scholarly journals «Վահագնի երգը» և հայկական էպոսը Նոր տեսակետ հայկական էպոսի ծագման և ձևավորման վերաբերյալ

2021 ◽  
pp. 148-168
Author(s):  
Արմեն Պետրոսյան
Keyword(s):  
Multiple Recurrences

Multiple recurrences of the sound combination erk- in the ancient Armenian hymn on the birth of Vahagn, the god of thunder and war, can be considered an anagram of the word erku (two) with an allusion to twins. Moreover, in the expression cov cirani (purple sea) one can see an anagram of Covinar, the name of the mother of the epic twins Sanasar and Baghdasar, first heroes of the epic "Daredevils of Sassoun". In this context it becomes obvious that the image of Sanasar, the elder of the twins, founder of the dynasty of heroes, directly goes back to Vahagn. The same picture of the birth of mythological twins occurs in the ancient epic “Vipasank”.

scholarly journals Identification of KRAS G12V associated clonal neoantigens and immune microenvironment in long-term survival of pancreatic adenocarcinoma

2021 ◽  
Author(s):  
Chao Wang ◽  
Min Shi ◽  
Lei Zhang ◽  
Jun Ji ◽  
Ruyan Xie ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Genomic Analysis ◽  
Molecular Characteristics ◽  
Immune Microenvironment ◽  
Term Survival ◽  
Long Term Survival ◽  
Tumor Immune Microenvironment ◽  
Genetic Features ◽  
Multiple Recurrences

Abstract Objective To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). Methods The tumor related genetic features of a female PAAD patient (over 13-year survival) who suffered from multiple recurrences and metastases, and six operations over one decade were investigated deeply. Genomic features and immune microenvironment signatures of her primary lesion as well as six metastatic tumors at different time-points were characterized. Results High-frequency clonal neoantigenic mutations identified in these specimens revealed the significant associations between clonal neoantigens with her prognosis after each surgery. Meanwhile, the TCGA and ICGC databases were employed to analyse the function of KRAS G12V in pancreatic cancer. Conclusions The genomic analysis of clonal neoantigens combined with tumor immune microenvironment could promote the understandings of personalized prognostic evaluation and the stratification of resected PAAD individuals with better outcome.

scholarly journals EPID-10. EPIDEMIOLOGY STUDY OF UNCOMMON CHILDHOOD BRAIN TUMOURS IN ASIAN CHILDREN

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii320-iii320
Author(s):  
Godfrey Chi-Fung Chan ◽  
Anthony Pak-Yin Liu ◽  
Matthew Ming-Kong Shing ◽  
Dennis Tak-Noi Ku
Keyword(s):  
Choroid Plexus ◽  
Brain Tumours ◽  
Clinical Characteristics ◽  
Interferon Beta ◽  
Choroid Plexus Papilloma ◽  
Epidemiology Study ◽  
Childhood Brain Tumours ◽  
Post Surgery ◽  
Asian Children ◽  
Multiple Recurrences

Abstract Our local registry identified 656 brain tumours from Jan 1999 to Dec 2018, (incidence: 29.8/yr/million). Other from Glioma, Medulloblastoma/PNET, Germ Cell tumours, Ependymoma, the remaining rarer tumours accounted for 18% (n=118). The 7 more common groups are: craniopharyngioma(n=28); ATRT(n=18); choroid plexus papilloma/CA(n=12); Ganglioglioma(n=11); ETMR(n=7); DNET(n=7); meningioma(n=6). Their respective incidences are 1.27; 0.81; 0.55; 0.5; 0.32; 0.32 0.27/yr/million. For craniopharyngioma, M:F=15:13 and median age was 7.4yrs (2mons-16.5yrs). 12/28 children had surgery alone and 13/28 had focal RT post-surgery with better outcome. 3 underwent intra-cystic interferon-beta also stable. For ATRT, M:F=7:8 and median age was 2.3yrs (4mos-14.2yrs). 2 had metastatic disease and 7/18 patients remained alive. For choroid plexus tumours, there were 7 papilloma, 2 atypia and 3 carcinoma. M:F=5:6 and median age was 1.5yrs (4mos-14yrs). All papilloma, 1/2 atypia and 1/3 carcinoma survived. For ganglioglioma, M:F=7:4 with median age of 5.5yrs (5mos-13.2yrs). They commonly presented with seizure and only one died (brainstem primary). The ETMR includes ependymoblastoma and medulloepithelioma, they had quite different clinical characteristics and outcome. 6/7 DNET had convulsion and M:F=6:1. Median age was 11.5yrs (2.66-14yrs). They all survived even if incompletely resected. For meningioma, 1/6 had germline mutation of NF-2 gene. M:F=3:3 and onset was >8yrs except the NF-2 patient. All survived but the NF-2 had multiple recurrences. 4 patients developed secondary meningioma due to irradiation but they were >18yrs so excluded. In summary, rarer forms of childhood brain tumours only accounted for <20% of all brain tumours and they had diverse presenting features and outcome.

scholarly journals The local spread of pheochromocytoma after adrenalectomy with a rupture of the tumor capsule at the time of the surgery

Open Medicine ◽  
2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Ryszard Pogorzelski ◽  
Sadegh Toutounchi ◽  
Patryk Fiszer ◽  
Ewa Krajewska ◽  
Izabela Łoń ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Chromaffin Cell ◽  
Cell Tumor ◽  
Cell Seeding ◽  
Case Presentation ◽  
Tumor Capsule ◽  
Exact Localization ◽  
Local Spread ◽  
The Right ◽  
Multiple Recurrences

AbstractIntroduction: We present a case of a 29-year-old patient treated due to fully symptomatic pheochromocytoma of the right adrenal gland. Case presentation: Patient was operated on and an open right-sided adrenalectomy was performed. At the time of the surgery, a rupture of the tumor capsule occurred. Five years post-operatively, a recurrence of the symptoms of chromaffin-cell tumor was noted. After the exact localization of the multiple recurrences, the patient was reoperated on. Conclusion: The case of pheochromocytoma is presented due to the possibility of chromaffin-cell seeding into the peritoneum, with no signs of distal metastases so far.

Impact of Early-Onset Acute Otitis Media on Multiple Recurrences and Associated Health Care Use

2016 ◽  
Vol 177 ◽  
pp. 286-291.e1 ◽  
Author(s):  
Marieke L.A. de Hoog ◽  
Alexandre C. Fortanier ◽  
Henriette A. Smit ◽  
CunoS.P.M. Uiterwaal ◽  
Cornelis K. van der Ent ◽  
...  
Keyword(s):  
Health Care ◽  
Otitis Media ◽  
Early Onset ◽  
Acute Otitis Media ◽  
Health Care Use ◽  
Multiple Recurrences

The Impact of Multiple Recurrences in Disease-Free Survival of Breast Cancer: An Extended Cox Model

2012 ◽  
Vol 98 (4) ◽  
pp. 428-433 ◽  
Author(s):  
Mahmood Reza Gohari ◽  
Reza Khodabakhshi ◽  
Javad Shahidi ◽  
Zeinab Moghadami Fard ◽  
Hossein Foadzi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cox Model ◽  
Disease Free Survival ◽  
Free Survival ◽  
Multiple Recurrences ◽  
The Impact ◽  
Disease Free ◽  
Extended Cox Model

Thyroid Abscess in Childhood

PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 465-467
Author(s):  
N. Olatunji Olambiwonnu ◽  
Robert Penny ◽  
S. Douglas Frasier
Keyword(s):  
Recent Article ◽  
Thyroid Nodules ◽  
Clinical Course ◽  
Low Grade ◽  
Anterior Portion ◽  
Thyroid Abscess ◽  
Multiple Recurrences

In a recent article by Kirkland et al.1 describing the nature of solitary thyroid nodules in 30 children, one child with thyroid abscess was reported. The authors reviewed 35 cases of abscesses in childhood, four of which were reported after 1950. We recently studied a child with thyroid abscess in whom the clinical course was characterized by multiple recurrences. The patient was a 5 4/12 year-old-girl who developed progressive swelling in the anterior portion of the neck two weeks after the onset of intermittent low grade fever, rhinorrhea, and cough.

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