scholarly journals HUBUNGAN ANTARA LAMA MENJALANI HEMODIALISIS DENGAN DEPRESI PADA PASIEN DENGAN PENYAKIT GINJAL KRONIK DI RSUP. PROF. Dr. R. D. KANDOU MANADO

e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Elizabeth M. Sompie ◽  
Theresia M. D. Kaunang ◽  
Herdy Munayang
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hemodialysis Patient ◽  
Analytic Method ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Physical Limitations

Abstract: Hemodialysis is a treatment that must be lived for a lifetime in patients with chronic kidney disease. Hemodialysis patient may suffer depression from physical limitations. This study aimed to find the relation between duration of hemodialysis and depression. This research used observational-analytic method with cross sectional approach. This research involved all patients who carry out hemodialysis at Dahlia and Melati hemodialysis units at RSUP. Prof. Dr. R. D. Kandou Manado who meet the inclusion criteria which are 34 people. The result of this study showed that the duration of hemodialysis (p = 0,17, p > 0,05) did not correlate significantly with depression. Conclusion: The duration of hemodialysis does not correlate significantly with depression.Keywords: the duration of hemodialysis, depressionAbstrak: Hemodialisis merupakan terapi yang harus dijalani seumur hidup pada pasien penyakit ginjal kronik. Keterbatasan secara fisik yang timbul pada pasien hemodialisis dapat menyebabkan munculnya keadaan depresi. Tujuan dari penelitian ini adalah untuk mencari hubungan antara lama menjalani hemodialisis dengan depresi. Metode penelitian yang digunakan adalah observasional-analitik dengan pendekatan potong lintang. Penelitian ini melibatkan semua pasien hemodialisis di unit hemodialisis Dahlia dan Melati RSUP. Prof. Dr. R. D. Kandou Manado yang memenuhi kriteria inklusi sebanyak 34 orang. Hasil penelitian ini menunjukkan lama menjalani hemodialisis (p = 0,17, p > 0,05) tidak berhubungan secara signifikan dengan depresi. Simpulan: Lama menjalani hemodialisis tidak berhubungan secara signifikan dengan depresi.Kata kunci: lama menjalani hemodialisis, depresi

scholarly journals Gambaran Tingkat Depresi pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis di RSUP DR. M. Djamil Padang

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Fitri Amalia ◽  
Nadjmir Nadjmir ◽  
Syaiful Azmi Azmi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Mood Disorders ◽  
Rating Scale ◽  
Sampling Technique ◽  
Entire Population ◽  
Inclusion Criteria ◽  
Mild Depression ◽  
Cross Sectional ◽  
Hamilton Rating Scale

AbstrakDepresi merupakan salah satu dari gangguan mood yang utama. Tanda dan gejala lain gangguan mood adalah perubahan tingkat aktivitas, kemampuan kognitif, pembicaraan dan fungsi vegetatif seperti tidur, nafsu makan, aktivitas seksual dan irama biologis lainnya. Perubahan tersebut hampir selalu menyebabkan gangguan fungsi interpersonal, social, dan pekerjaan. Tujuan penelitian ini adalah untuk mengetahui gambaran tingkat depresi pada pasien penyakit ginjal kronik yang menjalani hemodialisis di RSUP Dr. M. Djamil. Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional study. Subjek diambil dari seluruh populasi yang memenuhi kriteria inklusi menggunakan teknik total sampling, Subjek yang memenuhi kriteria inklusi diwawancarai menggunakan The Hamilton Rating Scale For Depression dari seluruh populasi didapatkan 16 subjek yang memenuhi kriteria. Hasil yang didapatkan ialah 9 responden (56,25%) tidak mengalami depresi, depresi ringan 6 responden (37,50%) dan depresi sedang 1 responden (6,25%). Dapat disimpulkan tingkat depresi terbanyak pada pasien penyakit ginjal kronik yang menjalani hemodialisis di RSUP DR. M. Djamil tahun 2013 adalah tingkat depresi ringan. Karakteristik responden terbanyak yang mengalami depresi adalah sebagai berikut: umur 40-49 tahun, perempuan, menikah, berpendidikan terakhir SMA, pekerjaan ibu rumah tangga dan tidak bekerja.Kata kunci: depresi, penyakit ginjal kronik, hemodialisisAbstractDepression is one of the major of mood disorders. Other signs and symptoms of mood disorders are changes in the level of activity, cognitive ability, speech and vegetative functions such as sleep, appetite, sexual activity and other biological rhythms. Such changes always lead to malfunction of interpersonal, social and employment. The objective of this study was to describe the level of depression in patients with chronic kidney disease who undergoing hemodialysis at RSUP Dr. M. Djamil Padang. This was a descriptive study using a cross sectional design. Subject were taken from the entire population who met the inclusion criteria using total sampling technique, subject who met the inclusion criteria were interviewed using the Hamilton Rating Scale for Depression, of the entire population obtained 16 subjects that meet the criteria. From this study, a 9 respondents (56.25%) did not experience depression, 6 respondents (37.50%) mild depression and 1 respondent (6.25%) moderate depression. It can be concluded highest rates of depression in patients with chronic kidney disease undergoing hemodialysis at RSUP DR. M. Djamil Padang in 2013 in the level of mild depression. Most characteristics of the respondents who were depressed were as follows : age 40-49 years, female, married, educated, past high school, housewives work and do not work, 13-18 months undergoing hemodialysis.Keywords: depression, chronic kidney disease, hemodialysis

scholarly journals Pengaruh Hemodialisis Terhadap Kadar Glutation Tereduksi (GSH) Plasma Pasien Hemodialisis RSUD Arifin Ahmad

2017 ◽  
Vol 5 (1) ◽  
pp. 13
Author(s):  
Hannan Khairu Anami ◽  
W. Ristua Butar-Butar ◽  
Enikarmila Asni
Keyword(s):  
Chronic Kidney Disease ◽  
Free Radicals ◽  
Kidney Disease ◽  
General Population ◽  
Blood Plasma ◽  
Hemodialysis Patient ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Before And After

Chronic kidney disease patients who received hemodialysis therapy have higher risks to get atherosclerosis, inflammation,and cancer than general population at the same age. Imbalance of free radicals level and antioxidants defense whichdefined as oxidative stres may cause these complications. This study investigated the influence of hemodialysis onreduced glutathione (GSH) level, one of antioxidant, in blood plasma of hemodialysis patient at RSUD Arifin Ahmad.This was a cross sectional study that compare plasma GSH level before and after hemodialysis process. Population ofthis study was 72 patient in RSUD Arifin Ahmad but only 17 patient fulfilled all the inclusion and exclusion criteria.Plasma GSH level was measured by using Ellman method. The result showed that there were no significant differenceof plasma GSH level in patient before and after hemodialysis process (p=0,426).

HUBUNGAN EFIKASI DIRI DENGAN KUALITAS HIDUP PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS

2018 ◽  
Vol 5 (2) ◽  
pp. 56-63
Author(s):  
Abdul Wakhid ◽  
Estri Linda Wijayanti ◽  
Liyanovitasari Liyanovitasari
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Self Efficacy ◽  
Healing Process ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Kolmogorov Smirnov

Background: Self efficacy can optimize the quality of life of clients who undergo the healing process due to chronic diseases. Individuals with higher self-efficacy move their personal and social resources proactively to maintain and improve the quality and length of their lives so that they experience a better quality of life. Objectives: the purpose of this study was to find the correlation between self efficacy and quality of life of patients with chronic kidney disease who undergo hemodialysis at RSUD Semarang Regency. Metode: This type of research was descriptive correlation with cross sectional approach. The samples in this study more 76 people with total sampling technique. The data collection tool for self efficacy was measured by General Self-Efficacy scale, for quality of life with WHOQoL-BREF. Statistical test used Kolmogorov-smirnov. Result: The result showed that self efficacy in patients with chronic kidney disease was mostly in moderate category (53,9%), quality of life in patients with chronic kidney disease was mostly in good category (68,4%). There was a correlation between self efficacy and quality of life of patients with chronic kidney disease who undergo hemodialysis at RSUD Semarang Regency, the result obtained p-value of 0.000 <α (0,05). Suggestion: Patients with chronic kidney disease can maintain good quality of life by helping to generate positive self-esteem and high self efficacy.

scholarly journals Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Hirotaka Ochiai ◽  
Takako Shirasawa ◽  
Takahiko Yoshimoto ◽  
Satsue Nagahama ◽  
Akihiro Watanabe ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
Relationship Of

Abstract Background Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) to ALT ratio (AST/ALT ratio) have been shown to be related to non-alcoholic fatty liver disease or insulin resistance, which was associated with chronic kidney disease (CKD). However, it is unclear whether ALT and AST/ALT ratio are associated with CKD. In this study, we examined the relationship of ALT and AST/ALT ratio to CKD among middle-aged females in Japan. Methods The present study included 29,133 women aged 40 to 64 years who had an annual health checkup in Japan during April 2013 to March 2014. Venous blood samples were collected to measure ALT, AST, gamma-glutamyltransferase (GGT), and creatinine levels. In accordance with previous studies, ALT > 40 U/L and GGT > 50 U/L were determined as elevated, AST/ALT ratio < 1 was regarded as low, and CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m2 and/or proteinuria. Logistic regression model was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for CKD. Results “Elevated ALT and elevated GGT” and “elevated ALT and non-elevated GGT” significantly increased the OR for CKD when compared with “non-elevated ALT and non-elevated GGT” (OR: 2.56, 95% CI: 2.10–3.12 and OR: 2.24, 95% CI: 1.81–2.77). Compared with “AST/ALT ratio ≥ 1 and non-elevated GGT”, “AST/ALT ratio < 1 and elevated GGT” and “AST/ALT ratio < 1 and non-elevated GGT” significantly increased the OR for CKD (OR: 2.73, 95% CI: 2.36–3.15 and OR: 1.68, 95% CI: 1.52–1.87). These findings still remained after adjustment for confounders. Conclusions Elevated ALT was associated with CKD regardless of GGT elevation. Moreover, low AST/ALT ratio was also associated with CKD independent of GGT elevation.

scholarly journals Heart Rate Variability and Long Chain n-3 Polyunsaturated Fatty Acids in Chronic Kidney Disease Patients on Haemodialysis: A Cross-Sectional Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2453
Author(s):  
Ana M Pinto ◽  
Helen L MacLaughlin ◽  
Wendy L Hall
Keyword(s):  
Chronic Kidney Disease ◽  
Fatty Acids ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Kidney Disease ◽  
Polyunsaturated Fatty Acids ◽  
Cardiac Death ◽  
Cross Sectional ◽  
Ckd Stage ◽  
Long Chain

Low heart rate variability (HRV) is independently associated with increased risk of sudden cardiac death (SCD) and all cardiac death in haemodialysis patients. Long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) may exert anti-arrhythmic effects. This study aimed to investigate relationships between dialysis, sleep and 24 h HRV and LC n-3 PUFA status in patients who have recently commenced haemodialysis. A cross-sectional study was conducted in adults aged 40–80 with chronic kidney disease (CKD) stage 5 (n = 45, mean age 58, SD 9, 20 females and 25 males, 39% with type 2 diabetes). Pre-dialysis blood samples were taken to measure erythrocyte and plasma fatty acid composition (wt % fatty acids). Mean erythrocyte omega-3 index was not associated with HRV following adjustment for age, BMI and use of β-blocker medication. Higher ratios of erythrocyte eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) were associated with lower 24 h vagally-mediated beat-to-beat HRV parameters. Higher plasma EPA and docosapentaenoic acid (DPAn-3) were also associated with lower sleep-time and 24 h beat-to-beat variability. In contrast, higher plasma EPA was significantly related to higher overall and longer phase components of 24 h HRV. Further investigation is required to investigate whether patients commencing haemodialysis may have compromised conversion of EPA to DHA, which may impair vagally-mediated regulation of cardiac autonomic function, increasing risk of SCD.

scholarly journals Gut Microbiome Composition Remains Stable in Individuals with Diabetes-Related Early to Late Stage Chronic Kidney Disease

Biomedicines ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 19
Author(s):  
Ashani Lecamwasam ◽  
Tiffanie M. Nelson ◽  
Leni Rivera ◽  
Elif I. Ekinci ◽  
Richard Saffery ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Relative Abundance ◽  
Cross Sectional Study ◽  
Early Event ◽  
Sectional Study ◽  
Cross Sectional ◽  
Microbiome Composition ◽  
Stool Samples ◽  
Late Stages

(1) Background: Individuals with diabetes and chronic kidney disease display gut dysbiosis when compared to healthy controls. However, it is unknown whether there is a change in dysbiosis across the stages of diabetic chronic kidney disease. We investigated a cross-sectional study of patients with early and late diabetes associated chronic kidney disease to identify possible microbial differences between these two groups and across each of the stages of diabetic chronic kidney disease. (2) Methods: This cross-sectional study recruited 95 adults. DNA extracted from collected stool samples were used for 16S rRNA sequencing to identify the bacterial community in the gut. (3) Results: The phylum Firmicutes was the most abundant and its mean relative abundance was similar in the early and late chronic kidney disease group, 45.99 ± 0.58% and 49.39 ± 0.55%, respectively. The mean relative abundance for family Bacteroidaceae, was also similar in the early and late group, 29.15 ± 2.02% and 29.16 ± 1.70%, respectively. The lower abundance of Prevotellaceae remained similar across both the early 3.87 ± 1.66% and late 3.36 ± 0.98% diabetic chronic kidney disease groups. (4) Conclusions: The data arising from our cohort of individuals with diabetes associated chronic kidney disease show a predominance of phyla Firmicutes and Bacteroidetes. The families Ruminococcaceae and Bacteroidaceae represent the highest abundance, while the beneficial Prevotellaceae family were reduced in abundance. The most interesting observation is that the relative abundance of these gut microbes does not change across the early and late stages of diabetic chronic kidney disease, suggesting that this is an early event in the development of diabetes associated chronic kidney disease. We hypothesise that the dysbiotic microbiome acquired during the early stages of diabetic chronic kidney disease remains relatively stable and is only one of many risk factors that influence progressive kidney dysfunction.

scholarly journals FGF-23 and Phosphate in Children with Chronic Kidney Disease: A Cross-Sectional Study in Kazakhstan

Medicina ◽  
2020 ◽  
Vol 57 (1) ◽  
pp. 15
Author(s):  
Altynay Balmukhanova ◽  
Kairat Kabulbayev ◽  
Harika Alpay ◽  
Assiya Kanatbayeva ◽  
Aigul Balmukhanova
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Fibroblast Growth Factor 23 ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Ckd Stage ◽  
Advanced Stages ◽  
Fgf 23 ◽  
Stage 1

Background and objectives: Chronic kidney disease (CKD) in children is a complex medical and social issue around the world. One of the serious complications is mineral-bone disorder (CKD-MBD) which might determine the prognosis of patients and their quality of life. Fibroblast growth factor 23 (FGF-23) is a phosphaturic hormone which is involved in the pathogenesis of CKD-MBD. The purpose of the study was to determine what comes first in children with CKD: FGF-23 or phosphate. Materials and Methods: This cross-sectional study included 73 children aged 2–18 years with CKD stages 1–5. We measured FGF-23 and other bone markers in blood samples and studied their associations. Results: Early elevations of FGF-23 were identified in children with CKD stage 2 compared with stage 1 (1.6 (1.5–1.8) pmol/L versus 0.65 (0.22–1.08), p = 0.029). There were significant differences between the advanced stages of the disease. FGF-23 correlated with PTH (r = 0.807, p = 0.000) and phosphate (r = 0.473, p = 0.000). Our study revealed that the elevated level of FGF-23 went ahead hyperphosphatemia and elevated PTH. Thus, more than 50% of children with CKD stage 2 had the elevating level of serum FGF-23, and that index became increasing with the disease progression and it achieved 100% at the dialysis stage. The serum phosphate increased more slowly and only 70.6% of children with CKD stage 5 had the increased values. The PTH increase was more dynamic. Conclusions: FGF-23 is an essential biomarker, elevates long before other markers of bone metabolism (phosphate), and might represent a clinical course of disease.

scholarly journals Anemia among Chinese patients with chronic kidney disease and its association with quality of life - results from the Chinese cohort study of chronic kidney disease (C-STRIDE)

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yan Shen ◽  
◽  
Jinwei Wang ◽  
Jing Yuan ◽  
Li Yang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Systematic Investigation ◽  
Chinese Patients ◽  
Cross Sectional ◽  
Five Dimensions ◽  
Anemia Treatment

Abstract Background Anemia is one of the common complications in patients with chronic kidney disease (CKD). However, there is no systematic investigation on the prevalence of anemia in CKD patients and its relationship with the quality of life in China. Methods The data for this study comes from baseline data from the Chinese Chronic Kidney Disease Cohort Study (C-STRIDE), which recruited predialysis CKD patients in China. The kidney disease quality of life summary (KDQOL-TM) was used to assess health-related quality of life (HRQoL). Use linear regression model to estimate the relationship between hemoglobin level and quality of life. Results A total of 2921 patients were included in this study. The adjusted prevalence of hemoglobin (Hb) less than 100 g/L was 10.3% (95% confidence interval [CI]: 9.9,11.4%), and showed an increased trend through reduced eGFR levels from 4.0% (95%CI:2.3,5.9%) in the 45-60 ml/min/1.73m2 group to 23.4% (95%CI:20.5,26.2%) in the 15–29 ml/min/1.73m2 group. The prevalence of anti-anemia treatment was 34.0% (95%CI: 28.7,39.3%) and it is shown by reducing eGFR levels from 15.8% (95%CI:0,36.7%) in the 45-60 ml/min/1.73m2 group to 38.2% (95%CI: 30.7,45.2%) in the 15–29 ml/min/1.73m2 group. All five dimensions of the KDQOL scores in patients with CKD decreased as hemoglobin declined. After multivariable adjustments,the degrees of decrease became somewhat blunted. For example, compared with hemoglobin of ≥130 g/L, regression coefficients in the hemoglobin of < 100 g/L were − 0.047(95%CI: − 0.049,-0.045) for Symptoms and Problems(S), − 0.047(95%CI: − 0.049,-0.044) for Effects of the Kidney Disease(E), − 0.207(95%CI: − 0.212,-0.203) for Burden of the Kidney Disease(B), − 0.112(95%CI: − 0.115,-0.109) for SF-12 Physical Functioning (PCS), − 0.295(95%CI: − 0.299, -0.292) for SF-12 Mental Functioning (MCS), respectively. Conclusions In our cross-sectional analysis of patients with CKD in China, prevalence of both anemia and anti-anemia treatment increased with decreased eGFR. In addition, anemia was associated with reduced HRQoL.

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