Serum levels of Branched Chain Amino Acids and its Correlation with CA disease severity in diabetics and non-diabetics

2021 ◽  
Vol 15 (12) ◽  
pp. 3302-3306
Author(s):  
Ahsan Mushtaq ◽  
Rizwan Munir ◽  
Zahid Hussain Shah ◽  
Sohail Bashir Sulehria ◽  
Rabia Arshad
Keyword(s):  
Coronary Artery Disease ◽  
Amino Acids ◽  
Coronary Artery ◽  
Disease Severity ◽  
Odds Ratio ◽  
Branched Chain Amino Acids ◽  
Male Gender ◽  
Gensini Score ◽  
Artery Disease ◽  
Branched Chain

Background: Branched chain amino acids are classified as essential amino acids, their role in metabolic disease has recently been established. The current research sort to identify the correlation of BCAAs with severity of coronary artery disease in diabetics and non-diabetics. Aim: To measure and compare blood levels of BCAAs in the following groups of subjects: Diabetics and Non diabetics undergoing angiography under the clinical suspicion of coronary artery disease. Secondly, to correlate serum BCAA levels with Coronary Artery Disease severity by using Gensini Score in each group. Methods: 119 patients who underwent angiography were recruited from cardiology department Mayo hospital, Lahore. They were allocated into two groups, diabetic and non-diabetic on the basis of HBA1c. 5 ml blood was collected, serum was separated and BCAA levels were measured by using internationally available calorimetric kit. Results were described as mean ± SD. Normality of continuous variables were assessed by using Shapiro Wilks test. Variables which were not normally distributed were log transformed. Results: Over all three factors affected BCAA levels; age (Beta= -0.32, p <0.001), male gender (Beta=-0.32, p=<0.001) and diabetic status (Beta=-0.20, p=0.03). Significant factors affecting severity of CAD as indicated by Gensini score were BMI (p=0.016, Beta=-0.22) and age (p=0.019, Beta=0.23). Factors determining the likely diabetes in CAD patients were male gender (p=0.013, Odds ratio 4.92s), BCAA levels (p=0.03, Odds ratio 1.05), age (p=0.01, odds ratio=1.08) and Gensini Score (p=0.05, odds ratio=1.013). Conclusions In CAD patient’s serum BCAA level are affected by age, male gender and diabetes status. Secondly the severity CAD is mainly affected by BMI and age. However the correlation between Gensini score and BCAA is not significant. Keywords: Coronary artery disease, branched chain amino acids, diabetic, serum level

Relation Between Globulin, Fibrinogen, and Albumin With the Presence and Severity of Coronary Artery Disease

Angiology ◽  
2020 ◽  
pp. 000331972095998
Author(s):  
Bülent Deveci ◽  
Emine Gazi
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Fibrinogen Level ◽  
Pearson Correlation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Close Relation ◽  
Male Gender ◽  
Gensini Score ◽  
Artery Disease

The albumin to globulin ratio (AGR) is used as a prognostic marker in acute ischemic cardiovascular events. We investigated whether serum AGR, fibrinogen, and fibrinogen to albumin ratio (FAR) are related to the presence and severity of coronary artery disease (CAD). Patients who underwent coronary angiography procedures were analyzed retrospectively. The severity of CAD was assessed by the Gensini score. The study population (3031 patients; 1071 females and 1960 males) was divided into 3 tertiles based on AGR values. Gensini score, lipid levels, diabetes mellitus (DM), hypertension (HT), age, and fibrinogen level were higher in the low AGR group. Pearson correlation analysis showed that AGR ( r = −0.068, P < .001) was negatively and fibrinogen ( r = 0.187, P < .001) was positively correlated with the Gensini score. Male gender, HT, smoking, DM, age, high triglyceride (TG) level, low-density lipoprotein cholesterol (LDL-C) >160 mg/dL, estimated glomerular filtration rate (eGFR) <60 mL/min, and fibrinogen level >3.5 g/L were independent predictors of CAD. Male gender, age, eGFR, DM, LDL-C, TG, and FAR had an independent positive relation to the Gensini score. In conclusion, similar to traditional risk factors, plasma fibrinogen and albumin levels showed a close relation with the presence and severity of CAD.

Abstract 12813: Assessment of Coronary Artery Disease Severity and Prognostic Factors for Cardiovascular Events in Patients With Lower Limb Artery Disease

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Hiroyuki Hikita ◽  
Yosuke Yamakami ◽  
Keisuke Kojima ◽  
Yuichiro Sagawa ◽  
Hirofumi Ohtani ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Prognostic Factors ◽  
Coronary Artery ◽  
Disease Severity ◽  
Lower Limb ◽  
Cardiovascular Events ◽  
Gensini Score ◽  
Lipoprotein A ◽  
Coronary Artery Disease Severity ◽  
Artery Disease

Introduction: Cardiovascular mortality in patients with lower limb artery disease is higher in critical limb ischemia (CLI) than in intermittent claudication (IC). We sought to evaluate differential characteristics of coronary artery disease severity and prognostic factors for cardiovascular events between CLI and IC patients. Methods: Coronary and lower limb angiography was performed on 242 patients (age 73±8 years, mean±sd, men 186) without cardiac symptoms and with symptoms of either CLI or IC. From the coronary angiogram of each study patient, Gensini Score as an index of coronary angiographic severity and an incidence of significant stenosis (AHA classification, ≥75% stenosis) in at least one of major coronary arteries were evaluated. High sensitivity troponin T (hs-TnT), eicosapentaenoic acid-arachidonic acid ratio (EPA/AA), and lipoprotein (a), as biomarkers for prognostic factors, were measured from blood samples at rest in the fasting state. Results: The study patients were divided into CLI-group (42 patients) and IC-group (200 patients). Coronary angiography showed that Gensini Score and an incidence of significant stenosis (AHA classification, ≥75% stenosis) in at least one of major coronary arteries were higher in the CLI-group than in the IC-group (39±32 vs 8±8, p<0.001, 59.5% vs 22.0%, p<0.001, respectively). Hs-TnT and lipoprotein (a) values were higher in the CLI-group than the IC-group (0.15±0.19 ng/ml vs 0.05±0.09, p<0.001, 45.9±23.3 mg/dl vs 26.2±27.7, p<0.001, respectively) and EPA/AA was lower in the CLI-group than in the IC-group (0.22±0.11 vs 0.38±0.29, p<0.005, respectively). Conclusions: Greater coronary artery disease severity, higher hs-TnT and lipoprotein (a), and lower EPA/AA were observed in the CLI patients, which may explain higher cardiovascular events in CLI patients than IC.

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

2013 ◽  
Author(s):  
Janusz Szkodzinski ◽  
Bartosz Hudzik ◽  
Aleksander Danikiewicz ◽  
Anna Pietka-Rzycka ◽  
Andrzej Lekston ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Severity ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Disease Severity ◽  
Artery Disease ◽  
Sensitive Marker

scholarly journals Impact of Coronary CT angiography in combination with CAD-RADS on the management of coronary artery disease patients

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
F Andre ◽  
S Seitz ◽  
P Fortner ◽  
R Sokiranski ◽  
F Gueckel ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Stratification ◽  
Coronary Ct Angiography ◽  
Patient Management ◽  
Male Gender ◽  
Coronary Ct ◽  
History Of ◽  
Artery Disease ◽  
The Impact

Abstract Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): Siemens Healthineers Introduction Coronary CT angiography (CCTA) plays an increasing role in the detection and risk stratification of patients with coronary artery disease (CAD). The Coronary Artery Disease – Reporting and Data System (CAD-RADS) allows for standardized classification of CCTA results and, thus, may improve patient management. Purpose Aim of this study was to assess the impact of CCTA in combination with CAD-RADS on patient management and to identify the impact of cardiovascular risk factors (CVRF) on CAD severity. Methods CCTA was performed on a third-generation dual-source CT scanner in patients, who were referred to a radiology centre by their attending physicians. In a total of 4801 patients, CVRF were derived from medical reports and anamnesis. Results The study population consisted of 4770 patients (62.0 (54.0-69.0) years, 2841 males) with CAD (CAD-RADS 1-5), while 31 patients showed no CAD and were excluded from further analyses. Age, male gender and the number of CVRF were associated with more severe CAD stages (all p &lt; 0.001). 3040 patients (63.7 %) showed minimal or mild CAD requiring optimization of CVRF i.e. medical therapy but no further assessment at his time. A group of 266 patients (5.6 %) had a severe CAD defined as CAD-RADS 4B/5. In the multivariate regression analysis, age, male gender, history of smoking, diabetes mellitus and hyperlipidaemia were significant predictors for severe CAD, whereas arterial hypertension and family history of CAD did not reach significance. Of note, a subgroup of 28 patients (10.5 %) with a severe CAD (68.5 (65.5-70.0) years, 26 males, both p = n.s.) had no CVRF. Conclusions CCTA in combination with the CAD-RADS allowed for effective risk stratification of CAD patients. The majority of the patients showed non-obstructive CAD and, thus, could be treated conservatively without the need for further CAD assessment. CVRF out of arterial hypertension and family history had an impact on CAD severity reflected in higher CAD-RADs gradings. Of note, a relevant fraction of patients with CAD did not have any CVRF and, thus, may not be covered by risk stratification models. CAD-RADS n Age (years) Males (%) 1 1453 56.0 (50.0-62.0) 623 (42.9 %) 2 1587 62.0 (55.0-69.0) 918 (57.8 %) 3 1067 66.0 (59.0-71.0) 749 (70.2 %) 4A 397 66.0 (59.0-72.0) 317 (79.8 %) 4B 162 67.0 (61.0-74.0) 139 (85.8 %) 5 104 66.0 (58.5.0-77.0) 95 (91.3 %)

Prospective Analysis after Coronary-artery Bypass Grafting: Platelet GP IIIa Polymorphism (HPA-1b /PlA2) Is a Risk Factor for Bypass Occlusion, Myocardial Infarction, and Death

2000 ◽  
Vol 83 (03) ◽  
pp. 404-407 ◽  
Author(s):  
Michael Klein ◽  
Hans Dauben ◽  
Christiane Moser ◽  
Emmeran Gams ◽  
Rüdiger Scharf ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Odds Ratio ◽  
Bypass Surgery ◽  
Artery Bypass ◽  
Bypass Grafting ◽  
Hereditary Risk ◽  
Artery Disease

SummaryRecently, we have demonstrated that human platelet antigen 1b (HPA-1b or PlA2) is a hereditary risk factor for platelet thrombogenicity leading to premature myocardial infarction in preexisting coronary artery disease. However, HPA-1b does not represent a risk factor for coronary artery disease itself. The aim of our present study was to evaluate the role of HPA-1b on the outcome in patients after coronaryartery bypass surgery. We prospectively determined the HPA-1 genotype in 261 consecutive patients prior to saphenous-vein coronaryartery bypass grafting. The patients were followed for one year. Among patients with bypass occlusion, myocardial infarction, or death more than 30 days after surgery, the prevalence of HPA-1b was significantly higher than among patients without postoperative complications (60 percent, 6/10, vs. 24 percent, 58/241, p <0.05, odds ratio 4.7). Using a stepwise logistic regression analysis with the variables HPA1b, age, sex, body mass index, smoking (pack-years), hypertension, diabetes, cholesterol and triglyceride concentration, only HPA-1b had a significant association with bypass occlusion, myocardial infarction, or death after bypass surgery (p = 0.019, odds ratio 4.7). This study shows that HPA-1b is a hereditary risk factor for bypass occlusion, myocardial infarction, or death in patients after coronary-artery bypass surgery.

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