The role of chemokine CC ligand 20 in patients with liver cirrhosis and hepatocellular carcinoma

2012 ◽  
Vol 27 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Hanan H. Soliman ◽  
Hala Nagy ◽  
Nesreen Kotb ◽  
Mohamed A. Alm El-Din
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Predictive Value ◽  
Serum Levels ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Asymptomatic Patients ◽  
Group I

Background and aim To evaluate the role of chemokine CC ligand 20 (CCL20) as a biomarker for hepatocellular carcinoma (HCC). Patients and methods Ninety patients in four groups were enrolled in this prospective cross-sectional study: 30 with HCC (group I), 30 with liver cirrhosis (group II), 15 with hepatitis C virus infection (group III), and 15 healthy blood donors as controls. Alpha fetoprotein (AFP), CCL20 and vascular endothelial growth factor (VEGF) were measured in all groups. Results Serum levels of CCL20 were significantly different among the study groups (F=230.979, p<0.001). The highest level was found in HCC patients (57.305 ± 6.386 pg/mL) followed by patients with cirrhosis (45.999 ± 5.165 pg/mL) compared with 22.781 ± 5.986 pg/mL and 18.585 ± 3.554 pg/mL in asymptomatic patients with HCV infection and controls, respectively. In HCC patients, CCL20 significantly correlated with VEGF (r=0.559, p=0.001), AFP (r=0.814, p<0.001), Child score (r=0.748, p<0.001), and tumor size (r=0.825, p<0.001). The cutoff value of CCL20 for the detection of HCC in HCV-infected patients was 54 pg/mL with 93.1% accuracy, 89.6% negative predictive value, 92.6% positive predictive value, 83.3% sensitivity, and 93.3% specificity. In patients with cirrhosis, CCL20 significantly correlated with VEGF (r=0.455, p=0.011), AFP (r=0.975, p<0.001), and Child score (r=0.977, p<0.001). Conclusion CCL20 may be used for the detection of HCC in HCV-infected patients with comparable specificity and higher sensitivity than AFP.

scholarly journals Serum levels of Vitamin D3, Zinc, and Parathyroid Hormone in HCV-induced Hepatocellular Carcinoma.

2021 ◽  
Author(s):  
Mahmoud Khattab ◽  
Mohammad Omar Abdelaziz ◽  
Arwa Mohamad ◽  
Ragaa Abd- Elshaheed Matta ◽  
Magdy Fouad ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Parathyroid Hormone ◽  
Vitamin D3 ◽  
Serum Levels ◽  
Cross Sectional ◽  
Multiple Stepwise Regression Analysis ◽  
The Metabolic Syndrome ◽  
Calcium And Phosphorus

Abstract Background and AimThe role of the metabolic syndrome in hepatocellular carcinoma (HCC) has been previously reported. This study aims to investigate the possible role of vitamin D3, Zinc, Parathyroid hormone (PTH), calcium and phosphorus serum levels as non-traditional metabolic risk factors in HCV-related HCC.MethodThis cross-sectional observational study recruited HCV infected patients with and without HCC. All patients were subjected to demographic, biochemical, and hematological assessment. Serum levels of vitamin D3, Zinc, PTH, calcium, and phosphorus were determined in all the study participants.ResultsThis study includes 50 patients with HCV-related HCC compared to 40 patients with HCV-related liver cirrhosis and 30 patients with HCV chronic hepatitis C (CHC) without HCC. Our results show significantly higher age, male sex, aspartate transaminase (AST), PTH and corrected serum calcium levels in the HCC patients compared to values in the other two groups, (p < 0.001); while significant lower vitamin D3 and zinc levels were detected among the HCC patients compared to patients with non-HCC liver cirrhosis and CHC, (p < 0.001).Vitamin D3 deficiency was detected in 96% of the HCC patients, while it was detected in only 22.5% of the cirrhotic patients and in none of the CHC patients, (p < 0.001). However, on multiple stepwise regression analysis, only the age, AST, PTH, and corrected calcium levels were the independent predictors for HCC when studied in relation to chronic liver disease.ConclusionThis study indicates the prevalent deficient levels of vitamin D3 and zinc in HCC patients; however, a causal relationship is not established in this study.

scholarly journals Role of CT (Computed Tomography) in the Evaluation of Fungal Diseases in Paranasal Sinus

2014 ◽  
Vol 31 (4) ◽  
pp. 189-193
Author(s):  
T Islam ◽  
SA Azad ◽  
ME Karim ◽  
L Khondker ◽  
K Rahman
Keyword(s):  
Fungal Infection ◽  
Ct Scan ◽  
Paranasal Sinus ◽  
Predictive Value ◽  
Cross Sectional Study ◽  
Fungal Diseases ◽  
Cross Sectional ◽  
Computed Tomographic ◽  
Histopathological Result

A cross sectional study carried out with patients having suspected paranasal sinus (PNS) mass during January 2009 to October 2010 to evaluate the fungal diseases in PNS by computed tomographic(CT) image and comparison of the findings of this modality with histopathological result. Among the total 76 patients, the mean age of the patients was 35.95 ± 18.24 and common complaints of the patients were nasal obstruction (73.7%) and maximum 53.9% patients had PNS mass in maxillary sinuses. Out of all cases 10 were diagnosed as having fungal infection/mass by CT scan and confirmed by histopathological evaluation. Two cases were diagnosed as having fungal infection/mass by CT scan but not confirmed by histopathological findings. Of 64 cases of other than fungal infection/mass, which were diagnosed by CT scan, six were confirmed as having fungal infection/mass and 58 were other than having fungal infection/mass by histopathology. Sensitivity of CT scan to diagnose fungal infection/mass was 62.5%, specificity 96.7%, positive predictive value 83.3%, negative predictive value 90.6% and accuracy 89.5%. CT scan of the fungal diseases in paranasal sinus provides more information and better image quality and CT diagnosis correlate well with the findings of histopathology. DOI: http://dx.doi.org/10.3329/jbcps.v31i4.21002 J Bangladesh Coll Phys Surg 2013; 31: 189-193

Expression levels of miR-21, miR-146b and miR-326 as potential biomarkers in Behcet's disease

2019 ◽  
Vol 13 (16) ◽  
pp. 1339-1348
Author(s):  
Golamreza Jadideslam ◽  
Khalil Ansarin ◽  
Ebrahim Sakhinia ◽  
Zohreh Babaloo ◽  
Alireza Abhari ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Behcet's Disease ◽  
Expression Rate ◽  
Eye Involvement

Aim: Behcet's disease (BD) is a vasculitis. Lines of evidence suggest miRNAs as diagnostic and prognostic markers in autoimmune diseases. This study was designed to investigate the potential role of miR-21, miR-146b and miR-326 as biomarkers for diagnosis, predicting organs involvement and measuring BD activity. Patients & methods: In this cross-sectional study, the study groups consisted of 46 BD patients and 70 age- and sex-matched healthy volunteers. The expression rates of three miRNAs were determined by quantitative real-time PCR. Results: Our results demonstrated significantly lower expression of miR-21 and miR-146b and higher expression of miR-326 in BD patients. MiR-21 expression rate in patients with severe eye involvement and miR-326 expression rate in patients with uveitis and severe eye involvement were increased. Conclusion: MiR-326 expression rate can be used as a biomarker for prediction of uveitis and severe eye involvement in patients with BD.

scholarly journals Role of Multidetector Computerised Tomography in Evaluation of Proptosis

2019 ◽  
Vol 9 (2) ◽  
pp. 24-31
Author(s):  
Elina Shrestha ◽  
Narayan Bikram Thapa ◽  
Shankar Bahadur Singh Rajbhandari
Keyword(s):  
Predictive Value ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Computerised Tomography ◽  
Cross Sectional ◽  
Female Ratio ◽  
Male Female Ratio ◽  
One Year ◽  
Female Male Female

Introduction: Proptosis is defined as bulging of eye anteriorly out of the orbit. Our main objective was to analyze the pattern of computerised tomographic findings in evaluation of proptosis. Computerised tomography (CT) is noninvasive, easily accessible, affordable and reliable imaging which helps in early diagnosis and prompt treatment. Methods: A descriptive cross sectional study of total 58 patients presenting with proptosis referred to our department of radiology for computerised tomography evaluation during one year period were undertaken into study. The clinical information provided by ophthalmologist also helped our study to derive into conclusion. SPSS version 20 software was used for statistical data analysis. Results: Out of 58 patients, the most common cause of proptosis was neoplasm constituting of 25 cases (43.1%). Retinoblastoma was the commonest orbital tumor. Out of remaining cases, 15 (25.8%) were infective, 14 (24.1%) were inflammatory, two (3.44%) were traumatic and remaining two cases (3.44%) had no definitive cause for proptosis. Bilateral proptosis was commonly associated with thyroid ophthalmopathy. Among the subjects 32 were male, 26 were female. Male: Female ratio was 1:1.23. Age group was ranging from 1 month to 73 years.Mean age was 26.4 ± 22 years. Conclusions: Computerised tomography has an important role in distinguishing the different types of lesions based on their characteristics, location and extension prior to undertaking definitive surgical and medical treatment. Overall accuracy of CT in our study was 81%, sensitivity of 82.6%, specificity of 80.6%, positive predictive value of 76% and negative predictive value of 86.2%.

scholarly journals Role of Transvaginal Ultrasonography in the evaluation of Uterine Fibroids: a regional observation in Bangladesh

2018 ◽  
Vol 7 (2) ◽  
pp. 17-23
Author(s):  
- Mukthadira ◽  
MutaTah Hira ◽  
Netay Kumer Sharma ◽  
ASM Mahbubur Rahman ◽  
MA Razzaque ◽  
...  
Keyword(s):  
Predictive Value ◽  
Uterine Fibroids ◽  
Detailed Examination ◽  
Cross Sectional Study ◽  
Transvaginal Ultrasonography ◽  
Histopathological Diagnosis ◽  
Uterine Neoplasms ◽  
Cross Sectional ◽  
Imaging Tool

Uterine fibroids, also known as leiomyomas, are the most common uterine neoplasms. Although benig, they can be associated with a significant number of morbidity and are the most common indication for hysterectomy. Transvaginal ultrasonography (TVS) has become essential in the diagnosis and management of the uterine fibroids. TVS provides a detailed examination of uterus and ovaries. However, there is no nation-wide and regional clinical study on the use of TVS for the evaluation of uterine fibroids in Bangladesh. In this work, a cross-sectional study toob serve the role of TVS in the evaluation of uterine fibroids in a region of Bangladesh (Greater Mymensingh). In the diagnosis of uterine fibroids by TVS, we observed that 35(81.4%) cases (out of 43) are fibroids and 8 (18.6%) cases are non-fibroids. In histopathological diagnosis, we found 36 (83.7%) cases are uterine fibroids, and 7 (16.3%) cases are without fibroids. In this study, TVS diagnosed uterine fibroids with a sensitivity of 94.4%, the specificity of 85.71%, the accuracy of 97.6%, the positive predictive value of 97.1% and negative predictive value of 75%. The results demonstrate that TVS has the potential to become a useful imaging tool for the evaluation of uterine fibroids. CBMJ 2018 July: Vol. 07 No. 02 P: 17-23

scholarly journals Diet and Women Fertility: A Descriptive Cross-sectional Study

2016 ◽  
Vol 7 (3) ◽  
pp. 82-88
Author(s):  
Ruaa E Alabd ◽  
Kefah H Abdulmajeed ◽  
Hayder G Oufi
Keyword(s):  
Cross Sectional Study ◽  
Dietary Factors ◽  
Control Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Infertile Women ◽  
Group I ◽  
The Mean ◽  
Infertile Group

ABSTRACT Aims This work was designed to assess the role of diet and dietary habits on women fertility. Materials and methods This study was carried out in seven different centers and hospitals in Baghdad in the period between January and September 2014. Participants were 400 adult women selected conveniently; their age ranged from 17 to 47 years and they were divided into two groups. Group I included 300 fertile women and group II included 100 infertile women. A specific questionnaire had been designed and used for data collection Results It was found that there was a significant difference in weight and body mass index (BMI) between the infertile group and control group. The mean of weights was 73.07 vs 69.06 kg for infertile and the control group respectively, while the mean BMI was 28.83 vs 26.70 for the infertile group and the control group respectively. Moreover, the infertile women consumed more of carbonated beverages, tea, chicken, and fish than the control group, while they consumed less milk and red meat than the control group. Also, the infertile group consumed less corn oil and olive oil than the control group (5 and 0% vs 21 and 2%) respectively, while they used to consume more solid fat and combined fat than the control group (2 and 6% vs 0 and 2.7%) respectively. Conclusion Although treatment options for infertility are available, their high cost and frequency of adverse events have motivated the identification of dietary factors related to infertility. The current study identified diet as one of the modifiable risk factors that potentially impacts fertility in the selected groups; hence, it is important to focus more on the role of diet in women fertility and increase the awareness of women to it, along with suggesting more educational programs at the primary health care level. How to cite this article Alabd RE, Abdulmajeed KH, Oufi HG. Diet and Women Fertility: A Descriptive Cross-sectional Study. Int J Infertil Fetal Med 2016;7(3):82-88.

scholarly journals CORRELATION BETWEEN SERUM C-REACTIVE PROTEIN LEVEL WITH SEVERITY OF THE DISEASE IN COVID-19 PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Sangeeta Gahlot ◽  
Surendra Yadav ◽  
Makkhan Lal Saini
Keyword(s):  
Severe Disease ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Group I ◽  
Moderate Disease ◽  
Severity Of The Disease

Background: To find the levels of serum CRP in confirmed Covid-19 patients and to compare their levels in patients with mild to moderate disease and patients with severe disease who required ICU care for management. Methods: A Cross sectional study was carried out on 100 confirmed cases of Covid-19, in whom Serum levels of Random sugar (RBS), Creatinine, Urea, C- reactive protein (CRP) were measured. Results: The levels of serum Urea, Creatinine were significantly increased in group II when compared to group 1, and the levels of CRP were significantly increased with p value <0.0001 in group IIwhen compared to group I. Conclusion: Findings of our study suggest that determination of biochemical parameters like CRP at the time of hospitalization helps in predicting the severity of disease and need for ICU for better treatment management and prevention of adverse outcome. Keywords: Severe acute respiratory syndrome, Covid-19, C- reactive protein, Intensive care unit.

scholarly journals Accuracy of Serum Golgi Protein 73 and Alpha Fetoprotein (AFP) to Diagnose Hepatocellular Carcinoma

2021 ◽  
Vol 8 (9) ◽  
pp. 468-473
Author(s):  
Karina Dwi Swastika ◽  
Gontar Alamsyah Siregar ◽  
Dharma Lindarto
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Cross Sectional Study ◽  
Alpha Fetoprotein ◽  
Control Group ◽  
Healthy Population ◽  
Sectional Study ◽  
Cross Sectional ◽  
Golgi Protein ◽  
Common Malignancy

Background: Hepatocellular Carcinoma (HCC) is one of the most common malignancy in the liver. Modalities of diagnostic are often an obstacle in HCC surveillance. Alpha fetoprotein (AFP) is one of protein that often used in the diagnostic of HCC in chronic liver disease. Golgi protein 73 (GP73), is one of the candidate biomarkers in early diagnostic of HCC and found in biliary epithelial cells but rarely expressed by normal hepatocytes. Expression of GP73 was reported to be increased in a large number of malignancies. Aims of this study to evaluate differences in Golgi protein 73 serum (sGP73) and AFP in diagnosing hepatocellular carcinoma in patients with liver cirrhosis. Materials and Methods: This cross-sectional study was conducted at Haji Adam Malik Hospital in 2020. Serum level of GP73 and others biomarker was detected using enzyme-like immunosorbent assay. Results: From 90 subjects, Liver cirrhosis and HCC group had significantly higher AFP than the control group. AFP was superior in determining HCC to GP73. At a cut off value of > 394.5.00 ng/mL, AFP yielded a sensitivity of 83.3% and specificity of 67%, for discriminating liver cirrhosis and HCC (AUC 0.84), while GP73 with cut off value of > 82.5 ng/mL, sensitivity of 70% and specificity of 57% (AUC 0.74). Conclusion:GP73 was significantly higher in HCC patients in comparison to non-HCC patients and healthy population. Compared with alpha fetoprotein, GP73 was superior in discriminating HCC in healthy population but inferior in group of liver cirrhosis. Keywords: Golgi Protein 73, Alpha Fetoprotein, Hepatocellular carcinoma.

Assessment of procalcitonin as a diagnostic marker of infection in pediatrics with cancer complicated by fever and neutropenia

2020 ◽  
Author(s):  
Soheila Zareifar ◽  
Anahita Sanaei Dashti ◽  
Tayebe Masoomzade ◽  
Mojtaba Anvarinejad ◽  
Omid Reza Zekavat ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Cancer Patients ◽  
Predictive Value ◽  
Urine Culture ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Pediatric Cancer Patients

Background: Febrile neutropenia is still one of the most important complications of treatment in cancer patients. These patients become prone to infection and consequently higher mortality and morbidity. This study aimed to determine the accuracy of serum procalcitonin (PCT) level in the detection of infection in pediatric cancer patients complicated with febrile neutropenia. Materials and Methods: In this cross-sectional study, all pediatric patients affected by cancer and febrile neutropenia following chemotherapy (n=107) were investigated from August 2014 to August 2015. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum levels of PCT, as well as blood and urine culture, were evaluated in all patients. Results: The mean age of the patients was 78 ± 55 months (3 - 214 months), and in terms of gender, 53 patients (49.5%) were male. Overall, 25 patients (23.4%) and 13 patients (12%) showed positive blood and urine culture, respectively. The area under the curve (AUC) receiver operating characteristic (ROC) curve was illustrated to determine how much PCT can couldpredict infection.(AUC =0.74, 95% CI: 0.61-0.87, P<0.001). Considering the cut-off of serum PCT levels as 0.70ng/mL, sensitivity, specificity, and positive and negative predictive valueof PCT were 0.76, 0.744, 0.475, and 0.91, respectively. In addition, PCT showed significant correlations with CRP (rs=0.415, P<0.001) and ESR (rs =0.262, P=0.009). Conclusion: According to the findings of this study, serum PCT levels can be used as a diagnostic test with acceptable sensitivity and specificity and high negative predictive value, but the low positive predictive value in the evaluation of infections in patients affected by cancer and complicated with fever and neutropenia.

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