Leiomyoma of the renal capsule: case report and literature review

2017 ◽  
Vol 85 (1) ◽  
pp. 34-35 ◽  
Author(s):  
Alessio Filianoti ◽  
Aurelio Paganelli ◽  
PierFrancesco Bassi ◽  
Giuseppe Simone ◽  
Antonio Ranieri
Keyword(s):  
Histopathological Examination ◽  
High Sensitivity ◽  
Abdominal Ultrasound ◽  
Good Prognosis ◽  
Renal Capsule ◽  
Mesenchymal Tumors ◽  
Renal Masses ◽  
Palpable Mass ◽  
Retroperitoneal Tumors

Introduction: Mesenchymal tumors are an exceptional finding in the urinary tract and renal leiomyoma is even more rare. They are usually discovered incidentally during ultrasonography examinations or autopsy. Sometimes they are clinically symptomatic with hematuria, flank pain, or palpable mass. Till today, it is still difficult to make a diagnosis of leiomyoma using the radiological examinations. Although conventional imaging has a high sensitivity and specificity in the detection of both retroperitoneal and renal masses, the diagnosis is based on histological examination, due to the poor discrimination accuracy between different retroperitoneal tumors. Case description: We report a case of renal leiomyoma in a 47-year-old woman, who incidentally discovered a retroperitoneal mass with an abdominal ultrasound scheduled for a conventional follow-up schedule of a mammary neoplasm. Partial nephrectomy was carried out with an open flank surgical approach and the diagnosis was “leiomyoma of the renal capsule”. Four years after surgery, the patient is disease-free. Conclusions: Renal leiomyomas are rare, benign, nonmetastasizing tumors with a good prognosis after surgical treatment. At present, the differential diagnosis is still possible by histopathological examination.

scholarly journals Rhabdomyosarcoma of the Cervix in a Post-Menopausal Woman—An Unparalleled Phenomenon

2021 ◽  
Vol 18 (15) ◽  
pp. 7851
Author(s):  
Jakub Pawlik ◽  
Weronika Pawlik ◽  
Dorota Branecka-Woźniak ◽  
Katarzyna Kotrych ◽  
Aneta Cymbaluk-Płoska
Keyword(s):  
Treatment Guidelines ◽  
Histopathological Examination ◽  
Embryonal Rhabdomyosarcoma ◽  
Surrounding Tissue ◽  
Menopausal Woman ◽  
Fallopian Tubes ◽  
Resonance Imaging ◽  
Palpable Mass ◽  
Post Menopausal

Rhabdomyosarcoma of the cervix is a soft tissue sarcoma that usually occurs in young women. It is very rare in adulthood. We discuss symptoms, the process of diagnosis of rhabdomyosarcoma embryonale of the cervix in a 61-year-old women and differences in treatment dependent on patient’s age. A 61-year-old woman with symptoms such as palpable mass in the external cervical opening and post-menopausal hemorrhaging was admitted to the oncology ward where excision of the polyp was performed. Embryonal rhabdomyosarcoma (ERMS) was diagnosed by histopathological examination of obtained tissues. The diagnosis was complemented by chest computed tomography and pelvis magnetic resonance imaging to exclude metastases. A Wertheim–Meigs operation and excision of the ovaries, the fallopian tubes and the surrounding tissue was performed in the course of treatment. In the patient’s follow-up of 25 months to date, there have been no signs of recurrence or symptoms connected to ERMS. Based on the therapeutic outcome, the decision to limit the treatment to a surgical resection was adequate for a post-menopausal patient. Because of the rarity of ERMS in the post-menopausal age, we think that the patient should be carefully followed up to further examine this issue and develop diagnostic and treatment guidelines.

scholarly journals Paediatric RCC with sarcomatoid variation: a rare entity

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Anuj Mahajan ◽  
Prashanth Adiga ◽  
Vivek Pai ◽  
Keerthi Raj
Keyword(s):  
Clear Cell ◽  
Histopathological Examination ◽  
Treatment Protocol ◽  
Age Group ◽  
Renal Masses ◽  
Case Presentation ◽  
Long Term Follow Up ◽  
Paediatric Age

Abstract Background Malignant renal masses in paediatric age group are mostly Wilms’ tumour. RCC is very rare in this age group, papillary variant being the most common. Sarcomatoid variation occurs in 5% of adult RCC, while it is extremely rare in children. No treatment protocol exists in the management of paediatric RCC. Case presentation Here, we present a case of 10-year-old female who presented with left flank mass. Radical nephrectomy was done which showed clear cell carcinoma with sarcomatoid variant on histopathological examination. Conclusion RCC with sarcomatoid variation can occur in children. However, further studies and long-term follow-up are needed for formulating a treatment protocol and prognostication factors for the same.

scholarly journals Contrast-Enhanced Spectral Mammography Assessment of Patients Treated with Neoadjuvant Chemotherapy for Breast Cancer

2021 ◽  
Vol 28 (5) ◽  
pp. 3448-3462
Author(s):  
Katarzyna Steinhof-Radwańska ◽  
Anna Grażyńska ◽  
Andrzej Lorek ◽  
Iwona Gisterek ◽  
Anna Barczyk-Gutowska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Histopathological Examination ◽  
Evaluation Criteria ◽  
High Sensitivity ◽  
Complete Response ◽  
Low Energy ◽  
Contrast Enhanced ◽  
Residual Lesions

Background: Evaluating the tumor response to neoadjuvant chemotherapy is key to planning further therapy of breast cancer. Our study aimed to evaluate the effectiveness of low-energy and subtraction contrast-enhanced spectral mammography (CESM) images in the detection of complete response (CR) for neoadjuvant chemotherapy (NAC) in breast cancer. Methods: A total of 63 female patients were qualified for our retrospective analysis. Low-energy and subtraction CESM images just before the beginning of NAC and as a follow-up examination 2 weeks before the end of chemotherapy were compared with one another and assessed for compliance with the postoperative histopathological examination (HP). The response to preoperative chemotherapy was evaluated based on the RECIST 1.1 criteria (Response Evaluation Criteria in Solid Tumors). Results: Low-energy images tend to overestimate residual lesions (6.28 mm) and subtraction images tend to underestimate them (2.75 mm). The sensitivity of low-energy images in forecasting CR amounted to 33.33%, while the specificity was 92.86%. In the case of subtraction CESM, the sensitivity amounted to 85.71% and the specificity to 71.42%. Conclusions: CESM is characterized by high sensitivity in the assessment of CR after NAC. The use of only morphological assessment is insufficient. CESM correlates well with the size of residual lesions on histopathological examination but tends to underestimate the dimensions.

scholarly journals A Rare Case of a Giant Retroperitoneal Gastrointestinal Stromal Tumor of Malignant Potential

2021 ◽  
Vol 6 (01) ◽  
pp. 67-72
Author(s):  
Abdullah M. Alshamrani ◽  
Meshare A Albattah ◽  
Rasha A Bssas ◽  
Fatemah Y Alhedaithy ◽  
Mshaeel H Almutairi ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Abdominal Mass ◽  
Gastrointestinal Symptoms ◽  
Abdominal Distension ◽  
Cystic Mass ◽  
Cystic Tumor ◽  
Mesenchymal Tumors ◽  
Once Daily ◽  
Initial Imaging

Gastrointestinal stromal tumors (GIST) are mesenchymal tumors that originate in the gastrointestinal tract. We present the case of a 30-year-old man who presented with progressive abdominal distension of one-years’ duration. A physical examination revealed a distended, tense, non-tender abdomen, and initial imaging investigations revealed a huge cystic, septate abdominal mass. A provisional diagnosis was made of a huge retroperitoneal, malignant, cystic mass. However, aspiration cytology showed signs suggestive of a benign cyst. Cystic tumor excision performed with control of drain site to prevent leakeage throughout the procedure. The tumor extending into the pelvis, measuring approximately 17 x 31 x 42 cm in diameter and weighing 3.78 kg. The tumor was resected, and a histopathological examination showed findings consistent with a GIST of mixed spindle and epithelioid type. Further evaluations revealed that the tumor was positive for CD 117 and CD 34, prompting the oncology team to start the patient on oral imatinib 400 mg once daily. No evidence of local recurrence or distant metastasis was noted on an abdominal computed tomography scan performed during the follow-up visit up to October 2020 last follow-up. The clinical presentation of GISTs is often complex, making its diagnosis challenging, especially in patients who present with non-specific gastrointestinal symptoms. The successful management of these tumors requires a multidisciplinary approach, and regular follow-ups.

scholarly journals Clinical and Diagnostic Presentation of Gastrointestinal Stromal Tumour (GIST): A 5-Year Follow-Up

2019 ◽  
Vol 11 (13) ◽  
pp. e996
Author(s):  
Davi Sérgio dos Santos Pacífico ◽  
Diego Aristeu Ramos Cruz ◽  
Luan Kelves Miranda de Sousa ◽  
Antonione Santos Bezerra Pinto
Keyword(s):  
Gastrointestinal Stromal Tumour ◽  
Good Prognosis ◽  
Gastrointestinal Tumor ◽  
Tumor Removal ◽  
Mesenchymal Tumors ◽  
Immunohistochemistry Analysis ◽  
Diagnostic Characteristics ◽  
Total Tumor Removal

Objective: To describe a clinical case of Stromal Gastrointestinal Tumor, highlighting the diagnostic characteristics and a 5-year follow-up of the patient after surgery. Case report: A 51-year-old patient presented with a tumor in the stomach region, diagnosed by the clinic, associated with imaging and immunohistochemistry, in which a partial abdominal gastrectomy was performed for total tumor removal and after a surgical procedure pharmacological treatment with GLIVEC chemotherapy for 3 years, with cure. Final considerations: Gastrointestinal stromal tumors are very common mesenchymal tumors in the region of the gastrointestinal tract. Its severity is known and investigated through the clinic for diagnosis, associated with imaging and immunohistochemistry analysis, in order to observe the tumor markers, mainly the c-KIT. The treatment involves several modalities seeking to improve the patients' quality of life and, generally, they present a good prognosis.       

scholarly journals A Case Report of Unicentric Castleman Disease

2015 ◽  
Vol 23 (2) ◽  
pp. 256-258
Author(s):  
Mafruha Akter ◽  
Ibrahim Khalil ◽  
Golam Nabi ◽  
Syed Zakir Hossain ◽  
Md Uzzwal Mallik ◽  
...  
Keyword(s):  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Good Prognosis ◽  
Castleman Disease ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Human Herpes Virus 8 ◽  
Medical College

Castleman disease (CD) or angiofollicular lymph node hyperplasia is an uncommon benign lymphoproliferative disorder. Sometimes it is related to the chronic human herpes virus 8 (HHV-8) infection and the human immunodeficiency virus (HIV). Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course. Also, three histopathological subtypes have been described: hyalinevascular, plasma cell, and a mixed variant.We report the case of a 22-year-old young man who was diagnosed as unicentric Castleman Disease. We found on routine physical examination a mass localized in the left abdomen without clinically important constitutional symptoms for 3 years. Abdominal ultrasound and computed tomography scans revealed minimally enhancing soft tissue density lesion & it was seen in the left para aortic region measuring about 71mm x 42 mm in size. The patient subse-quently underwent an exploratory laparotomy. After opening of the abdomen, a lump measuring about 8 cm x 5 cm was found in the mesentery. The whole lump was dissected out and the gap in the mesentery was closed. No other lymphadenopathy was found. The specimen was sent for histopathology which revealed Castleman disease, plasma cell type. The patient completely recovered after surgery. Castleman disease is commonly misdiagnosed as malignant lymphoma, lymphadenitis or ectopic thymoma. So far, its diagnosis is mainly achieved via histopathological examination of surgically obtained tissue. Local or unicentric CD has a good prognosis if surgically excised properly.J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 256-258

Multislice imaging of gastrointestinal stromal tumors

2018 ◽  
pp. 3-14
Keyword(s):  
Computed Tomography ◽  
Key Words ◽  
Gold Standard ◽  
Gastrointestinal Stromal Tumors ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Preferential Localization ◽  
Multislice Imaging ◽  
Computed Tomography Diagnosis

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract (1%). These tumors express the CD 117 in 95% of cases. The stomach is the preferential localization (70%). Diagnosis is difficult and sometimes late. Progress of imaging has greatly improved the management and the prognosis. Computed tomography (CT) is the gold standard for diagnosis, staging, and treatment follow-up. The increasing recognition of GIST’s histopathology and the prolonged survival revealed some suggestive imaging aspects. Key words: gastro-intestinal stromal tumors; computed tomography; diagnosis

Immunohistochemistry Particularities of Retroperitoneal Tumors

2018 ◽  
Vol 69 (7) ◽  
pp. 1813-1816 ◽  
Author(s):  
Ovidiu Gabriel Bratu ◽  
Radu Dragos Marcu ◽  
Bogdan Socea ◽  
Tiberiu Paul Neagu ◽  
Camelia Cristina Diaconu ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Good Reason ◽  
Definitive Diagnosis ◽  
Histological Type ◽  
Not Given ◽  
Medical Specialties ◽  
Retroperitoneal Tumors ◽  
Extreme Variability ◽  
The One

Retroperitoneal space is called sometimes no man�s land�and for a good reason: this is disputed anatomical territory for many surgical and medical specialties. Their wide histological diversity and unspecific clinical presentation make them a challenge for the surgeon. In order to improve their detection immunohistochemistry seems to show promising results. Methods of detection have evolved over time to identify as much as possible the histological type of tumor. Because of this extreme variability immunohistochemistry through its various markers is the one that often sets the definitive diagnosis, the simple histopathological examination being insufficient. This paper aims to highlight the main markers used in retroperitoneal tumors. As it can be seen there is a huge histologic areal for these tumors. Some have proven some of them still not. Given the fact that there is a tendency toward personalized therapy it is imperative to identify the histological type of tumor as soon as possible.

scholarly journals Perigastric Hyaline-Vascular Variant Castleman’s Disease

2021 ◽  
pp. 632-638
Author(s):  
Yu Ming Jin ◽  
Gui Ying Jing
Keyword(s):  
Histopathological Examination ◽  
Immunohistochemical Analysis ◽  
Lymphoproliferative Disease ◽  
Castleman Disease ◽  
Unknown Etiology ◽  
Mesenchymal Tumors ◽  
Imaging Characteristics ◽  
Contrast Enhanced ◽  
Hyaline Vascular Variant ◽  
Vascular Variant

Castleman disease (CD) is a rare chronic lymphoproliferative disease with unknown etiology and pathogenesis disease. When the lesion is located in the mediastinum, the diagnosis of CD is easy. However, if the lesion presents as a perigastric mass mimicking other subserosal gastric mesenchymal tumors, the diagnosis can be challenging. As few sonographic manifestations of hyaline-vascular variant CD, especially contrast-enhanced ultrasound (CEUS) imaging, as well as computed tomography (CT) and histopathological imaging, have been reported in literature, this case may provide a vivid example of a comprehensive CEUS and CT usage in the diagnosis and surgery with regard to CD. This report presents a case of a 50-year-old female diagnosed with hyaline-vascular variant CD in a random physical examination, the ultrasound examination first revealed a 24.3 mm × 15.4 mm hypoechogenic lesion abutting the stomach, esophagus, and liver, which was under the suspicion of gastrointestinal stromal tumor. Following a series of medical examinations, including CEUS, CT, postoperative histopathological examination, and immunohistochemical analysis, the patient was diagnosed with hyaline-vascular variant unicentric CD. After the mass was completely excised through laparoscopic surgery, the woman recovered very well without recurrence during a follow-up period of 15 months. Thus, mastering ultrasound and CT-imaging characteristics of CD and applying ultrasound and CT examination together would do help to preoperative diagnosis.

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