OZONE FEATURES IN THE CONTEXT OF ADVANCING COVID-19 PANDEMIC

Coronavirus disease 2019 represents a serious challenge for modern society worldwide because of the considerable and unfavourable consequences of the pandemic in terms of human health, economics and social life. In the present survey, some essential peculiarities of ozone as an air pollutant and powerful oxidant under the conditions of the COVID-19 pandemic as reflected in the recent literature are described. The understanding of ozone chemistry during COVID-19 lockdown can improve ozone parameterization in models of chemical transport. Ozone peroxides such as ozonides, aldehydes, hydrogen peroxides, and organic peroxide serve as messengers to modulate the human immune system and improve blood rheology.

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Book Review: Toshchenko Zh.T. Trauma Society: Between Evolution and Revolution (The Experience of Theoretical and Empirical Analysis). Moscow: Ves’ Mir, 2020

Russian Journal of Philosophical Sciences ◽

10.30727/0235-1188-2020-63-4-152-159 ◽

2020 ◽

Vol 63 (4) ◽

pp. 152-159

Author(s):

Vladimir V. Krivosheev

Keyword(s):

Social Life ◽

Social Dynamics ◽

Sociological Theory ◽

Modern Society ◽

Russian Society ◽

Trauma Society ◽

The Social ◽

New Research ◽

Further Development

The review reveals the basic conceptions elaborated by one of the major Russian modern sociologists Zh.T. Toshchenko in his new research. The reviewer argues that the book’s author thoroughly examines the various methodological grounds for identifying the essential characteristics of social dynamics. At the same time, the reviewer focuses on the further development of the theory of modern society, proposed by the book’s author. Thus, Zh.T. Toshchenko, who spent many years researching social deformations, formulates an important concept – the concept of a society of trauma as the third modality of social development along with evolution and revolution. The book offers a fundamentally new view of social life, there is a holistic, systematic approach to all its processes and phenomena. The reviewer concludes that the new book of the social theorist Zh.T. Toshchenko is a significant contribution to sociological theory, since it develops ideas about the state and prospects of Russian society, gives accurate assessments of all social processes.

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SOCIAL CONFLICT: ARCHETYPAL NATURE AND RESOLUTION MECHANISM

UKRAINIAN ASSEMBLY OF DOCTORS OF SCIENCES IN PUBLIC ADMINISTRATION ◽

10.31618/vadnd.v1i11.35 ◽

2018 ◽

Vol 1 (11) ◽

pp. 294-305

Author(s):

Ruslan Rafisovich Hasanov

Keyword(s):

Social Life ◽

Social Space ◽

Interpersonal Relations ◽

Human Life ◽

Social Groups ◽

Optimal Solution ◽

Modern Society ◽

Constructive Development ◽

The Social ◽

Interdisciplinary Knowledge

On the basis of the archetypic analysis of development trends of a conflictological paradigm the author’s model of minimization of conflict potential in modern society is offered. Institutional construction is the basis for model that is harmonized with a factor of societal identity.It is noted that the problems of social conflicts, according to data from monitor- ing studies of the Ukrainian school of archetype, are increasingly shifted into the sphere of interpersonal relations. It is stimulated by the progression in society of so-called self-sufficient personalities, the “subjectification” of the social space, and at the same time narrowing down to the solution of entirely specific situations in which there is a collision of the interests of two or more parties.Instead, in order to find the optimal solution for resolving the conflict, it is necessary to have interdisciplinary knowledge, in particular understanding of the deep nature of such conflicts. Collision of points of view, thoughts, positions — a very frequent phenomenon of modern social life. In order to develop the correct line of behavior in various conflict situations, it is important to adequately under- stand the nature of the emergence of the modern conflict and the mechanisms for resolving them in substance. Knowledge of conflict nature enriches the culture of communication and makes human life and social groups not only more calm, but also creates conditions for constructive development. It is proved that in modern life one can not but agree with the statement that an individual carries first re- sponsibility for his own life and only then for the life of the social groups to which he belongs. And while making decisions within the framework of modern mecha- nisms (consensus), the properties of human psychology such as extroversion, emo- tionality, irrationality, intuition, externality, and executive ability will not at least contribute to such a task.That is why in the author’s research attracted attention to the archetypal na- ture of the conflict — the primitive images, ideas, feelings inherent in man as a bearer of the collective unconscious.

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SOCIAL CONFLICT: ARCHETYPAL NATURE AND RESOLUTION MECHANISM

UKRAINIAN ASSEMBLY OF DOCTORS OF SCIENCES IN PUBLIC ADMINISTRATION ◽

10.31618/vadnd.v1i12.70 ◽

2018 ◽

Vol 1 (12) ◽

pp. 294-305

Author(s):

Ruslan Rafisovich Hasanov

Keyword(s):

Social Life ◽

Social Space ◽

Interpersonal Relations ◽

Human Life ◽

Social Groups ◽

Optimal Solution ◽

Modern Society ◽

Constructive Development ◽

The Social ◽

Interdisciplinary Knowledge

On the basis of the archetypic analysis of development trends of a conflictological paradigm the author’s model of minimization of conflict potential in modern society is offered. Institutional construction is the basis for model that is harmonized with a factor of societal identity. It is noted that the problems of social conflicts, according to data from monitoring studies of the Ukrainian school of archetype, are increasingly shifted into the sphere of interpersonal relations. It is stimulated by the progression in society of so-called self-sufficient personalities, the “subjectification” of the social space, and at the same time narrowing down to the solution of entirely specific situations in which there is a collision of the interests of two or more parties. Instead, in order to find the optimal solution for resolving the conflict, it is necessary to have interdisciplinary knowledge, in particular understanding of the deep nature of such conflicts. Collision of points of view, thoughts, positions — a very frequent phenomenon of modern social life. In order to develop the correct line of behavior in various conflict situations, it is important to adequately understand the nature of the emergence of the modern conflict and the mechanisms for resolving them in substance. Knowledge of conflict nature enriches the culture of communication and makes human life and social groups not only more calm, but also creates conditions for constructive development. It is proved that in modern life one can not but agree with the statement that an individual carries first responsibility for his own life and only then for the life of the social groups to which he belongs. And while making decisions within the framework of modern mechanisms (consensus), the properties of human psychology such as extroversion, emotionality, irrationality, intuition, externality, and executive ability will not at least contribute to such a task. That is why in the author’s research attracted attention to the archetypal nature of the conflict — the primitive images, ideas, feelings inherent in man as a bearer of the collective unconscious.

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Faculty Opinions recommendation of The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725390605.793505391 ◽

2015 ◽

Author(s):

Toshihiro Nakajima ◽

Satoko Aratani

Keyword(s):

Immune System ◽

Genetic Architecture ◽

Human Immune System ◽

Disease Pathogenesis ◽

System A ◽

Human Immune

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Mother Culture, Meet Mother Nature

10.1093/oso/9780199367511.003.0017 ◽

2018 ◽

Author(s):

Luc Faucher ◽

Pierre Poirier

Keyword(s):

Evolutionary Algorithms ◽

Cultural Change ◽

Evolutionary Information ◽

Multiple Forms ◽

Human Immune System ◽

Units Of Selection ◽

Pluralistic Approach ◽

Human Immune ◽

Plausible Theory ◽

Different Time Scales

Research on the adaptive characteristics of the human immune system reveals that evolutionary algorithms are not strictly matters of replication. And research in genomics suggests that there is no a single source of evolutionary information that carries the same content in every environment. A plausible theory of cultural evolution must acknowledge the possibility that multiple selective algorithms are operating at different time-scales, on different units of selection, with different logical structures; but it must explain how different selective processes are interfaced to yield culturally stable phenomena. This paper advances an empirically plausible approach to memetics that recognizes a wider variety of evolutionary algorithms; and it advances a pluralistic approach to cultural change. Finally, it shows that multiple forms of processing, operating at different timescales, on different units of selection, collectively sustain the human capacity to form and use certain types of representations.

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Esteem and self-esteem as an interweaving polarity. Max Weber´s analysis from the Protestant ethic to the ideal-type of politician

Human Affairs ◽

10.1515/humaff-2020-0031 ◽

2020 ◽

Vol 30 (3) ◽

pp. 353-364

Author(s):

Cristiana Senigaglia

Keyword(s):

Social Life ◽

Max Weber ◽

Modern Society ◽

Self Esteem ◽

Protestant Ethic ◽

Social Reputation ◽

Conduct Of Life ◽

The Social ◽

The Relationship ◽

The Ideal

AbstractAlthough Max Weber does not specifically analyze the topic of esteem, his investigation of the Protestant ethic offers interesting insights into it. The change in mentality it engendered essentially contributed to enhancing the meaning and importance of esteem in modern society. In his analysis, Weber ascertains that esteem was fundamental to being accepted and integrated into the social life of congregations. Nevertheless, he also highlights that esteem was supported by a form of self-esteem which was not simply derived from a good social reputation, but also achieved through a deep and continual self-analysis as well as a strict discipline in the ethical conduct of life. The present analysis reconstructs the different aspects of the relationship between social and self-esteem and analyzes the consequences of that relationship by focusing on the exemplary case of the politician’s personality and ethic.

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Metabolic Swifts Govern Normal and Malignant B Cell Lymphopoiesis

International Journal of Molecular Sciences ◽

10.3390/ijms22158269 ◽

2021 ◽

Vol 22 (15) ◽

pp. 8269

Author(s):

Aikaterini Poulaki ◽

Stavroula Giannouli

Keyword(s):

B Cell ◽

B Lymphocytes ◽

Control Program ◽

Memory B Cells ◽

Immunologic Memory ◽

Human Immune System ◽

B Cell Malignancies ◽

Stringent Control ◽

Human Immune ◽

New Research

B lymphocytes are an indispensable part of the human immune system. They are the effective mediators of adaptive immunity and memory. To accomplish specificity against an antigen, and to establish the related immunologic memory, B cells differentiate through a complicated and strenuous training program that is characterized by multiple drastic genomic modifications. In order to avoid malignant transformation, these events are tightly regulated by multiple checkpoints, the vast majority of them involving bioenergetic alterations. Despite this stringent control program, B cell malignancies are amongst the top ten most common worldwide. In an effort to better understand malignant pathobiology, in this review, we summarize the metabolic swifts that govern normal B cell lymphopoiesis. We also review the existent knowledge regarding malignant metabolism as a means to unravel new research goals and/or therapeutic targets.

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721 AT1412, a patient-derived CD9 antibody in preclinical development promoting tumor immune infiltration and inducing tumor rejection

Journal for ImmunoTherapy of Cancer ◽

10.1136/jitc-2020-sitc2020.0721 ◽

2020 ◽

Vol 8 (Suppl 3) ◽

pp. A763-A763

Author(s):

Remko Schotte ◽

Julien Villaudy ◽

Martijn Kedde ◽

Wouter Pos ◽

Daniel Go ◽

...

Keyword(s):

T Cells ◽

Immune System ◽

T Cell ◽

Tumor Cells ◽

Tumor Rejection ◽

Human Immune System ◽

Preclinical Development ◽

High Affinity ◽

Human Immune ◽

A375 Melanoma

BackgroundAdaptive immunity to cancer cells forms a crucial part of cancer immunotherapy. Recently, the importance of tumor B-cell signatures were shown to correlate with melanoma survival. We investigated whether tumor-targeting antibodies could be isolated from a patient that cured (now 13 years tumor-free) metastatic melanoma following adoptive transfer of ex vivo expanded autologous T cells.MethodsPatient‘s peripheral blood B cells were isolated and tested for the presence of tumor-reactive B cells using AIMM’s immmortalisation technology. Antibody AT1412 was identified by virtue of its differential binding to melanoma cells as compared to healthy melanocytes. AT1412 binds the tetraspanin CD9, a broadly expressed protein involved in multiple cellular activities in cancer and induces ADCC and ADCP by effector cells.ResultsSpontaneous immune rejection of tumors was observed in human immune system (HIS) mouse models implanted with CD9 genetically-disrupted A375 melanoma (A375-CD9KO) tumor cells, while A375wt cells were not cleared. Most notably, no tumor rejection of A375-CD9KO tumors was observed in NSG mice, indicating that blockade of CD9 makes tumor cells susceptible to immune rejection.CD9 has been described to regulate integrin signaling, e.g. LFA-1, VLA-4, VCAM-1 and ICAM-1. AT1412 was shown to modulate CD9 function by enhancing adhesion and transmigration of T cells to endothelial (HUVEC) cells. AT1412 was most potently enhancing transendothelial T-cell migration, in contrast to a high affinity version of AT1412 or other high affinity anti-CD9 reference antibodies (e.g. ALB6). Enhanced immune cell infiltration is also observed in immunodeficient mice harbouring a human immune system (HIS). AT1412 strongly enhanced CD8 T-cell and macrophage infiltration resulting in tumor rejection (A375 melanoma). PD-1 checkpoint blockade is further sustaining this effect. In a second melanoma model carrying a PD-1 resistant and highly aggressive tumor (SK-MEL5) AT1412 together with nivolumab was inducing full tumor rejection, while either one of the antibodies alone did not.ConclusionsThe safety of AT1412 has been assessed in preclinical development and is well tolerated up to 10 mg/kg (highest dose tested) by non human primates. AT1412 demonstrated a half-life of 8.5 days, supporting 2–3 weekly administration in humans. Besides transient thrombocytopenia no other pathological deviations were observed. No effect on coagulation parameters, bruising or bleeding were observed macro- or microscopically. The thrombocytopenia is reversible, and its recovery accelerated in those animals developing anti-drug antibodies. First in Human clinical study is planned to start early 2021.Ethics ApprovalStudy protocols were approved by the Medical Ethical Committee of the Leiden University Medical Center (Leiden, Netherlands).ConsentBlood was obtained after written informed consent by the patient.

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