scholarly journals Effect on lipid profile due to prolong Valproic acid intake

2021 ◽  
Vol 15 (7) ◽  
pp. 1497-1499
Author(s):  
Rao. S Aziz ◽  
Usman Saeed ◽  
Liaqat Ali ◽  
Muhammad Arshad ◽  
Roman Abbas ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Oxidase ◽  
Venous Blood ◽  
Case Group ◽  
Long Duration ◽  
And Control ◽  
Relationship Of

Background: Valproic acid (VA) serve as the antimigraine , anti-mental disturbances agent and antiepileptic medicine. After using va, metabolic rearrangements seen in patients that include alteration in lipoproteins levels; Aim: To discuss the effects of VA after using for long duration on total levels of cholesterol in adult. Methods: About Eighty candidates participated and they were divided into two groups namely, case group (40 candidates) and control groups (40 candidates). All the candidates were asked for collection of venous blood sample in order to determine total cholesterol serum level among them via aid of enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. Results: By the aid of the logistic regression analysis, the relationship of the long-term VA treatment and the level of total cholesterol was obtained. With respect to our analysis, there is a co relation between total levels of cholestrol and long term usage of VA (P=0.003). Conclusions: In a net shell, by using VA for long duration, the total level of cholesterol in adults reduces. Keywords: Lipid profile, side effects, total cholesterol, valproic acid

Chronic intake of valproic acid decreases total cholesterol level in adult population

2021 ◽  
Vol 15 (7) ◽  
pp. 1665-1667
Author(s):  
Rao S Aziz ◽  
Usman Saeed ◽  
Liaqat Ali ◽  
Muhammad Arshad ◽  
Roman Abbas ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Total Cholesterol ◽  
Cholesterol Oxidase ◽  
Total Cholesterol Level ◽  
Adult Population ◽  
Venous Blood ◽  
Case Group ◽  
Long Duration ◽  
And Control

Background: Valproic acid (VA) serve as the antimigraine, anti-mental disturbances agent and antiepileptic medicine. After using VA, metabolic rearrangements seen in patients that include alteration in lipoproteins levels; however, this topic is still under discussion and disputable. Aim: To discuss the effects of VA after using for long duration on total levels of cholesterol in adult. Methods: About Eighty candidates participated and they were divided into two groups namely, case group (40 candidates) and control groups40 candidates). All the candidates were asked for collection of venous blood sample in order to determine total cholesterol serum level among them via aid of enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. By the aid of the logistic regression analysis, the relationship of the long-term VA treatment and the level of total cholesterol was obtained. With respect to our analysis, there is a co relation between total levels of cholesterol and long term usage of VA (P=0.003). Results: There were no noteworthy link for age, sex, body BMI, height medication usage, smoking, diabetes mellitus and VA dosage , except combination of anti-epileptic drugs Conclusion: In a net shell, by using VA for long duration, the total level of cholesterol in adults reduces. Keywords: Lipid profile, side effects, total cholesterol, valproic acid

scholarly journals Effect of prolonged venostasis on lipid profile parameters among apparently healthy University students: A case-control study in Ghana

2021 ◽  
Vol 1 (1) ◽  
pp. 1-7
Author(s):  
Richard K.D. Ephraim
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Short Duration ◽  
Venous Blood ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Medical Laboratory ◽  
Cape Coast ◽  
Long Duration

Background: The effect of prolonged tourniquet application on lipid profile parameters (total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c)) among healthy students in the University of Cape Coast was assessed in this study. Methods: A total of 30 participants were sampled and venous blood was taken from both arms at different duration of tourniquet application. Blood was allowed to clot, centrifuged and serum separated and stored until assay. Lipid profile parameters were measured using the enzymatic techniques with the aid of a spectrophotometer. Lipid parameters were expressed in mmol/L. The relationship between the concentrations was analyzed using GraphPad Prism version 6.0. Results: The mean serum levels of total cholesterol and HDL-c were significantly (p<0.05) elevated after long duration (13.44±2.40 s) of tourniquet application compared to short duration (11.20±0.38 s) of tourniquet application. Despite the fact that the serum levels of triglyceride and LDL-c increased after long duration of tourniquet application compared to short duration, the difference was not significant (p>0.05). There was significant % mean differences of 7.0% (p<0.0001) and 11.2% (p=0.0082) in the concentrations of total cholesterol and HDL-c respectively following prolonged tourniquet application of 120-180 s. A significant increase of up to 7% (5.01±0.04, 5.352±0.05, p<0.0001) and 11% (2.41±0.07, 2.674±0.07, p=0.0082) in the concentrations of total cholesterol and HDL-c respectively was also recorded. Conclusion: Prolonged venostasis has a direct effect on the concentration of serum total cholesterol and HDL-c but not triglyceride and LDL-c. Nonapplication of tourniquet in patients with prominent veins, the application of standardized external pressure as well the early release of tourniquet after needle insertion in the vein should be followed during sample taking for lipid profile. Annals of Medical Laboratory Science (2021) 1(1), 1 - 7

scholarly journals A study of lipid parameters among GDM and non GDM pregnant women: a hospital based study

2017 ◽  
Vol 6 (12) ◽  
pp. 5488 ◽  
Author(s):  
Bharathi K. R. ◽  
Vijayalakshmi S. ◽  
Shrunga R. P.
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Statistical Significance ◽  
Serum Triglyceride ◽  
Normal Pregnancy ◽  
P Value ◽  
Case Group ◽  
Lipid Levels ◽  
Lipid Parameters

Background: Altered maternal lipid metabolism is common in pregnancy. In women with GDM physiological changes in insulin and lipid levels are exaggerated during pregnancy, leading to significant alterations in lipid levels compared to normal pregnancy. Assessment of raise in certain lipid parameters in pregnant women with GDM and non GDM.Methods: A hospital based case control study done in the Department of OBG AIMS Bellur, Mandya, Karnataka, with sample size of 100 pregnant women. 50 cases of GDM (confirmed by OGCT) and 50 controls (non GDM cases) pregnant women were taken during 1 year study period from June 2015 to June 2016. Mean age of presentation of women was 20-25 yrs. Ethical committee clearance was taken and consent from control and cases was taken. Fasting lipid profile was sent. Parameters obtained were analyzed using student t test for statistical significance.Results: There was no statistical difference in age and parity between control and case group. Triglyceride (cases- 286.4±77.60 mg/dl) (controls-166±26mg/dl), total cholesterol (cases-256.5±41.7 mg/dl) (controls -202.5±20.18mg/dl), VLDL (cases-53.4±13.2 mg/dl) (controls-46.6±13.1mg/dl) showed statistically significant values (p value<0.001). HDL and LDL values did not show any statistical significance (p value >0.5) among GDM and non GDM group. Lipid profile was performed predominately in women in II trimester.Conclusions: Serum triglyceride, total cholesterol and VLDL level are significantly higher among woman with GDM compared to non GDM pregnant women, where in the lipid profile can be used as predictor for gestational diabetes mellitus in future which needs further research.

scholarly journals Alterations in Lipids and Adipocyte Hormones in Female-to-Male Transsexuals

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Prakash Chandra ◽  
Sukhdeep S. Basra ◽  
Tai C. Chen ◽  
Vin Tangpricha
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Statistical Significance ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Testosterone Therapy ◽  
Serum Leptin ◽  
Atherogenic Lipid Profile

Testosterone therapy in men and women results in decreased high-density lipoprotein cholesterol (HDL) and increased low-density lipoprotein cholesterol (LDL). We sought to determine whether testosterone therapy has this same effect on lipid parameters and adipocyte hormones in female-to-male (FTM) transsexuals. Twelve FTM transsexuals provided a fasting lipid profile including serum total cholesterol, HDL, LDL, and triglycerides prior to and after 1 year of testosterone therapy (testosterone enanthate or cypionate 50–125 mg IM every two weeks). Subjects experienced a significant decrease in mean serum HDL (52±11to40±7 mg/dL)(P<.001). The mean LDL(P=.316), triglyceride(P=.910), and total cholesterol(P=.769)levels remained unchanged. In a subset of subjects, we measured serum leptin levels which were reduced by 25% but did not reach statistical significance(P=.181)while resistin levels remained unchanged. We conclude that testosterone therapy in FTM transsexuals can promote an increased atherogenic lipid profile by lowering HDL and possibly reduce serum leptin levels. However, long-term studies are needed to determine whether decreases in HDL result in adverse cardiovascular outcomes.

scholarly journals Calcium intake and the associations with faecal fat and energy excretion, and lipid profile in a free-living population

2017 ◽  
Vol 6 ◽  
Author(s):  
Louise Kjølbæk ◽  
Janne K. Lorenzen ◽  
Lesli H. Larsen ◽  
Arne Astrup
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Calcium Intake ◽  
Blood Lipid ◽  
Normal Weight ◽  
Urine Collection ◽  
Free Living ◽  
Blood Lipid Profile ◽  
Habitual Diet

AbstractThe aim of the present study was to investigate the associations between the habitual Ca intake and faecal fat and energy excretion as well as blood lipid profile in free-living normal-weight and overweight individuals. The participants were enrolled for an 8-d period where data from a 7-d diet registration (days 1–7), a 5-d faeces collection (days 3–7), a 2-d urine collection (days 5–7), and anthropometric measurements and a fasting blood sample (day 8) were collected. Analyses showed that dietary Ca intake (g/10 MJ per d) was positively associated with excretion of faecal fat (P = 0·004) and energy (P = 0·031) when adjusted for BMI, age, sex and intake of Ca-containing supplements. However, after adjustment for intake of fibre, the effect of Ca intake disappeared. Nevertheless, total cholesterol (CHOL) and LDL-CHOL concentrations were associated negatively with Ca intake (β −0·62 (95 % CI −0·96, −0·28) mmol/l, P < 0·001, and β −0·49 (95 % CI −0·78, −0·20) mmol/l, P = 0·001, respectively, per 1000 mg/10 MJ per d increase in Ca intake). In conclusion, incorporation of Ca-rich food products in a habitual diet was associated with reduced total CHOL and LDL-CHOL concentrations, which may lower the risk of CVD in the long term.

scholarly journals The Description of Lipid Profile on Injectable DMPA Contraception Acceptors in Public Health Center Banjarsengon, Jember District

2021 ◽  
Vol 8 (1) ◽  
pp. 043-048
Author(s):  
Ririn Handayani ◽  
Rizki Fitrianingtyas
Keyword(s):  
Lipid Profile ◽  
Cholesterol Oxidase ◽  
Lipoprotein Metabolism ◽  
The Body ◽  
High Cholesterol ◽  
Exclusion Criteria ◽  
Cholesterol Levels ◽  
Very High ◽  
High Triglyceride

Injectable DMPA contraception can cause changes in lipoprotein metabolism. Changes in fat metabolism occur because of the hormonal influence of progesterone, causing disruption of the balance of lipid profiles in the body. The change in serum lipid profile (trgliseride, total cholesterol, HDL and LDL) in long-term use of DMPA is a risk factor for atherosclerosis and cardiovascular disease. The purpose of this study was to look at the description of the lipid profile at 3 months injection acceptors. The design of the study was descriptive. The population in this study was 76, the number of samples that met the inclusion and exclusion criteria in this study was 30. Examination of the lipid profile was carried out with an enzymatic colorimetric (cholesterol oxidase method / CHOD PAP). The results of lipid profile examination showed that 13.33% had high cholesterol levels, 3.33% had high triglyceride levels, 13.33% had high HDL levels, 20% had high LDL levels and 3.33% have very high LDL levels. The conclusion of this study was long term use of DMPA injection contraception could cause changes in the lipid profile, so it is recommended for acceptors who want to use contraception in the long term to use MKJP as an option so as not to affect the fat profile in the body.

scholarly journals Effect of Long Term Use of Carbamazepine on Lipid Profile in Adult Epileptic Patients

2014 ◽  
Vol 30 (1) ◽  
pp. 27-34
Author(s):  
Md Khairul Kabir Patwary ◽  
Shakila Sultana ◽  
- Md Salahuddin ◽  
Abu Jafor Md Salahuddin ◽  
Mohammed Sayeed Hassan ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Focal Epilepsy ◽  
Serum Triglyceride ◽  
Control Group ◽  
Case Group ◽  
Healthy Population ◽  
Female Patients ◽  
Epileptic Patients ◽  
The Mean

Objective: To evaluate the effect of long term use of carbamazepine on lipid profile in adult epileptic patients Methodology: The study was conducted in the Department of Neurology at BSMMU, Dhaka over a period of 2 years from January 2010 to December 2011. Adult epileptic patients taking carbamazepine as anticonvulsant and attending the Epilepsy Clinic and Neurology OPD of BSMMU, Dhaka were the study population. A total of 107 cases and 107 controls were included in the study. Data were collected by interview of the patients, clinical examination and laboratory investigations using the research instrument Result: The mean age of case and control groups were almost identical (23.3 ± 6.8 vs. 23.8 ± 6.4 years, p = 0.972). The proportion of male and female patients was similar in both the study groups. Of the 107 cases, more than 70% had generalized epilepsy and the rest (29%) focal epilepsy. Of the 107 cases, 8% had family history of epilepsy. The prevalence of raised triglycerides and raised LDL were observed to be significantly higher in the case group than those in the control group (35.5% vs. 23.4%, p = 0.049 and 15% vs. 0.9%, p < 0.001 respectively). The prevalence of low HDL was also significantly higher in the former group than that in the latter group (43.9% vs. 18.7%, p < 0.001). The mean serum triglyceride and LDL were higher and mean HDL was lower in the case group than those in the control group. Over half (51.4%) of the case group exhibited dyslipidemia compared to the control group (27.1%). The risk of developing dyslipidemia in epileptic patients receiving carbamazepine for longer duration was nearly three-fold (95% of CI = 1.6 – 5.0) higher than that in the control group (p < 0.001). There is positive correlation between duration of carbamazepine treatment and lipid profile. Serum total cholesterol and triglycerides bear linear relationship with duration of treatment with carbamazepine (r = 0.201, p = 0.038 and r = 0.223, p = 0.021 respectively). The association of dyslipidemia with sex in epileptic patients receiving carbamazepine for more than 2 years. The proportion of dyslipdemia was considerably higher in the female patients than their male counterparts, although the difference was not statistically significant (55.3% vs. 41.9%, p < 0.211). Conclusion: A conclusion can be made from the above mentioned result that long-term use of carbamazepine in epileptic patients may cause dyslipidemia and the risk of having dyslipidemia in such patients is 3 times greater than the normal healthy population. Bangladesh Journal of Neuroscience 2014; Vol. 30 (1): 27-34

scholarly journals Vitamin D levels in epileptic children on long-term anticonvulsant therapy

2015 ◽  
Vol 55 (3) ◽  
pp. 164
Author(s):  
Fathy Pohan ◽  
Aryono Hendarto ◽  
Irawan Mangunatmadja ◽  
Hartono Gunardi
Keyword(s):  
Vitamin D ◽  
Valproic Acid ◽  
Vitamin D Deficiency ◽  
Anticonvulsant Therapy ◽  
Control Group ◽  
Case Group ◽  
Vitamin D Levels ◽  
Epileptic Children ◽  
The Mean

Background Long-term anticonvulsant therapy, especially with enzyme inducers, has been associated with low 25-hydroxyvitamin D [25(OH)D] levels and high prevalence of vitamin D deficiency. However, there have been inconsistent results in studies on the effect of long-term, non-enzyme inducer anticonvulsant use on vitamin D levels.Objective To compare 25(OH)D levels in epileptic children on long-term anticonvulsant therapy and non-epileptic children. We also assessed for factors potentially associated with vitamin D deficiency/insufficiency in epileptic children.Methods This cross-sectional study was conducted at two pediatric neurology outpatient clinics in Jakarta, from March to June 2013. Subjects in the case group were epileptic children, aged 6-11 years who had used valproic acid, carbamazepine, phenobarbital, phenytoin, or oxcarbazepine, as a single or combination therapy, for at least 1 year. Control subjects were non-epileptic, had not consumed anticonvulsants, and were matched for age and gender to the case group. All subjects’ 25(OH)D levels were measured by enzyme immunoassay.Results There were 31 epileptic children and 31 non-epileptic control children. Their mean age was 9.1 (SD 1.8) years. Most subjects in the case group were treated with valproic acid (25/31), administered as a monotherapy (21/31). The mean duration of anticonvulsant consumption was 41.9 (SD 20) months. The mean 25(OH)D level of the epileptic group was 41.1 (SD 16) ng/mL, lower than the control group with a mean difference of 9.7 (95%CI 1.6 to 17.9) ng/mL. No vitamin D deficiency was found in this study. The prevalence of vitamin D insufficiency in the epileptic group was higher than in the control group (12/31 vs. 4/31; P=0.020). No identified risk factors were associated with low 25(OH)D levels in epileptic children.Conclusion Vitamin D levels in epileptic children with long-term anticonvulsant therapy are lower than that of non-epileptic children, but none had vitamin D deficiency.

scholarly journals Long-Term Abnormalities of Lipid Profile After a Single Episode of Sepsis

2021 ◽  
Vol 8 ◽  
Author(s):  
Nicholas Felici ◽  
Da Liu ◽  
Josh Maret ◽  
Mariana Restrepo ◽  
Yuliya Borovskiy ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Septic Episode ◽  
Sepsis Survivors

Background: Acute disturbances of the lipid profile are commonplace during acute sepsis episode. However, their long-term persistence has not to be investigated despite pivotal role of dyslipidemia in several comorbidities excessively noted in sepsis survivors (stroke, cardiomyopathy).Methods: A total of 9,861 individuals hospitalized for a singular episode of sepsis between 2009 and 2019 were identified from electronic medical records. Lab measurements of total cholesterol (Tchol), high-density lipoprotein (HDL-c), low-density lipoprotein (LDL-c), very low-density lipoprotein (VLDL), triglycerides (TG), lipoprotein(a) [Lp (a)], apolipoprotein B (ApoB), and C-reactive protein (CRP). The data were examined as baseline values before sepsis, during hospitalization, and &lt;3 months, 3–6 months, 6–12 months, 1–2 years, and more than 2 years from initial sepsis.Results: Significant reductions in HDL-c (HDLbaseline = 44.06 vs. HDLsepsis = 28.2; U = −37.79, p &lt; 0.0001, Cohen's d = 0.22) and LDL-c serum levels were observed during and up to three months post sepsis, with females much less affected. In contrast, male subjects had derangement in HDL present for up to two years after a singular septic episode. Total cholesterol levels were slightly yet significantly elevated for up to two years after sepsis. TG were elevated up to one year [TGbaseline = 128.26 vs. TGsepsis = 170.27, t(8255) = −21.33, p &lt; 0.0001, Cohen's d = 0.49] and normalized. Lp(a) was elevated up to two years after initial episode [Lp(a)baseline = 24.6 ± 16.06; Lp(a)sepsis−2year = 8.25 ± 5.17; Lp(a)morethan2years = 61.4 ± 40.1; ANOVA F(2, 24) = 7.39; p = 0.0032]. Response to statin therapy was blunted in sepsis survivors for several years after sepsis resolution. Significant drop-out in prescription of statins and niacin after sepsis was observed. Serum high sensitivity C-reactive protein was elevated for up to five years after sepsis resolution (H [6;1685] = 502.2; p &lt; 0.0001).Discussion: Lipid abnormalities persisted long after the initial septic insult suggesting potential role in accelerating atherosclerosis and other abnormalities. In addition, sepsis seems to blunt statin effectiveness. Additionally, a significant and unexplained drop in statin use was seen in post-septic period.Conclusions: Our study suggests that persistent derangements of lipid profile components for up to two years after sepsis may be associated with altered risk of atherosclerosis-related events among sepsis survivors.

Relationship of hemostasis indicators with the dynamics of steroid hormones in healthy test volunteers in 120-day isolation in a hermetic facility

2020 ◽  
Vol 60 (11) ◽  
pp. 811-814
Author(s):  
Dmitry S. Kuzichkin ◽  
Svetlana A. Chistokhodova
Keyword(s):  
Steroid Hormones ◽  
Protein C ◽  
Venous Blood ◽  
International Normalized Ratio ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Free Androgen Index ◽  
Relationship Of ◽  
The Relationship

Introduction. Evaluation of the relationship between hemostasis and steroid hormones is an important area of research due to the high risk of hemorrhages and, especially, thromboembolic complications in their abnormal state, but this has not been practically studied in long-term isolation. The aim of study was to study the relationship between hemostasis and steroid hormones of participants in 120 - day isolation in a hermetic object. Materials and methods. Before, 3 times during and on the 7th day after 120-day isolation, venous blood samples were taken from the international crew members (3 men and 3 women) to measure the concentrations of cortisol, aldosterone, total testosterone, sex hormone-binding globulin, determine the free androgen index, and evaluate 9 hemostasis indicators. Results. In conditions of long-term isolation, the relationship of steroid hormones with the activity of the procoagulant hemostasis link and the state of the plasmin and antiplasmin systems was revealed. Conclusions. Anthropometric and hormonal parameters in isolation were significantly correlated with the dynamics of the international normalized ratio, activated partial thromboplastin time, fibrinogen, antithrombin III, plasminogen, α2-antiplasmin and protein C, and the gender of the subjects significantly affected only the activity of α2-antiplasmin, and the age of volunteers and the dynamics of testosterone had the most pronounced effect on hemostasis in isolation.

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