Histological alterations in Rabbit liver after treatment with dexamethasone

2021 ◽  
Vol 15 (9) ◽  
pp. 2373-2375
Author(s):  
Faiza Irshad ◽  
Kanwal Saeed ◽  
Muhammad Adeel Qama ◽  
Jamshad Latif ◽  
Zia Ul Mustafa ◽  
...  
Keyword(s):  
Side Effects ◽  
Sodium Phosphate ◽  
Periodic Acid ◽  
Morphological Variations ◽  
Histological Alterations ◽  
Dexamethasone Sodium Phosphate ◽  
Veterinary Research ◽  
Hepatic Cells ◽  
Metabolic Side Effect ◽  
Animal House

Background One of the most potent glucocorticoids is known as Dexamethasone. Many metabolic side effect shave been reported on almost every organ after dexamethasone treatment specially its effect on liver. Aim: To investigate harmful side effects of dexamethasone sodium phosphate on rabbit’s liver that serve as human liver model via using light microscope, by administration of two doses (extreme) and two durations in order to depict the duration as well as dosage dependency. Methods: Liver samples were taken via rabbits who were administered dexamethasone sodium phosphate. Then two Stratas were made namely, 1 and 2. The fixations of liver samples were carried out and underwent into evaluation in order to observe any histochemical and histological alterations. Study duration is from February to May 2021 Rabbits were brought from Veterinary Research Institute, Lahore. These Rabbits were kept in cages in the animal house of PGMI, Bird wood road Lahore. Results: The ballooning and vacuolation of hepatic cells were seen in the liver in case of Stratas that were treated along with the degenerative alterations of these cells, congestion and dilatation of central hepatic vein with sinusoidal capillaries, positive periodic acid schiff's stain (PAS) reactions. The severity of all these alterations was dependent upon duration and dosage. Conclusion: Morphological variations induced in the liver by dexamethasone sodium phosphate could be accepted as side effects of these drugs. Keywords: Liver, dexamethasone, histology, glycogen.

Spinal Modulation by Dexamethasone Sodium Phosphate, Cyclophosphamide and Miconazole Iontophoresis in Asymptomatic SARS-CoV-2 Patient with Extensive Myelitis

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Mushtaq W ◽  
Keyword(s):  
Side Effects ◽  
Sodium Phosphate ◽  
Neurological Complication ◽  
Transverse Myelitis ◽  
Electrical Current ◽  
The Body ◽  
Substantia Gelatinosa ◽  
Systemic Absorption ◽  
Dexamethasone Sodium Phosphate ◽  
Transdermal Application

A very rare neurological complication of SARS-CoV-2 infection includes transverse myelitis. I assume a post-infectious etiology in terms of secondary immunogenic overreaction. Iontophoresis is the process of the permeation of ionic (charged) drugs into the body under the influence of electrical current. Besides increasing therapeutic efficiency by, by passing first pass metabolism there are less risks of systemic absorption and undesirable side effects. The study was conducted in a SARS-CoV-2 patient with transverse myelitis, by transdermal application of dexamethasone sodium phosphate, cyclophosphamide and miconazole by iontophoresis at corresponding vertebral levels to look for the neurological outcome who had been unresponsive to intravenous methylprednisolone. With Dexamethasone sodium phosphate and cyclophosphamide iontophoresis there was modulation of the activity of posterior grey column, fasiculus gracilis and corticospinal tracts, and with miconazole iontophoresis I was able to ameliorate the dyesthesias, fasiculations and muscle atrophy probably due to neuromodulation at substantia gelatinosa and lamina IX and remyelination effect. There were no systemic or localized side effects and no adverse effects occurred during the treatment period.

A comparative study of treatment for brain edema: Magnesium sulphate versus dexamethasone sodium phosphate

2008 ◽  
Vol 15 (1) ◽  
pp. 60-65 ◽  
Author(s):  
Omer Faruk Turkoglu ◽  
Hakan Eroglu ◽  
Ozerk Okutan ◽  
M. Kagan Tun ◽  
Ebru Bodur ◽  
...  
Keyword(s):  
Comparative Study ◽  
Brain Edema ◽  
Magnesium Sulphate ◽  
Sodium Phosphate ◽  
Dexamethasone Sodium Phosphate

Dexamethasone Sodium Phosphate (Decadron) versus Saline Placebo Injections in Strabismus Surgery

1982 ◽  
Vol 19 (3) ◽  
pp. 140-143
Author(s):  
Andrew E Choy ◽  
Sidney Weiss ◽  
Chris Chow ◽  
Don Kato ◽  
Larry Cacace
Keyword(s):  
Sodium Phosphate ◽  
Strabismus Surgery ◽  
Dexamethasone Sodium Phosphate

Stability of Diluted Dexamethasone Sodium Phosphate Injection at Two Temperatures

1994 ◽  
Vol 28 (9) ◽  
pp. 1018-1019 ◽  
Author(s):  
Ralph A. Lugo ◽  
Milap C. Nahata
Keyword(s):  
Lung Disease ◽  
Bronchopulmonary Dysplasia ◽  
Chronic Lung Disease ◽  
Sodium Phosphate ◽  
Hplc Method ◽  
Dexamethasone Sodium Phosphate ◽  
Usp 4 ◽  
Two Temperatures ◽  
Phosphate Injection ◽  
The Stability

OBJECTIVE: Premature neonates with bronchopulmonary dysplasia frequently are treated with intravenous dexamethasone for their chronic lung disease. The injection volumes of the commercially available products often are too small to measure accurately. The objective of this study was to evaluate the stability over 28 days of dexamethasone sodium phosphate injection 4 mg/mL diluted with bacteriostatic NaCl 0.9% to 1 mg/mL. DESIGN: Ten vials of dexamethasone 1 mg/mL were prepared from dexamethasone sodium phosphate injection, USP 4 mg/mL and bacteriostatic NaCl 0.9% injection. Five vials were stored at 4 °C and five at 22 °C. Dexamethasone was measured on days 0, 1, 3, 7, 14, 21, and 28 by an accurate, reproducible, and stability-indicating HPLC method. Samples were also inspected visually for precipitation or discoloration on each study day. RESULTS: The samples retained at least 97.7 percent of the original concentration of dexamethasone sodium phosphate when stored at either 4 or 22 °C for 28 days. No discoloration or precipitation was observed. CONCLUSIONS: Dexamethasone sodium phosphate injection 1 mg/mL in bacteriostatic NaCl 0.9% was stable for 28 days at 4 and 22 °C.

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