scholarly journals Automation of the wet disinfection process during the production of suture threads from natural collagen, catgut

2021 ◽  
Vol 1 (1) ◽  
pp. e004
Author(s):  
Juan A. Vega Farje ◽  
Ana Gonzalez ◽  
Fanny L. Casado
Keyword(s):  
Medical Devices ◽  
Fiber Quality ◽  
Automated System ◽  
Process Efficiency ◽  
Turbulent Regime ◽  
Wet Process ◽  
Process Stage ◽  
Surgical Suture ◽  
Disinfection Process ◽  
Surgical Sutures

Surgical sutures are the simplest yet most used medical devices in modern healthcare,  they are the preferred type because of its biocompatibility and ability to be resorbed. Bovine intestinal fibers are converted into catgut that serves as the starting material of absorbable surgical suture threads. The mechanical and control subsystems of industrial equipment were designed to automate disinfection of bovine intestinal fibers to increase efficiency during the wet process stage of disinfection without altering its fiber quality. A turbulent regime of the water and disinfectant mix was designed, implemented and validated, this automatic aeration system in the disinfection thank          increased the process efficiency by reducing the time used to handle a load of fibers by 50%, and the working time of the personnel involved in the process was reduced from 220 to 20 minutes. Tests on the final product showed that LAL levels comply with what is established by the American Pharmacopoeia: USP <85> Bacterial Endotoxin Test and USP <161> Medical Devices - Bacterial and Pyrogen Endotoxin Test. These results indicate that the disinfected catgut using the proposed automated system complies with all mechanical quality control tests.

scholarly journals Development of a Novel Polymer-Based mRNA Coating for Surgical Suture to Enhance Wound Healing

Coatings ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 374
Author(s):  
Antonia Link ◽  
Hanna Haag ◽  
Tatjana Michel ◽  
Markus Denzinger ◽  
Hans Peter Wendel ◽  
...  
Keyword(s):  
Wound Healing ◽  
Population Aging ◽  
Keratinocyte Growth Factor ◽  
Functional Protein ◽  
Wound Area ◽  
Surgical Suture ◽  
Surgical Sutures ◽  
Rising Incidence ◽  
Complete Wound Healing

A therapeutic strategy to improve wound healing has become an increasingly important medical task due to the rising incidence of adiposity and type II diabetes as well as the proceeding population aging. In order to cope with the resulting burdens, new strategies to achieve rapid and complete wound healing must now be developed. Accordingly, the development of a bioactive wound dressing in the form of a messengerRNA (mRNA)-bearing poly(lactide-co-glycolide acid) (PLGA) coating on surgical suture is being pushed further with this study. Furthermore, the evaluation of the polymer-based transfection reagent Viromer RED has shown that it can be used for the transfection of eukaryotic cells: The mRNA gets properly complexed and translated into a functional protein. In addition, the mRNA-PLGA coating triggered the expression of the keratinocyte growth factor (KGF) in HaCat cells although KGF is not expressed under physiological conditions. Moreover, transfection via surgical sutures coated with mRNA does not affect the cell viability and a proinflammatory reaction in the transfected cells is not induced. These properties make the mRNA-PLGA coating very attractive for the in vivo application. For the future, this could mean that through the use of mRNA-coated sutures in surgical wound closure, cells in the wound area can be transfected directly, thus accelerating and improving wound healing.

Piezo-catalytic persulfate activation system for water advanced disinfection: Process efficiency and inactivation mechanisms

2020 ◽  
Vol 400 ◽  
pp. 125894 ◽  
Author(s):  
Dehua Xia ◽  
Zhuoyun Tang ◽  
Yunchen Wang ◽  
Ran Yin ◽  
Huanjunwa He ◽  
...  
Keyword(s):  
Process Efficiency ◽  
Disinfection Process ◽  
Activation System ◽  
Persulfate Activation

scholarly journals ANALYSIS ON THE HALAL STATUS OF A MEDICAL DEVICE: A STUDY ON THE SURGICAL SUTURE

2021 ◽  
Vol 1 (1) ◽  
pp. 01-07
Author(s):  
Nur Farhani Zarmani ◽  
Mohd Anuar Ramli ◽  
Shaikh Mohd Saifuddeen Shaikh Mohd Salleh ◽  
Mohd Zaid Daud ◽  
Mohd Amzari Tumiran
Keyword(s):  
Medical Device ◽  
Medical Devices ◽  
Field Studies ◽  
The Body ◽  
Healthcare Sector ◽  
Medical Practitioners ◽  
Library Research ◽  
Surgical Suture ◽  
The Status ◽  
Depth Interviews

There is a recent demand for halal certification from another healthcare sector which is medical devices, which cover all types of medical equipment used in hospitals from simple equipment such as bandages to complex equipment such as ventilators. This matter has been raised by the industry as halal labelling is a requirement to penetrate the market of Islamic countries such as Saudi Arabia, Turkey, and Pakistan. Even it seems critical to proving halal status for the medical devices that incorporate animal tissues, in contact with or invasive to the body, and produce a reaction to the body, this does not deny the demand for other types of devices. This study will focus on the halal issues related to medical devices which are widely used to stitch and close the wounds of patients after surgery or injury, namely sutures. This study seeks to identify the status of suture usage from the perspective of Islamic ruling. To achieve this objective, a qualitative research method through library research, as well as field studies involving in-depth interviews with the industry players, both medical device and religious authorities, Islamic scholars, and medical practitioners. The interviews were recorded, transcribed, translated, coded, and reconciled with the aid of Atlas.ti software (version 7) to identify themes and subthemes for this study. The results show that with regard to the status of resources and processes, and the application of al-darurah (necessity) concept.

scholarly journals Endovascular Embolization with Radiopaque Silk Threads: A Feasibility Study in Swine

2006 ◽  
Vol 12 (2) ◽  
pp. 109-112 ◽  
Author(s):  
G. Guglielmi ◽  
A. Benati ◽  
S. Perini
Keyword(s):  
Experimental Study ◽  
Feasibility Study ◽  
Arteriovenous Malformations ◽  
Endovascular Embolization ◽  
Preoperative Treatment ◽  
Major Drawback ◽  
Brain Arteriovenous Malformations ◽  
Surgical Suture ◽  
Surgical Sutures

Surgical suture endovascular embolization of brain arteriovenous malformations (AVMs) is an accepted method of preoperative treatment. A major drawback of AVM embolization with surgical sutures is that the sutures are not visible under fluoroscopy. An experimental study using swine is presented where surgical sutures were rendered radiopaque using platinum markers.

Optimization of Processing Modes of Disinfection of Vegetable Storehouses With the Use of Ozone

2020 ◽  
pp. 27-52
Author(s):  
Alexander Smirnov ◽  
Victoria Ukhanova ◽  
Irina Georgievna Ershova ◽  
Bibigul Koshoeva
Keyword(s):  
Fruits And Vegetables ◽  
Dynamic Balance ◽  
Automated System ◽  
Ozone Treatment ◽  
Ozone Decomposition ◽  
Ozone Generator ◽  
Factors Affecting ◽  
Disinfection Process ◽  
Processing Modes

The ozonation of fruits and vegetables may increase their storage life nearly twice as long. The chapter presents the results of research completed on the ozone treatment of vegetable storehouses with the use of ozone generators, with barrier and corona types of discharge, and reveals factors affecting disinfection process. The results show that ozone concentration depends on the dynamic balance of the two basic processes – the ozone-air mixture supply and ozone decomposition. Formulas for calculating ozone generator capacity in the recirculation mode have been derived. The automated system for controlling the disinfection process in a vegetable storehouse is described. The experimental test has shown that the ozone effect is long-term and the efficiency of the sterilization of surface microflora contaminants is 100%.

scholarly journals Organic bench model applied to surgical suture training

2020 ◽  
Vol 9 (10) ◽  
pp. e3939108614
Author(s):  
João Moreira Da Costa Neto ◽  
Gabriel Menezes Rodrigues ◽  
Pollyana Linhares Sala ◽  
Rafael Da Cruz Morais ◽  
Alysson Ramalhais ◽  
...  
Keyword(s):  
Ethylene Vinyl Acetate ◽  
Human Medicine ◽  
Legal Issues ◽  
Surgical Suture ◽  
Surgical Technical ◽  
Technical Discipline ◽  
Surgical Sutures ◽  
Ethical And Legal Issues ◽  
Green Banana ◽  
Bench Model

Veterinary and human medicine students should be trained in skills necessary to perform surgical procedures. Regarding the practice of surgical sutures, the methods used include the use of various materials such as fabric device, sponge, pieces of the animals and pieces of ethylene vinyl acetate. This article proposes to use banana and eggplant to train surgical suture techniques. The work was carried out by monitors from the veterinary surgical technical discipline. These monitors performed sutures in the vegetables (green banana and eggplant) and completed a questionnaire on the method. All monitors agreed that vegetables are easy to handle. Most stated that it was a pleasant experience for not using live animals. An advantage of using vegetables is handling, including storage and disposal. Besides, they do not transmit diseases. Animal materials such as bovine tongue, and swine parts that are widely used in suture teaching, present the risk of zoonosis transmission. The proposed organic bench model (banana and eggplant) may be indicated as a complementary alternative to advanced surgical sutures training. In addition, the model in question avoids the use of animals, while respecting ethical and legal issues.

scholarly journals PLGA-Collagen Composite Synthesis with the Antibacterial Addition of Jatropha curcas L. Leaf Extract as Absorbable Surgical Suture Candidate

2017 ◽  
Vol 32 ◽  
pp. 90-97 ◽  
Author(s):  
Karina Dwi Saraswati ◽  
Prihartini Widiyanti ◽  
Dwi Gustiono ◽  
Jan Setiawan
Keyword(s):  
Jatropha Curcas ◽  
Inhibition Zone ◽  
Test Results ◽  
Jatropha Curcas L ◽  
Optimal Sample ◽  
Activity Test ◽  
Surgical Suture ◽  
Electrospinning Method ◽  
Surgical Sutures ◽  
Suture Thread

The prevalence rate of surgical wound infections caused by bacteria is an average of 9% of the 1.4 million patients worldwide. For this reason, a modification of an absorbable surgical suture coated with extract of Jatropha curcas L. leaves to kill and inhibit the growth of microorganisms needs to be made. The forming of multifilament fibers is done by electrospinning method. The test results of the functional groups showed the presence of interaction between PLGA-Collagen with the extract of Jatropha Curcas L. leaves indicated by an absorption band at 2924 cm-1 which showed the vibrations of C-H. The tensile test results showed that all samples were in the range of 19.5-87.1 MPa values which corresponded with the modulus of elasticity of the suture thread in the forehead and elbows. The MTT Assay results showed that the percentage of living cells of all samples was above 50%. The bacterial activity test showed that the inhibition zone were in the range of 5-10 mm. The optimal sample showed the degradation rate of 82.2% on the 60th day of the soaking period. It can be concluded that PLGA-collagen Jatropha curcas L. extracts is safe composite and has potential as antibacterial absorbable surgical sutures.

Thermal Disinfection Validation: The Relationship Between A0 and Microbial Reduction

2021 ◽  
Vol 55 (3) ◽  
pp. 85-90
Author(s):  
Terra A. Kremer ◽  
Gerald McDonnell ◽  
Emily Mitzel ◽  
Nupur Jain ◽  
Henri Hubert ◽  
...  
Keyword(s):  
Medical Devices ◽  
Microbial Reduction ◽  
Conservative Approach ◽  
Traditional Use ◽  
Moist Heat ◽  
Considerable Research ◽  
Disinfection Process ◽  
Testing Techniques ◽  
The Relationship ◽  
Thermal Disinfection

Abstract Validating a thermal disinfection process for the processing of medical devices using moist heat via direct temperature monitoring is a conservative approach and has been established as the A0 method. Traditional use of disinfection challenge microorganisms and testing techniques, although widely used and applicable for chemical disinfection studies, do not provide as robust a challenge for testing the efficacy of a thermal disinfection process. Considerable research has been established in the literature to demonstrate the relationship between the thermal resistance of microorganisms to inactivation and the A0 method formula. The A0 method, therefore, should be used as the preferred method for validating a thermal disinfection process using moist heat.

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