scholarly journals Frequency of Different Types of Arthritis in patients of Psoriasis

2021 ◽  
Vol 15 (6) ◽  
pp. 1331-1334
Author(s):  
A. Ashraf ◽  
M. S. Aman ◽  
A. Z. K. Chachar ◽  
M. A. Bukhari ◽  
U. Sarwar ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Joint Involvement ◽  
Care Hospital ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Psoriatic Arthropathy ◽  
Different Types ◽  
Distal Interphalangeal

Background: Psoriatic arthritis (PsA) is type of inflammatory arthritis associated with psoriasis. There are multiple patterns of joint involvement in patients with psoriasis Aim: To determine the frequency of arthritis and its different types in patients of psoriasis presenting at a tertiary care hospital in Lahore Methods: This cross Sectional study was conducted in Dermatology Department of Services Hospital, Lahore from 11th April, 2017 to 10th October, 2017. Two hundred and sixty patients having psoriasis were enrolled in the study, Patients’ detailed history about psoriasis, duration of psoriasis and joint pain or stiffness was taken. After written and informed consent Physical examination was done to determine the type of psoriasis and nail involvement. All the joints were examined for tenderness and deformities to assess the evidence of arthritis and its different types according to the site of involved joints. Results: Total numbers of patients included in the study was 260; in which 176 (67.7%) patients were males and 84 (32.3%) were females with the total mean age of 38 ±13.22 years. Out of 260 patients, 62(23.8%) patients had psoriatic arthritis (PsA), Out of these 62 patients having PsA, 23(37.1%) patients had Oligoarthritis, followed by Symmetric arthritis 19(30.6%) patients, Distal interphalangeal arthritis (DIP) in 15 (24.2 %). Conclusion: Our study concluded that almost one fourth of psoriasis patients had arthritis, asymmetrical oligoarthritis/monoarthritis came out to be the most common type in our study followed by symmetric polyarthritis, distal interphalangeal arthritis (DIP), Arthritis mutilans and axial arthritis Keywords: Psoriasis, types of psoriasis, arthritis, psoriatic arthropathy

scholarly journals How Often Excitation Precipitates Seizure? Relative Difference of Frequency and Significance in Different Types of Epilepsy

2012 ◽  
Vol 13 (2) ◽  
pp. 143-146 ◽  
Author(s):  
KM Rahman ◽  
RN Chowdhury ◽  
ATMH Hasan ◽  
KFM Ayaz ◽  
T Miah ◽  
...  
Keyword(s):  
Strong Association ◽  
Tertiary Care ◽  
Relative Difference ◽  
Cross Sectional Study ◽  
Outpatient Department ◽  
Care Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Different Types ◽  
Generalized Epilepsy

Background: Epilepsy is a chronic neurological disorder, which presents with recurrent, unprovoked seizures. Seizure occurs spontaneously usually, but there may be association of various triggers. These triggers may act as seizure precipitating factors (SPFs). Objective: To find out the frequency of excitation as a SPF and its relationship to different types of epileptic patients attending Neurology and Medicine outpatient department (OPD) of a tertiary care hospital in Bangladesh. Methods: This was a cross sectional study carried out in specialized epilepsy weekly outdoor clinic of Neurology and Medicine outpatient department (OPD) of Dhaka Medical College Hospital from January 2008 to July 2011. Epilepsy syndromes were broadly classified into four categories using the classification system of International League Against Epilepsy (ILAE) namely, generalized epilepsy (GE), localization related epilepsy (LRE), symptomatic and unclassified. Each patient was evaluated and classified by consultant neurologist. All participants were interviewed through a predesigned close ended questionnaire to identify frequency of excitation as a SPF. Result: Among all the patients 71.5% were male, with most common age group at the time of interview was 11-20 years (36.8%). About 62% could identify at least one precipitator. Excitation (25.2%) was the most common SPF reported by patients followed by emotional stress in 17.7%. Excitation was found to be significantly associated with generalized epilepsy (p<.000). Conclusion: Most of the patients can identify their seizure precipitant. Excitation showed a strong association with generalized epilepsy. DOI: http://dx.doi.org/10.3329/jom.v13i2.12748 J Medicine 2012; 13 : 143-146

scholarly journals A STUDY ON POTENTIAL DRUG-DRUG INTERACTIONS AMONG PATIENTS ADMITTED UNDER DEPARTMENT OF MEDICINE IN A TERTIARY CARE HOSPITAL IN INDIA

2021 ◽  
Vol 10 (1) ◽  
pp. 29-32
Author(s):  
Sanjib Bandyopadhyay ◽  
Kaushik Mitra ◽  
Dipankar Bhaumik ◽  
Saibal Das
Keyword(s):  
Drug Interactions ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Controlled Study ◽  
Care Hospital ◽  
Potential Drug ◽  
Sectional Study ◽  
Cross Sectional ◽  
Different Types

Objective: This study was conducted to evaluate the potential drug-drug interactions (pDDIs) among patients admitted in a tertiary care hospital in India. Methods: This was anobservational and cross sectional study for 3 months. All the patients admitted in the general ward under Department of Medicine. Pre-structured proforma and patient’s charts were be used for data collection on the 2nd day of admission. For drug interactions, online ‘Medscape Drug Interaction Checker’ was used. Results: A total of 61 charts were screened. A total of 304 drugs with 57 different types were admitted to these patients (including all dosage forms and routes). The total number of pDDIs were 217, of them 69 were minor, 130 were significant and 18 were serious (including repetitions in different patients). There were 13 unique serious pDDIs. Conclusion: The incidence of pDDIs in our study was high. Controlled study to evaluate whether good clinical management of DDIs can reduce drug-related morbidity or mortality is needed. Keywords:Potential drug-drug interactions (pDDIs), adverse drug reactions (ADRs), poly-medication, hospitalization, pharmacokinetic and pharmacodynamics interactions.

scholarly journals Study on Corticosteroids use Pattern in Dermatological Practice and Investigating Adverse Effect of Corticosteroids Including its Associated Factors

2017 ◽  
Vol 13 (3) ◽  
pp. 261-267
Author(s):  
S. Shakya Shrestha ◽  
M. Bhandari ◽  
R. Shrestha ◽  
S.R. Thapa ◽  
A. Karki ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Adverse Effects ◽  
Tertiary Care ◽  
Common Adverse Effect ◽  
Cross Sectional Study ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Use Pattern

Background Corticosteroids are highly effective drugs with anti-inflammatory and immunosuppressive properties. Due to this, they have become a mainstay of pharmacotherapy in dermatology. However, improper and long term uses are associated with a number of serious adverse effects.Objective To investigate the corticosteroids use pattern, adverse effects and various factors associated with adverse effects in dermatological practice.Method A cross-sectional study was conducted in a dermatology department of tertiary care hospital. All patients using at least one corticosteroids, either topically or systemically or the combination were included in this study. Informed consent was taken from the patients and interviewed using structured questionnaire. Statistical analysis was performed by using SPSS 20. p-value < 0.05 was considered as statistically significant.Result Among the 60 participants under this study, 81.67% of them were females. The mean (±SD) age of the patients was 31.03 years (±15.0). A majority (58.30%) of the patients was prescribed with topical corticosteroids with low potency (25%). Most of them had used corticosteroids for urticaria. Adverse effects were reported by 33.30% of the patients. The most common adverse effect reported was the shedding of skin. Adverse effects was significantly associated with gender; use of systemic corticosteroids; regular use of corticosteroids; discontinuation of dose abruptly; and missed dose. However, there was no significant association between adverse effects and the duration of use of corticosteroids.Conclusion In conclusion, the present study suggested that the proper counselling and clear instruction regarding the use of corticosteroid should be provided to the patients for avoiding the abrupt discontinuation of the prescribed medication leading to treatment failure.

scholarly journals MEDICAL PROFILE OF ALLERGIC RHINITIS CASES IN CENTRAL INDIA: A CROSS SECTIONAL STUDY

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Devendra Chikara
Keyword(s):  
Allergic Rhinitis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Central India ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Different Types ◽  
Hospital Patients ◽  
History Of

Objective: To investigate the clinical profile of patients with allergic rhinitis in Central India. Material and Methods: Tertiary care hospital patients attending the E.N.T. OPD have been taken into account. The history of all sampled patients and the clinical evaluation were detailed and 800 cases were included in this study. Statistical Analysis: They were articulated in terms of plain proportion. Results: The majorities of patients are under the age of 30 years and are in the third decade of life. It was observed that the proportion of blockers was much higher than sneezers and runners. Most of the predisposing factors were seasonal and house dust. Conclusion: Allergic rhinitis can affect the physical, psychological and social aspects as well as the productivity of the job. There is an important need to raise awareness of different types of illness, including prevention, in the community. Keywords: allergic rhinitis, central India, sneezers.

scholarly journals THU0619-HPR PREVALENCE OF DISTAL INTERPHALANGEAL JOINT ULTRASONOGRAPHY FEATURES IN PSORIATIC ARTHRITIS, SKIN PSORIASIS, OSTEOARTHRITIS AND HEALTHY INDIVIDUALS: A CROSS-SECTIONAL STUDY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 552-553
Author(s):  
J. Guldberg-Møller ◽  
M. Henriksen ◽  
M. Boesen ◽  
L. Dreyer ◽  
K. Ellegaard ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Extensor Tendon ◽  
Cross Sectional Study ◽  
Advisory Board ◽  
Joint Involvement ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
High Prevalence ◽  
Distal Interphalangeal

Background:Distal interphalangeal (DIP) joint involvement is a feature of both psoriatic arthritis (PsA) and hand osteoarthritis (OA), and nail-changes are features seen both in PsA and nail psoriasis patients without joint involvement (PsO). In both PsA and OA, ultrasonography (US) is used to quantify DIP joint inflammation.Objectives:To explore disease-specific US-detected characteristics in the DIP-joints and extensor tendon entheses in patients with DIP-joint OA, PsA, PsO with nail involvement, and healthy controls (HC).Methods:In PsA, PsO, OA and HC US examination of DIP joints 2-5 and the extensor tendon were performed. The US images were scored for DIP joint grey-scale synovitis, DIP joint Doppler, osteophytes and erosions (grade 0-3) and presence/absence of enthesitis and peritendonitis of the extensor tendon according to OMERACT standards. Prevalences were calculated on all included fingers (i.e. four fingers per participant), and differences in prevalences were tested using Chi-square statistics.Results:Fifty PsA patients (44% females; mean age: 55y), 13 PsO patients (38% females; mean age 54y), 12 OA patients (100% females, mean age 71y), and 29 HC (52% females, mean age 48y) participated. The prevalences across the diagnosis groups are shown in figure 1, and the distribution of US outcomes was significantly different (highest Chi-square P-value: 0.0127). The PsA group had the largest prevalence of extensor tendon enthesitis (45.5%), peritendonitis (15%), and DIP joint erosions (11%), but also exhibited a considerable prevalence of osteophytes (46%). In the PsO group, the most marked findings were synovitis (33%) and enthesitis (35%). The OA group had the largest prevalence of DIP joint synovitis (67%) and osteophytes (88%) but also 25% prevalence of enthesitis. 24% of the HC group had a grade 1 synovitis.Conclusion:This cross-sectional study found significant patterns of US findings distributed dependent on the underlying condition. PsA patients were mainly differentiated by the presence of extensor tendon enthesitis and peritendonitis. A high prevalence of enthesitis and synovitis was seen in patients with DIP joint OA. The high prevalence of enthesitis in PsO is consistent with a preclinical phase of PsA in this group.Disclosure of Interests:Jørgen Guldberg-Møller Speakers bureau: Novartis, Ely Lilly, AbbVie, BK Ultrasound, Marius Henriksen: None declared, Mikael Boesen Speakers bureau: Image Analysis Group, AbbVie, AstraZeneca, Eli Lilly, Esaote, Glenmark, Novartis, Pfizer, UCB, Lene Dreyer: None declared, Karen Ellegaard: None declared, Marie Skougaard: None declared, Christine Ballegaard: None declared, Ai Lyn Tan: None declared, Richard Wakefield Speakers bureau: Novartis, Janssen, GE, Lars Erik Kristensen Consultant of: UCB Pharma (Advisory Board), Sannofi (Advisory Board), Abbvie (Advisory Board), Biogen (Advisory Board), Speakers bureau: AbbVie, Amgen, Biogen, Bristol-Myers Squibb,Celgene, Eli Lilly, Gilead, Forward Pharma, Janssen Pharmaceuticals, MSD, Novartis, Pfizer, and UCB Pharma

scholarly journals A hospital based cross sectional study on synovial fluid analysis among patients with different types of knee joint disorders at a tertiary care hospital

2018 ◽  
Vol 4 (6) ◽  
pp. 959
Author(s):  
Arvind Gandra
Keyword(s):  
Synovial Fluid ◽  
Knee Joint ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Fluid Analysis ◽  
Synovial Fluid Analysis ◽  
Different Types

<p class="abstract"><strong>Background:</strong> Patients presenting with knee joint disorders are subjected to variety of investigations which are often inconclusive. Instead if they are subjected for synovial fluid analysis, they will be benefited. The objective of the study was to study synovial fluid analysis among patients with different types of knee joint disorders at a tertiary care hospital.</p><p class="abstract"><strong>Methods:</strong> A hospital based cross sectional study was carried out among 30 patients attending the outpatient Department of Orthopedics and suffering from knee joint pain of either left or right or both the sides. Present study was carried out over a period of two years from January 2011 to December 2012 at Department of Orthopedics, Global Hospitals, Secunderabad. All patients were examined in detail and subjected to all necessary investigations.<strong></strong></p><p class="abstract"><strong>Results:</strong> Males were more than females. The most common joint disease in the study population was tubercular synovitis in 20% of the cases. The most common condition among males was osteoarthritis while there was no such case in females. Rheumatoid arthritis was most common in females while there was no such case in males. Polymorphs were seen in all cases except osteoarthritis and villonodular synovitis. On biochemical analysis of synovial fluid it was found that gouty arthritis did not have proteins. Proteins were minimum in the synovial fluid in case of osteoarthritis while maximum range was found in cases of tubercular arthritis and rheumatoid arthritis.</p><p class="abstract"><strong>Conclusions:</strong> Synovial fluid analysis is very important to understand the etiopathogenesis of knee joint diseases. Our study showed that synovial fluid of the knee joint analysis was very informative in the diagnosis and proper management of the patients presenting with knee joint disorders.</p>

scholarly journals Fungal Infections among Teledermatology Consultations in Dermatology Department of a Tertiary Care Hospital: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (243) ◽  
pp. 1094-1097
Author(s):  
Sagar Mani Jha ◽  
Anil Kumar Singh Dangol ◽  
Bhabendra Suwal ◽  
Jyotshna Yadav
Keyword(s):  
Confidence Interval ◽  
Binary Data ◽  
Tertiary Care Hospital ◽  
Fungal Infections ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dermatology Department

Introduction: Teledermatology provides virtual consultation to patients using telecommunication technology. Using this method dermatologists can diagnose a condition with the help of pictures of the lesions and short history. During the COVID-19 pandemic, practicing this method has become more relevant. Providing teleconsultations to patients with fungal skin infections can prevent inadvertent use of topical corticosteroids. The objective of this study was to find the prevalence of fungal infections among teledermatology consultations done in a tertiary care hospital. Methods: It was a descriptive cross-sectional study where the store and forward and real-time methods were used between February 2020 to July 2020. Ethical clearance was taken from the institutional review board (reference number: 245). Data of those patients who wanted consultations from this department were sent by medical officers deployed in military hospitals that are under the central army hospital located in Kathmandu. Convenient sampling was used. The collected data was entered and analyzed in the Statistical Package of Social Sciences version 20. Point estimate at 95% Confidence Interval was calculated along with frequency and percentage for binary data. Results: A total of 451 (33.45%) (30.93-35.97 at 95% Confidence Interval) were diagnosed with fungal infections out of 1348 patients who were enrolled for the study. About 361 (80%) of the patients suffering from fungal infections belonged to the Terai region and 90 (20%) belonged to mountainous areas. Conclusions: The prevalence of fungal infection among teledermatology consultation was lower than the findings from a similar international study.

scholarly journals Clinicoepidemiological Profile of Pityriasis Versicolor in a Tertiary Care Hospital in Kathmandu, Nepal

2019 ◽  
Vol 21 (4) ◽  
pp. 294-300
Author(s):  
S Shrestha ◽  
P Koirala ◽  
U Timothy
Keyword(s):  
Seborrheic Dermatitis ◽  
Tertiary Care ◽  
College Teaching ◽  
Cross Sectional Study ◽  
Pityriasis Versicolor ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Predisposing Factor ◽  
Cross Sectional ◽  
Dermatology Department

Pityriasis versicolor (PV) also known as Tinea versicolor is a benign, chronic superficial fungal infection of the skin caused by Malassezia furfur. It is characterized by dyspigmented macules with fine branny scales. The purpose of this study was to assess the epidemiological profile and clinical pattern of PV in a group of patients visiting a tertiary care centre of Nepal. A descriptive cross-sectional study was carried out including 150 patients diagnosed to have PV at the outpatient dermatology department of Nepal Medical College Teaching Hospital. Patients with the diagnosis of PV were included in the study. A detailed history was taken and it was followed by a thorough clinical examination. The findings of history and clinical examinations were documented in a predesigned proforma. Statistical Package for the Social Sciences (SPSS) version 16 was used to tabulate the data and analyze the results. There was a slight male preponderance with maximum patients of the age group 11 – 20 years. A majority of patients were students. Forty three (28.7%) patients had similar problem in close contacts and 42% had recurrent disease. Wearing of occlusive synthetic clothing was the commonest predisposing factor. Upper chest and upper back were the most involved sites. Hypopigmented macules were the commonest lesions in 72.7%. Coexisting seborrheic dermatitis (commonly pityriasis capitis ) was present in 44.67% of patients. Clinicoepidemiological profile of PV in our setting is similar to many studies done mostly in India. But few findings differ which indicates the need for further studies in Nepal especially from Terai regions where the prevalence is expected to be more.

CLINICAL AND RADIOLOGICAL STUDY OF PSORIATIC ARTHRITIS IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 68-70
Author(s):  
Kurimilla Narasimha Prasad ◽  
P.Vijay Sekhar ◽  
Gopinath Mogilicherla ◽  
Boppani Praveen Kumar
Keyword(s):  
Psoriatic Arthritis ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Clinical History ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Female Ratio ◽  
Chronic Progressive Disease ◽  
Detailed Clinical History

Introduction: Psoriatic Arthritis (PA) is an autoimmune inammatory disease involving ligaments, tendons, fascia and spinal and/or peripheral joints in association with or without psoriasis of the skin and/or nails. This study done to determine the natural course, clinical presentation and radiological ndings of the disease. To ascertain the incidence of Psoriati Objective: c arthritis, analyse the different clinical manifestations of PA and to evaluate the clinical and radiological correlation in patients. This Materials and Methods: was a non-interventional, cross-sectional study comprised of 12 patients of PA. In all patients, detailed clinical history was taken followed by clinical and radiological examination were done depending on the joint involved. Out of the total attendance of 5801 new patients at Results: tended, 224 patients had psoriasis (5.35%), there were 12 cases of PA detected, thus accounting for 0.21%. Out of the 12 patients of PA, there were 8 males and 4 females. The male to female ratio was found to be 2: 1, The mean age was 40 years. The joints involved were Proximal inter-phalangeal joints of hands in 7 patients (58.34%), Distal interphalangeal joints of hands in 3 patients (25%), Knee joint and ankle joint in each one patient respectively (8.33%). Majority of the patients on radiographic lms, revealed bony erosions, narrowing of joint spaces, minimal periosteal reaction. One case revealed osteoporosis and fusion of PIP-joints. Five cases didn't reveal any abnormal radiological features. This Conclusion: study conrms that PA is a chronic, progressive disease in the majority of patients. Despite clinical improvement with current DMARD treatment, PA results in radiological damage.

A cross sectional study to observe the diversity of fungal species in Onychomycosis isolated from a tertiary care hospital in Karachi.

2020 ◽  
pp. 1-12
Author(s):  
Raziuddin Ahmed ◽  
Bahram Khan Khoso ◽  
Fakhur Uddin ◽  
Nida Rehman ◽  
Muhammad Sohail ◽  
...  
Keyword(s):  
Potassium Hydroxide ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Medical Centre ◽  
Fungal Culture ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dermatology Department ◽  
Microscopic Evaluation

Abstract Objective: To study the frequency and diversity of fungi involved in onychomycosis. Method: The cross-sectional study was conducted from February 2018 to February 2019 at the Department of Microbiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, and the University of Karachi. Specimens were taken from patients suffering with onychomycosis attending the Dermatology Department of Jinnah Postgraduate Medical Centre and were processed for the isolation of fungi. Specimens were processed for the diagnosis by potassium hydroxide mount for microscopic evaluation and mycological culture to determine the type of fungus involved in onychomycosis. Fungi were isolated using Sabouraud Dextrose Agar with antibiotics cycloheximide and chloramphenicol, and without antibiotics. Plates were observed for the growth periodically until 4th week. Appearance of any colony was studied further for identification on the basis of cultural characteristics and microscopy. Precise identification of Candida species was done. Results: Of the 230 samples, 85(36.96%) were from males and 145(63.04%) from females. Potassium hydroxide mount showed fungal element in 134(58.26%) specimens, while in 111(48.26%) patients the fungal culture was positive. Nine (3.9%) cases were culture-positive but potassium hydroxide-negative, while among the 134(58.26%) potassium hydroxide-positive cases, 32(23.9%) were culture-negative. Key Words: Candida, Dermatophytes, Fungal infections of nail, KOH mount, Non-dermatophyte molds, Onychomycosis, Tinea unguium. Continuous...

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