scholarly journals Radiation preparation of drug carriers for dexamethasone and tegafur based on poly(n-isopropylacrylamide) hydrogels

2015 ◽  
Vol 5 (1) ◽  
pp. 39-45
Author(s):  
Dang Sang Hoang ◽  
Van Binh Nguyen ◽  
Bang Diep Tran ◽  
Thi Thom Nguyen ◽  
Phuong Thao Hoang ◽  
...  
Keyword(s):  
Skin Irritation ◽  
In Vitro Release ◽  
Drug Carriers ◽  
Solution Temperature ◽  
Critical Solution Temperature ◽  
Human Body Temperature ◽  
Drug Incorporation ◽  
Water Swelling ◽  
Vitro Release

Poly(N-isopropylacrylamide) (PNIPAM) based hydrogels with the lower critical solution temperature (LCST) near the human body-temperature have been obtained from 10% solutions of N-isopropylacrylamide (NIPA) and N,N’-dimethyl acrylamide(DMA) mixture of 90:10 and 85:15 (w/w) by radiation copolymerization and crosslinking using a gamma Co-60 source at a dose of 20 kGy. Water swelling behaviour of the resulting hydrogels was much dependent on the initial ratio of NIPA and DMA. The hydrogels of 85:15 NIPA/DMA was chosen for further investigation for the use as drug cariers.Two kinds of drug carriers were prepared by immerging the hydrogels in solutions containing dexamethasone and tegafur. Then the drug incorporation efficiencies and in-vitro release behaviors of the ingredient were analysed. Loading capacities of the hydrogels were about 48.6 and 95.7 mg per g of dried gel for dexamethasone and tegafur, respectively. The results also revealed that the presence of ions in simulated body fluid and solution temperature much affected to the release behaviors of hydrogels for both dexamethasone and tegafur. Release rates of the ingredients were quite fast for both drug models. These drug-loaded hydrogels were biocompatibility without skin irritation suggesting that they may be used as controlled release drug carriers.

scholarly journals FORMULATION AND EVALUATION OF GLIBENCLAMIDE GEL FOR TRANSDERMAL DRUG DELIVERY

2020 ◽  
pp. 35-39
Author(s):  
NOSHEEN ANWAR ◽  
SYED UMER JAN ◽  
REHMAM GUL
Keyword(s):  
Oleic Acid ◽  
Skin Irritation ◽  
In Vitro Release ◽  
Acid Effect ◽  
Release Studies ◽  
Franz Diffusion Cells ◽  
Physical And Chemical ◽  
Gel Formulations ◽  
Vitro Release

Objective: The purpose of the recent study was to formulate glibenclamide gels for transdermal drug release, and to evaluate the oleic acid effect on the release of the preparations. Methods: Oleic acid was used at a range of concentrations in the gel formulations and its effects observed in Glibenclamide gel using In vitro release of drug was done in Franz diffusion cells, whereas pH 7.4 Phosphate buffer was used for release studies. Formulations were characterized by clarity, pH, homogeneity, viscosity, spreadabilty, skin irritation, drug content, stability studies. Scanning calroimetry analysis (SCA) and XRD studies were performed to assess the physical and chemical interactions. Results: Release profiles in vitro were observed. The released quantity of drug recovered from the glibenclamide gel after the addition of 1% oleic acid, increased with increasing concentration of the enhancer that is oleic acid. Whereas drug quantity recovered in the receptor solvent was 69.999% of Glibenclamide gel having 3% oleic acid. All the formulation were physicochemically stable. The data was statistically analyzed by using SPSS and DD solver. Conclusion: The drug is released and the oleic acid does enhance the release of the drug with the increase in its concentration.

FORMULATION AND EVALUATION OF OXICONAZOLE B-CYCLODEXTRIN COMPLEX INCORPORATED TOPICAL GEL

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (06) ◽  
pp. 11-17
Author(s):  
S. S Wagle ◽  
◽  
A. P., Gadad ◽  
P. M. Dandagi ◽  
A. S Patil
Keyword(s):  
Solid Dispersion ◽  
Skin Irritation ◽  
In Vitro Release ◽  
Water Soluble ◽  
Gelling Agent ◽  
Topical Gel ◽  
Drug Content ◽  
Percentage Yield ◽  
Vitro Release

Oxiconazole nitrate is antifungal drug having low solubility. An attempt was made to increase the solubility by solid dispersion technique. Twelve solid dispersion formulations were prepared by solvent evaporation and kneading method using β-cyclodextrin and 2-hydroxypropyl β-cyclodextrin as carrier. In vitro release profiles of all solid dispersions were evaluated and were compared with that of pure drug. Optimized formulation (F-3) was then incorporated in gel using Carbopol 940p as gelling agent. The formulated gel was evaluated for various parameters like percentage yield, drug content, pH, viscosity, spreadability, extrudability, drug content, in vitro drug release, in vitro kinetics, antifungal properties, skin irritation and stability studies. The percentage yield obtained was 98.9% and the pH was 6.83. The viscosity was 50,000cp and also showed good spreadability and extrudability. Drug content was found to be 91.6%. The gel formulation showed in vitro release 92.48% whereas marketed formulation showed 76.66% at the end of 8 hrs. The antifungal activity showed greater zone of inhibition than that of marketed formulation and there was no skin irritation on rats. Hence, complex incorporated in gel can be a potential method to improve the solubility of poorly water soluble drugs.

In vitro release of chloramphenicol from poly[N-(2-hydroxypropyl)methacrylamide] carriers by Cathepsin B

1988 ◽  
Vol 53 (5) ◽  
pp. 1078-1085 ◽  
Author(s):  
Karel Ulbrich ◽  
Olga Nazarova ◽  
Eugenii Panarin ◽  
Miroslav Baudyš ◽  
Michail V. Solovskii
Keyword(s):  
Drug Release ◽  
Cathepsin B ◽  
Active Drug ◽  
Wide Spectrum ◽  
In Vitro Release ◽  
Drug Carriers ◽  
Hydroxypropyl Methacrylamide ◽  
Polymer Compound ◽  
Vitro Release

It has been shown in recent years that copolymers of N-(2-hydroxypropyl)methacrylamide may be used as targeted polymer drug carriers. The wide-spectrum antibiotic chloramphenicol has been bound to these carriers by means of biodegradable oligopeptidic sequences. The rate of drug release from the carrier in aqueous buffer solutions pH 7·4 and 6·0 was measured and the rates were compared with that of the enzymatic drug release from the carrier by means of the enzyme Cathepsin B. It was shown that the active drug may be released from the carrier by simple hydrolysis or by acting with an enzyme and that the rate of drug release depends on the structure of the oligopeptidic sequence which acts as a link between the drug and the polymer. The results obtained may be employed in the synthesis of a polymer compound potentially possessing antimicrobial activity.

Evaluation of in vitro release and skin irritation of benzoyl peroxide-containing products

2006 ◽  
Vol 16 (6) ◽  
pp. 449-454 ◽  
Author(s):  
Ö.Özer ◽  
I. Özcan ◽  
E.Ö. Çetin ◽  
I. Tekmen ◽  
Ü. Sönmez ◽  
...  
Keyword(s):  
Benzoyl Peroxide ◽  
Skin Irritation ◽  
In Vitro Release ◽  
Vitro Release

Study on in vitro release patterns of fentanyl-loaded PLGA microspheres

2003 ◽  
Vol 20 (5) ◽  
pp. 569-579 ◽  
Author(s):  
S.-A. Seo ◽  
G. Khang ◽  
J. M. Rhee ◽  
J. Kim ◽  
H. B. Lee
Keyword(s):  
In Vitro Release ◽  
Plga Microspheres ◽  
Vitro Release

Reliability of a Single β-Thromboglobulin Measurement in a Diabetic Population : Importance of PGE1 in Anticoagulant Mixture

1987 ◽  
Vol 57 (02) ◽  
pp. 201-204 ◽  
Author(s):  
P Y Scarabin ◽  
L Strain ◽  
C A Ludlam ◽  
J Jones ◽  
E M Kohner
Keyword(s):  
In Vitro Release ◽  
Mean Value ◽  
Reliable Estimate ◽  
Diabetic Patients ◽  
Single Measurement ◽  
Diabetic Population ◽  
The Difference ◽  
Vitro Release

SummaryDuring the collection of samples for plasma β-thromboglobulin (β-TG) determination, it is well established that artificially high values can be observed due to in-vitro release. To estimate the reliability of a single β-TG measurement, blood samples were collected simultaneously from both arms on two separate occasions in 56 diabetic patients selected for a clinical trial. From each arm, blood was taken into two tubes containing an anticoagulant mixture with (tube A) and without (tube B) PGE!. The overall mean value of B-TG in tube B was 1.14 times higher than in tube A (p <0.01). The markedly large between-arms variation accounted for the most part of within-subject variation in both tubes and was significantly greater in tube B than in tube A. Based on the difference between B-TG values from both arms, the number of subjects with artifically high B-TG values was significantly higher in tube B than in tube A on each occasion (overall rate: 28% and 14% respectively). Estimate of between-occasions variation showed that B-TG levels were relatively stable for each subject between two occasions in each tube. It is concluded that the use of PGEi decreases falsely high B-TG levels, but a single measurement of B-TG does not provide a reliable estimate of the true B-TG value in vivo.

Preparation and In-vitro Evaluation of Fe3O4 Encapsulated by Chitosan Loaded Capecitabine Nanoparticles for the Treatment of Breast Cancer

2016 ◽  
Vol 6 (3) ◽  
Author(s):  
Shanmuganathan S. ◽  
Nigma S. ◽  
Anbarasan B. ◽  
Harika B.
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Polymer Concentration ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
In Vitro Evaluation ◽  
Sem Image ◽  
Therapeutic Molecules ◽  
Dialysis Method ◽  
Vitro Release

Nanoparticulate Carriers which is biodegradable, biocompatible and bio adhesive have significant feasible applications for administration of therapeutic molecules. The present study was aimed to formulate and optimise Capecitabine loaded Chitosan-Fe3O4 Nanoparticles and to study the in-vitro evaluation by sigma dialysis method. Capecitabine loaded chitosan – Fe3O4 nanoparticles batches with different ratios of drug: polymer (1:1, 1:2, 1:3, 1:4, 1:5, 1:6) were prepared by ionic gelation method. Increase in polymer concentration increases the nanoparticle drug content. Entrapment efficiency was 60.12% with drug to polymer ratio F3 (1:3). In-vitro release was found to be 65.20% for 12 hrs. Capecitabine from chitosanFe3O4 nanoparticles SEM image reveals discrete spherical structure and particles with size range of 100-500nm. FTIR studies represent the functional groups present with no characteristics change in formulations. Samples stored at refrigerator conditions showed better stability compared with samples kept at other conditions during 8 weeks of storage.

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

2015 ◽  
Vol 5 (3) ◽  
Author(s):  
Laxman Devkota ◽  
Bhupendra Poudel ◽  
Junu Silwal
Keyword(s):  
In Vitro Release ◽  
Magnesium Stearate ◽  
Physical Parameters ◽  
Artificial Sweetener ◽  
Leukotriene Receptor Antagonist ◽  
Montelukast Sodium ◽  
Chewable Tablets ◽  
Leukotriene Receptor ◽  
Vitro Release

The objective of the present study is to develop chewable tablets containing different pharmaceutical compositions with simple manufacturing procedures using different excipients. Mannitols, L-HPC 11, Aspartame, Crospovidone, Crospovidone, Aerosil, and Magnesium Stearate are used as excipients for effective formulation of anti-asthmatic drug Montelukast. Montelukast is a selective, orally acting leukotriene receptor antagonist that is used for the treatment of asthma and seasonal allergic rhinitis. Montelukast chewable tablets were prepared by Direct Compression methods using suitable excipients. The chewable tablets were better presented using artificial sweetener Aspartame as flavouring agent. A total of forteen formulations were prepared and the granules were evaluated for pre-compression parameters. The formulated tablets were evaluated for post-compression parameters .The results showed that all the physical parameters were within the acceptable limits. The in vitro release study of all the formulations showed good release. The study concludes that aforementioned excipients can be used to design chewable montelukast sodium tablets.

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