THE RESULTS OF SURGICAL TREATMENT OF VARIOUS FORMS OF FOCAL LESIONS OF THE LIVER

Vestnik ◽  
2021 ◽  
pp. 387-390
Author(s):  
М.М. Сахипов ◽  
В.М. Мадьяров ◽  
Г.Р. Жапаркулова
Keyword(s):  
Liver Disease ◽  
Surgical Treatment ◽  
Liver Diseases ◽  
Large Scale ◽  
Postoperative Mortality ◽  
Focal Liver Lesions ◽  
Technical Equipment ◽  
Liver Lesions ◽  
Focal Lesions

Объем резекции очень важен при хирургическом лечении очаговых заболеваний печени. Операции с использованием современного технического оборудования позволили снизить количество осложнений с 42,9% до 19,7%, а при масштабных резекциях - с 54,9% до 20,9%. Общая послеоперационная смертность снизилась с 7,1% до 2,5%. Долгосрочные улучшения результатов (с 74,3% до 89,6%) и снижение неудовлетворительных результатов с 17,6% до 5,8% могут быть достигнуты путем применения радикальных методов хирургического лечения различных форм очаговых поражений печени. У пациентов с заболеваниями печени может быть возможно улучшить выживаемость два и три года с 37,5% до 53,3% и с 25 до 40%. The volume of resection is very important in the surgical treatment of focal liver diseases. Operations using modern technical equipment allowed to reduce the number of complications from 42.9% to 19.7%, and with large-scale resections - from 54.9% to 20.9%. Total postoperative mortality decreased from 7.1% to 2.5%. Long-term improvement of results (from 74.3% to 89.6%) and a decrease in unsatisfactory results from 17.6% to 5.8% can be achieved by applying radical methods of surgical treatment of various forms of focal liver lesions. In patients with liver disease, it may be possible to improve survival for two and three years from 37.5% to 53.3% and from 25 to 40%.

scholarly journals Hepatocellular Carcinoma Is the Most Frequent Final Diagnosis of Focal Liver Lesions Identified in a Cross-Sectional Evaluation of Patients with Chronic Liver Disease in Saudi Arabia

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Adnan Agha ◽  
Manuele Furnari ◽  
Rafaat Morched Chakik ◽  
Mamdouh M. Abdulhadi Ali ◽  
Dib Alsaudi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Odds Ratio ◽  
Final Diagnosis ◽  
Liver Lesion ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Benign Lesions ◽  
Cross Sectional

Background. Hepatocellular carcinoma (HCC) is a frequent diagnosis in patients with chronic liver disease (CLD) and a newly identified liver lesion, although benign diseases may also be responsible for this finding. Objective. To evaluate the characteristics of focal liver lesions in a population of patients with CLD not under surveillance for HCC in the Middle East. Methods. We performed a cross-sectional study evaluating 77 patients with CLD and a focal liver lesion identified during ultrasonography. Patients’ characteristics were analyzed on the basis of the final diagnosis (HCC versus benign lesions). Results. The most frequent diagnosis was HCC (64.9%). These patients were older (median age 64 versus 55 years, P=0.003) and cirrhotics (80.0% versus 51.9%, P=0.018), with multinodular lesions (58.0% versus 29.6%, P=0.031) and portal vein thrombosis (24.0% versus 0%, P=0.001) compared to patients with benign lesions. Prevalence of elevated alpha-fetoprotein (>10 ng/mL) was similar in both groups (80.0% versus 88.9%, P=0.198). Cirrhosis (odds ratio: 3.283) and multinodularity (odds ratio: 2.898) were independently associated with HCC. Conclusions. HCC is the most common diagnosis in Middle-Eastern patients with CLD and a liver lesion identified outside HCC surveillance programs, especially in cirrhotic patients. In these patients, elevated alpha-fetoprotein does not differentiate HCC from benign lesions.

scholarly journals Diffusion-Weighted Imaging with Two Differentb-Values in Detection of Solid Focal Liver Lesions

2016 ◽  
Vol 2016 ◽  
pp. 1-9
Author(s):  
Da-wei Yang ◽  
Ke-yang Wang ◽  
Xun Yao ◽  
Hui-yi Ye ◽  
Tao Jiang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Prospective Study ◽  
Diffusion Weighted Imaging ◽  
Detection Rate ◽  
Focal Liver Lesions ◽  
Liver Lesions ◽  
Diffusion Weighted ◽  
Subgroup Analyses ◽  
To Receive ◽  
Mr Sequences

One hundred and eighty-two consecutive patients with suspected liver disease were recruited to receive diffusion-weighted imaging (DWI) with two differentb-values, in comparison with T2-weighted imaging (T2WI). The detection rate of three MR sequences in solid focal liver lesions (FLLs) and subgroup analyses were performed. Our prospective study found that DWI600 was equivalent to DWI100 and T2WI for the detection of solid FLLs overall but was significantly more accurate in the detection of malignant solid FLLs and lesions larger than 10 mm.

scholarly journals Liver diseases: The pathogenetic role of the gut microbiome and the potential of treatment for its modulation

2017 ◽  
Vol 89 (8) ◽  
pp. 120-128 ◽  
Author(s):  
K A Aitbaev ◽  
I T Murkamilov ◽  
V V Fomin
Keyword(s):  
Liver Disease ◽  
Gut Microbiome ◽  
Liver Diseases ◽  
Large Scale ◽  
Fecal Microbiota Transplantation ◽  
Clinical Manifestations ◽  
Mucosal Barrier ◽  
Multicenter Studies ◽  
Nonalcoholic Fatty Liver

The paper gives an update on the role of the gut microbiome (GM) in the development of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, alcoholic liver disease, liver cirrhosis (LC), and its complications, such as hepatic encephalopathy (HE) and hepatocellular carcinoma (HCC), and discusses the possibilities of its correction with prebiotics, probiotics, synbiotics, antibiotics, and fecal microbiota transplantation (FMT). The pathophysiology of the liver diseases in question demonstrates some common features that are characterized by pathogenic changes in the composition of the gastrointestinal tract microflora, by intestinal barrier impairments, by development of endotoxemia, by increased liver expression of proinflammatory factors, and by development of liver inflammation. In progressive liver disease, the above changes are more pronounced, which contributes to the development of LC, HE, and HCC. GM modulation using prebiotics, probiotics, synbiotics, antibiotics, and FMT diminishes dysbacteriosis, strengthens the intestinal mucosal barrier, reduces endotoxemia and liver damage, and positively affects the clinical manifestations of HE. Further investigations are needed, especially in humans, firstly, to assess a relationship of GM to the development of liver diseases in more detail and, secondly, to obtain evidence indicating the therapeutic efficacy of GM-modulating agents in large-scale, well-designed, randomized, controlled, multicenter studies.

scholarly journals LIVER HYDATIDOSIS: OPTIMIZATION OF SURGICAL TREATMENT METHODS

2018 ◽  
Vol 3 (4) ◽  
pp. 20-26
Author(s):  
S A Ivanov ◽  
M V Kenarskaya ◽  
K A Panfilov
Keyword(s):  
Data Analysis ◽  
Surgical Treatment ◽  
Postoperative Mortality ◽  
Liver Cyst ◽  
Long Term Results ◽  
Modern Approach ◽  
Liver Hydatidosis ◽  
Hepatic Echinococcosis

Objectives - optimization of hepatic echinococcosis treatment schemes based on the data analysis of the immediate and long-term results. Material and methods. The study included 373 clinical cases of patients with liver echinococcosis who received treatment in 2005-2018 in Samara Regional Clinical Hospital n. a. V.D. Seredavin. 342 patients underwent a traditional operation, the surgical puncture was performed in 31 patient. Starting from 2003 all patients received the antirelapse chemotherapy with albendazole according to the WHO's recommendations in the postoperative period. Results. The treatment tactics in patients with liver hydatidosis was defined according to the parasite's developmental stage, its localization, and the size of liver cyst. The traditional surgery was successful after one operation in more than 93% of cases, postoperative mortality was 1.46%, the number of postoperative complications - 12.5%, the number of relapses in 5 year follow-up period was 6.8%. In 31 patients we used the puncture surgery treatment of hepatic echinococcosis PAIR and PEVAC-methods. Conclusion. Modern approach to hepatic echinococcosis treatment should provide differentiated

Molecular tools for studies on the transmission biology ofEchinococcus multilocularis

Parasitology ◽  
2003 ◽  
Vol 127 (S1) ◽  
pp. S53-S61 ◽  
Author(s):  
P. DEPLAZES ◽  
A. DINKEL ◽  
A. MATHIS
Keyword(s):  
Environmental Samples ◽  
Large Scale ◽  
Diagnostic Method ◽  
Epidemiological Studies ◽  
Liver Lesions ◽  
Molecular Tools ◽  
Faecal Samples ◽  
Novel Approaches ◽  
Transmission Biology

Two novel approaches for diagnosis of intestinalEchinococcus multilocularisinfection, the detection ofE. multilocularis-specific coproantigens in ELISA and of copro-DNA by PCR, have been successfully implemented. These methods have proven their value for thepost mortemand theintra vitamdiagnosis ofE. multilocularisin definitive hosts. They have also made novel approaches possible to study the transmission biology of the parasite as they allow detection of the infection in faecal samples collected in the environment. Coproantigen detection is the diagnostic method of choice as it is sensitive, fast and cheap. Studies on faecal samples collected in the field revealed that coproantigen detection did reflect the different prevalences in fox populations as assessed from foxes at necropsy and also the effect of deworming efforts in foxes as achieved by long-term distribution of praziquantel-containing baits. The use of PCR for routine diagnostic or large-scale purposes is hampered by the fact that DNA extraction from faecal material is a very laborious task. Therefore, PCR is rationally used for confirmatory purposes of copro-antigen-positive samples. As taeniid eggs cannot further be differentiated morphologically, PCR is the method of choice to identifyE. multilocularisinfections in faecal or environmental samples containing taeniid eggs. In intermediate rodent hosts, PCR is routinely used in epidemiological studies for identifyingE. multilocularisfrom liver lesions which are often very small, atypical or calcified.

scholarly journals Nutraceutical Properties of Polyphenols against Liver Diseases

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3517
Author(s):  
Jorge Simón ◽  
María Casado-Andrés ◽  
Naroa Goikoetxea-Usandizaga ◽  
Marina Serrano-Maciá ◽  
María Luz Martínez-Chantar
Keyword(s):  
Liver Disease ◽  
Liver Diseases ◽  
Dietary Habits ◽  
Structural Diversity ◽  
The Body ◽  
Attractive Alternative ◽  
Drug Induced ◽  
Alcoholic Fatty Liver ◽  
Drug Induced Liver Injury

Current food tendencies, suboptimal dietary habits and a sedentary lifestyle are spreading metabolic disorders worldwide. Consequently, the prevalence of liver pathologies is increasing, as it is the main metabolic organ in the body. Chronic liver diseases, with non-alcoholic fatty liver disease (NAFLD) as the main cause, have an alarming prevalence of around 25% worldwide. Otherwise, the consumption of certain drugs leads to an acute liver failure (ALF), with drug-induced liver injury (DILI) as its main cause, or alcoholic liver disease (ALD). Although programs carried out by authorities are focused on improving dietary habits and lifestyle, the long-term compliance of the patient makes them difficult to follow. Thus, the supplementation with certain substances may represent a more easy-to-follow approach for patients. In this context, the consumption of polyphenol-rich food represents an attractive alternative as these compounds have been characterized to be effective in ameliorating liver pathologies. Despite of their structural diversity, certain similar characteristics allow to classify polyphenols in 5 groups: stilbenes, flavonoids, phenolic acids, lignans and curcuminoids. Herein, we have identified the most relevant compounds in each group and characterized their main sources. By this, authorities should encourage the consumption of polyphenol-rich products, as most of them are available in quotidian life, which might reduce the socioeconomical burden of liver diseases.

scholarly journals A State-of-the-Art Review on the Evolving Utility of Endoscopic Ultrasound in Liver Diseases Diagnosis

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 512
Author(s):  
Wisam Sbeit ◽  
Anas Kadah ◽  
Mahmud Mahamid ◽  
Rinaldo Pellicano ◽  
Amir Mari ◽  
...  
Keyword(s):  
Endoscopic Ultrasound ◽  
Liver Diseases ◽  
Diagnostic Yield ◽  
Therapeutic Option ◽  
Focal Liver Lesions ◽  
Focal Lesions ◽  
Chronic Patients ◽  
Comprehensive Overview ◽  
Diagnostic Work ◽  
Complications Rate

Liver diseases are amongst the most common diseases worldwide and manifest as a parenchymatic and/or biliary injury due to several causes as well as focal liver lesions, ranging from benign to malignant ones. The diagnosis of liver diseases is based mainly on biochemical and advanced imaging studies and, when required, on liver biopsy. Endoscopic ultrasound (EUS), which combines endoscopy and ultrasonography, is one of the main examination techniques used in gastroenterology as it is applied to evaluate abnormalities in the lumen of the upper and lower gastrointestinal tract and to define pancreatic and hepato-biliary features, often in chronic patients. Given its high spatial resolution and its proximity to the liver, EUS is gaining popularity in the diagnostic work up of liver diseases. This is a comprehensive overview of the current literature on the diagnostic indications for EUS use in patients with liver diseases. We performed a MEDLINE\PubMed and Embase search, and all articles that were relevant, after reviewing abstracts, were assessed and the full text was analyzed to extract data regarding technical success, diagnostic yield, bioptic characteristics, and complications rate. EUS-guided imaging and biopsy techniques in liver diseases have shown consistent favorable promising results among the reports through the literature, with an excellent diagnostic yield and safety profile, especially in the context of focal lesions and portal hypertension. The application of EUS in the diagnosis of liver diseases is a promising technique and should be considered as a first-line therapeutic option in selected cases.

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