scholarly journals Recurrent ‘Lactic’ Acidosis-a Cautionary Tale

2007 ◽  
Vol 6 (3) ◽  
pp. 128-130
Author(s):  
Partha Kar ◽  
◽  
V Walker ◽  
Patrick Sharp ◽  
◽  
...  

Lactic acidosis can be caused by a variety of pathological conditions. We present a case of recurrent ‘lactic’ acidosis, which was eventually diagnosed to be secondary to ethylene glycol poisoning. Though there are a handful of cases reported in the literature, it is not widely known that glycolic acid (a metabolite of ethylene glycol) is measured spuriously as lactic acid by some point of care analysers. Literature review would indicate that this is a rare but potentially confounding factor in diagnosis. Given the nature of the pathology, we would suggest that greater awareness of the problem is important.

2019 ◽  
Vol 4 (2) ◽  
pp. 1-3
Author(s):  
Mayanka Kamboj ◽  
Harini Bejjanki ◽  
Saraswathi Gopal ◽  
Rupam Ruchi

A high lactic acid level in critically ill patients is a marker of poor prognosis. However, lactic acidosis in ethylene glycol (EG) poisoning should be interpreted cautiously as analytical interference is observed with EG metabolites.


2018 ◽  
Vol 290 ◽  
pp. e9-e14 ◽  
Author(s):  
Gaspar Tuero ◽  
Jesús González ◽  
Laura Sahuquillo ◽  
Anna Freixa ◽  
Isabel Gomila ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
B. Achappa ◽  
D. Madi ◽  
T. Kanchan ◽  
N. K. Kishanlal

Ethylene glycol poisoning is not uncommon in India. The ill effects are primarily caused by its toxic metabolites: glycolic acid and oxalic acid. A 70-year-old female presented to our hospital with ataxia after ingestion of ethylene glycol. The reported case describes the management of ethylene glycol poisoning using oral ethyl alcohol as an alternative to the recommended intravenous ethyl alcohol and fomepizole that are not available for use in India. The need for high degree of clinical suspicion, targeted investigations, and early instigation of treatment is of prime importance in cases of ethylene glycol poisoning as it can lead to long-term complications or even death.


2008 ◽  
Vol 55 (5) ◽  
pp. 318-319 ◽  
Author(s):  
Diego Castanares-Zapatero ◽  
Catherine Fillée ◽  
Marianne Philippe ◽  
Philippe Hantson

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Linn E. Hauvik ◽  
Mercy Varghese ◽  
Erik W. Nielsen

Ethylene glycol poisoning is a medical emergency. The metabolites glycolate and glyoxylate give metabolic acidosis. Because of similar structure, these metabolites are misinterpreted as lactate by many point-of-care blood gas analyzers. The falsely high lactate values can lead to misdiagnosis, inappropriate laparotomies, and delayed antidotal therapy. As laboratory analyzers measure plasma lactate only, the difference or the “lactate gap” aids in early diagnosis. We present a patient with severe metabolic acidosis and elevated lactate levels on the point-of-care analyzer. A lactate gap supported the diagnosis of ethylene glycol poisoning. Hemodialysis and fomepizole treatment could be started immediately.


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