scholarly journals Levels of marker lysosomal hydrolases in women with coronary heart disease depending on age and sex hormone level

2021 ◽  
Vol 17 (1) ◽  
pp. 21-28
Author(s):  
O. V. Tsygankova ◽  
N. E. Evdokimova ◽  
Yu. I. Ragino ◽  
L. D. Latyntseva ◽  
V. V. Veretyuk ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cathepsin D ◽  
Lysosomal Enzymes ◽  
Age Groups ◽  
Lysosomal Hydrolases ◽  
Anthropometric Parameters ◽  
Negative Effect ◽  
Acid Dnase ◽  
High Level

Aim of the study was to evaluate the serum concentrations of three marker lysosomal hydrolases (cathepsin D, acid phosphatase (AP) and acid DNase (aDNAase)) in women with coronary heart disease (CHD) depending on the level of follicle-­stimulating hormone (FSH), testosterone (T), age and find if those parameters associated with anthropometric parameters, glycemia, insulinemia and HOMA-IR index, biomarkers of atherosclerosis. The study included 285 women aged 35–65 years (median age was 54.4 years (25% and 75% percentiles — 43.2 and 61.3 years, respectively) who had had myocardial infarction no earlier than 30 days before the examination. Patients were divided into the following age groups: 35–55 and 56–65 years (first and second age groups, respectively), and into groups according to the levels of sex hormones: FSH ≥ and <30 mIU/mL and testosterone ≥ and <3 nmol/L. Results of comparative and correlation analyzes demonstrates that in women 35–65 years old with FSH ≥30 mIU/mL, the levels of cathepsin D are higher (p<0.05) than in patients with FSH <30 mIU/mL, and in women 35–55 years old, the content of AP was also higher (p=0.025). Associations of a high level of androgen with lysosomal hyperenzymemia were demonstrated only in the second age group, where at a level of T ≥3 nmol/L, higher values of all three lysosomal enzymes were recorded. Multivariate analysis in both age groups is confirmed direct impact of periand postmenopausal periods on the levels of lysosomal enzymemia and, accordingly, a negative effect on the state of lysosomal membranes. Thus, FSH levels directly determined the concentrations of AP and cardiotropic cathepsin D. The levels of aDNAase in women with CHD of 56–65 years of age were positively correlated with indicators that determine insulin-­glucose homeostasis: glycemia (p<0.001), HOMA-IR index (p<0.001). Such associations of three marker lysosomal enzymes demonstrate the primary contribution of FSH ≥30 mIU/mL to an increase in the concentration of lysosomal hydrolases in women with CHD35–65 years old and the correlation of aDNAase with the processes triggered by insulin resistance.

Medical service demands of older patients in different age groups in a new model of free Telemedicine

2020 ◽  
Author(s):  
Yu Gong ◽  
Jianyuan Zhou
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
Older Patients ◽  
Medical Service ◽  
Age Groups ◽  
New Model

Abstract Background Medical service for the older patients is a worldwide challenge for public health system. Telemedicine can provide convenient and effective medical service for older patients. But the existing telemedicine models rely upon a direct communication between a doctor and a patient via the Internet but the doctor would be unable to give the patient a direct physical examination, it may lead to diagnostic errors. A new model of telemedicine jointly performed by general practitioners in community health centers and specialists in a university teaching hospital has been established. It is supervised by the government health department and is free for older patients. However, medical service demands of older patients in different age groups applying the new telemedicine are not well characterized. This study is to analyze medical service demands of older patients in different age groups applying the new telemedicine. Methods 472 older patients (aged ≥ 60) were enrolled and were divided into the young older group (aged 60 to 74), the old older group (aged 75 to 89) and the very old group (aged ≥ 90) according to the age stratification for older people defined by World Health Organization. Proportion of the top 10 diseases of older patients of different age groups was analyzed. Results Coronary heart disease and type 2 diabetes mellitus were identified as the top two diseases in the older patients and the young older patients as well as the old older patients applying the new telemedicine. Conclusions The new telemedicine model can provide effective free medical services to older patients. Different medical service demands were identified in different age groups of older patients. Coronary heart disease and type 2 diabetes mellitus were the main diseases of the older patients and young older patients as well as the old older patients applying the new telemedicine. Results of this study will provide basis for the health administrative departments to formulate health policies for older patients. Familiar with the main diseases in different age groups of older patients may provide better medical services to older patients.

Changes Of Plasma Thromboxane B22 And Cyclic Nucleotides At Exercise Test In Patients Of Coronary Heart Disease

1981 ◽  
Author(s):  
F Numano ◽  
M Yajima ◽  
T Hosaka ◽  
K Nishiyama ◽  
K Shimokado ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Treadmill Exercise ◽  
Poor Response ◽  
Vascular Wall ◽  
Treadmill Test ◽  
Haemodynamic Change ◽  
Previous Level ◽  
High Level ◽  
Camp And Cgmp

To search the response of vascular wall at exercise, submaximal treadmill test was performed in 30 patients with the complaint of chest pain and plasma thromboxane B2(TXB2), cyclic AMP(cAMP) and cyclic GMP(cGMP) levels were measured before, immediately and 30 minutes after the test by radioimmunoassay. Using Hollenberg’s treadmill exercise score modified by us. 15 patients were judged as “positive” (P- group) and others as “negative” (N-group). Plasma levels of TXB2 in P-group were 262.4 ± 30.9 pg/ml, a statistically high level as compared with 186.7 ± 17.5 in N-group. In N-group no changes of plasma TXB2 levels were recognized after exercise. However, in P-group this level revealed a statistically significant decrease immediately after exercise and restored to the previous level 30 minutes after exercise. Although there were high levels of both cAMP and cGMP in N-group (cAMP: 11.9 ± 1.0 pmoles/ml; cGMP: 3.1 ± 0.5), as compared with these in P-group (10.9 ± 1.5, 2.6 ± 0.5), the significance was not statistical. However, in N-group levels of cAMP and cGMP increased significantly immediately after exercise and restored to the levels before test. On the other hand, no significant changes of these levels were found in P-group. These data may suggest that the poor response of vascular wall for haemodynamic change exists in patients of coronary heart disease which breaks the exquisite balance of the interrelationship between platelets and vascular wall.

scholarly journals No-Synthase Activity in Patients with Coronary Heart Disease Associated with Hypertension of Different Age Groups/ Aktivnost no-sintaze kod pacijenata s koronarnom bolešću srca povezanom s hipertenzijom kod različitih starosnih grupa

2016 ◽  
Vol 35 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Anna Besedina
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Age Groups ◽  
No Synthase ◽  
Control Group ◽  
Aged Patients ◽  
Inos Activity ◽  
Major Mechanism ◽  
Enos Activity

SummaryBackground: Coronary heart disease is the leading cause of death and disability worldwide. Hypertension is a major independent risk factor for the development of CHD. Abnormalities in NO generation or activity have been proposed as a major mechanism of CHD. The purpose of this article is to determine the activity of eNOS and iNOS in patients with isolated CHD and CHD associated with HT of different age groups.Methods: Fifty patients with isolated CHD and 42 patients with CHD associated with HT were enrolled in this study. NOS activity was determined by nitrite anion formed in the reaction.Results: A statistically significant increase in iNOS activity is observed in elderly donors. In patients with isolated coronary heart disease cNOS activity is statistically significantly reduced with respect to the control group. The reduction of enzymatic activity of cNOS is more expressed in elderly patients than in middle-aged patients with coronary heart disease. Alterations in eNOS activity are more expressed in patients with coronary heart disease associated with hypertension than in patients with isolated coronary heart disease. Against the background of cNOS inhibition in the patients, a sharp increase in iNOS activity is observed.Conclusions: It has been shown that disturbance of endo - thelial function in patients with coronary heart disease associated with hypertension is characterized by reduced endothelial NO synthesis by cNOS and increased systemic NO synthesis due to increased iNOS activity. It has been found that the lack of endothelial NO and hyperproduction of »harmful« NO by iNOS are more expressed in elderly patients.

scholarly journals LDL-C/HDL-C and carotid plaques in patients with coronary heart disease: A Chinese cohort study

2021 ◽  
Author(s):  
Zhu Li ◽  
Qi Cheng ◽  
Yijia Liu ◽  
Xufeng Cheng ◽  
Shuo Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Large Scale ◽  
Healthy Lifestyle ◽  
Density Lipoprotein ◽  
Estimating Equation ◽  
Carotid Plaques ◽  
Cholesterol Ratio ◽  
Beneficial Effects ◽  
High Level

Abstract Background: Evidence of the association the low-/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) with the carotid plaques remains limited. The purpose of this study is to examine the association between LDL-C/HDL-C and carotid plaques of coronary heart disease (CHD), and to study what extent a healthy lifestyle reduces the risk of carotid plaques.Methods: In this large-scale and multi-center retrospective study, a total of 9,426 participants to explore the association between LDL-C/HDL-C and carotid plaques. No smoking and no drinking were considered healthy lifestyle. Generalised estimating equation models and conditional logistic regressions were used in statistical analyses.Results: In all the 9,426 participants, there were 6,989 (74.15%) patients having identified carotid plaques. High levels of LDL-C/HDL-C had a higher risk of carotid plaques than other lipid variables (OR:1.63; 95%CI:1.43-1.86). In stratified analyses by LDL-C/HDL-C triplet, participants in the LDL-C/HDL-C (＞3mmol/L) group had a higher risk of carotid plaques compared to other two groups. Compared with the unfavourable lifestyle, intermediate lifestyle or favourable lifestyle was associated with a significant 30% or 67% decrease in carotid plaques risk among patients with the LDL-C/HDL-C(＞3mmol/L) respectively. There were significantly additive and multiplicative interactions between lifestyle and LDL-C/HDL-C on carotid plaques.Conclusion: Our findings provide evidence that a high level of LDL-C/HDL-C can increase the risk of carotid plaques in patients with CHD. And adhering to a healthy lifestyle has additive beneficial effects on reducing the risk of carotid plaques.

scholarly journals Chronic obstructive pulmonary disease in patients with coronary heart disease of elderly age groups

2020 ◽  
pp. 19-19
Author(s):  
G.P. Voinarovska ◽  
E.O. Asanov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Old Age ◽  
Age Groups ◽  
The Elderly ◽  
Chronic Obstructive ◽  
Bronchial Obstruction ◽  
Obstructive Pulmonary Disease

Background. Among the combinations of comorbid conditions, a special role belongs to the combination of coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD). Because COPD is often associated with CHD, most authors believe that there is a direct link between COPD, progression of bronchial obstruction, and pathological conditions of the cardiovascular system, including mortality from myocardial infarction. In elderly patients, according to some researchers, the link between COPD and CHD is most pronounced. Objective. To establish the frequency of COPD in patients with CHD in older age groups. Materials and methods. The studies are based on the results of a comprehensive survey of 635 patients with CHD aged 60-89 years, who were observed for a long time of the State Institution “Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine”. Results and discussion. The share of patients with CHD in whom COPD was detected in the group of elderly people is 19.4 %. This is much more than the average population. The frequency of COPD in patients with CHD decreases significantly with further aging. The prevalence of COPD among elderly patients is much lower than among elderly patients. This can most likely be explained by the fact that a significant proportion of patients with CHD with COPD do not live to old age. The analysis revealed that in elderly patients there is bronchial obstruction of more severe stages. This is due to the fact that CHD patients with COPD who live to old age have worsening bronchial patency due to the longer duration of the disease. It has been established that the majority of patients with CHD with COPD, both elderly and senile, are male. This can be explained by the negative effects of smoking. Conclusions. The incidence of COPD in patients with CHD in the elderly is much higher than in the population. At the same time, the incidence of COPD among patients with CHD in the elderly is much lower than among the elderly. In patients of advanced age bronchial obstruction is more expressed.

scholarly journals RELATION OF ANTHROPOMETRIC INDEXES AND CORONARY HEART DISEASE

2018 ◽  
Vol 17 (3) ◽  
pp. 11-16 ◽  
Author(s):  
S. A. Shalnova ◽  
A. D. Deev ◽  
G. A. Muromtseva ◽  
J. A. Balanova ◽  
A. E. Imaeva ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Odds Ratio ◽  
Roc Analysis ◽  
Visceral Obesity ◽  
Anthropometric Parameters ◽  
Obesity Index ◽  
Study Evaluation ◽  
Oncological Diseases ◽  
Anthropometric Indexes

An epidemics of obesity in the world during recent two decades, has already led to increased prevalence of diabetes, metabolic syndrome, oncological diseases, etc. Obesity is assessed with a variety of indexes, and recently the number of such tools was added with the two additional: visceral obesity index (VOI) and index of lipid products deposition (ILPD). The aim of the study — evaluation of the relation of anthropometric parameters with coronary heart disease. Materials of the study were representative selections from 13 regions of the ESSE-RF trial. In analysis of associations of body mass index (BMI), waist circumference (WC), relation of WC to height (WC/height x 100), VOI and IPLD with correction on the age and region, it was found that all studied parameters are significantly correlated with ischemic heart disease, however when the main risk factors were added, only two remained — odds ratio (95% confidence interval) for: WC/height×100 — 1,030 (1,019;1,040) (р<0,0001) and VOI — 1,053 (1,020;1,087) (р<0,0015) in males and WC/height×100 — 1,027 (1,021;1,033) (р<0,0001) and VOI — 1,052 (1,022;1,083) (р<0,0007) in females. It is important to note almost identical values of odds ratio for the indexes in both sexes. Reliability of the models obtained is confirmed by ROC analysis, where the area under curve for males was 0,68 and for females 0,67. The results witness on legitimacy of search for novel parameters of obesity that would have good reproducibility and are also simple and easy to use.

scholarly journals Apo(a) isoforms do not predict risk for coronary heart disease in a Gulf Arab population

2000 ◽  
Vol 37 (3) ◽  
pp. 360-366 ◽  
Author(s):  
Abayomi O Akanji
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sodium Dodecyl ◽  
Enzyme Linked Immunosorbent Assay ◽  
Simple Relationship ◽  
Atherosclerotic Vascular Disease ◽  
Anthropometric Parameters ◽  
Arab Population ◽  
Ethnic Grouping ◽  
Chd Risk

It is well recognized that blood lipoprotein A [Lp(a)] levels constitute an important risk factor for atherosclerotic vascular disease. In some populations, mainly Caucasian, Lp(a) levels and coronary heart disease (CHD) risk are determined by the pattern of apolipoprotein a [apo(a)] polymorphism. It is currently unclear if these observations apply to other populations and ethnic groups. The aim of the current study is to determine to what extent known apo(a) polymorphisms associate with development of CHD in a Kuwaiti Arab population. Serum Lp(a) levels were measured by enzyme-linked immunosorbent assay and apo(a) isoforms determined by a high-resolution sodium dodecyl sulphate/agarose gel electrophoresis with immunoblotting in two groups of Kuwaiti subjects: healthy controls ( n = 140) and subjects with CHD ( n=140). Blood lipids and anthropometric parameters were also determined in these subjects by standard methods. Serum Lp(a) levels were greater in those with CHD than in those in the healthy group ( P<0·001). There was no consistent trend in the pattern of serum Lp(a) levels found with specific apo(a) isoforms in either group of subjects. There was, therefore, no simple relationship between the isoform pattern (and number of kringle-IV repeats) and serum Lp(a) concentration, unlike in certain other populations. Additionally, almost identical proportions of subjects in either group had singlebanded (homozygous, ~ 70%), double-banded (heterozygous, ~ 23%) and no-band (null, ~ 7%) phenotypes. The distribution of the five identified isoforms (F, S1, S2, S3 and S4) also was almost identical for both groups of subjects, whether homozygous or heterozygous, and whether classified into fast-moving (F, S1 and S2) or slow-moving (S3 and S4) isoforms. We conclude that the frequency and pattern of distribution of apo(a) phenotypes did not differ significantly between healthy control Kuwaiti Arab subjects and those with CHD. It is thus unlikely that an individual's apo(a) phenotype can predict both serum Lp(a) level and risk for CHD, irrespective of race and/or ethnic grouping.

scholarly journals Clinically Classified Periodontitis and Its Association in Patients with Preexisting Coronary Heart Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-9
Author(s):  
Nikolaos A. Chrysanthakopoulos ◽  
Panagiotis A. Chrysanthakopoulos
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Analysis Model ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Related Information ◽  
Probing Pocket Depth ◽  
Health Related ◽  
High Level

The aim of this retrospective study was to investigate possible associations between clinically classified periodontitis as determined by assessing its severity and diagnosed coronary heart disease in outpatients referred to a specialist clinic for neurosurgery treatment. A total of 2,912 individuals were clinically examined for periodontal disease experience by using probing pocket depth (PPD) and clinical attachment loss (CAL). Socioeconomic, oral health behaviour, and general health related information was collected by using a self-administered questionnaire. Statistical analysis of the questionnaire items was performed by using multivariate logistic regression analysis model. The results showed that the occurrence of hypertension (OR=2.42, 95% CI = 1.52–3.84), smoking (OR=1.97, 95% CI = 1.25–3.11), classified periodontitis (OR=1.79, 95% CI = 1.15–2.77), and the high level of serum C-reactive protein (OR=1.74, 95% CI = 1.05–2.89) were significantly associated with the presence of coronary heart disease. These observations strengthen the role of some of the traditional causative risk factors for coronary heart disease while a significant association was recorded between diagnosed coronary heart disease and clinically classified periodontitis which is considered as a risk factor for coronary heart disease.

The impact of smoking in elderly people

1999 ◽  
Vol 9 (3) ◽  
pp. 273-280 ◽  
Author(s):  
Norman J Vetter
Keyword(s):  
Lung Cancer ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Causes Of Death ◽  
Age Groups ◽  
The Elderly ◽  
Death Rates ◽  
Younger Age ◽  
Prevention Programmes ◽  
The Impact

Smoking has been closely implicated in many cardiovascular, lung and other diseases which are prevalent in the elderly, but most prevention programmes tend to be aimed at younger age groups.The prevention of smoking in retired people is a subject which is not yet fully researched, but there is a little information which suggests that it may be a worthwhile pursuit. Certainly, work has shown that longevity can be improved even in older people by stopping smoking. Coronary heart disease death rates for 65-74 year olds who have recently given up are similar to non-smokers. For other causes of death, especially lung cancer and bronchitis, the benefits of stopping smoking take up to five years to appear. In terms of morbidity, there are suggestions that ex-smokers move reasonably quickly towards the state of non-smokers for bone density, pulmonary function and muscle strength.

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