FEATURES OF THE CLINICAL COURSE OF RETROBULBAR NEURITIS

Vestnik ◽  
2021 ◽  
pp. 296-298
Author(s):  
Т.С. Телеуова ◽  
Ж.Б. Меерманова ◽  
Ф.Е. Жумагельдиева ◽  
А.Е. Каиров ◽  
А.Д. Мендыбаева ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Picture ◽  
Clinical Course ◽  
Retrobulbar Neuritis

В данной статье представлена особенности клинической картины ретробульбарного неврита вследствие рассеянного склероза. This article presents the features of the clinical picture of retrobulbar neuritis due to multiple sclerosis.

scholarly journals The peculiarities of multiple sclerosis clinical course in the South of Russia (on the example of Rostov Region)

2009 ◽  
Vol 8 (3(2)) ◽  
pp. 19-21
Author(s):  
Z. A. Goncharova
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Picture ◽  
Clinical Course ◽  
The South ◽  
Geographic Factors ◽  
Rostov Region ◽  
Slow Progression

In order to improve multiple sclerosis (MS) diagnosing and specify the influence of climatic and geographic factors on the clinical picture of the disease, the peculiarities of its course and clinical polymorphism in the population of Rostov region were studied. The analysis was conducted to compare the main characteristics of MS in Rostov Region (prevalence — 27,2 : 100 000 of its population) and the area with a considerably bigger rate (Novosibirsk — 54,36 : 100 000). The distinctive peculiarities of the disease among people living in the South of Russia (on the example of Rostov Region) are slow progression and wide clinical polymorphism.

Ophthalmological aspects of multiple sclerosis

2021 ◽  
pp. 91-96
Author(s):  
G.H. Zaynutdinova ◽  
◽  
A.E. Babushkin ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Literature Review ◽  
Key Words ◽  
Clinical Picture ◽  
Key Words Multiple Sclerosis ◽  
Treatment Approaches ◽  
Retrobulbar Neuritis ◽  
Ocular Manifestations ◽  
Diagnostic Capabilities ◽  
Multiple Sclerosis Diagnosis

The article presents a literature review on the issue of multiple sclerosis (MS) and its ophthalmological manifestations: etiopathogenesis, possible causes of development, peculiarities of the clinical picture, including the eyes, modern diagnostic capabilities and treatment approaches. Special attention is paid to such a typical for MS ophthalmopathology as optical (retrobulbar) neuritis. The authors present their own practical cases. Key words: multiple sclerosis, diagnosis, treatment, ocular manifestations, optical (retrobulbar) neuritis.

Mild gray matter atrophy in patients with long-standing multiple sclerosis and favorable clinical course

2021 ◽  
pp. 135245852110196
Author(s):  
Rosa Cortese ◽  
Marco Battaglini ◽  
Francesca Parodi ◽  
Maria Laura Stromillo ◽  
Emilio Portaccio ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Gray Matter ◽  
Clinical Course ◽  
Resonance Imaging ◽  
Volume Changes ◽  
Magnetic Resonance Imaging Mri ◽  
Global Brain ◽  
Diffuse Brain

The mechanisms responsible for the favorable clinical course in multiple sclerosis (MS) remain unclear. In this longitudinal study, we assessed whether magnetic resonance imaging (MRI)-based changes in focal and diffuse brain damage are associated with a long-term favorable MS diseases course. We found that global brain and gray matter (GM) atrophy changes were milder in MS patients with long-standing disease (⩾30 years from onset) and favorable (no/minimal disability) clinical course than in sex-age-matched disable MS patients, independently of lesions accumulation. Data showed that different trajectories of volume changes, as reflected by mild GM atrophy, may characterize patients with long-term favorable evolution.

Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

2004 ◽  
Vol 10 (3) ◽  
pp. 266-271 ◽  
Author(s):  
B Zakrzewska-Pniewska ◽  
M Styczynska ◽  
A Podlecka ◽  
R Samocka ◽  
B Peplonska ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Apolipoprotein E ◽  
Brain Atrophy ◽  
Genetic Factors ◽  
Clinical Course ◽  
Progression Rate ◽  
Disease Course ◽  
Familial Cases ◽  
Sporadic Cases ◽  
The Relationship

The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized. In a large group of Polish patients we have tested the hypothesis that polymorphism in ApoE and MPO genes may influence the course of the disease. G enotypes were determined in 117 MS patients (74 females and 43 males; 99 sporadic and 18 familial cases) with mean EDSS of 3.6, mean age of 44.1 years, mean duration of the disease 12.8 years and mean onset of MS at 31.2 years, and in 100 healthy controls. The relationship between ApoE and MPO genes’ polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. The ApoE o4 allele was not related to the disease course or the ApoE o2 to the intensity of demyelination on MRI. The genotype MPO G/G was found in all familial MS and in 57% (56/99) of sporadic cases. This genotype was also related to more pronounced brain atrophy on MRI. The MPO G/G subpopulation was characterized by a significantly higher proportion of patients with secondary progressive MS (PB- 0.05) and by a higher value of EDSS. A ccording to our results the MPO G allele is frequently found (in 96% of cases) among Polish patients with MS. More severe nervous tissue damage in the MPO G/G form can be explained by the mechanism of accelerated oxidative stress. It seems that MPO G/G genotype may be one of the genetic factors influencing the progression rate of disability in MS patients.

scholarly journals HIV infection and multiple sclerosis: a case with unexpected “no evidence of disease activity” status

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199957
Author(s):  
Fernando Labella ◽  
Fernando Acebrón ◽  
María del Carmen Blanco-Valero ◽  
Alba Rodrígez-Martín ◽  
Ángela Monterde Ortega ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Hiv Infection ◽  
Disease Activity ◽  
Demyelinating Disease ◽  
Clinical Course ◽  
Disease Modifying Drugs ◽  
Immunodeficiency Virus ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Disease Modifying

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system whose etiology remains unclear. It has been suggested that MS can be triggered by certain viruses; however, human immunodeficiency virus (HIV) infection is associated with reduced incidence of MS. We present the case of a young patient diagnosed with active relapsing-remitting MS whose clinical course substantially improved following HIV infection and treatment. The patient achieved no evidence of disease activity status without any disease-modifying drugs. Both HIV-induced immunosuppression and antiretroviral therapy may have attenuated the clinical course in this patient.

Clinical course of multiple sclerosis and labour‐force absenteeism: a longitudinal population‐based study

2019 ◽  
Vol 26 (4) ◽  
pp. 603-609 ◽  
Author(s):  
A. Castelo‐Branco ◽  
E. Landfeldt ◽  
A. Svedbom ◽  
E. Löfroth ◽  
A. Kavaliunas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Course ◽  
Labour Force ◽  
Population Based ◽  
Population Based Study

At the heart of primary progressive multiple sclerosis: three cases with diffuse MRI abnormalities only

2008 ◽  
Vol 14 (3) ◽  
pp. 428-430 ◽  
Author(s):  
JNP Zwemmer ◽  
JCJ Bot ◽  
B. Jelles ◽  
F. Barkhof ◽  
CH Polman
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Course ◽  
Progressive Multiple Sclerosis ◽  
Primary Progressive Multiple Sclerosis ◽  
Resonance Imaging ◽  
Focal Lesions ◽  
Primary Progressive ◽  
Magnetic Resonance Imaging Mri ◽  
Brain And Spinal Cord ◽  
Made In

We present three patients with a clinical course and cerebrospinal fluid findings consistent with a diagnosis of primary progressive multiple sclerosis (PPMS). Extensive and repeated magnetic resonance imaging (MRI) examinations showed only diffuse abnormality in brain and spinal cord, but no focal lesions. We propose that these cases represent the most pure form of PPMS, even though according to currently applied criteria this diagnosis can not be made in the absence of focal lesions on MRI. Multiple Sclerosis 2008; 14: 428—430. http://msj.sagepub.com

scholarly journals Infectious and Noninfectious Granulomatosis in Patient with Multiple Sclerosis: Diagnostic Dilemmas and Followup

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Jelena Paovic ◽  
Predrag Paovic ◽  
Vojislav Sredovic
Keyword(s):  
Multiple Sclerosis ◽  
Immune System ◽  
Pulmonary Tuberculosis ◽  
Cataract Surgery ◽  
Systemic Infection ◽  
Neurological Manifestations ◽  
Initial Attack ◽  
Mri Findings ◽  
Retrobulbar Neuritis ◽  
Preoperative Procedures

Patient was followed up over the course of 30 years. In 1978, after severe systemic infection followed by fever, pulmonary edema, and numerous neurological manifestations, patient was differentially diagnosed with apoplectic form of multiple sclerosis (MS), which was confirmed a year later via neurological and MRI findings. Approximately 20 years following the initial attack, sarcoidosis was diagnosed during the regular preoperative procedures required for cataract surgery. As consequence of lower immune system, infectious granulomatosis in form of pulmonary tuberculosis developed. Ophthalmological findings revealed bilateral retrobulbar neuritis (RBN) approximately six years after initial attack. This developed into total uveitis with retinal periphlebitis and anterior granulomatous uveitis—all of which are clinically similar in both MS and sarcoidosis.

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