients taking new antiresorptive drugs; moreover, our protocol based on surgical treatment guided by dimensional staging could be considered effective in view of the low recurrence rate.

Prenatal diagnosis of urinoma

2018 ◽  
Author(s):  
O.I. Guseva , A.N. Baratova , L.E. Egorskaya
Keyword(s):  
Renal Function ◽  
Prenatal Diagnosis ◽  
Literature Review ◽  
Functional Ability ◽  
Large Size ◽  
Significant Damage ◽  
The Subject

Objective: to evaluate the functional ability of the kidneys in patients with prenatally diagnosed urinoma Materials: we retrospectively reviewed 2 cases of antenatally diagnosed urinoma. With the aim of establishing the overall prognosis prenatally diagnosed urinoma we reviewed the literature on the subject. The analysis included 38 published cases of prenatal urinoma detection followed by newborn follow-up. 260 Пренатальная диагностика уриномы 2018 Т 17 № 3; 255-260 ПРЕНАТАЛЬНАЯ ДИАГНОСТИКА Конфликт интересов: отсутствует. Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах. Для цитирования: Гусева О.И., Баратова А.Н., Егорская Л.Е. Пренатальная диагностика уриномы. Пренат. Диагн. 2018; 17(3): 255–260. doi: 10.21516/2413-1458-2018-17-3-255-260 Results: urinoma was diagnosed at 32 and 33 weeks of pregnancy. The development of children was traced to 5 and 7 months. In the case of urinoma of large size, there was no renal function after birth. According to the literature review, renal function was retained after birth in only 8 of 38 children (21 %). Conclusion: urinoma is a rare serious complication that indicates significant damage to the kidney after obstruction, which often leads to a violation or absence of the function of the affected kidney. If the diagnosis of urinoma was in prenatal life, it is important to inform parents about the bad prognosis.

Critical Review on Suicide Among Nurses

Crisis ◽  
2015 ◽  
Vol 36 (2) ◽  
pp. 91-101 ◽  
Author(s):  
Marie Alderson ◽  
Xavier Parent-Rocheleau ◽  
Brian Mishara
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
High Stress ◽  
Related Factors ◽  
Work Settings ◽  
Work Related ◽  
High Prevalence ◽  
Full Text Review ◽  
The Subject ◽  
Psychiatric Problems

Background: Research shows that there is a high prevalence of suicide among nurses. Despite this, it has been 15 years since the last literature review on the subject was published. Aim: The aim of this article is to review the knowledge currently available on the risk of suicide among nurses and on contributory risk factors. Method: A search was conducted in electronic databases using keywords related to prevalence and risk factors of suicide among nurses. The abstracts were analyzed by reviewers according to selection criteria. Selected articles were submitted to a full-text review and their key elements were summarized. Results: Only nine articles were eligible for inclusion in this review. The results of this literature review highlight both the troubling high prevalence of suicide among nurses as well as the persistent lack of studies that examine this issue. Conclusion: Considering that the effects of several factors related to nurses' work and work settings are associated with high stress, distress, or psychiatric problems, we highlight the relevance of investigating work-related factors associated with nurses' risk of suicide. Several avenues for future studies are discussed as well as possible research methods.

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