scholarly journals Diagnostic Considerations and Analytical Characteristics of Methods for the Determination of Cardiac Troponins: Traditional Review

2021 ◽  
Vol 33 (3) ◽  
pp. 149-160
Author(s):  
Aleksey Michailovich CHAULIN
Keyword(s):  
Cardiac Troponins

scholarly journals Cardiac Troponins: Analytical Characteristics and Diagnostic Capabilities of Modern (High-sensitive) Determination Methods

2021 ◽  
Author(s):  
Aleksey Michailovich Chaulin ◽  
Duplyakov V Dmitry
Keyword(s):  
Myocardial Infarction ◽  
Physiological State ◽  
Economic Damage ◽  
Routine Practice ◽  
Coronary Syndrome ◽  
Highly Sensitive ◽  
Sensitive Determination ◽  
Determination Methods ◽  
Cardiac Troponins

Cardiovascular diseases have a leading role in terms of morbidity, mortality, and disability of the population, causing significant socio-economic damage to all countries of the world. This circumstance requires researchers to constantly seek for new biomarkers and improve methods for determining existing biomarkers, and search for new therapeutic targets to improve diagnostic and treatment strategies. Recently, there have been some important changes in laboratory diagnostics of patients with acute coronary syndrome, due to the introduction into the routine practice of new high and ultrasensitive methods for the determination of biomarkers of injury, specific to cardiac muscle tissue, namely cardiac troponins. A key advantage of highly sensitive immunochemical assays is the ability to detect cardiac troponins in the early stages of myocardial infarction. This allows making the optimal decision on the early choice and conduct of reperfusion therapy, which significantly improves the further prognosis of patients. Among the most significant generally recognised disadvantages of highly sensitive determination methods are low specificity and a huge variety of troponin immunoassays. The decrease in specificity is reflected in the fact that cardiac troponins are no longer considered the “gold standard” of diagnosis related to Acute Myocardial Infarction (AMI) (irreversible ischaemic damage to cardiomyocytes). As a result, any damage to the myocardium, even insignificant and reversible under physiological state (physical activity, stress) and several pathological conditions, can lead to an increase in serum levels of cardiac troponins and affect the accuracy of the diagnosis. Each method for the determination of cardiac troponins, among the existing wide variety of troponin immunoassays, possesses different analytical characteristics, and detects different concentrations of troponins in the same patient. This article provides a view of current data on the biology of cardiac troponins, and defines the analytical characteristics of new high-sensitive methods for the determination of cardiac troponins.

scholarly journals Biochemical markers of cardiac diseases

2004 ◽  
Vol 23 (3) ◽  
pp. 201-211 ◽  
Author(s):  
Mauro Panteghini
Keyword(s):  
Biochemical Markers ◽  
Coronary Plaque ◽  
Plaque Instability ◽  
Coronary Syndrome ◽  
Early Markers ◽  
Early Injury ◽  
Cardiac Troponins ◽  
Rule Out

This article reviews the current contribution of the determination of biochemical markers to clinical cardiology and discusses some important developments in this field. Biochemical markers play a pivotal role in the diagnosis and management of patients with acute coronary syndrome (ACS), as witnessed by the incorporation of cardiac troponins into new international guidelines for patients with ACS and in the redefinition of myocardial infarction. Despite the success of cardiac troponins, there is still a need for development of early markers that can reliably rule out ACS from the emergency room at presentation and detect myocardial ischemia also in the absence of irreversible myocyte injury. Under investigation are two classes of indicators: markers of early injury/ischemia and markers of coronary plaque instability and disruption. Finally, with the characterization of the cardiac natriuretic peptides, Laboratory Medicine is also assuming part in the assessment of cardiac function.

scholarly journals On the potential effect of circadian rhythms of cardiac troponins on the diagnosis of acute myocardial infarction

2021 ◽  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Circadian Rhythms ◽  
Potential Effect ◽  
Diagnostic Process ◽  
Test Results ◽  
Laboratory Test Results ◽  
Increased Sensitivity ◽  
Cardiac Troponins

Methods for the determination of cardiac troponins have been significantly improved, facilitating further advancement of the therapeutic and diagnostic process of the cardiovascular diseases case management. In particular, acceleration of the acute myocardial infarction testing (early diagnostic algorithms: 0-1 h, 0-3 h) enabled earlier detection and choice of the optimal treatment tactics. At the same time, with the increased sensitivity in the laboratory test results interpretation, there emerged a necessity to take into account some additional factors that may affect the concentration of cardiac troponins in blood serum. Several recent studies have reported the existence of circadian rhythms in cardiac troponins. This article aims to discuss the possible mechanisms of how circadian rhythms of cardiac troponins develop and their influence on the diagnosis of acute myocardial infarction.

scholarly journals Main Aspects of Biochemistry, Physiology of Cardiac Troponins

2020 ◽  
Vol 6 (5) ◽  
pp. 105-112 ◽  
Author(s):  
A. Chaulin ◽  
Yu. Grigoryeva
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Cardiovascular Diseases ◽  
Heart Muscle ◽  
Troponin I ◽  
Contractile Function ◽  
Structure And Functions ◽  
Cardiac Troponins

Cardiac troponins (troponin I, T, and C) play an important role in the regulation of contractile function of the heart muscle. Mutations in cardiac troponins are associated with the development of various types of cardiomyopathies, which lead to heart failure and death. The determination of the concentration of cardiac troponins in the blood is used in the diagnosis of some cardiovascular diseases, including acute myocardial infarction, myocarditis, heart failure. This review summarizes the available data on the structure and functions of cardiac troponins, their role in the regulation of myocardial contractions and clinical application.

Nanomaterial-based biosensors and immunosensors for quantitative determination of cardiac troponins

2018 ◽  
Vol 159 ◽  
pp. 425-436 ◽  
Author(s):  
Alireza Nezami ◽  
Sadegh Dehghani ◽  
Rahim Nosrati ◽  
Negar Eskandari ◽  
Seyed Mohammad Taghdisi ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Cardiac Troponins

Biomarkers in diagnosing and treatment of acute heart failure

2019 ◽  
Vol 13 (14) ◽  
pp. 1235-1249 ◽  
Author(s):  
Leili Pourafkari ◽  
Arezou Tajlil ◽  
Nader D Nader
Keyword(s):  
Heart Failure ◽  
Risk Stratification ◽  
Acute Heart Failure ◽  
Natriuretic Peptides ◽  
Morbidity And Mortality ◽  
Disease Monitoring ◽  
New Targets ◽  
Complex Disorder ◽  
Cardiac Troponins

Acute heart failure (AHF) is a complex disorder involving different pathophysiological pathways. In recent years, there is an increased focus on biomarkers that help with diagnosis, risk stratification and disease monitoring of AHF. Finding a reliable set of biomarkers not only improves morbidity and mortality but it can also potentially reveal the new targets of therapy. In this paper, we have reviewed the biomarkers found useful for the diagnosis as well as for risk stratification and prognostication in patients with AHF. We have discussed the established biomarkers for AHF including cardiac troponins and natriuretic peptides and emerging biomarkers including adiponectin, mi-RNA, sST2, Gal-3, MR-proADM, OPG, CT-proAVP and H-FABP for the purposes of making diagnosis, their use as a guide of therapy or for determination of prognosis.

Galactic orbits of stars

1966 ◽  
Vol 25 ◽  
pp. 93-97
Author(s):  
Richard Woolley
Keyword(s):  
Globular Cluster ◽  
Potential Field ◽  
High Velocity ◽  
Velocity Vector ◽  
Variable Stars ◽  
The Sun ◽  
Proper Motions ◽  
Rr Lyrae ◽  
The Galaxy

It is now possible to determine proper motions of high-velocity objects in such a way as to obtain with some accuracy the velocity vector relevant to the Sun. If a potential field of the Galaxy is assumed, one can compute an actual orbit. A determination of the velocity of the globular clusterωCentauri has recently been completed at Greenwich, and it is found that the orbit is strongly retrograde in the Galaxy. Similar calculations may be made, though with less certainty, in the case of RR Lyrae variable stars.

Distance to SN 1987A and the LMC

1999 ◽  
Vol 190 ◽  
pp. 549-554
Author(s):  
Nino Panagia
Keyword(s):  
Angular Size ◽  
Large Magellanic Cloud ◽  
Magellanic Cloud ◽  
Light Curves ◽  
Distance Modulus ◽  
Absolute Size ◽  
Sn 1987A

Using the new reductions of the IUE light curves by Sonneborn et al. (1997) and an extensive set of HST images of SN 1987A we have repeated and improved Panagia et al. (1991) analysis to obtain a better determination of the distance to the supernova. In this way we have derived an absolute size of the ringRabs= (6.23 ± 0.08) x 1017cm and an angular sizeR″ = 808 ± 17 mas, which give a distance to the supernovad(SN1987A) = 51.4 ± 1.2 kpc and a distance modulusm–M(SN1987A) = 18.55 ± 0.05. Allowing for a displacement of SN 1987A position relative to the LMC center, the distance to the barycenter of the Large Magellanic Cloud is also estimated to bed(LMC) = 52.0±1.3 kpc, which corresponds to a distance modulus ofm–M(LMC) = 18.58±0.05.

International determination of the total motion of the pole

1961 ◽  
Vol 13 ◽  
pp. 29-41
Author(s):  
Wm. Markowitz
Keyword(s):  
Secular Motion ◽  
The Future

A symposium on the future of the International Latitude Service (I. L. S.) is to be held in Helsinki in July 1960. My report for the symposium consists of two parts. Part I, denoded (Mk I) was published [1] earlier in 1960 under the title “Latitude and Longitude, and the Secular Motion of the Pole”. Part II is the present paper, denoded (Mk II).

Sign in / Sign up

Export Citation Format

Share Document