scholarly journals The Effect of Premedication with Curcumin on Post-Operative Pain in Single Visit Endodontic Treatment of Acute Pulpitis in Mandibular Molars: A Randomized Controlled Trial

2021 ◽  
Vol 1 (3) ◽  
pp. 1-8
Author(s):  
Ghada El Hilaly Mohamed Eid
Keyword(s):  
Repeated Measure ◽  
Rank Test ◽  
P Value ◽  
Visual Analogue Pain Scale ◽  
Visual Analogue Pain ◽  
Time Points ◽  
Single Visit ◽  
Mandibular Molars ◽  
Post Operative Pain ◽  
Irreversible Pulpitis

Objective: The purpose of this randomized double-blind clinical trial was to compare the effect of a single pretreatment dose of Curcumin and placebo on post-operative pain for patients diagnosed with symptomatic irreversible pulpitis in mandibular molars treated in single visit. Methods: Forty-four patients with severe to moderate pain randomly received either Curcumin (400mg +20 mg pepper) or placebo (420 mg Starch) one hour before starting root canal treatment (n = 22 per group). Participants rated their pain using visual analogue pain scale (VAS): preoperatively and at 5 time points: immediately post-operative, 8, 12, 24 and 48 hours postoperative. Patients also stated emergency analgesic intake. The need for supplemental anesthesia during treatment was recorded. Mann-Whitney U-test compared the two groups at each time point, while Repeated-Measure ANOVA and Wilcoxon Signed Rank test compared time points within each group. A p-value <0.05 was considered statistically significant. Results: Baseline characteristics of both groups showed non-significant differences (P > 05). Curcumin group at 8, 12 and 24 hours revealed statistically significantly less VAS values (44.2, 26.7, 19.1) than the placebo (58.5, 43.3, 30.3), respectively, (P > 05). All patients in Curcumin group did not need emergency analgesics. Curcumin group revealed statistically significantly lower percentages for the need of supplemental anesthesia (27.3%) compared to placebo (68.2%), (P < 05). Conclusion: Single preoperative oral dose of Curcumin proved to be an effective premedication that reduced post-operative pain as well as the need of supplemental anesthesia for patients diagnosed with symptomatic irreversible pulpitis of mandibular molars.

scholarly journals Effect of Posterior Bite Raiser on Periodontium of Lower Molars in Orthodontic Patients

2021 ◽  
Vol 10 (23) ◽  
pp. 1756-1759
Author(s):  
Arya S. Prasad ◽  
Arvind Sivakumar
Keyword(s):  
Pain Score ◽  
Pain Scale ◽  
Rank Test ◽  
Visual Analogue Pain Scale ◽  
Posterior Teeth ◽  
Deep Bite ◽  
Visual Analogue Pain ◽  
Probing Depth ◽  
Class 1 ◽  
The Mean

BACKGROUND Temporary bite opening with occlusal composite is performed routinely during orthodontic treatment of patients with deep bite and cross bite. There have been no studies yet to assess its effect on periodontium. This study was done to assess the effect of temporary bite-raising on periodontium when placed on the mandibular molars. METHODS A prospective clinical trial which was a pilot study conducted on fifteen subjects attending the Department of Orthodontics, Saveetha Dental College and Hospitals, (SIMATS), Chennai. Probing depth and pain score on percussion were recorded bilaterally on subjects with class 1 malocclusion, before and after placing bite blocks in the posterior teeth. The bite-raising was done using light cured orthodontic composite Blu BiteTM on both mandibular first molars. Probing depth was measured using a Williams probe at mesiobuccal, mid-buccal and distobuccal sites on molars and pain score on percussion was recorded using visual analogue scale. The pocket probing, before (T0) and after one month of temporary bite-raising (T1) was recorded and statistically analysed using paired t test and Wilcoxon sign rank test based on normality of variables. RESULTS There was a significant increase in the mean probing depth after bite raising with a mean difference of 1.07 ± 0.04 (P = 0.000). The mean pain score also significantly increased after temporary bite-raising (P = 0.002). CONCLUSIONS There were minor yet significant changes in the periodontium that occurred after temporary bite rising with Blu BiteTM. KEY WORDS Composite Resin, Periodontium, Occlusal Force, Orthodontic Adhesive, Visual Analogue Pain Scale

scholarly journals Comparison of post operative pain in tonsillectomy: a three year prospective study

2020 ◽  
Vol 6 (12) ◽  
pp. 2189
Author(s):  
Akshay Jain ◽  
Smruti Milan Tripathy
Keyword(s):  
Prospective Study ◽  
Pain Scale ◽  
Visual Analogue Pain Scale ◽  
Bipolar Cautery ◽  
Visual Analogue Pain ◽  
Pain Scores ◽  
Post Operative Period ◽  
Post Operative Pain ◽  
Significant Difference ◽  
Cold Dissection

<p><strong>Background:</strong> Tonsillectomy is the oldest surgery performed by otorhinolaryngologists worldwide. Through ages different techniques have been tried to improve the post surgical outcome and reduce morbidity among patients. Aim of the current study was to compare the post-operative pain among the patients undergoing tonsillectomy by cold dissection, bipolar cautery dissection and coblation dissection.</p><p><strong>Methods:</strong> 142 Patients undergoing tonsillectomy in ENT department of TMMC during the period of 3 year were included in the study. Patients were randomly distributed to undergo different techniques of tonsillectomy. The post-operative pain in patients was assessed using the pre-standardized visual analogue pain scale and results were analyzed.</p><p><strong>Results:</strong> No statistically significant difference was found among the groups undergoing tonsillectomy by cold dissection, bipolar dissection and coblator dissection as the p&gt;0.05. The immediate post-operative pain was found to be slightly higher among the group undergoing tonsillectomy by coblator dissection and the analgesics dose needed in the post-operative period remained the same for all for patients of all the three groups.</p><p><strong>Conclusions:</strong> No statistically significant difference was found in the post-operative pain scores of patients undergoing tonsillectomy by CD, BD and CBD techniques.</p>

scholarly journals Management of Pain with Morphine in cancer patients in a Tertiary Care Centre of Nepal

2021 ◽  
Vol 23 (3) ◽  
pp. 210-215
Author(s):  
Rita Kumari Mahaseth ◽  
Rashmey Pun ◽  
Kriti Shrestha
Keyword(s):  
Cancer Pain ◽  
Cancer Patients ◽  
Health Care Professionals ◽  
Tertiary Care ◽  
Dose Titration ◽  
P Value ◽  
Visual Analogue Pain Scale ◽  
Policy Document ◽  
Visual Analogue Pain ◽  
Relieve Pain

Pain is one of the most afflicting symptoms reported by cancer patients, mainly those with metastatic disease. The prevalence of cancer has increased, with an estimated projection of 17 million new cases in 2020. This means that there will be an increase in individuals with pain caused by the disease and by treatment. Morphine has been used to relieve pain in cancer patients for centuries. WHO, created a global health policy document for management of cancer pain entitled “Cancer Pain Relive,1 in which morphine was central. In a retrospective study of 1229 patients with cancer pain, the author reported that the analgesic ladder was effective in 71%. Many patients do not get adequate pain relief. Rationale of this study was to assess cancer related pain by using visual analogue pain scale and to prescribe optimal dose of morphine through dose titration to relieve pain and to improve quality of life. An interventional hospital-based study was done in fifty-two different types of cancer patients from 1st Jan, 2020 to 31st Dec, 2020 at Department of Oncology, Nepal Medical college and Teaching Hospital (NMCTH), Kathmandu. Among them 31 were male and 21 were female with mean age 63.87 and 58.19 respectively and SD +/- 12.10 in male and 16.07 in female with p value 0.152 significant. These patients were assessed for severity of pain through visual pain analogue. Improvement in daily activities after administration of morphine according to ECOG performance scale was done. Constipation was the most common complication induced by morphine 38.5%, sedation 32.7% and nausea in 25%. By understanding the context and social meaning surrounding the use of morphine to treat cancer pain, health care professionals can begin to anticipate, acknowledge and address some of the barrier to its use, thereby enhancing the pain control.

Change in Visual Acuity in Relation to Central Macular Thickness after Intravitreal Bevacizumab in Diabetic Macular Edema

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Muhammad Ali Haider ◽  
Uzma Sattar ◽  
Syeda Rushda Zaidi
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Intravitreal Bevacizumab ◽  
Macular Thickness ◽  
Rank Test ◽  
P Value ◽  
Central Macular Thickness ◽  
Anti Vegf ◽  
Quasi Experimental

Purpose: To evaluate the change in visual acuity in relation to decrease in central macular thickness,after a single dose of intravitreal Bevacizumab injection.Study Design: Quasi experimental study.Place and Duration of Study: Punjab Rangers Teaching Hospital, Lahore, from January 2019 to June 2019.Material and Methods: 70 eyes with diabetic macular edema were included in the study. Patients having high refractive errors (spherical equivalent of > ± 7.5D) and visual acuity worse than +1.2 or better than +0.2 on log MAR were excluded. Central macular edema was measured in μm on OCT and visual acuity was documentedusing Log MAR chart. These values were documented before and at 01 month after injection with intravitrealBevacizumab. Wilcoxon Signed rank test was used to evaluate the difference in VA beforeand after the anti-VEGF injection. Difference in visual acuity and macular edema (central) was observed,analyzed and represented in p value. P value was considered statistically significant if it was less than 0.01%.Results: Mean age of patients was 52.61 ± 1.3. Vision improved from 0.90 ± 0.02 to 0.84 ± 0.02 on log MARchart. The change was statistically significant with p value < 0.001. Central macular thickness reduced from 328 ±14 to 283 ± 10.6 μm on OCT after intravitreal anti-VEGF, with significant p value < 0.001.Conclusion: A 45 μm reduction in central macular thickness was associated with 0.1 Log MAR unit improvementin visual acuity after intravitreal Bevacizumab in diabetic macular edema.

THE ROLE OF MANUAL THERAPY IN THE TREATMENT OF CHRONIC CERVICAL PAINS

2020 ◽  
pp. 1-4
Author(s):  
George-Sebastian Iacob ◽  
Constantin Munteanu
Keyword(s):  
Manual Therapy ◽  
Therapy Group ◽  
Neck Disability Index ◽  
Initial Assessment ◽  
Visual Analogue Pain Scale ◽  
Rehabilitation Protocol ◽  
Visual Analogue Pain ◽  
Therapeutic Exercises ◽  
Group A ◽  
Group B

Cervical back pain is one of the most important and common musculoskeletal disorders in medical recovery clinics and clinics. The main objective of the study was to highlight the effectiveness of an individualized therapeutic program adapted to the particularities of 22 subjects, which combines physical exercise with manual therapy. Subjects were randomly assigned to two equal groups. Group A - rehabilitation protocol consisting of therapeutic exercises (specific to the head, neck and upper limbs). Group B - rehabilitation protocol that included both therapeutic exercises and manual therapy (specific maneuvers of vertebral mobilization, massage, myofascial techniques, stretching and manipulations). The Visual Analogue Pain Scale (VAS) and the Neck Disability Index (NDI) were used to monitor the evolution of the research subjects, both of which have a specific applicability character to chronic pain. According to VAS (p <0.001), Group B showed mean values reduced to 2.2 ± 0.9 at week 12, compared to 7.3 ± 0.92, following the initial assessment. NDI values indicate better functional status after 12 weeks of treatment for both groups of subjects. NDI showed a beneficial decrease for Group B (13.2 ± 2.2 after 12 weeks, compared to 25.8 ± 2.3 in the first week). The mean results of VAS and NDI indicated a better evolution of symptoms in the case of the protocol that combined exercise and manual therapy (group B), but there were no statistically significant differences (compared to group A).

Self Management Menentukan Kualitas Hidup Pasien Diabetes Mellitus

2019 ◽  
Vol 4 (2) ◽  
pp. 402
Author(s):  
Iskim Luthfa ◽  
Nurul Fadhilah
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Correlation Study ◽  
Self Management ◽  
Rank Test ◽  
P Value ◽  
Cross Sectional ◽  
Spearman Rank ◽  
Consecutive Sampling

<p><em>People with diabetes mellitus are at risk of developing complications, so that it affects the quality of life. These complications can be minimized through self-care management. This study aims to determine the relationship between self management with the quality of life for people with diabetes mellitus. This research is a kind of quantitative research with correlation study. This research used cross sectional design. The sampling technique uses non probability with estimation consecutive sampling. The number of respondents in this research are 118 respondents. Instrument for measuring self management used diabetes self management questionnaire (DSMQ), and instruments to measure quality of life used quality of life WHOQOL-BREEF. The data obtained were processed statistically by using spearman rank test formula and p value of 0,000 There is a significant relationship of self management with the quality of life of people with diabetes mellitus.</em></p><p> </p><p><em>Penderita </em><em>Diabetes mellitus </em><em>beresiko mengalami komplikasi yang dapat mempengaruhi kualitas hidupnya. Komplikasi tersebut dapat diminimalkan melalui manajemen perawatan diri (self management). Penelitian ini bert</em><em>ujuan </em><em>untuk</em><em> menganalisis hubungan self management dengan kualitas hidup pasien diabetes melitus. </em><em>Jenis p</em><em>enelitian ini </em><em>adalah</em><em> deskriptif korelasi</em><em> dengan desain cross sectional</em><em>. Teknik pengambilan sampel menggunakan non probability </em><em>sampling </em><em>dengan pendeka</em><em>t</em><em>an consecutive sampling</em><em>.</em><em> </em><em>J</em><em>umlah </em><em>sampel sebanyak</em><em> </em><em>118 responden.</em><em> </em><em>Instrumen </em><em>penelitian </em><em>untuk mengukur self management </em><em>menggunakan</em><em> </em><em>diabetes self management questionnaire</em><em> (DSMQ), </em><em>dan instrumen untuk mengukur kualitas hidup menggunakan </em><em>quality of life </em><em>WHOQOL-BREEF.</em><em> Analisis data menggunakan spearman rank dan didapatkan hasil nilai </em><em>p value 0,000</em><em> dan r 0,394.Terdapat </em><em>hubungan </em><em>antara </em><em>self management</em><em> dengan kualitas hidup pasien diabetes mellitus</em><em> dengan arah korelasi positif.</em></p>

scholarly journals Pediatric Multi-Organ Dysfunction Syndrome: Analysis by an Untargeted “Shotgun” Lipidomic Approach Reveals Low-Abundance Plasma Phospholipids and Dynamic Recovery over 8-Day Period, a Single-Center Observational Study

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 774
Author(s):  
Mara L. Leimanis-Laurens ◽  
Karen Ferguson ◽  
Emily Wolfrum ◽  
Brian Boville ◽  
Dominic Sanfilippo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Intensive Care ◽  
Critically Ill ◽  
Organ Dysfunction ◽  
Lipid Profiles ◽  
Critically Ill Children ◽  
P Value ◽  
Time Points ◽  
Logistic Organ Dysfunction ◽  
Multi Organ Dysfunction Syndrome

Lipids are molecules involved in metabolism and inflammation. This study investigates the plasma lipidome for markers of severity and nutritional status in critically ill children. Children with multi-organ dysfunction syndrome (MODS) (n = 24) are analyzed at three time-points and cross-referenced to sedation controls (n = 4) for a total of N = 28. Eight of the patients with MODS, needed veno-arterial extracorporeal membrane oxygenation (VA ECMO) support to survive. Blood plasma lipid profiles are quantified by nano-electrospray (nESI), direct infusion high resolution/accurate mass spectrometry (MS), and tandem mass spectrometry (MS/MS), and compared to nutritional profiles and pediatric logistic organ dysfunction (PELOD) scores. Our results show that PELOD scores were not significantly different between MODS and ECMO cases across time-points (p = 0.66). Lipid profiling provides stratification between sedation controls and all MODS patients for total lysophosphatidylserine (lysoPS) (p-value = 0.004), total phosphatidylserine (PS) (p-value = 0.015), and total ether-linked phosphatidylethanolamine (ether-PE) (p-value = 0.03) after adjusting for sex and age. Nutrition intake over time did not correlate with changes in lipid profiles, as measured by caloric and protein intake. Lipid measurement in the intensive care environment shows dynamic changes over an 8-day pediatric intensive care unit (PICU) course, suggesting novel metabolic indicators for defining critically ill children.

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