A Systematic Review on Pharmacological Activities of 4-Methylumbelliferon

2018 ◽  
Vol 9 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Yasmeen Al-Majedy ◽  
Abdul Amir Kadhum ◽  
Hiba Ibraheem ◽  
Ahmed Al-Amiery ◽  
Ahmed Abdel Moneim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pharmacological Activities

The pharmacological activities and mechanisms of artemisinin and its derivatives: a systematic review

2017 ◽  
Vol 26 (5) ◽  
pp. 867-880 ◽  
Author(s):  
Yi-Fei Dai ◽  
Wei-Wei Zhou ◽  
Jing Meng ◽  
Xin-Liang Du ◽  
Yun-Peng Sui ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pharmacological Activities

scholarly journals The Phytochemical Constituents and Pharmacological Activities of Annona atemoya: A Systematic Review

2020 ◽  
Vol 13 (10) ◽  
pp. 269
Author(s):  
Bassam S. M. Al Kazman ◽  
Joanna E. Harnett ◽  
Jane R. Hanrahan
Keyword(s):  
Systematic Review ◽  
South America ◽  
Annona Squamosa ◽  
Pharmacological Activities ◽  
Annona Cherimola ◽  
Pharmacological Studies ◽  
Custard Apple ◽  
Phytochemical Constituents ◽  
North And South America ◽  
North And South

Annona atemoya also known as the custard apple is a hybrid between two Annonaceae species: Cherimoya (Annona cherimola) and the sugar apple (Annona squamosa). It is widely cultivated in tropical and subtropical continents including north and south America, Asia, Africa and Australia. Despite becoming an increasingly important commercial fruit plant due to its’ creamy succulent flesh, compared to other Annonaceae species relatively few studies have investigated the phytochemistry and bioactivities of A. atemoya. Studies that evaluated A. atemoya extracts and its constituents were searched through the databases Scopus, Pubmed and Embase from inception to June 2020. Constituents of A. atemoya include alkaloids, flavonoids, terpenes and acetogenins. The results indicate that the constituents of A. atemoya possess cytotoxic, anti-angiogenic, hypolipidemic, antioxidant, anti-inflammatory and neuroprotective activities. However, many of these studies are currently limited in quality and further phytochemical and pharmacological studies are required.

Bridging Indigenous Knowledge and Scientific Evidence for Pharmacological Studies of Phaleria macrocarpa: A Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Md. Abdur Rashd Mia ◽  
Sahena Ferdosh ◽  
Qamar Uddin Ahmed ◽  
Abul Bashar Mohammed Helaluddin ◽  
Md. Zaidul Islam Sarker
Keyword(s):  
Systematic Review ◽  
Skin Diseases ◽  
Scientific Evidence ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Related Data ◽  
Online Databases ◽  
Phaleria Macrocarpa ◽  
Online Library ◽  
Identification Techniques

Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all the year in tropical countries including Malaysia, Indonesia, Papua New Guinea and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine, acne and skin ailments. Objective: The purpose of this systematic review is to provide important insight on P. macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities thus identifying the gap in scientific analysis and potential analytical opportunities for future directions on this herb. Method: The related data for this systematic review were collected from renowned online databases, namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus, and Google scholar. Results: Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives, flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids and so on were identified from different parts. These constituents and different solvent extracts using various identification techniques have been reported to show a broad range of pharmacological activities. Besides various traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological aspects has been well-documented. Studies found that the plant demonstrates antidiabetic, antioxidant, antimicrobial, anticancer, anti-hypercholesterolemia and antihypertensive. Conclusion: Despite various claims, there is still inadequate scientific evidence particularly on P. macrocarpa’s benefit in the management of dysentery, asthma, skin diseases and rheumatoid arthritis, necessitates future studies. There is also a need to test its pharmacokinetics and toxicological data on humans to verify its potential bioactive properties.

An over view of medicinal uses of Ayurvedic drug Pippali (piper longum)

2019 ◽  
Vol 7 (4) ◽  
Author(s):  
Prashant Sakharam Bhokardankar
Keyword(s):  
Systematic Review ◽  
Traditional Medicine ◽  
Therapeutic Agent ◽  
Scientific Literature ◽  
Experimental Studies ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Piper Longum ◽  
Review Criterion ◽  
Phytochemical Constituents

Background:  Pippali, Piper longum (P.longum)  usually called pippali which is a member of the Piperaceae family, is frequently used medicinal herb in Ayurved, Unani & Siddha system of medicine. In traditional  medicine world it is being used to treat most of the systemic disorders. This systematic review was conducted with an objective to search, explore & compile the phytochemical constituents & their efficacies both in modern and traditional part to understand as a potential therapeutic agent.  Material & method: Published details scientific literature on P. Longum by various research scholars, organizations & Pharmacopeias were reviewed. The review criterion was restricted to bio-efficacy and phyto-pharmacological activities of  longum. Results and Conclusions: This review shows various experimental studies conducted on Bio-active compounds isolated from P. longum has prospective uses as anticancer, antilipidemic, antifungal and  radioprotective.

A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

2021 ◽  
Vol 19 (7) ◽  
pp. 505-520
Author(s):  
Li MI ◽  
Yu-Chen LI ◽  
Meng-Ru SUN ◽  
Pei-Lin ZHANG ◽  
Yi LI ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pharmacokinetic Studies ◽  
Pharmacological Activities ◽  
Aconitum Alkaloids

Carvone and its pharmacological activities: A systematic review

2022 ◽  
Vol 196 ◽  
pp. 113080
Author(s):  
Lícia T.S. Pina ◽  
Mairim R. Serafini ◽  
Marlange A. Oliveira ◽  
Laeza A. Sampaio ◽  
Juliana O. Guimarães ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pharmacological Activities

scholarly journals Mulinane- and Azorellane-Type Diterpenoids: A Systematic Review of Their Biosynthesis, Chemistry, and Pharmacology

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1333 ◽  
Author(s):  
Angel de Jesús Dzul-Beh ◽  
Andrés Humberto Uc-Cachón ◽  
Jorge Bórquez ◽  
Luis A. Loyola ◽  
Luis Manuel Peña-Rodríguez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Biological Properties ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Anti Inflammatory

Mulinane- and azorellane-type diterpenoids have unique tricyclic fused five-, six-, and seven-membered systems and a wide range of biological properties, including antimicrobial, antiprotozoal, spermicidal, gastroprotective, and anti-inflammatory, among others. These secondary metabolites are exclusive constituents of medicinal plants belonging to the Azorella, Laretia, and Mulinum genera. In the last 30 years, more than 95 mulinanes and azorellanes have been reported, 49 of them being natural products, 4 synthetics, and the rest semisynthetic and biotransformed derivatives. This systematic review highlights the biosynthetic origin, the chemistry, and the pharmacological activities of this remarkably interesting group of diterpenoids.

scholarly journals Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Marine Drugs ◽  
2019 ◽  
Vol 18 (1) ◽  
pp. 5 ◽  
Author(s):  
Alejandro M. S. Mayer ◽  
Aimee J. Guerrero ◽  
Abimael D. Rodríguez ◽  
Orazio Taglialatela-Scafati ◽  
Fumiaki Nakamura ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nervous System ◽  
Mechanisms Of Action ◽  
Marine Natural Product ◽  
Therapeutic Approaches ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Preclinical Pharmacology ◽  
Marine Compounds ◽  
Anti Inflammatory

The systematic review of the marine pharmacology literature from 2014 to 2015 was completed in a manner consistent with the 1998–2013 reviews of this series. Research in marine pharmacology during 2014–2015, which was reported by investigators in 43 countries, described novel findings on the preclinical pharmacology of 301 marine compounds. These observations included antibacterial, antifungal, antiprotozoal, antituberculosis, antiviral, and anthelmintic pharmacological activities for 133 marine natural products, 85 marine compounds with antidiabetic, and anti-inflammatory activities, as well as those that affected the immune and nervous system, and 83 marine compounds that displayed miscellaneous mechanisms of action, and may probably contribute to novel pharmacological classes upon further research. Thus, in 2014–2015, the preclinical marine natural product pharmacology pipeline provided novel pharmacology as well as new lead compounds for the clinical marine pharmaceutical pipeline, and thus continued to contribute to ongoing global research for alternative therapeutic approaches to many disease categories.

scholarly journals A systematic review of pharmacological activities and safety of Moringa oleifera

2020 ◽  
Vol 9 (3) ◽  
pp. 174-190
Author(s):  
Jacob O. Popoola ◽  
Oluwadurotimi S. Aworunse ◽  
Olusola L. Oyesola ◽  
Olayemi O. Akinnola ◽  
Olawole O. Obembe
Keyword(s):  
Systematic Review ◽  
Moringa Oleifera ◽  
Bibliographic Databases ◽  
Leaf Extracts ◽  
Pharmacological Activities ◽  
Cytotoxic Effects ◽  
Research Attention ◽  
Document Type ◽  
Biological Assays ◽  
Treatment And Prevention

In the last few decades, Moringa oleifera, a multipurpose medicinal plant (MMP) has received increased research attention and commercial interest for its nutritional, therapeutic and pharmacological properties. Rigorous approaches including biological assays, animal and clinical trials are required towards safe usage as herbal therapy. We conducted a systematic review of the known pharmacological activities, toxicity, and safety of M. oleifera, usually used locally in the treatment and prevention of myriads of illnesses. Five major bibliographic databases (SCOPUS, Web of Science, Science Direct, PubMed, and Mendeley) were searched for studies reported on pharmacological activities, toxicity, and safety assessment of M. oleifera in the last 29 years (1990 – 2019). Studies on animals and humans involving aqueous leaf extracts and different preparations from M. oleifera seed and bark were also considered. All articles retained, and data collected were evaluated based on the period of the article, country where such studies were conducted and the document type. Our search results identified and analyzed 165 articles while 63 studies were eventually retained. Diverse pharmacological activities including neuroprotective, antimicrobial, antiasthmatic, anti-malaria, cardioprotective, antidiabetic, antiobesity, hepatoprotective and cytotoxic effects, amongst others, were recorded. Toxicity studies in animal models and few human studies showed that M. oleifera is safe with no adverse effect reported. The importance of the plant is highlighted in the search for new bioactive compounds to explore its therapeutic potentials towards drug discovery and development in the pharmaceutical and allied industries.

scholarly journals A Review: The Triterpenoid Saponins and Biological Activities of Lonicera Linn.

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3773 ◽  
Author(s):  
Zhongying Fang ◽  
Jia Li ◽  
Ran Yang ◽  
Lei Fang ◽  
Yongqing Zhang
Keyword(s):  
Systematic Review ◽  
Scientific Community ◽  
Functional Foods ◽  
Biological Activities ◽  
Bioactive Components ◽  
Immunomodulatory Effects ◽  
Pharmacological Activities ◽  
Triterpenoid Saponins ◽  
The Family ◽  
Hemolytic Toxicity

Lonicera Linn. is an important genus of the family Caprifoliaceae comprising of approximately 200 species, and some species of which have been usually used in traditional Chinese medicine for thousands of years. Some species of this genus can also be used in functional foods, cosmetics and other applications. The saponins, as one of most important bioactive components of the Lonicera Linn. genus, have attracted the attention of the scientific community. Thus, a comprehensive and systematic review on saponins from the genus is indispensable. In this review, 87 saponins and sapogenin from the genus of Lonicera Linn., together with their pharmacological activities including hepatoprotective, anti-inflammatory, anti-bacterial, anti-allergic, anti-tumor, and immunomodulatory effects, and hemolytic toxicity were summarized.

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