scholarly journals Anti-Cancer Activity of Cayratia Auriculata Ethanolic Extracts Against Cancer Cell Line A549 An In Vitro Analysis

2020 ◽  
Vol 13 (2) ◽  
pp. 495-499
Author(s):  
Lalitha S Lalitha ◽  
Anusha D Anusha ◽  
Yogeshkumar Murkunde ◽  
Viji Devanand ◽  
Maheshkumar K Maheshkumar
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Anti Cancer ◽  
Ethanolic Extracts ◽  
Vitro Analysis ◽  
Cancer Activity ◽  
In Vitro Analysis

In silico and in vitro Analysis of Alkylated Salicylic Acid Inhibition Activity on Cervical HeLa Cancer Cell Line

2021 ◽  
Vol 21 (2) ◽  
pp. 59-69
Author(s):  
Priscilla Ardianto ◽  
Ade Arsianti ◽  
Khaerunissa Anbar Isti ◽  
Fadilah Fadilah
Keyword(s):  
Salicylic Acid ◽  
Cell Line ◽  
Cancer Cell ◽  
In Silico ◽  
Cancer Cell Line ◽  
Acid Inhibition ◽  
Inhibition Activity ◽  
Vitro Analysis ◽  
In Vitro Analysis

scholarly journals Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kotaro Sakamoto ◽  
Teruaki Masutani ◽  
Takatsugu Hirokawa
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Human Lung Cancer ◽  
Human Pancreatic Cancer ◽  
Inhibitory Peptide ◽  
Anti Cancer ◽  
Cancer Activity

AbstractRas mutations (e.g., occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and promising drug targets in chemotherapy treatments for cancer. However, there are still no approved drugs directly targeting mutated Ras. In 2017, an artificial cyclic peptide, KRpep-2d, was discovered as the first selective inhibitor of K-Ras(G12D), the most frequent K-Ras mutation. Here, we report the generation of KS-58, a KRpep-2d derivative that is identified as a bicyclic peptide and possess unnatural amino acid structures. Our in vitro data and molecular dynamics simulations suggest that KS-58 enters cells and blocks intracellular Ras–effector protein interactions. KS-58 selectively binds to K-Ras(G12D) and suppresses the in vitro proliferation of the human lung cancer cell line A427 and the human pancreatic cancer cell line PANC-1, both of which express K-Ras(G12D). Moreover, KS-58 exhibits anti-cancer activity when given as an intravenous injection to mice with subcutaneous or orthotropic PANC-1 cell xenografts. The anti-cancer activity is further improved by combination with gemcitabine. To the best of our knowledge, this is the first report of K-Ras(G12D)-selective inhibitory peptide presenting in vivo anti-cancer activity. KS-58 is an attractive lead molecule for the development of novel cancer drugs that target K-Ras(G12D).

Redox Mediated Synthesis of Ag‐CuO Hybrid Nanoparticles – DNA/BSA Binding Studies and in vitro Evaluation of Anti‐cancer Activity on MCF‐7 Cancer Cell Line

2020 ◽  
Vol 34 (5) ◽  
Author(s):  
Joel C. ◽  
Ivan Jebakumar D.S. ◽  
Biju Bennie R. ◽  
Gershom Stuart J. ◽  
Nirmal Paul Raj A. ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Hybrid Nanoparticles ◽  
Binding Studies ◽  
Bsa Binding ◽  
Anti Cancer ◽  
Cancer Activity ◽  
Mcf 7

scholarly journals In Vitro Analysis of Breast Cancer Cell Line Tumourspheres and Primary Human Breast Epithelia Mammospheres Demonstrates Inter- and Intrasphere Heterogeneity

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e64388 ◽  
Author(s):  
Chanel E. Smart ◽  
Brian J. Morrison ◽  
Jodi M. Saunus ◽  
Ana Cristina Vargas ◽  
Patricia Keith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Breast ◽  
Primary Human Breast ◽  
Vitro Analysis ◽  
In Vitro Analysis

scholarly journals In Vitro Cytotoxic and Antiproliferative Activity of Cydonia oblonga flower petals, leaf and fruit pellet ethanolic extracts. Docking simulation of the active flavonoids on anti-apoptotic protein Bcl-2

2018 ◽  
Vol 16 (1) ◽  
pp. 591-604 ◽  
Author(s):  
Lucia Pirvu ◽  
Amalia Stefaniu ◽  
Georgeta Neagu ◽  
Bujor Albu ◽  
Lucia Pintilie
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Docking Simulation ◽  
Leaf Extracts ◽  
Strong Inhibitor ◽  
Caffeoylquinic Acid ◽  
Apoptotic Protein ◽  
Ethanolic Extracts

AbstractThis study aimed to compare in vitro cell cytotoxicity and antiproliferative potency of three standardized ethanolic extracts (5mg GAE/mL sample) from quince flower petals, leaves and fruit pellet on four cell lines (L-929, and HepG2, Caco-2 and BT-20 respectively). Comparative analytical qualitative studies (HPTLC) indicated that if quince leaf extracts (Col40) mainly contain quercetin and kaempferol derivates, the flower petal extracts (Cof40) contain caffeoylquinic acid derivates, while the fruit pellet extracts (Cop40) are comprised of quercetin and caffeoylquinic acid derivates. Pharmacological studies demonstrated the lack of toxicity of test extracts; the most important antiproliferative effects were observed on the hepatic cancer cell line HepG2 (up to 75%, 53% and 70% inhibition in the case of Col40, Cof40 and Cop40 test extracts), followed by the colon cancer cell line Caco-2 (up to 69%, 77% and 40% inhibition) and breast cancer cell line BT-20 (up to 54%, 61% and 19% inhibition). The docking simulations on hyperoside, isoquercitrin, astragalin, and quercetin and kaempferol compared to the synthetic co-crystallized LI0 A1000 ligand (a strong inhibitor of anti-apoptotic protein Bcl-2) indicated astragalin as the most feasible protein inhibitor, but quercetin and kaempferol respected all the parameters involved in the Lipinski rule, making them the most promising antiproliferative candidates.

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