scholarly journals Reevaluation of the University of Wisconsin 2-Year Protocol for Treating Canine Lymphosarcoma

2007 ◽  
Vol 43 (2) ◽  
pp. 85-92 ◽  
Author(s):  
Claire Inderbinen Kaiser ◽  
Janean L. Fidel ◽  
Malgorzata Roos ◽  
Barbara Kaser-Hotz
Keyword(s):  
Stage Iv ◽  
World Health ◽  
Treatment Delays ◽  
Prior Therapy ◽  
University Of Wisconsin ◽  
Chemotherapy Protocol ◽  
First Remission ◽  
Health Organization ◽  
Reported Data ◽  
The University

This retrospective study investigated a population of 96 dogs with newly diagnosed malignant lymphosarcoma that were treated with the commonly used University of Wisconsin-Madison (UW-M) chemotherapy protocol. Pretreatment characteristics were analyzed to determine prognostic factors. Dogs with higher World Health Organization (WHO) stages (including stage IV) and dogs with hypercalcemia were at significantly higher risk of relapse (P=0.018 and P=0.016, respectively). Dose reduction, treatment delays, and prior therapy with cortico-steroids were not associated with clinical outcome. First remission duration of 270 days was similar to historically reported data. Overall survival time of 218 days was much shorter than historical data.

Factors influencing first remission and survival in 145 dogs with lymphoma: a retrospective study

2000 ◽  
Vol 36 (5) ◽  
pp. 404-409 ◽  
Author(s):  
CR Baskin ◽  
CG Couto ◽  
TE Wittum
Keyword(s):  
Progressive Disease ◽  
Inflammatory Diseases ◽  
Clinical Signs ◽  
Stage Iv ◽  
World Health ◽  
B Lymphoma ◽  
Relative Risks ◽  
Factors Influencing ◽  
First Remission ◽  
Health Organization

Records of 145 dogs diagnosed with lymphoma were reviewed to evaluate for factors influencing duration of remission and survival. Dogs with histories of certain chronic inflammatory diseases were 3.23 times more likely to relapse (relative risk, 3.23) than the overall population. Dogs with World Health Organization (WHO) stage IV lymphoma or those treated with a protocol containing cyclophosphamide, doxorubicin, vincristine, prednisone, and sulfatrimethoprim (CHOP) had lower relative risks of relapse (0.32 and 0.085, respectively). Progressive disease after induction, gastrointestinal toxicity from induction, and clinical signs (i.e., substage b lymphoma) were associated with higher relative risks of death (3.5, 2.64, and 2.02, respectively).

scholarly journals Optimizing COVID-19 testing capabilities and clinical management using pathology informatics

JAMIA Open ◽  
2020 ◽  
Author(s):  
Srikar Chamala ◽  
Sherri Flax ◽  
Petr Starostik ◽  
Kartikeya Cherabuddi ◽  
Nicole M Iovine ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Management ◽  
World Health ◽  
University Of Florida ◽  
Pathology Informatics ◽  
Large Numbers ◽  
The World ◽  
Health Organization ◽  
The University ◽  
Reporting Data

Abstract Coronavirus disease 2019, first reported in China in late 2019, has quickly spread across the world. The outbreak was declared a pandemic by the World Health Organization on March 11, 2020. Here, we describe our initial efforts at the University of Florida Health for processing of large numbers of tests, streamlining data collection, and reporting data for optimizing testing capabilities and superior clinical management. Specifically, we discuss clinical and pathology informatics workflows and informatics instruments which we designed to meet the unique challenges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We hope these results benefit institutions preparing to implement SARS-CoV-2 testing.

scholarly journals Survey of Radon Concentrations in the University of Granada in Southern Spain

2021 ◽  
Vol 18 (6) ◽  
pp. 2885
Author(s):  
Irene Calvente ◽  
María Isabel Núñez ◽  
Rachid Chahboun Karimi ◽  
Juan Villalba-Moreno
Keyword(s):  
Southern Spain ◽  
World Health ◽  
Maximal Level ◽  
15Th Century ◽  
The World ◽  
Time Periods ◽  
Health Organization ◽  
The University ◽  
Analyze Data ◽  
Radon Concentrations

The objective of this pilot study was to gather and analyze data on radon concentrations in workplaces in three buildings of Granada University (Southern Spain) constructed in different centuries. All measurements were made at basement or ground floor level under normal use conditions except for one space (mineral store), in which measurements were compared between the door closed and open. Measurements were conducted during different time periods between October 2013 and March 2019 with a Radon-Scout PLUS portable Radonmonitor. The duration of continuous recordings at different sites ranged between 42 and 1104 h. Mean accumulated radon concentrations ranged between 12 and 95 Bq/m3, below the maximal level of 300 Bq/m3 set by the World Health Organization (WHO). Relatively high values were recorded in the oldest building (15th century), which was also poorly ventilated. Ventilation appeared to be an important factor in reducing radon levels, especially in areas less exposed to radon, such as Southern Spain.

COVID-19: implications for NHS Staff

2020 ◽  
Vol 14 (4) ◽  
pp. 193-197
Author(s):  
Alan Glasper
Keyword(s):  
World Health ◽  
The Novel ◽  
Emeritus Professor ◽  
The World ◽  
Clinical Environments ◽  
Public Health Institutions ◽  
Health Institutions ◽  
Health Organization ◽  
The University

In light of the emergence in China of COVID-19, the novel corona virus, emeritus professor Alan Glasper, from the University of Southampton discusses the role of the World Health Organization and other public health institutions in responding to potential new global pandemics and deliberates on the role of NHS staff in coping with infectious disease in clinical environments.

scholarly journals Coronavirus Is A Biological Warfare Weapon

2020 ◽  
Vol 1 (2) ◽  
pp. 01-06
Author(s):  
Robert Skopec
Keyword(s):  
International Law ◽  
World Health ◽  
Biological Weapons ◽  
Biological Warfare ◽  
University Of Illinois ◽  
College Of Law ◽  
Health Organization ◽  
The University ◽  
Biological Weapons Convention ◽  
The U.S

Dr. Francis Boyle, who drafted the Biological Weapons Act has given a detailed statement admitting that the 2019 Wuhan Coronavirus is an offensive Biological Warfare Weapon and that the World Health Organization (WHO) already knows about it. Francis Boyle is a professor of international law at the University of Illinois College of Law. He drafted the U.S. domestic implementing legislation for the Biological Weapons Convention, known as the Biological Weapons Anti-Terrorism Act of 1989, that was approved unanimously by both Houses of the U.S. Congress and signed into law by President George H.W. Bush.

Editorial

2021 ◽  
Vol 30 (2) ◽  
pp. 4-4
Keyword(s):  
Gifted Education ◽  
The United States ◽  
World Health ◽  
Special Issue ◽  
University Of Georgia ◽  
University Of British Columbia ◽  
Australasian Journal ◽  
University Of Arizona ◽  
Health Organization ◽  
The University

Welcome to the second issue of the Australasian Journal of Gifted Education for 2021. I am proud to introduce this issue of the journal, which is a special issue of the work of Professor Emerita C. June Maker and her colleagues on the fidelity of implementation of the Real Engagement in Active Problem Solving (REAPS) model. All four studies that form a part of the special issue were undertaken with Australian participants. The institutions that the authors of the articles represent include the University of Arizona, the University of Georgia, the University of British Columbia, the World Health Organization, and the Vail Unified School District in the United States.

Diuretic Drug Utilization Study

1996 ◽  
Vol 12 (4) ◽  
pp. 169-176
Author(s):  
Jaime Torelló ◽  
José A Durán ◽  
María I Serrano
Keyword(s):  
Adverse Drug Reactions ◽  
Diuretic Therapy ◽  
University Hospital ◽  
World Health ◽  
Drug Reactions ◽  
Cardiac Symptoms ◽  
Medicine Service ◽  
Combined Use ◽  
Health Organization ◽  
The University

Objective: To evaluate the present use of diuretics in our institution, and determine the appropriateness of that use and the incidence of adverse reactions and interactions. Design: This retrospective study describes the indications for use of an identified drug or combination of drugs. By the time the data were collected, some patients had been discharged or had died. Setting: The study was carried out in a referral center, the University Hospital “Virgen Macarena,” Seville, Spain. Patients: All patients receiving diuretic therapy. Those undergoing hemodialysis or receiving home care were excluded from the study. Intervention: A therapeutic audit was performed using specific standards of reference. Two models were used — one for each of the most frequent indications, ascites and congestive heart failure (CHF). Main Outcome Measures: A structured protocol gathered data on (1) demographic characteristics, (2) causes of admission and pathologic antecedents, (3) diuretic treatment, (4) basic controls (24-h diuresis and daily basal weight), (5) clinical evolution, and (6) concurrent complementary studies. The protocol included a checklist of the most frequent adverse drug reactions and interactions whose degree of causality was determined by applying the modified algorithm of Karch-Lasagna, used in the World Health Organization voluntary reporting system of adverse drug reactions. Results: One hundred twenty-six patients (16% of total admissions) received diuretic therapy. Of these, 71% were analyzed; information in the medical records was incomplete for the rest (29%). Fifty-one percent of the patients were more than 60 years old. The most frequent admission diagnoses were cardiovascular (51.5%), followed by digestive (16.7%) diseases. A total of 134 cardiac symptoms was seen in 50 patients. The most notable were acute pulmonary edema (26%), ischemic cardiopathy (12%), and cardiogenic shock (8%). Most patients receiving diuretic therapy (47.3%) were admitted to the internal medicine service. The most-prescribed diuretic was furosemide (59%), followed by spironolactone (27%). The combined use of furosemide and spironolactone occurred in all but 1 of the patients with hepatic ascites (92%), whereas in those with CHF the figure for the combined use of furosemide and spironolactone fell to 38% (p = 0.001). In 63% of the patients with ascites, the spironolactone dosage was changed in the first 48 hours of treatment. There was a high percentage of deaths (21%) in the study patients. Conclusions: Therapeutic strategy often does not follow the guidelines laid down in the standards of reference on diuretic use in serious CHF and/or ascites in this institution.

Immunogenicity and Safety of the Measles Vaccine in HIV-Infected Children: An Updated Systematic Review

2019 ◽  
Author(s):  
Nicky J Mehtani ◽  
Lori Rosman ◽  
William J Moss
Keyword(s):  
Latin American ◽  
Prevalence Ratio ◽  
Vaccine Safety ◽  
World Health ◽  
Measles Vaccine ◽  
Serious Adverse Events ◽  
Increased Risk ◽  
Hiv Exposed ◽  
Health Organization ◽  
Reported Data

Abstract Children infected with human immunodeficiency virus (HIV) are at increased risk of measles morbidity and mortality. We searched abstracts from the PubMed, Embase, and Latin American and Caribbean Center on Health Sciences Information databases for articles published from the earliest date available through September 26, 2017. The primary outcome of interest was serological responses to measles vaccine, stratified by HIV infection status. A total of 2,858 potentially eligible articles were identified, and the final review included 12 studies published between 1992 and 2013, 9 of which reported data on vaccine safety. The studies we included represented 3,573 children, of whom at least 335 were infected with HIV, 788 were HIV-exposed but not infected, and 1,478 were unexposed to HIV. Four of the 12 studies found statistically significant reductions in seropositivity among HIV-infected children compared with HIV-uninfected children within 4 months of vaccination (prevalence ratio range, 0.44–0.70), and forest plots provided visual trends of decreasing immunity over time among HIV-infected children in 2 additional studies. No vaccine-related deaths or serious adverse events were reported. This updated review demonstrated limitations of the existing published literature but supported evidence of reduced immunogenicity of measles vaccine among HIV-infected children, supporting the World Health Organization recommendation to revaccinate HIV-infected children against measles following immune reconstitution with combination antiretroviral therapy.

scholarly journals Aerosol and surface contamination of SARS-CoV-2 observed in quarantine and isolation care

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Joshua L. Santarpia ◽  
Danielle N. Rivera ◽  
Vicki L. Herrera ◽  
M. Jane Morwitzer ◽  
Hannah M. Creager ◽  
...  
Keyword(s):  
Medical Center ◽  
World Health ◽  
Infection Prevention And Control ◽  
The Novel ◽  
Viral Shedding ◽  
Surface Samples ◽  
Significant Public Health ◽  
Health Organization ◽  
The University ◽  
And Control

Abstract The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originated in Wuhan, China in late 2019, and its resulting coronavirus disease, COVID-19, was declared a pandemic by the World Health Organization on March 11, 2020. The rapid global spread of COVID-19 represents perhaps the most significant public health emergency in a century. As the pandemic progressed, a continued paucity of evidence on routes of SARS-CoV-2 transmission has resulted in shifting infection prevention and control guidelines between classically-defined airborne and droplet precautions. During the initial isolation of 13 individuals with COVID-19 at the University of Nebraska Medical Center, we collected air and surface samples to examine viral shedding from isolated individuals. We detected viral contamination among all samples, supporting the use of airborne isolation precautions when caring for COVID-19 patients.

Epidemiology of overweight and obesity among Italian early adolescents: relation with physical activity and sedentary behaviour

2005 ◽  
Vol 14 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Alessio Vieno ◽  
Massimo Santinello ◽  
Maria Cristiana Martin
Keyword(s):  
Physical Activity ◽  
Sedentary Behaviour ◽  
Early Adolescents ◽  
Overweight And Obesity ◽  
World Health ◽  
National Study ◽  
Related Factors ◽  
School Aged Children ◽  
Health Organization ◽  
The University

SUMMARYAims – The prevalence of overweight and obesity and the role of possible related factors were analysed among Italian early adolescents. Method – The survey reported here is part of the larger “Health Behaviour in School Aged Children” (HBSC) trans-national study, which is co-ordinated by the European Office of the World Health Organization. The data were gathered through self-administered questionnaires filled out by a representative sample of 4,386 (48.4% males) Italian students (11-, 13- and 15-year old). Results – The overall prevalence is 16.7% for overweight and 2.5% for obesity. Boys are more at risk than girls for the two phenomena. Moreover, age group, mother's education, area of residence, physical activity, and sedentary behaviour show a significant association with both outcomes. Conclusion – Findings of the present study are in agreement with similar studies carried out on early adolescents population, showing that prevalence in overweight and obesity decreases during this phase and is more diffused among boys than girls. The prevalence of both diseases is higher in the South and Islands. Sedentary behaviour and physical activity are substantive factors which preventive interventions could act on.Declaration of Interest: the HBSC study is partly funded by the University of Padova through a scholarship attributed to Dr. Alessio Vieno (Year 2001 – prot. CPDR013233).

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