Chronic intake of valproic acid decreases total cholesterol level in adult population

2021 ◽  
Vol 15 (7) ◽  
pp. 1665-1667
Author(s):  
Rao S Aziz ◽  
Usman Saeed ◽  
Liaqat Ali ◽  
Muhammad Arshad ◽  
Roman Abbas ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Total Cholesterol ◽  
Cholesterol Oxidase ◽  
Total Cholesterol Level ◽  
Adult Population ◽  
Venous Blood ◽  
Case Group ◽  
Long Duration ◽  
And Control

Background: Valproic acid (VA) serve as the antimigraine, anti-mental disturbances agent and antiepileptic medicine. After using VA, metabolic rearrangements seen in patients that include alteration in lipoproteins levels; however, this topic is still under discussion and disputable. Aim: To discuss the effects of VA after using for long duration on total levels of cholesterol in adult. Methods: About Eighty candidates participated and they were divided into two groups namely, case group (40 candidates) and control groups40 candidates). All the candidates were asked for collection of venous blood sample in order to determine total cholesterol serum level among them via aid of enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. By the aid of the logistic regression analysis, the relationship of the long-term VA treatment and the level of total cholesterol was obtained. With respect to our analysis, there is a co relation between total levels of cholesterol and long term usage of VA (P=0.003). Results: There were no noteworthy link for age, sex, body BMI, height medication usage, smoking, diabetes mellitus and VA dosage , except combination of anti-epileptic drugs Conclusion: In a net shell, by using VA for long duration, the total level of cholesterol in adults reduces. Keywords: Lipid profile, side effects, total cholesterol, valproic acid

scholarly journals Effect on lipid profile due to prolong Valproic acid intake

2021 ◽  
Vol 15 (7) ◽  
pp. 1497-1499
Author(s):  
Rao. S Aziz ◽  
Usman Saeed ◽  
Liaqat Ali ◽  
Muhammad Arshad ◽  
Roman Abbas ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Oxidase ◽  
Venous Blood ◽  
Case Group ◽  
Long Duration ◽  
And Control ◽  
Relationship Of

Background: Valproic acid (VA) serve as the antimigraine , anti-mental disturbances agent and antiepileptic medicine. After using va, metabolic rearrangements seen in patients that include alteration in lipoproteins levels; Aim: To discuss the effects of VA after using for long duration on total levels of cholesterol in adult. Methods: About Eighty candidates participated and they were divided into two groups namely, case group (40 candidates) and control groups (40 candidates). All the candidates were asked for collection of venous blood sample in order to determine total cholesterol serum level among them via aid of enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. Results: By the aid of the logistic regression analysis, the relationship of the long-term VA treatment and the level of total cholesterol was obtained. With respect to our analysis, there is a co relation between total levels of cholestrol and long term usage of VA (P=0.003). Conclusions: In a net shell, by using VA for long duration, the total level of cholesterol in adults reduces. Keywords: Lipid profile, side effects, total cholesterol, valproic acid

scholarly journals Vitamin D levels in epileptic children on long-term anticonvulsant therapy

2015 ◽  
Vol 55 (3) ◽  
pp. 164
Author(s):  
Fathy Pohan ◽  
Aryono Hendarto ◽  
Irawan Mangunatmadja ◽  
Hartono Gunardi
Keyword(s):  
Vitamin D ◽  
Valproic Acid ◽  
Vitamin D Deficiency ◽  
Anticonvulsant Therapy ◽  
Control Group ◽  
Case Group ◽  
Vitamin D Levels ◽  
Epileptic Children ◽  
The Mean

Background Long-term anticonvulsant therapy, especially with enzyme inducers, has been associated with low 25-hydroxyvitamin D [25(OH)D] levels and high prevalence of vitamin D deficiency. However, there have been inconsistent results in studies on the effect of long-term, non-enzyme inducer anticonvulsant use on vitamin D levels.Objective To compare 25(OH)D levels in epileptic children on long-term anticonvulsant therapy and non-epileptic children. We also assessed for factors potentially associated with vitamin D deficiency/insufficiency in epileptic children.Methods This cross-sectional study was conducted at two pediatric neurology outpatient clinics in Jakarta, from March to June 2013. Subjects in the case group were epileptic children, aged 6-11 years who had used valproic acid, carbamazepine, phenobarbital, phenytoin, or oxcarbazepine, as a single or combination therapy, for at least 1 year. Control subjects were non-epileptic, had not consumed anticonvulsants, and were matched for age and gender to the case group. All subjects’ 25(OH)D levels were measured by enzyme immunoassay.Results There were 31 epileptic children and 31 non-epileptic control children. Their mean age was 9.1 (SD 1.8) years. Most subjects in the case group were treated with valproic acid (25/31), administered as a monotherapy (21/31). The mean duration of anticonvulsant consumption was 41.9 (SD 20) months. The mean 25(OH)D level of the epileptic group was 41.1 (SD 16) ng/mL, lower than the control group with a mean difference of 9.7 (95%CI 1.6 to 17.9) ng/mL. No vitamin D deficiency was found in this study. The prevalence of vitamin D insufficiency in the epileptic group was higher than in the control group (12/31 vs. 4/31; P=0.020). No identified risk factors were associated with low 25(OH)D levels in epileptic children.Conclusion Vitamin D levels in epileptic children with long-term anticonvulsant therapy are lower than that of non-epileptic children, but none had vitamin D deficiency.

scholarly journals Effect of prolonged venostasis on lipid profile parameters among apparently healthy University students: A case-control study in Ghana

2021 ◽  
Vol 1 (1) ◽  
pp. 1-7
Author(s):  
Richard K.D. Ephraim
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Short Duration ◽  
Venous Blood ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Medical Laboratory ◽  
Cape Coast ◽  
Long Duration

Background: The effect of prolonged tourniquet application on lipid profile parameters (total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c)) among healthy students in the University of Cape Coast was assessed in this study. Methods: A total of 30 participants were sampled and venous blood was taken from both arms at different duration of tourniquet application. Blood was allowed to clot, centrifuged and serum separated and stored until assay. Lipid profile parameters were measured using the enzymatic techniques with the aid of a spectrophotometer. Lipid parameters were expressed in mmol/L. The relationship between the concentrations was analyzed using GraphPad Prism version 6.0. Results: The mean serum levels of total cholesterol and HDL-c were significantly (p<0.05) elevated after long duration (13.44±2.40 s) of tourniquet application compared to short duration (11.20±0.38 s) of tourniquet application. Despite the fact that the serum levels of triglyceride and LDL-c increased after long duration of tourniquet application compared to short duration, the difference was not significant (p>0.05). There was significant % mean differences of 7.0% (p<0.0001) and 11.2% (p=0.0082) in the concentrations of total cholesterol and HDL-c respectively following prolonged tourniquet application of 120-180 s. A significant increase of up to 7% (5.01±0.04, 5.352±0.05, p<0.0001) and 11% (2.41±0.07, 2.674±0.07, p=0.0082) in the concentrations of total cholesterol and HDL-c respectively was also recorded. Conclusion: Prolonged venostasis has a direct effect on the concentration of serum total cholesterol and HDL-c but not triglyceride and LDL-c. Nonapplication of tourniquet in patients with prominent veins, the application of standardized external pressure as well the early release of tourniquet after needle insertion in the vein should be followed during sample taking for lipid profile. Annals of Medical Laboratory Science (2021) 1(1), 1 - 7

scholarly journals Pengaruh susu kedelai dan jahe terhadap kadar kolesterol total pada wanita hiperkolesterolemia

2016 ◽  
Vol 4 (2) ◽  
pp. 89-95
Author(s):  
Deny Yudi Fitranti ◽  
Diassafons Marthandaru
Keyword(s):  
Treatment Group ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Intervention Group ◽  
Control Group ◽  
Soy Milk ◽  
Cholesterol Levels ◽  
Before And After ◽  
And Control

Background: Hypercholesterolemia is one of the risk factor of coronary heart disease. Soy contains protein, fiber and isoflavones which can reduce total cholesterol levels. Soy milk added by ginger might increase antioxidant activity. Ginger consist of oleoresin that can  reduce total cholesterol level.Objective: To investigate the effect of soy milk and ginger to the total cholesterol levels in hypercholesterolemic women Methods: The study was true experiment with the control group pre-post test design. Subjects were 16 women aged 30-55 years with serum total cholesterol level 200-250 mg / dl. Subject were divided into two group. The intervention group receive 430 ml soy milk with 3 gram ginger and control group receive placebo. Total cholesterol level was measured by CHOD-PAP method. Food intake during the intervention was measured using food records and 24-hours food recall.. Data was analyzed by using  Independent t test, Wilcoxon and Multiple Linear Regression.Results: Mean of total cholesterol level in treatment group decreased 5,50 mg/dl and the placebo group had increased total cholesterol l9.44 mg/dl. There were no differences in total cholesterol levels before and after intervention in the treatment group (p = 0.204) and control group (p = 0.093). There were differences in variations in total cholesterol levels between the two groups (p = 0.041). Conclusion: Consumed soy milk with ginger as much as 430ml/day during 14 days there was no difference in total cholesterol levels before and after intervention with decreased total cholesterol by 5,50 mg/dl.

scholarly journals Comparison of biochemical blood traits after long-term selection on high or low locomotory activity in mice

2000 ◽  
Vol 43 (5) ◽  
pp. 513-522 ◽  
Author(s):  
H. Falkenberg ◽  
M. Langhammer ◽  
U. Renne
Keyword(s):  
Total Cholesterol ◽  
Total Cholesterol Level ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Locomotory Activity ◽  
Laboratory Mice ◽  
Term Selection ◽  
Long Term Experiment ◽  
Males And Females

Abstract. In a long term experiment laboratory mice were selected for high (line DU-hTP) or low (line DU-ITP) paternal treadmill Performance to differentiate the endurance fitness. In generation 54 six enzymes and seven Substrates were investigated in the blood plasma of males and females in DU-hTP (n = 104) and DU-ITP (n = 141). Compared with line DU-ITP in line DU-hTP significantly higher enzyme activities, increased glucose concentration and lower level of triglycerides were found. The components of total cholesterol were divergent between the two lines and positively effected in DU-hTP for higher HDL-cholesterol. Animals with high endurance fitness showed a higher gain in the HDL-cholesterol concentration with increased total cholesterol level in the blood than gain of LDL + VLDL-cholesterol concentration.

scholarly journals Effect of Bortezomib on Total Cholesterol, Triglycerides and Histopathology Abdominal Aorta in Rats of Atherosclerosis Model

2020 ◽  
Vol 31 (2) ◽  
pp. 95
Author(s):  
Ismawati Ismawati ◽  
Ilhami Romus ◽  
Esy Maryanti ◽  
Nopi Permatasari ◽  
Elfiah Luthfianty
Keyword(s):  
Total Cholesterol ◽  
Abdominal Aorta ◽  
Cholesterol Oxidase ◽  
Proteasome Inhibitors ◽  
Serum Triglyceride ◽  
Serum Total Cholesterol ◽  
Serum Triglycerides ◽  
Atherosclerotic Lesions ◽  
Abdominal Aortic ◽  
And Control

<p>The effects of using proteasome inhibitors on atherosclerosis could be beneficial or detrimental. This study aimed to analyze the effects of proteasome inhibitors in the progression stage. Experimental animals (18 rats) were divided into three groups, namely control (C) as a group of rats given standard feed, P1 as atherosclerosis-induced rat group, and P2 as atherosclerosis-induced rat group and given proteasome inhibitors. Proteasome inhibitor administered was bortezomib at a dose of 50µg/kgBW/day intraperitoneally on day 1 and 3. After four days of treatment, the termination and measurement of serum total cholesterol, serum triglycerides, and abdominal aorta histopathology with hematoxylin-eosin staining were carried out. Serum total cholesterol levels were measured using the CHOD-PAP (Cholesterol Oxidase-Peroxidase Aminoantypirin) method, whereas serum triglyceride levels were measured using the GPO-PAP (glycerol phosphatase oxidase−phenol4-amino antipyrene peroxidase) method. Histopathological assessment was carried out with a scoring system in 9 fields of view with a 400x magnification, which was then averaged. The ANOVA test showed significant differences in serum total cholesterol, serum triglycerides, and abdominal aortic histopathology between atherosclerosis and control groups, but there were no significant differences in the administration of bortezomib in atherosclerosis except in serum triglyceride levels. It can be concluded that the administration of 50µg/kg bortezomib for four days in the rats model of the progression stage of atherosclerosis can decrease serum triglyceride levels, although it can not inhibit the formation of atherosclerotic lesions and has no effect on serum total cholesterol. </p>

Is post-trabeculectomy serous choroidal detachment a risk factor for failure in the long term

2020 ◽  
pp. 112067212097262
Author(s):  
Maryam Yadgari ◽  
Kiana Hassanpour ◽  
Nader Nassiri
Keyword(s):  
Glaucoma Surgery ◽  
Cumulative Probability ◽  
Control Group ◽  
Case Group ◽  
Choroidal Detachment ◽  
Surgical Success ◽  
Long Term Effect ◽  
Advanced Glaucoma ◽  
And Control

Background: To investigate the long-term effect of serous choroidal detachment on the success of trabeculectomy in glaucoma patients. Methods: In this case-control study, 17 patients who underwent trabeculectomy and developed choroidal detachment, and completed at least 3 years of follow-up were included. The controls were matched based on age, sex, preoperative intraocular pressure, and glaucoma type, and lack of choroidal detachment. Surgical success was defined based on two definitions of 5 < IOP < 16 and 20% reduction from the baseline and no need for further glaucoma surgery and all the same but 5 < IOP < 22. Results: The mean estimated duration of survival ±SD was 2.73 ± 0.35 years (CI 95% 2.1, 3.4), which was significantly shorter than 3.98 ± 0.38 years (CI 95% 3.3, 4.7) in the control group. (LogRank = 5.03 p = 0.02). Cumulative probability of success was 76.5%, 52.9%, 29.4%, 17.6%, and 11.8% in year 1, 2, 3, 4, and 5 in the case group, respectively. Corresponding values were 88.2%, 82.4%, 68.6%, 58.8%, and 47.1%. In the control group, respectively. At baseline, average IOP was 22.3 ± 2.7 and 23.8 ± 8.3 mmHg in the case and control groups, respectively ( p = 0.17). Mean IOP was significantly higher in the case group than in the control group in years 2, 3, 4, and 5. Conclusion: Serous choroidal detachment affects the long-term surgical success of trabeculectomy, especially in patients with advanced glaucoma when lower target pressure is required.

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