scholarly journals Regenerative Medicine Requires A Paradigm Shift In Outcome Measures

2021 ◽  
Vol 2 (1) ◽  
pp. 1-15
Author(s):  
Gordon Slater
2014 ◽  
Vol 26 (19) ◽  
pp. 3024-3034 ◽  
Author(s):  
Abhigyan Satyam ◽  
Pramod Kumar ◽  
Xingliang Fan ◽  
Alexander Gorelov ◽  
Yury Rochev ◽  
...  

2021 ◽  
Author(s):  
David B. Berry ◽  
Erin K. Englund ◽  
Shaochen Chen ◽  
Lawrence R. Frank ◽  
Samuel R. Ward

This review discusses key outcome measures for TERM constructs and various imaging techniques that can be used to assess them.


2021 ◽  
Vol 2 ◽  
Author(s):  
Qasem Ramadan ◽  
Mohammed Zourob

3D printing technology has emerged as a key driver behind an ongoing paradigm shift in the production process of various industrial domains. The integration of 3D printing into tissue engineering, by utilizing life cells which are encapsulated in specific natural or synthetic biomaterials (e.g., hydrogels) as bioinks, is paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds' new frontiers in medicine, pharmaceutical, and food industries. Here, we present a synthesis of the available 3D bioprinting technology from what is found and what has been achieved in various applications and discussed the capabilities and limitations encountered in this technology.


2020 ◽  
Vol 40 (5) ◽  
pp. 1132-1134 ◽  
Author(s):  
Brooke Bonsack ◽  
Rays HY Jiang ◽  
Cesar V Borlongan

Peripheral inflammatory responses accompany many neurological disorders, including stroke. The gut-brain axis opens new avenues in our understanding of stroke progression and abrogation of secondary cell death. Certain microbiomes, especially those related to inflammation, appear to closely reflect the homeostasis and dysbiosis of both the brain and the gut, suggesting their potential application as biomarkers and therapeutic targets. A paradigm shift from purely central towards incorporating peripheral sequestration of cell death pathways may improve stroke therapeutic outcomes. Recognizing this gut-brain axis as key to disease pathology and treatment is likely to usher innovative approaches in cell-based regenerative medicine for stroke.


2017 ◽  
Vol 20 (1) ◽  
Author(s):  
Jonathan P. Mochel ◽  
Albert E. Jergens ◽  
Dawn Kingsbury ◽  
Hyun Jung Kim ◽  
Martín G. Martín ◽  
...  

2019 ◽  
Vol 37 (3) ◽  
pp. 11-12
Author(s):  
P. R. Van Weeren

Regenerative medicine aims at restoring or improving lost or affected functions of the body by stimulating the inherent healing capacity of tissues. The central paradigm of tissue engineering is that such repair is facilitated and enhanced using several approaches that may range from application of biologically active products (such as growth factor containing platelet rich plasma (PRP) or stem cells from a variety of sources) to the use of biofabricated implants. In all cases the aim is that in the end the body’s own healing capacity will result in the production of tissues that are identical to or at least functionally equivalent to the original tissues of which the function has been (partially) lost. In the case of the use of biofabricated implants, these are meant as temporary scaffolds that will stimulate the body’s own cells through a variety of cues but are destined to finally degrade and be replaced by newly made tissue. Ideally, this is a well-balanced gradual process in which there is a match between the disappearance (and loss of biological effect) of the engineered tissues and the formation (and increased biological effect) of the native tissues that replace the implant.There are many examples of successful applications of this theory, e.g. in the areas of bladder reconstruction (Londono & Badylak 2015). However, recently, it has become clear that this concept (and hence the paradigm) does not hold for articular cartilage because the collagen network, which is crucial for the biomechanical functions of articular cartilage, will, once damaged, not be reconstituted to any degree in mature individuals (Heinemeier et al. 2016). For this reason, a paradigm shift is necessary in the field of regenerative medicine of articular cartilage and attempts at tissue engineering in this field will have to be redirected. There are in principle two ways to achieve such a paradigm shift: either by recreating the tissue homeostatic and (epi)genetic environment as present in fetuses and young, growing, individuals in which remodeling of the collagen network is still possible, or by adopting Nature’s approach in the mature individual, i.e. by creating a life-long persisting, immutable structural component of articular cartilage. Both ways face considerable challenges before they can become reality.


2003 ◽  
Vol 11 (2) ◽  
pp. 7-9
Author(s):  
Linda M. Thibodeau
Keyword(s):  

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