scholarly journals INNOVATIVE AND NOVEL STRATEGY: MICROSPONGES FOR TOPICAL DRUG DELIVERY

2018 ◽  
Vol 8 (5) ◽  
pp. 28-34 ◽  
Author(s):  
Jyoti Jyoti ◽  
Sandeep Kumar
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
Systemic Exposure ◽  
Spherical Particles ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Novel Strategy

Microsponge type of drug delivery is the latest technology which has been introduced in topical skin care, drug products to facilitate the controlled release of the active medicament into the skin in order to reduce systemic exposure and control local cutaneous reactions to active drugs. Microsponge can be loaded into a topical route of drug delivery system for the residue of dosage form of skin and thus controlled release drug delivery system is achieved and in return improving the patient compliance by providing target drug delivery system and prolonging dosage intervals. Microsponge is polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles and posses large porous surface area. Furthermore, they may enhance stability, reduce side effects, improve patient compliance and modify drug release. Microsponges are the polymer-based microspheres system that has the capacity to entrap a wide variety of substances, and can then be incorporated into a different formulation. Keywords: Microsponge Delivery System, Quasi- emulsion solvent diffusion.

scholarly journals Synthesis, Characterization, and Evaluation of a Novel Amphiphilic Polymer RGD-PEG-Chol for Target Drug Delivery System

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Shi Zeng ◽  
Fengbo Wu ◽  
Bo Li ◽  
Xiangrong Song ◽  
Yu Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Large Scale ◽  
Film Formation ◽  
Low Cost ◽  
Amphiphilic Polymer ◽  
Target Drug Delivery ◽  
H Nmr ◽  
Target Drug

An amphiphilic polymer RGD-PEG-Chol which can be produced in large scale at a very low cost has been synthesized successfully. The synthesized intermediates and final products were characterized and confirmed by1H nuclear magnetic resonance spectrum (1H NMR) and Fourier transform infrared spectrum (FT-IR). The paclitaxel- (PTX-) loaded liposomes based on RGD-PEG-Chol were then prepared by film formation method. The liposomes had a size within 100 nm and significantly enhanced the cytotoxicity of paclitaxel to B16F10 cell as demonstrated by MTT test (IC50= 0.079 μg/mL of RGD-modified PTX-loaded liposomes compared to 9.57 μg/mL of free PTX). Flow cytometry analysis revealed that the cellular uptake of coumarin encapsulated in the RGD-PEG-Chol modified liposome was increased for HUVEC cells. This work provides a reasonable, facile, and economic approach to prepare peptide-modified liposome materials with controllable performances and the obtained linear RGD-modified PTX-loaded liposomes might be attractive as a drug delivery system.

Preparation and anti-cancer activity of transferrin/folic acid double-targeted graphene oxide drug delivery system

2020 ◽  
Vol 35 (1) ◽  
pp. 15-27 ◽  
Author(s):  
Taicheng Lu ◽  
Zhenzhen Nong ◽  
Liying Wei ◽  
Mei Wei ◽  
Guo Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Target Drug Delivery System

In this study, a transferrin/folic acid double-targeting graphene oxide drug delivery system loaded with doxorubicin was designed. Graphene oxide was prepared by ultrasound improved Hummers method and was modified with Pluronic F68, folic acid, and transferrin to decrease its toxicity and to allow dual-targeting. The results show that the double target drug delivery system (TFGP*DOX) has good and controllable drug delivery performance with no toxicity. Moreover, TFGP*DOX has a better inhibitory effect on SMMC-7721 cells than does a single target drug delivery system (FGP*DOX). The results of drug release analysis and cell inhibition studies showed that TFGP*DOX has a good sustained release function that can reduce the drug release rate in blood circulation over time and improve the local drug concentration in or near a targeted tumor. Therefore, the drug loading system (TFGP*DOX) has potential application value in the treatment of hepatocellular carcinoma.

Formulation and Development of Aceclofenac loaded Microsponges Topical Drug Delivery System using quality by Design Approach

2021 ◽  
pp. 185-192
Author(s):  
Urvish M. Choudhary ◽  
Rinku Y. Mistree ◽  
Disha N. Patel ◽  
Shreyas V. Desai ◽  
Naimish A. Patoliya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Liquid Paraffin ◽  
Systemic Exposure ◽  
Diffusion Method ◽  
Topical Drug Delivery ◽  
Phase Volume

The proposed study is focussed at developing Aceclofenacmicrosponges for topic drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment was to prepare a safe, efficacious, stable and patient compliant microsponge dosage form of Aceclofenac. Materials and methods: Pre-formulation studies were carried out which helped in developing an accurate dosage form. UV, FTIR, DSC, and SEM studies were done for pre-formulation and post-formulation evaluations. These study deals with the design and optimization of Aceclofenacmicrosponges loaded topical drug delivery system to the controlled release of active drug into the skin in order to minimize the systemic exposure and minimize local cutaneous reactions to active drugs by DoE method of QbD Approach. AceclofenacMicrosponges were prepared by quasi emulsion solvent diffusion method using Eudragit-RS100 as a polymer, polyvinyl alcohol, Ethanol as Internal phase volume and Liquid paraffin as External phase volume. In this study, we found that the controlled release of aceclofenac microsponges.

scholarly journals Microsponges: A Novel Strategy to Control the Delivery Rate of Active Agents with Reduced Skin Irritancy

2019 ◽  
Vol 9 (6-s) ◽  
pp. 238-247
Author(s):  
PRAMILA VISHWAKARMA ◽  
Ramraj Choudhary
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Skin Irritation ◽  
Systemic Circulation ◽  
Release Mechanism ◽  
Porous Microspheres ◽  
Wide Range ◽  
Novel Strategy

Microsponges are particulate system which is composed by porous polymeric material. As compare to Conventional topical formulations, microsponge provide controlled release of the drug in the epidermis, it is to ensure that the drug is mainly localized and does not unduly entering the systemic circulation, it is a new area of research. The active ingredient needs to maximize the time to stay on the skin, while reducing transdermal penetration. Apart from this, there is a problem of unethical vehicles that can be viscous sticky deformation and skin irritation.  One of the biggest challenges of now a days is to control irritability for a predetermined site of active agents in the human body. Microsponges delivery system is a unique technique for controlled release with low irritant involving many triggers of Mechanism for the release of drugs. The Microsponge Delivery system is a polymeric porous microspheres, which can trap a wide range of effective elements such as anti-fungus, anti-infected, anti- inflammatory agent, fragrance and essential agent. This review includes different techniques used to prepare microsponges, formulation consideration, safety consideration, drug release mechanism, and challenges with microsponge drug delivery system along with their advantages, disadvantages and applications. In the current review, we summarize the updated application and capacity of Microsponge as an effective drug-delivery system to reduce skin irritation. Keywords: Microsponges; quasi-emulsion solvent diffusion; Porous microspheres; Controlled release.

scholarly journals TAT-modified serum albumin nanoparticles for sustained-release of tetramethylpyrazine and improved targeting to spinal cord injury

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yan Lin ◽  
Yujie Wan ◽  
Xingjie Du ◽  
Jian Li ◽  
Jun Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Spinal Cord ◽  
Drug Delivery System ◽  
Delivery System ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Cord Injury ◽  
Target Drug Delivery System ◽  
Targeting Ability

Abstract Background Spinal Cord injury (SCI) is a kind of severe traumatic disease. The inflammatory response is a significant feature after SCI. Tetramethylpyrazine (TMP), a perennial herb of umbelliferae, is an alkaloid extracted from ligustici. TMP can inhibit the production of nitric oxide and reduce the inflammatory response in peripheral tissues. It can be seen that the therapeutic effect of TMP on SCI is worthy of affirmation. TMP has defects such as short half-life and poor water-solubility. In addition, the commonly used dosage forms of TMP include tablets, dropping pills, injections, etc., and its tissue and organ targeting is still a difficult problem to solve. To improve the solubility and targeting of TMP, here, we developed a nanotechnology-based drug delivery system, TMP-loaded nanoparticles modified with HIV trans-activator of transcription (TAT-TMP-NPs). Results The nanoparticles prepared in this study has integrated structure. The hemolysis rate of each group is less than 5%, indicating that the target drug delivery system has good safety. The results of in vivo pharmacokinetic studies show that TAT-TMP-NPs improves the bioavailability of TMP. The quantitative results of drug distribution in vivo show that TAT-TMP-NPs is more distributed in spinal cord tissue and had higher tissue targeting ability compared with other treatment groups. Conclusions The target drug delivery system can overcome the defect of low solubility of TMP, achieve the targeting ability, and show the further clinical application prospect.

Versatile Use of Nanosponge in the Pharmaceutical Arena: A Mini-Review

2020 ◽  
Vol 14 (4) ◽  
pp. 351-359
Author(s):  
Shubham Shrestha ◽  
Sankha Bhattacharya
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Porous Structure ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Carrier System ◽  
Current Review ◽  
Long Time ◽  
Preparation Techniques

Drug delivery for a long time has been a major problem in the pharmaceutical field. The development of a new Nano-carrier system called nanosponge has shown the potential to solve the problem. Nanosponge has a porous structure and can entrap the drug in it. It can carry both hydrophilic and hydrophobic drugs. They also provide controlled release of the drugs and can also protect various substances from degradation. Nanosponge can increase the solubility of drugs and can also be formulated into an oral, topical and parenteral dosage form. The current review explores different preparation techniques, characterization parameters, as well as various applications of nanosponge. Various patents related to nanosponge drug delivery system have been discussed in this study.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

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