scholarly journals The irrational fixed dose combinations in the Indian drug market: an evaluation of prescribing pattern using WHO guidelines

2013 ◽  
Vol 2 (4) ◽  
pp. 452 ◽  
Author(s):  
Somesh Rayasam ◽  
Sujata Dudhgaonkar ◽  
Ganesh Dakhale ◽  
Rohan Hire ◽  
Prashant Deshmukh ◽  
...  
Keyword(s):  
Drug Market ◽  
Fixed Dose ◽  
Who Guidelines ◽  
Prescribing Pattern

3D printing in pharmacy

2020 ◽  
pp. 58-60
Author(s):  
Yuliya Prozherina ◽  
Keyword(s):  
3D Printing ◽  
Cost Effective ◽  
Drug Market ◽  
Dosage Forms ◽  
Fixed Dose ◽  
Major Step ◽  
Combination Drugs ◽  
Effective Technology ◽  
Dose Combination ◽  
Research Stage

3D printing of drugs is an innovative and cost-effective technology, which is a major step towards personalized medicine. This technology can be used for the development of controlled-release drugs; fixed-dose combination drugs, as well as for the creation of orodispersible dosage forms. The global 3D drug market is still largely at the research stage, but its rapid growth is expected in the coming decade [1].

scholarly journals Prescribing pattern in patients of asthma visiting outpatient departments of a tertiary care hospital: a cross-sectional, observational study

2017 ◽  
Vol 6 (3) ◽  
pp. 587
Author(s):  
Nitant Trivedi ◽  
Hemangini R. Acharya ◽  
Manish J. Barvaliya ◽  
C. B. Tripathi
Keyword(s):  
Average Cost ◽  
Tertiary Care ◽  
Treatment Guideline ◽  
Oral Route ◽  
Brand Names ◽  
Beta Agonist ◽  
Fixed Dose ◽  
Care Hospital ◽  
Prescribing Pattern ◽  
Cross Sectional

Background: Objective of the study was to evaluate the prescribing pattern in patients of asthma visiting outpatient departments.Methods: Collected prescriptions were analyzed for demographic variables, proportions of various comorbid conditions, average number of drugs per prescription, average number of anti-asthmatic drugs per prescription, proportion of prescription with antibiotics, fixed dose combinations, and generic/brand names, proportion of formulations utilized, proportion of concomitant medications and possible drug interactions, average cost per prescription, average cost of antiasthmatic drugs per prescription, proportion of irrational prescription and adverse drug reactions.Results: Total 139 prescriptions were evaluated. Deriphyllin was the most commonly prescribed anti-asthmatic drug followed by beta agonist- steroid combination. Majority drugs were prescribed by inhalational route. Deriphyllin, and dexamethasone were prescribed by oral route and salbutamol was by both oral and inhalational route of administration. Antibiotics were prescribed to 24 patients. Possible drug interaction with deriphyllin was found in 15 prescriptions. Average cost per prescription was Rs. 193.4 (95%CI: 171.6-215.3).Conclusions: Prescribing pattern of asthma in our hospital shows more use of anti-asthmatic drugs. Standard treatment guideline should be followed. Role of methylxanthine in long term management of asthma should be justified.

scholarly journals Prescribing pattern of antidiabetic drugs in tertiary care hospital

2021 ◽  
Vol 10 (3) ◽  
pp. 251
Author(s):  
Anil Kumar P. ◽  
Raj Kumar K.
Keyword(s):  
Diabetes Mellitus ◽  
Lifestyle Modification ◽  
Tertiary Care ◽  
Hypoglycemic Agents ◽  
Fixed Dose ◽  
Multiple Drug ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Prescribing Pattern

Background: The aim of the current study was to investigate the prescribing pattern of anti-diabetic drugs in diabetic patients attending tertiary care teaching hospital in Kurnool.Methods: A prospective, cross-sectional, observational survey was carried out in 100 patients of diabetes mellitus attending diabetes outpatient/medicine outpatient departments, to assess their prescribing pattern of anti-diabetic drugs.Results: Average number of anti-diabetic drugs per prescription was 1.4. Metformin (biguanide) was the commonest prescribed individual drug among oral hypoglycemic agents. Fixed dose combination of biguanide and sulfonylurea was prescribed commonly. Monotherapy dominated over polytherapy and there was a higher percentage of use of insulin in type 2 diabetics.Conclusions: OHAs still dominate the prescribing pattern, but there was a shifting trend toward the use of insulin preparations in the management of type 2 diabetes mellitus. Intensification of current drug treatment as well as planning multiple drug interventions with lifestyle modification is necessary.

Evaluation of an outpatient department (OPD)-based prescribing pattern of fixed-dose combinations in a tertiary care institute in Central India

2020 ◽  
Vol 31 (3) ◽  
Author(s):  
Satish Chandel ◽  
Niket Rai ◽  
Sadashivam Balakrishnan ◽  
Ratinder Jhaj ◽  
Akash Vishwe ◽  
...  
Keyword(s):  
Descriptive Analysis ◽  
Tertiary Care ◽  
Essential Medicine ◽  
Central India ◽  
Fixed Dose ◽  
Medical Sciences ◽  
Prescribing Pattern ◽  
Prescribing Trends ◽  
Inflammatory Drugs ◽  
Male Patients

AbstractBackgroundFixed-dose combinations (FDCs) are being widely prescribed for the treatment of various disorders in India. However, not all FDCs are rational. To know the awareness of physicians in prescribing rational FDCs was the need of the hour in order to assess the prescribing trends and rationality of FDCs. Eventually, this will help to formulate the guideline for rational use of FDCs.MethodsThis was a prospective observational study conducted in All India Institute of Medical Sciences Bhopal, MP, India. Prescriptions were collected over a period of 2 months by the convenience sampling method from hospital pharmacy. The data were subjected to descriptive analysis using Microsoft Excel and Graph Pad Prism. Results were expressed in mean ± standard deviation (SD), percentages and 95% confidence interval.ResultsA total of 2496 drugs were prescribed in 1008 prescriptions, of which 945 (37.82%) were FDCs with an average of 0.93 ± 0.94 (mean ± SD) per prescription. Of 945, 67 (7.09%) were included in National List of Essential Medicine 2015 considered as rational. The number of prescriptions containing one or more FDCs was 629 (62.40%). FDCs were more frequently prescribed to male patients (54.92%) and in the age group of 18–30 years (33.44%). FDCs containing a proton pump inhibitor were prescribed most frequently (16.29%) followed by nonsteroidal anti-inflammatory drugs (13.96%) and multivitamins (7.83%).ConclusionsPrescribing irrational FDCs was very common, and hence there is an obvious need to update our prescribers about the irrationality of FDC and motivate them to develop a habit of rational prescribing.

Psychotropic drug utilization in psychiatric outpatient department of a tertiary care teaching hospital in India

2017 ◽  
Vol 5 (4) ◽  
pp. 1612
Author(s):  
Mohanraj Rathinavelu Mudhaliar ◽  
Ishrar Shaik Mohammad Ghouse ◽  
Priyanka Sadubugga ◽  
Swaroop Reddy Narala ◽  
Vidyasagar Chinnakotla ◽  
...  
Keyword(s):  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
Psychiatric Illness ◽  
Tertiary Care ◽  
Real Life ◽  
Psychotropic Medications ◽  
World Health ◽  
Fixed Dose ◽  
Care Hospital ◽  
Prescribing Pattern

Background: Although psychotropic medications have had a remarkable impact on psychiatric practice that legitimately can be called revolutionary, their utilization and consequences on real life effectiveness and safety in actual clinical practice need continuous study.Methods: The current retrospective study of six months’ duration was designed to assess the utilization of antipsychotics and its prescribing pattern in a tertiary care hospital of south India, which included prescriptions of patients suffering from a psychiatric illness with at least one psychotropic drug of all ages and both sexes.Results: Out of 150 cases reviewed, 46% were of schizophrenia, where male (60.67%) at higher incidence of psychiatric illness, and maximum patients were under the age group of 29-39 years (54.67%). In present study of 355 prescribed drugs 72.67% were psychotropic medications. As per World Health Organization/International Network for Rational Use of Drugs (INRUD) drug use indicators average number of drugs per prescription (2.37%), average number of psychotropic drugs per prescription (1.72%), psychotropic drugs prescribed as Fixed Dose Combinations (FDCs) was 26.36%, and percentage of drugs prescribed by generic name (91.08%). In our study, 48.09% of psychotropic drugs were utilized in the treatment of schizophrenia, diazepam (17.06%) was the only psychotropic medication distributed in the management of all three observed psychiatric disorders and the study showed a higher utilization of psychotropic drugs as FDCs (25.98%) in the management of schizophrenia.Conclusions: The study advocated an overall rational utilization of psychotropic drugs with a fewer deviations due to socio-economic status of patients and prescription practices of healthcare providers. 

scholarly journals Prescribing Pattern of Antimicrobial Agents in Neonates at Nepalgunj Medical College, Kohalpur, Banke, Nepal

2017 ◽  
Vol 15 (1) ◽  
pp. 36-39
Author(s):  
Ganesh Prasad Neupane ◽  
Maya Rai ◽  
Dabal Bahadur Dhami ◽  
Ritesh Singh
Keyword(s):  
Intensive Care ◽  
Neonatal Intensive Care ◽  
Antimicrobial Agents ◽  
Health Care Cost ◽  
Fixed Dose ◽  
High Morbidity ◽  
Prescribing Pattern ◽  
Medical College ◽  
Dose Combination ◽  
Nicu Admission

Introduction: Neonates are most vulnerable to infections due to poor immune system leading to high morbidity and mortality, which justifies early diagnosis and prompt treatment with antibiotics. Antibiotics are the most frequently used drugs in Neonatal Intensive care units. Aim and Objective: The objective of present study was to identify the pattern of use of antimicrobial agents in neonates at the neonatal intensive care unit (NICU) of NGMC. Materials and Methods: A hospital-based, retrospective study (prescription audit) was conducted over a period of 5-month duration at Nepalgunj Medical College by reviewing case records of NICU. Data were collected and analyzed. Results: A total of 150 case records were reviewed and were included in the study. Out of the 150, Neonates 86 (57.33%) were male babies and 64 (42.67%) were female babies. Maximum number (72.66%) neonates admitted to NICU were of low birth weight and most common reason for NICU admission was neonatal septicaemia. The majority of neonates (68.67%) received 2 antimicrobial agents (AMAs), 21.33% received 3 AMAs and average number of antibiotic per case was 2.44. The most commonly prescribed antimicrobial agent was Cefotaxime (58.66%), followed by Amikacin (48%), Ceftriaxone (32%). In fixed dose combination Piperacillin + Tazobactum (28%) was most commonly prescribed. All of the antimicrobial agents were prescribed by brand name.  Conclusion: Measures need to be undertaken to encourage physicians to prescribe AMAs in generic names to minimize health care cost. Present study suggests that Antibiotics policy to be framed & periodically reviewed: to reduce unnecessary use of antibiotics and associated problems.

scholarly journals A prospective observational study of prescription pattern in a tertiary care teaching hospital of Jharkhand

2019 ◽  
Vol 8 (12) ◽  
pp. 2620
Author(s):  
Abha Kumari ◽  
Keshav Kumar ◽  
Manju Gari ◽  
Kumari Pallavi ◽  
Subhankar Choudhury
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Care Delivery ◽  
Tertiary Care ◽  
Health Care Delivery System ◽  
World Health ◽  
Fixed Dose ◽  
Prescribing Pattern ◽  
Prescribing Practice ◽  
Health Organization

Background: Prescription error and irrational prescribing are the avoidable problems imposed on health care delivery system from prescriber side which must be addressed. Periodic prescription audit helps to curtail the error and irrational prescribing.Methods: A prospective observational study was conducted on patients visiting various Outpatient Department of RIMS, Ranchi, Jharkhand on all working days at 11:00 AM to 12:00 PM from 1 August 2018 to 31 July 2019. Various aspects of collected prescriptions were analyzed by using World Health Organization (WHO) prescribing indicators.Results: In this study, out of 700 prescriptions collected, 76 were excluded. Out of total 624 patients analyzed, 382 (61.28%) were male and 242 (38.72%) were female. 48 (7.69%) patients belonged to ≤18, 464 (74.36%) to 19-64 and 112 (17.95%) to ≥65 years of age group. Tablet (71%) was the most common dosage form. None of prescriptions were having registration number of the doctor. 242 (38.78%) prescriptions did not have a diagnosis duly written. The total no. of drugs prescribed in 624 prescriptions was 2176. Only 32 (5.13%) prescriptions were found to have medicines prescribed in block letters. Antibiotics (29%) were the most common class of drugs prescribed. Average number of drugs per prescription was 3.47. Only 48 (2.20%) drugs were prescribed by their generic name while total of injectables prescribed were 102 (4.68%). Total number of drugs from NLEM was 848 (38.97%). 196 (9.00%) drugs were fixed-dose combination.Conclusions: In our study, we found deficiencies in various parts of prescriptions. Prescribing pattern was not in accordance with WHO recommendation for prescribing practice.

scholarly journals A PROSPECTIVE STUDY OF DENTAL DISEASE PATTERN AND DRUG UTILIZATION AT THE DENTAL DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL IN EASTERN NEPAL

2003 ◽  
Vol 40 (137) ◽  
pp. 1-5
Author(s):  
G P Rauniyar ◽  
M S Shahanas ◽  
B P Das ◽  
M A Nagarani
Keyword(s):  
Dental Caries ◽  
Drug Utilization ◽  
Drug Combination ◽  
Antimicrobial Agents ◽  
Tertiary Care ◽  
Age Groups ◽  
Fixed Dose ◽  
Prescribing Pattern ◽  
A Prospective Study ◽  
Microbial Agent

To find out the pattern of dental diseases and drug utilization at dental out patientdepartment (OPD) of B.P. Koirala Institute of Health Sciences (BPKIHS), a tertiarycare hospital. A prospective prescription audit was conducted for a period of 10 daysin the dental OPD and the data was analyzed using WHO drug indicators. The totalnumber of prescriptions analyzed were 279. Dental caries (37%), Periodontitis (14%)and chronic gingivitis (11%) were the most common diseases with a maximum incidencebetween the age groups of 9 to 40 years. Mean number of drugs per prescription was2.79. Of the total prescriptions, 223 (79.9%) had 314 antimicrobial agents (AMA)constituting 40.3% of total drugs prescribed. The mean number of antimicrobial agentsper prescription was 1.13. The most commonly prescribed antimicrobial agents wasamoxycillin (33.1%) followed by metronidazole (24.9%), doxycycline (17.2%) andtinidazole (12.7%). Fixed dose drug combination of amoxycillin + cloxacillin (26) andampicillin + cloxacillin (10) were prescribed in 36 of the prescriptions. Povidone iodinegargle (41.2%) was the most commonly prescribed oropharyngeal preparation followedby Chlorhexidine gluconate mouthwash (32.4%). Non- steroidal anti-inflammatoryagents (20.66%), multi-vitamins (19.51%) and oropharyngeal preparations (17.45%)constituted the rest of the drugs prescribed. Diclofenac (60.86%) was the mostcommonly prescribed among NSAIDs and fixed dose drug combination of ibuprofenand paracetamol was prescribed in 19 of the prescriptions. All drugs were given byoral route (except for gentamicin in one prescription) and were prescribed underbrand names. None of the prescriptions had instructions whether the drug should betaken before or after food. The results indicate that dental caries was the most commondental disease, anti-microbial agents were prescribed to majority of the patients andconstituted a little less than half of the total drugs prescribed. Commonly used anti-microbial agent was amoxycillin which in two thirds of the cases was prescribed as anfixed dose drug combination. The high incidence of anti-microbial agent prescribingmay be modified by a feedback to the prescribers.Key words: Dental morbidity, prescribing pattern, drug utilization, dental OPD,antimicrobial agents.

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