PHYSICO CHEMICAL EVALUATION OF AVIPATTIKARA CHURNA AND ITS DEVELOPED FORM OF SYRUP

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (06) ◽  
pp. 38-42
Author(s):  
G.G. Gadad ◽  
◽  
K. S. Gudaganatti ◽  
V.S. Mannur
Keyword(s):  
Dosage Form ◽  
Oral Route ◽  
Physicochemical Analysis ◽  
Dosage Forms ◽  
Solid Dosage ◽  
Chemical Evaluation ◽  
Physico Chemical ◽  
Limit Test ◽  
Loss Of Appetite ◽  
Liquid Dosage Form

Development and modification of Ayurvedic classical formulations into widely acceptable dosage forms is an important area to be focused in the present era. The designing of liquid dosage form has generally been emphasized on the basis of ease of administration to those individuals who have difficulty in swallowing solid dosage forms, specially in pediatric and geriatric group. Churna (powders) are the preferentially administered Ayurvedic formulations by oral route. Most of these powders are hygroscopic, bitter to taste and should be administered with suitable vehicle. Avipattikara Churna is one of the unique formulation widely practiced in the management of common ailments like Amlapitta (hyperacidity), Vibandha (constipation), Agnimandya (loss of appetite), Arsha (hemorrhoids). Modification of the classical Churna (solid dosage form) into a more acceptable and convenient syrup (liquid dosage form) with modern pharmaceutical methods and its physico-chemical analysis is the main aim of the study. In the present study Avipattikara syrup was developed with 66.7 % w/V of Khandasharkara (sugar candy powder) without any pharmaceutical additives. Physicochemical analysis, microbial limit test, and physical quality tests for Avipattikara Churna and syrup were carried out respectively. Results suggest that, the developed syrup had a quality of ideal syrup.

scholarly journals REVIEW: FAST DISSOLVING TABLET

2018 ◽  
Vol 10 (2) ◽  
pp. 5
Author(s):  
Aher Smita S. ◽  
Saudagar R. B. ◽  
Shinde Mayuri S.
Keyword(s):  
Dosage Form ◽  
Geriatric Patients ◽  
Oral Route ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Tablet Disintegration ◽  
Physical And Chemical ◽  
Pass Metabolism

Fast dissolving tablets is one of the most widely accepted dosage forms and also most popular dosage form, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Some solid dosage forms like tablets and capsules are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like the first-pass metabolism. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. Some tablets are designed to dissolve fastly in saliva, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate.

scholarly journals Updated List of Light-Sensitive Oral Medications

2019 ◽  
Vol 55 (6) ◽  
pp. 349-365
Author(s):  
Scott Perkins ◽  
Adam Evans ◽  
Allison King
Keyword(s):  
Dosage Form ◽  
Drug Information ◽  
Dosage Forms ◽  
Drug Products ◽  
Solid Dosage ◽  
Oral Medications ◽  
Information Center ◽  
Oral Liquid ◽  
Liquid Products ◽  
Professional Resources

The Campbell University Drug Information Center supports health professionals by providing responses to drug-related inquiries. An inquiry was received by the Drug Information Center for a comprehensive list of oral solutions which should be protected from light. In investigating this request for information, a list of light-sensitive oral prescription drug products published in Hospital Pharmacy in 2009 was identified. This discovery highlighted the need for both an updated list and one which distinguished oral solid products and oral liquid products. The purpose of this project was to update the previously published list and to distinguish between oral solid and liquid dosage forms. The process of updating this list entailed several professional resources. A list of all oral products was obtained and then sorted to clearly identify which products were available in oral solid dosage form only, oral liquid dosage form only, and both dosage forms. Once delineated, the product labels for each medication were scoured for language indicating the product is light sensitive.

scholarly journals Hot-Melt 3D Extrusion for the Fabrication of Customizable Modified-Release Solid Dosage Forms

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 738 ◽  
Author(s):  
Jaemin Lee ◽  
Chanwoo Song ◽  
Inhwan Noh ◽  
Sangbyeong Song ◽  
Yun-Seok Rhee
Keyword(s):  
Dissolution Rate ◽  
Dosage Form ◽  
Amorphous State ◽  
Dosage Forms ◽  
Modified Release ◽  
Solid Dosage Forms ◽  
Solid Dosage Form ◽  
Solid Dosage ◽  
Enhanced Solubility ◽  
Hot Melt

In this work, modified-release solid dosage forms were fabricated by adjusting geometrical properties of solid dosage forms through hot-melt 3D extrusion (3D HME). Using a 3D printer with air pressure driving HME system, solid dosage forms containing ibuprofen (IBF), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) were printed by simultaneous HME and 3D deposition. Printed solid dosage forms were evaluated for their physicochemical properties, dissolution rates, and floatable behavior. Results revealed that IBF content in the solid dosage form could be individualized by adjusting the volume of solid dosage form. IBF was dispersed as amorphous state with enhanced solubility and dissolution rate in a polymer solid dosage form matrix. Due to absence of a disintegrant, sustained release of IBF from printed solid dosage forms was observed in phosphate buffer at pH 6.8. The dissolution rate of IBF was dependent on geometric properties of the solid dosage form. The dissolution rate of IBF could be modified by merging two different geometries into one solid dosage form. In this study, the 3D HME process showed high reproducibility and accuracy for preparing dosage forms. API dosage and release profile were found to be customizable by modifying or combining 3D modeling.

scholarly journals INFORMATION-ALGORITHMIC SUPPORT FOR DEVELOPMENT OF SOLID PHARMACEUTICAL FORM

2018 ◽  
Vol 13 (5) ◽  
pp. 73-81 ◽  
Author(s):  
V. F. Kornushk ◽  
I. V. Bogunova ◽  
A. A. Flid ◽  
O. M. Nikolaeva ◽  
A. A. Grebenshchikov
Keyword(s):  
System Approach ◽  
Dosage Form ◽  
Dosage Forms ◽  
Information Modeling ◽  
Relational Model ◽  
Information Support ◽  
Solid Dosage Forms ◽  
Pharmaceutical Development ◽  
Solid Dosage Form ◽  
Solid Dosage

The article deals with the application of the system approach for constructing informationalgorithmic support for the pharmaceutical development of solid dosage forms. Information modeling of the life cycle of pharmaceutical drug development has been carried out starting from the stage of studying the active pharmaceutical substance and ending with the utilization of the drug. These models are built in the IDEF0 nomination. A generalized block diagram is presented that reflects, in its most general form, the iterative process of developing a ready-made dosage form as applied to the further transfer of technology. The basis of the system approach is QbD - "Quality planned in the development". To implement the QbD principle on the basis of the system approach, systemic set-theoretic models of information support of pharmaceutical development in the nomenclature of Melentiev have been constructed. A model for controlling the pressing process is also provided, which takes into account all the technological stages in the development of a solid dosage form. Functional models in the IDEF0 nomenclature of the technological process are constructed from the preparation of premises, personnel and components of the dosage form to the stage of packing and packaging of the finished dosage form. The construction of an informational intellectual control system for pharmaceutical development has been considered in detail with particular attention paid to the construction of a database of medicinal and auxiliary substances using the example of solid dosage forms. In Melentiev's bracket notation, the database of auxiliary substances necessary for the design of a solid dosage form is filled. The "Entity-relationship" model and the relational model for the database of medicinal and auxiliary substances have been constructe

scholarly journals Aerosol vaccine of Influenza-A Critical Review

2020 ◽  
Vol 11 (2) ◽  
pp. 2247-2255
Author(s):  
Amit B Patil ◽  
Garemella Lakshmi Gayathri
Keyword(s):  
Influenza A ◽  
Dosage Form ◽  
Viral Infections ◽  
Effective Means ◽  
Age Groups ◽  
Age Group ◽  
Immunological Activity ◽  
Solid Dosage ◽  
Direct Administration ◽  
Liquid Dosage Form

Viruses are the most important mortal pathogens. The influenza virus is accountable for mortality and chronic illness in the world. Today we study the methods of vaccine administration i.e. aerosol method and its evaluation for the improvement of the changes in this method before given to humans and their immunological activity. The aerosol method is taken because it provides the advantages of direct administration of the antigens into bronchi of the lungs thereby producing the antibodies directly for the strains of influenza introduced since its presently nonreplicable viruses. Since vaccination can be done at age of 6 months to 65 years, the aerosol vaccination can be given for the age group of 2 -65 years, it can be self-medicated so that dependence is not required as such of the injectables, and it is directed for localized action and there by systemic action. The study also helps in understanding and better the development of vaccines which are useful for the mankind in future, there by chances of eradicating the deadly diseases, this review helps in understanding of the vaccine developments and also in formation of antigen antibodies, comparative studies between the aerosol vaccines, liquid dosage form and solid dosage form help in better understanding of the design of the vaccinations which is useful for all age groups and also useful for the better recovery from diseases and also the effective means for eradication of the viral infections   

scholarly journals Modification of Kakubhadi Churna into malahara and its physicochemical analysis

2021 ◽  
Vol 12 (4) ◽  
pp. 866-872
Author(s):  
Neha Semwal ◽  
Rakshitha D ◽  
Govinda Sharma K
Keyword(s):  
Chemical Analysis ◽  
Shelf Life ◽  
Physicochemical Analysis ◽  
Dosage Forms ◽  
Raw Material ◽  
Physico Chemical

Samskara is the process of modification of Guna of a given substance which is responsible for conversion of a raw material into medicine. These Samskara are responsible for the change in quality and property of any medicine. Primary preparations of Bhaisajya Kalpana known as Panchavidha kashaya Kalpana are modified into secondary dosage forms like Vati, Avaleha, Malahara, Sneha kalpana etc in order to achieve better shelf life, easy administration and palatability. Churna kalpana is an Upkalapana of Kalka kalpana, it is mentioned to be used in many disease conditions. One among these is Kakubhadi churna, which is indicated to be sprinkled externally on Dushta Vrana. As this method of application is cumbersome and not patient friendly, an attempt has been made to modify Kakubhadi churna into Malahara. Malahara is similar to ointments and creams in modern pharmaceutics. When compared to Churna, it has as an extended shelf life and also drugs in the form of Malahara are easy to apply and store. Taking all this under consideration, present study was taken up to modify Kakubhadi churna into Malahara. Physico chemical analysis of prepared Churna and Malahara was also done to achieve preliminary standard.

scholarly journals FAST DISSOLVING TABLETS: A REVIEW

2017 ◽  
Vol 9 (2) ◽  
pp. 8
Author(s):  
Ashish Masih ◽  
Amar Kumar ◽  
Shivam Singh ◽  
Ajay Kumar Tiwari
Keyword(s):  
Dosage Form ◽  
Pediatric Patients ◽  
Psychiatric Patients ◽  
Physical Stability ◽  
Transition Process ◽  
Oral Route ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Release Time

Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bedridden and uncooperative patients. FDTs are disintegrating or dissolve quickly in the saliva without a need of water. Fast dissolving tablets are designed to dissolve in saliva remarkably faster, within a few seconds (less than 60 seconds), and those are real fast-dissolving tablets. FDTs formulations contain super disintegrants to enhance the disintegration rate of a tablet in the buccal cavity. FDTs have advantages such as easy portability and manufacturing, accurate dosing, good chemical and physical stability and an ideal alternative for geriatric and pediatric patients. FDTs have disintegrated quickly, absorb faster so, in vitro drug release time improve and this property of drugs (dosage form) enhanced bioavailability. FDT formulations have the advantage of both conventional tablet formulation and liquid dosage form. There are several technologies that are conventional or patented based on spray drying, cotton candy process, sublimation, melt granulation, direct compression freezes drying/lyophilization, phase transition process, mass extrusion, etc. have been developed for manufacturing of FDTs. In this review contain brief information about FDTs including definition, advantages, needs or requirements of FDTs, salient features of FDTs, limitations, challenges to developing FDT, marketed formulations of fast dissolving tablets, etc.

scholarly journals LYOPHILIZED INJECTION: A MODERN APPROACH OF INJECTABLE DOSAGE FORM

2018 ◽  
Vol 8 (5) ◽  
pp. 10-18
Author(s):  
U Sheena ◽  
KG Parthiban ◽  
R Selvakumar
Keyword(s):  
Patient Compliance ◽  
Freeze Drying ◽  
Dosage Form ◽  
Dosage Forms ◽  
Solid Dosage Forms ◽  
Modern Approach ◽  
Solid Dosage ◽  
Liquid Injection ◽  
Improved Stability ◽  
Injectable Dosage

Now-a-days, lyophilized injection dosage form is extensively used to improve the bioavailability, stability, solubility and patient compliance. The lyophilized injection has considered as alternative to oral solid dosage forms for better patient compliance especially in bed ridden patients and for attaining maximum bioavailability, improved stability. The lyophilized injection reconstitute before injection to produce liquid injection. This review includes a detailed updated concept on lyophilized injection. Keywords: Lyophilized injection, parenteral, freeze drying

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