Hard tissue formation after direct pulp capping with osteostatin and MTA in vivo

Direct pulp capping involves the application of dental materials to the exposed pulp in an attempt to act as a barrier, protect the dental pulp complex and preserve its vitality. The materials for direct pulp capping should ideally adhere to dental pulp tissue as soft tissue and dentin as hard tissue with tight sealing. We therefore developed visible light-induced crosslinkable gelatin which is capable of adhesive to soft tissue and hard tissue.

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THE USE OF BIOCERAMICS IN ENDODONTICS - LITERATURE REVIEW

Medicine and Pharmacy Reports ◽

10.15386/cjmed-612 ◽

2016 ◽

Vol 89 (4) ◽

pp. 470-473 ◽

Cited By ~ 12

Author(s):

Stefan Jitaru ◽

Ioana Hodisan ◽

Lucia Timis ◽

Anamaria Lucian ◽

Marius Bud

Keyword(s):

Literature Review ◽

Clinical Outcome ◽

Reliable Data ◽

Chemical Processes ◽

Direct Pulp Capping ◽

Pulp Capping ◽

Ceramic Compounds ◽

Endodontic Sealers

Background and aim. Bioceramics are ceramic compounds obtained both in situ and in vivo, by various chemical processes. Bioceramics exhibit excellent biocompatibility due to their similarity with biological materials, like hydroxyapatite. Bioceramics and multi-substituted hydroxyapatite or similar compounds have the ability to induce a regenerative response in the organism.The aim of this paper is to make a literature review on the main bioceramic materials currently used in endodontics and on their specific characteristics.Methods. We conducted a search in the international databases (PubMed), to identify publications in the last 10 years, using the following key words: "bioceramics endodontics", "bioceramic endodontic cement", "bioceramic sealer" and "direct pulp capping bioceramic".Results. Commonly used endodontic sealers (e.g., containing zinc oxide, calcium hydroxide and a resin) have a long tradition in scientific research and clinical use in endodontics. For specific cases, like root resorptions, perforations, apexification, and retrograde fillings, new biocompatible materials were developed in order to improve the clinical outcome: ProRooT MTA (Dentsply Company,Germany); Biodentine (Septodont, France); Endosequence BC sealer (Brassler, SUA); Bioaggregate (IBC, Canada); Generex A (Dentsply Tulsa Dental Specialties, USA).Conclusion. The studies are generally in favor of bioceramic materials even if there are not many products available on the market for endodontic use. As more products are launched and more research is performed regarding these materials, we will provide more reliable data on clinical outcome.

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Reparative Dentinogenesis Induced by Mineral Trioxide Aggregate: A Review from the Biological and Physicochemical Points of View

International Journal of Dentistry ◽

10.1155/2009/464280 ◽

2009 ◽

Vol 2009 ◽

pp. 1-12 ◽

Cited By ~ 72

Author(s):

Takashi Okiji ◽

Kunihiko Yoshiba

Keyword(s):

Calcium Hydroxide ◽

Healing Process ◽

Mineral Trioxide Aggregate ◽

Wound Healing Process ◽

Direct Pulp Capping ◽

Hard Tissue ◽

Molecular Events ◽

Points Of View

This paper aims to review the biological and physicochemical properties of mineral trioxide aggregate (MTA) with respect to its ability to induce reparative dentinogenesis, which involves complex cellular and molecular events leading to hard-tissue repair by newly differentiated odontoblast-like cells. Compared with that of calcium hydroxide-based materials, MTA is more efficient at inducing reparative dentinogenesis in vivo. The available literature suggests that the action of MTA is attributable to the natural wound healing process of exposed pulps, although MTA can stimulate hard-tissue-forming cells to induce matrix formation and mineralization in vitro. Physicochemical analyses have revealed that MTA not only acts as a “calcium hydroxide-releasing” material, but also interacts with phosphate-containing fluids to form apatite precipitates. MTA also shows better sealing ability and structural stability, but less potent antimicrobial activity compared with that of calcium hydroxide. The clinical outcome of direct pulp capping and pulpotomy with MTA appears quite favorable, although the number of controled prospective studies is still limited. Attempts are being conducted to improve the properties of MTA by the addition of setting accelerators and the development of new calcium silicate-based materials.

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Theracal lc: A boon to dentistry

Archives of Dental Research ◽

10.18231/j.adr.2021.019 ◽

2021 ◽

Vol 11 (2) ◽

pp. 112-117

Author(s):

Kalyani G Umale ◽

Vandana J Gade ◽

Reema N Asani ◽

Priya R. Kosare ◽

Snehal Gaware ◽

...

Keyword(s):

Calcium Hydroxide ◽

Calcium Silicate ◽

Tissue Formation ◽

Hard Tissue ◽

Setting Reaction ◽

Pulp Capping ◽

Composition Method ◽

Calcium Silicates ◽

Pulp Vitality ◽

Postoperative Sensitivity

TheraCal LC, the focus of this article, is a material that creates a new category of resin-modified calcium silicates (RMCS). It is a light-cured, resin-based, and highly radiopaque liner designed to release calcium to promote hard-tissue formation, and is indicated for use under direct restorative materials as a replacement to calcium hydroxide and other calcium silicate-based materials, glass ionomers, eugenol-based sedative materials, and pulp capping restoratives. TheraCal LC exhibits several properties to help maintain ideal hard-tissue health and to reduce the incidence of postoperative sensitivity. This article is aimed to review the composition, method of application, setting reaction, properties and uses of TheraCal LC. TheraCal LC is interesting and promising product, which have the potential of creating major contributions to maintaining pulp vitality.

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Histological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials: in vivo study

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh160719063o ◽

2017 ◽

Vol 145 (7-8) ◽

pp. 370-377 ◽

Cited By ~ 1

Author(s):

Vanja Opacic-Galic ◽

Violeta Petrovic ◽

Vukoman Jokanovic ◽

Slavoljub Zivkovic

Keyword(s):

Inflammatory Reaction ◽

Calcium Silicate ◽

Subcutaneous Tissue ◽

Male Rats ◽

Histological Evaluation ◽

Direct Pulp Capping ◽

Pulp Tissue ◽

Pulp Capping ◽

Tissue Reactions

Introduction/Objective. Development of materials which could be used as biological bone substitutes is one of the most valuable and active fields of biomaterial research. The goal of the study was to research the reaction of tissue on calcium silicate- (CS) and hydroxyapatitebased (CS-HA) newly synthesized nanomaterials, after being implanted into the subcutaneous tissue of a rats and direct pulp capping of rabbit teeth. Methods. The tested materials were implanted in 40 Wistar male rats, sacrificed after seven, 15, 30, and 60 days. The direct pulp capping was performed on the teeth of rabbits. Cavities were prepared on the vestibular surface of the incisors. The animals were sacrificed after 10 and 15 days. The control material was mineral trioxide aggregate (MTA). Histological analysis covered the tracking of inflammatory reaction cellular components, presence of gigantic cells, and necrosis of the tissue. Results. Seven days after the implantation, the strongest inflammatory response was given by the MTA (3.3 ?} 0.48), while CS and CS-HA scored 3 ? 0.71. After 60 days, the rate of inflammatory reactions dropped, which was the least visible with CS-HA (0.2 ? 0.45). The least visible inflammatory reaction of the rabbits? pulp tissue was spotted with the CS (1.83 ? 0.75), than with the MTA and CS-HA (2.67 ? 1.53, 3 ? 0.63). Conclusion. The newly synthesized materials caused a slight reaction of the subcutaneous tissue. CS-HA showed the best tissue tolerance. Nanostructural biomaterials caused a slight to moderate inflammatory reaction of the rabbits? pulp tissue only in the immediate vicinity of the implanted material.

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