Chronic Kidney Disease Among Workers Exposed To Perfluorooctanoic Acid (PFOA)

Background: Perfluorooctanoic acid (PFOA), a class of perfluorocarbons, are synthetic environmental contaminants. Their long biological half-lives and their poor ability to metabolize likely add to any chronic health effects they may pose, such as chronic kidney disease (CKD). The causal relationship between PFOA and CKD is still unclear, so it is necessary to look for some evidence regarding this relationship. The search for evidence is also complemented by a seven-step occupational disease assessment to establish occupational diseases. Aim: This study aims to justify chronic kidney disease of workers exposed to perfluorooctanoic acid can be diagnosed as occupational diseases.Methods: Searching literature for the evidence-based has been conducted with a clinical question through “PICO” method. Then continued with literature searching using the electronic database “PubMed”, “JSTOR”, and “Scopus” search engine. The keyword is “PFOA” “perfluoroalkyl substances” “perfluorooctanoic acid” “chronic kidney” “chronic kidney disease” “CKD” and combined with MeSH terms and Boolean operation. The inclusion criteria are research on humans, English language, and the exclusion is retracted articles.Result: From the five literatures obtained, there are differences in results. A study of workers exposed to perfluorooctanoic acid in a DuPont chemical plant with chronic kidney disease was (Standardized Mortality Ratios (SMR) = 3.11, 95% CI: 1.66, 5.32). Study in China found that perfluorooctanoic acid is not associated with renal function and higher risk of CKD (OR = 0.73, 95% CI: 0.57, 0.95; p=0.019).Conclusion: There are insignificant associations between perfluorooctanoic acid and chronic kidney disease.

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Thyroid Disease Among Workers Exposed To Perfluorooctanoic Acid (PFOA)

The Indonesian Journal of Community and Occupational Medicine ◽

10.53773/ijcom.v1i2.12.114-9 ◽

2021 ◽

Vol 1 (2) ◽

pp. 114-9

Author(s):

Vera ◽

Muhammad Ilyas

Keyword(s):

Causal Relationship ◽

Thyroid Disease ◽

English Language ◽

Perfluorooctanoic Acid ◽

Thyroid Diseases ◽

Disease Assessment ◽

Health It ◽

Inclusion Criteria ◽

Occupational Setting ◽

Hpt Axis

Background: Perfluorooctanoic Acid (PFOA) is one of the Perfluoroalkyl acids family that can affect human health. It can act as an endocrine disruptors which interfered the hypothalamus–pituitary–thyroid (HPT) axis and targeted the biosynthesis and secretion of thyroid hormones, which can caused thyroid diseases. To determine the causal relationship between PFOA and thyroid diseases, it is necessary to look for some evidence regarding this relationship. The search for evidence is also complemented by a seven-step occupational disease assessment to establish occupational diseases.Methods: The literature searching using the electronic database “PubMed”, “Cochrane”, and “Scopus” search engine. The keyword is “PFOA” “perfluoroalkyl substances” “perfluorooctanoic acid” “perfluorooctanoate” AND “thyroid disease” “thyroid function” “thyroid parameters” combined with MeSH and Title/Abstract terms. The inclusion criteria are research on humans, English language, free full article and the exclusion is duplicate articles.Result: From the five literature obtained, there are differences in results. Four articles stated that there are association between PFOA and thyroid diseases but one articles stated PFOA concentrations measured in this study were not associated with thyroid hormones.Conclusion: Althought most articles stated there are associations between PFOA and thyroid disease but it does not mean that PFOA can caused thyroid disease so it is still not clear the causal relationship between PFOA and thyroid disease especially in occupational setting.

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Gastrointestinal Microbiota in Patients with Chronic Kidney Disease: A Systematic Review

Advances in Nutrition ◽

10.1093/advances/nmz028 ◽

2019 ◽

Vol 10 (5) ◽

pp. 888-901 ◽

Cited By ~ 10

Author(s):

SeonYoon Chung ◽

Jennifer L Barnes ◽

Kim Schafer Astroth

Keyword(s):

Systematic Review ◽

Chronic Kidney Disease ◽

Microbial Community ◽

Kidney Disease ◽

Potential Role ◽

English Studies ◽

Gastrointestinal Microbiota ◽

Mesh Terms ◽

Host Physiology ◽

Nitrogen Containing Compounds

ABSTRACT Emerging evidence suggests that gastrointestinal (GI) microbiota dysbiosis is associated with chronic kidney disease (CKD) and metabolite concentrations. The purpose of this systematic review was to evaluate and contextualize the research characterizing GI microbiota in patients with CKD. We searched for full-text, peer-reviewed, English studies in PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Google Scholar using a combination of MeSH terms and keywords. Eleven of the 20 studies examined GI microbiota in patients with CKD, and 9 studies focused on the effect of interventions on GI microbiota or metabolites. Available data characterizing GI microbiota in patients with CKD suggest a decline in saccharolytic bacteria and an increase in fermenters of nitrogen-containing compounds, serving as a source for circulating uremic toxins. However, studies examined limited sets of predetermined microbes, which do not reflect the entire GI microbial community and its influence on host physiology. We recommend further studies examining the entire microbial community and the potential role in regulating host physiology in CKD.

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Perfluorooctanoic acid and chronic kidney disease: Longitudinal analysis of a Mid-Ohio Valley community

Environmental Research ◽

10.1016/j.envres.2015.11.018 ◽

2016 ◽

Vol 145 ◽

pp. 85-92 ◽

Cited By ~ 8

Author(s):

Radhika Dhingra ◽

Cathy Lally ◽

Lyndsey A. Darrow ◽

Mitch Klein ◽

Andrea Winquist ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Longitudinal Analysis ◽

Perfluorooctanoic Acid ◽

Ohio Valley

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Gambaran Tingkat Depresi pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis di RSUP DR. M. Djamil Padang

Jurnal Kesehatan Andalas ◽

10.25077/jka.v4i1.209 ◽

2015 ◽

Vol 4 (1) ◽

Author(s):

Fitri Amalia ◽

Nadjmir Nadjmir ◽

Syaiful Azmi Azmi

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Mood Disorders ◽

Rating Scale ◽

Sampling Technique ◽

Entire Population ◽

Inclusion Criteria ◽

Mild Depression ◽

Cross Sectional ◽

Hamilton Rating Scale

AbstrakDepresi merupakan salah satu dari gangguan mood yang utama. Tanda dan gejala lain gangguan mood adalah perubahan tingkat aktivitas, kemampuan kognitif, pembicaraan dan fungsi vegetatif seperti tidur, nafsu makan, aktivitas seksual dan irama biologis lainnya. Perubahan tersebut hampir selalu menyebabkan gangguan fungsi interpersonal, social, dan pekerjaan. Tujuan penelitian ini adalah untuk mengetahui gambaran tingkat depresi pada pasien penyakit ginjal kronik yang menjalani hemodialisis di RSUP Dr. M. Djamil. Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional study. Subjek diambil dari seluruh populasi yang memenuhi kriteria inklusi menggunakan teknik total sampling, Subjek yang memenuhi kriteria inklusi diwawancarai menggunakan The Hamilton Rating Scale For Depression dari seluruh populasi didapatkan 16 subjek yang memenuhi kriteria. Hasil yang didapatkan ialah 9 responden (56,25%) tidak mengalami depresi, depresi ringan 6 responden (37,50%) dan depresi sedang 1 responden (6,25%). Dapat disimpulkan tingkat depresi terbanyak pada pasien penyakit ginjal kronik yang menjalani hemodialisis di RSUP DR. M. Djamil tahun 2013 adalah tingkat depresi ringan. Karakteristik responden terbanyak yang mengalami depresi adalah sebagai berikut: umur 40-49 tahun, perempuan, menikah, berpendidikan terakhir SMA, pekerjaan ibu rumah tangga dan tidak bekerja.Kata kunci: depresi, penyakit ginjal kronik, hemodialisisAbstractDepression is one of the major of mood disorders. Other signs and symptoms of mood disorders are changes in the level of activity, cognitive ability, speech and vegetative functions such as sleep, appetite, sexual activity and other biological rhythms. Such changes always lead to malfunction of interpersonal, social and employment. The objective of this study was to describe the level of depression in patients with chronic kidney disease who undergoing hemodialysis at RSUP Dr. M. Djamil Padang. This was a descriptive study using a cross sectional design. Subject were taken from the entire population who met the inclusion criteria using total sampling technique, subject who met the inclusion criteria were interviewed using the Hamilton Rating Scale for Depression, of the entire population obtained 16 subjects that meet the criteria. From this study, a 9 respondents (56.25%) did not experience depression, 6 respondents (37.50%) mild depression and 1 respondent (6.25%) moderate depression. It can be concluded highest rates of depression in patients with chronic kidney disease undergoing hemodialysis at RSUP DR. M. Djamil Padang in 2013 in the level of mild depression. Most characteristics of the respondents who were depressed were as follows : age 40-49 years, female, married, educated, past high school, housewives work and do not work, 13-18 months undergoing hemodialysis.Keywords: depression, chronic kidney disease, hemodialysis

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HUBUNGAN ANTARA LAMA MENJALANI HEMODIALISIS DENGAN DEPRESI PADA PASIEN DENGAN PENYAKIT GINJAL KRONIK DI RSUP. PROF. Dr. R. D. KANDOU MANADO

e-CliniC ◽

10.35790/ecl.3.1.2015.6834 ◽

2015 ◽

Vol 3 (1) ◽

Author(s):

Elizabeth M. Sompie ◽

Theresia M. D. Kaunang ◽

Herdy Munayang

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Hemodialysis Patient ◽

Analytic Method ◽

Inclusion Criteria ◽

Cross Sectional ◽

Physical Limitations

Abstract: Hemodialysis is a treatment that must be lived for a lifetime in patients with chronic kidney disease. Hemodialysis patient may suffer depression from physical limitations. This study aimed to find the relation between duration of hemodialysis and depression. This research used observational-analytic method with cross sectional approach. This research involved all patients who carry out hemodialysis at Dahlia and Melati hemodialysis units at RSUP. Prof. Dr. R. D. Kandou Manado who meet the inclusion criteria which are 34 people. The result of this study showed that the duration of hemodialysis (p = 0,17, p > 0,05) did not correlate significantly with depression. Conclusion: The duration of hemodialysis does not correlate significantly with depression.Keywords: the duration of hemodialysis, depressionAbstrak: Hemodialisis merupakan terapi yang harus dijalani seumur hidup pada pasien penyakit ginjal kronik. Keterbatasan secara fisik yang timbul pada pasien hemodialisis dapat menyebabkan munculnya keadaan depresi. Tujuan dari penelitian ini adalah untuk mencari hubungan antara lama menjalani hemodialisis dengan depresi. Metode penelitian yang digunakan adalah observasional-analitik dengan pendekatan potong lintang. Penelitian ini melibatkan semua pasien hemodialisis di unit hemodialisis Dahlia dan Melati RSUP. Prof. Dr. R. D. Kandou Manado yang memenuhi kriteria inklusi sebanyak 34 orang. Hasil penelitian ini menunjukkan lama menjalani hemodialisis (p = 0,17, p > 0,05) tidak berhubungan secara signifikan dengan depresi. Simpulan: Lama menjalani hemodialisis tidak berhubungan secara signifikan dengan depresi.Kata kunci: lama menjalani hemodialisis, depresi

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A Systematic Review of Screening Tests for Chronic Kidney Disease: An Accuracy Analysis

Galen Medical Journal ◽

10.31661/gmj.v9i0.1573 ◽

2020 ◽

Vol 9 ◽

pp. 1573

Author(s):

Fatemeh Keshvari-Shad ◽

Sakineh Hajebrahimi ◽

Maria Pilar Laguna Pes ◽

Alireza Mahboub-Ahari ◽

Mohammad Nouri ◽

...

Keyword(s):

Systematic Review ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

English Language ◽

Scale Up ◽

Final Analysis ◽

Screening Tests ◽

Cochrane Library ◽

Screening Methods ◽

Dipstick Test

This systematic review was conducted to assess the diagnostic accuracy of chronic kidney disease screening tests in the general population. MEDLINE, EMBASE, Web of Science, Scopus, The Cochrane Library and ProQuest databases were searched for English-language publications up to November 2016. Two reviewers independently screened studies and extracted study data in standardized tables. Methodological quality was assessed using the QUADAS-2 tool. Sensitivity and specificity of all available screening methods were identified through included studies. Ten out of 1349 screened records included for final analysis. Sensitivities of the dipstick test with a cutoff value of trace were ranged from 37.1% to 69.4% and specificities from 93.7% to 97.3% for the detection of ACR>30 mg/g. The diagnostic sensitivities of the UAC>10 mg/dL testing was shown to vary from 40% to 87%, and specificities ranged from 75% to 96%. While the sensitivities of ACR were fluctuating between 74% and 90%, likewise the specificities were between 77% and 88%. Sensitivities for C-G, Grubb and Larsson equations were 98.9%, 86.2%, and 70.1% respectively. In the meantime the study showed specificities of 84.8%, 84.2% and 90.5% respectively for these equations. Individual studies were highly heterogeneous in terms of target populations, type of screening tests, thresholds used to detect CKD and variations in design. Results pointed to the superiority of UAC and dipstick over the other tests in terms of all parameters involved. The diversity of methods and thresholds for detection of CKD, necessitate considering the cost parameter along with the effectiveness of tests to scale-up an efficient strategy. [GMJ.2020;9:e1573]

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A Single Arm Clinical Trial to Assess the Combined Effectiveness of Anubhuta Kashaya and Kaishora Guggulu in the Management of Chronic Kidney Disease (CKD)

International Journal of Ayurveda and Pharma Research ◽

10.47070/ijapr.v9i9.2013 ◽

2021 ◽

pp. 11-20

Author(s):

Rajshekar N. Shettar ◽

Prashanth A.S

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Filtration Rate ◽

Signs And Symptoms ◽

Good Health ◽

The Body ◽

Inclusion Criteria ◽

Waste Products ◽

Progressive Decline ◽

General Signs

CKD encompasses a spectrum of pathophysiologic processes associated with abnormal kidney function and a progressive decline in the glomerular filtration rate (GFR). Elimination of Malas from the body is also an inductive of good health. There are totally three Malas explained by the Samhitas namely Purisha, Mutra & Sweda. In Chronic Kidney Disease (CKD) where there is a less formation of Mutra, the Karma of Mutra is removing Kleda (waste products) from the body. So, the Kleda which resides in the body causes Pratiloma gati of Vata leading to different variety of diseases which involves Dusti of Rakta. Therefore, use of Mutrala & Raktashodhaka Dravyas may be helpful in the subjects of CKD. There is no availability of direct description of CKD in Ayurvedic science, except Vrukka roga Adhikara of Bhaishajya Ratnavali. So, we studied the disease with Ayurvedic concepts on the basis of general signs and symptoms. Here 28 subjects diagnosed with Chronic Kidney Disease (CKD) fulfilling the inclusion criteria were selected incidentally for study. For each subject of CKD Amapachana and Koshtashodhana was done with Hareetakyadi churna, Anubhuta Kashaya and Kaishora Guggulu are administered as Shamanoushadhi. With this intervention, we are able to give mild to moderate improvement in subjective and objective parameters. During the study improvement of subjective parameters are well appreciated than the objective parameters. The objective of the study is to establish the combined effectiveness of Anubhuta Kashaya and Kaishora guggulu in the management of Chronic Kidney Disease.

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The Effects of Self-Management Interventions on the Health Outcomes of Individuals With Chronic Kidney Disease After Critical Illness: An Integrative Review

Connect The World of Critical Care Nursing ◽

10.1891/wfccn-d-20-00006 ◽

2019 ◽

Vol 13 (3) ◽

pp. 126-144

Author(s):

Claudia Leung Ho Yau ◽

Janita Chau Pak Chun

Keyword(s):

Quality Of Life ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Health Outcomes ◽

English Language ◽

Well Being ◽

Management Program ◽

Self Management ◽

Management Interventions

BackgroundSelf-management is a crucial step towards achieving better physical and mental well-being and a better health-related quality of life for individuals with chronic kidney disease (CKD). Despite the high prevalence of CKD and the significant burdens faced by the individuals with CKD, their caregivers, and healthcare systems, very few studies have explored CKD and its consequences compared to other chronic diseases.ObjectiveTo synthesize and present the best available evidence on the effectiveness of CKD self-management interventions in terms of the biomedical, psychosocial, and behavioral aspects of health outcomes.MethodsThree electronic English-language literature databases were searched from inceptions to March 2018. Two reviewers independently selected articles according to pre-specified criteria, critically appraised and extracted data from relevant research. Narrative summaries were presented because the interventions and study features of the included articles were heterogeneous.ResultsOf the five included articles, three were interventional and two were systematic reviews. Effective self-management interventions have beneficial effects on biomedical outcomes such as blood pressure, psychosocial outcomes such as quality of life and self-efficacy, and behavioral outcomes such as CKD knowledge, self-management techniques, and adherence to self-care regimens and treatments.ConclusionsA self-management program that could provide better education and guidance for individuals with CKD is needed, as this would improve the provision of resources and preparations for foreseeable and avoidable CKD complications. The findings from the included articles demonstrate that limited amount of research has focused on CKD management. Additional randomized controlled trials that compare interventions with usual care are needed to determine the efficacy of CKD self-management programs.

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Chronic Kidney Disease-Associated Pruritus

Toxins ◽

10.3390/toxins13080527 ◽

2021 ◽

Vol 13 (8) ◽

pp. 527

Author(s):

Puneet Agarwal ◽

Vinita Garg ◽

Priyanka Karagaiah ◽

Jacek C. Szepietowski ◽

Stephan Grabbe ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

End Stage Renal Disease ◽

English Language ◽

Advanced Chronic Kidney Disease ◽

Primary Care Doctors ◽

Stage Renal Disease ◽

End Stage ◽

Distressing Condition

Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients. It has been reported to range from 20% to as high as 90%. The mechanism of CKD-associated pruritus (CKD-aP) has not been clearly identified, and many theories have been proposed to explain it. Many risk factors have been found to be associated with CKD-aP. The pruritus in CKD presents with diverse clinical features, and there are no set features to diagnose it.The patients with CKD-aP are mainly treated by nephrologists, primary care doctors, and dermatologists. Many treatments have been tried but nothing has been effective. The search of literature included peer-reviewed articles, including clinical trials and scientific reviews. Literature was identified through March 2021, and references of respective articles and only articles published in the English language were included.

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