An over view of medicinal uses of Ayurvedic drug Pippali (piper longum)

2019 ◽  
Vol 7 (4) ◽  
Author(s):  
Prashant Sakharam Bhokardankar
Keyword(s):  
Systematic Review ◽  
Traditional Medicine ◽  
Therapeutic Agent ◽  
Scientific Literature ◽  
Experimental Studies ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Piper Longum ◽  
Review Criterion ◽  
Phytochemical Constituents

Background:  Pippali, Piper longum (P.longum)  usually called pippali which is a member of the Piperaceae family, is frequently used medicinal herb in Ayurved, Unani & Siddha system of medicine. In traditional  medicine world it is being used to treat most of the systemic disorders. This systematic review was conducted with an objective to search, explore & compile the phytochemical constituents & their efficacies both in modern and traditional part to understand as a potential therapeutic agent.  Material & method: Published details scientific literature on P. Longum by various research scholars, organizations & Pharmacopeias were reviewed. The review criterion was restricted to bio-efficacy and phyto-pharmacological activities of  longum. Results and Conclusions: This review shows various experimental studies conducted on Bio-active compounds isolated from P. longum has prospective uses as anticancer, antilipidemic, antifungal and  radioprotective.

scholarly journals The Phytochemical Constituents and Pharmacological Activities of Annona atemoya: A Systematic Review

2020 ◽  
Vol 13 (10) ◽  
pp. 269
Author(s):  
Bassam S. M. Al Kazman ◽  
Joanna E. Harnett ◽  
Jane R. Hanrahan
Keyword(s):  
Systematic Review ◽  
South America ◽  
Annona Squamosa ◽  
Pharmacological Activities ◽  
Annona Cherimola ◽  
Pharmacological Studies ◽  
Custard Apple ◽  
Phytochemical Constituents ◽  
North And South America ◽  
North And South

Annona atemoya also known as the custard apple is a hybrid between two Annonaceae species: Cherimoya (Annona cherimola) and the sugar apple (Annona squamosa). It is widely cultivated in tropical and subtropical continents including north and south America, Asia, Africa and Australia. Despite becoming an increasingly important commercial fruit plant due to its’ creamy succulent flesh, compared to other Annonaceae species relatively few studies have investigated the phytochemistry and bioactivities of A. atemoya. Studies that evaluated A. atemoya extracts and its constituents were searched through the databases Scopus, Pubmed and Embase from inception to June 2020. Constituents of A. atemoya include alkaloids, flavonoids, terpenes and acetogenins. The results indicate that the constituents of A. atemoya possess cytotoxic, anti-angiogenic, hypolipidemic, antioxidant, anti-inflammatory and neuroprotective activities. However, many of these studies are currently limited in quality and further phytochemical and pharmacological studies are required.

scholarly journals Pharmacological Activity of Garcinia indica (Kokum): An Updated Review

2021 ◽  
Vol 14 (12) ◽  
pp. 1338
Author(s):  
Sung Ho Lim ◽  
Ho Seon Lee ◽  
Chang Hoon Lee ◽  
Chang-Ik Choi
Keyword(s):  
Traditional Medicine ◽  
Pharmacological Activity ◽  
Therapeutic Agent ◽  
Industrial Applications ◽  
Pharmacological Activities ◽  
Garcinia Indica ◽  
Hydroxycitric Acid ◽  
Promising Therapeutic Agent

Garcinia indica (commonly known as kokum), belonging to the Clusiaceae family (mangosteen family), is a tropical evergreen tree distributed in certain regions of India. It has been used in culinary and industrial applications for a variety of purposes, including acidulant in curries, pickles, health drinks, wine, and butter. In particular, G. indica has been used in traditional medicine to treat inflammation, dermatitis, and diarrhea, and to promote digestion. According to several studies, various phytochemicals such as garcinol, hydroxycitric acid (HCA), cyanidin-3-sambubioside, and cyanidin-3-glucoside were isolated from G. indica, and their pharmacological activities were published. This review highlights recent updates on the various pharmacological activities of G. indica. These studies reported that G. indica has antioxidant, anti-obesity, anti-arthritic, anti-inflammatory, antibacterial, hepatoprotective, cardioprotective, antidepressant and anxiolytic effects both in vitro and in vivo. These findings, together with previously published reports of pharmacological activity of various components isolated from G. indica, suggest its potential as a promising therapeutic agent to prevent various diseases.

A review on phytochemical constituents of pharmaceutically important mangrove plants, their medicinal uses and pharmacological activities.

2018 ◽  
Vol 6 (1) ◽  
pp. 1
Author(s):  
Md. Ahasun Habib ◽  
Fahmida Khatun ◽  
Mastura Khatun Ruma ◽  
A. S. M. Homaun Kabir Chowdhury ◽  
Al Rumanan Silve ◽  
...  
Keyword(s):  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Mangrove Plants ◽  
Phytochemical Constituents

scholarly journals Medicinal Uses, Phytochemistry and Pharmacological Properties of Elaeodendron transvaalense

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 545
Author(s):  
Alfred Maroyi ◽  
Sebua Semenya
Keyword(s):  
Herbal Medicine ◽  
Southern Africa ◽  
Skin Infections ◽  
Journal Articles ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Phytochemical Compounds ◽  
Phytochemical Constituents ◽  
The University ◽  
Anti Hiv

Elaeodendron transvaalense is a plant species, which is in high demand as a herbal medicine in southern Africa. This study critically reviewed the medicinal applications, phytochemistry and pharmacological activities of E. transvaalense. The literature on medicinal applications, phytochemical, and pharmacological activities of E. transvaalense, was collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, Pubmed, BMC, Science Direct, and Scopus. Complementary information was gathered from pre-electronic sources, such as books, book chapters, theses, scientific reports, and journal articles obtained from the University library. This study revealed that the species is used as herbal medicine in 62.5% of the countries where E. transvaalense is native in southern Africa. It is mainly used as herbal medicine for diarrhoea, menorrhagia, stomach aches, skin infections, inflammations, and rashes. Phytochemical compounds identified from the species, include flavonoids, peltogynoid, phenols, proanthocyanidins, tannin, and triterpenes. Ethnopharmacological research revealed that extracts and phytochemical constituents isolated from E. transvaalense have antibacterial, antifungal, anti-HIV, anti-inflammatory, antioxidant, antiplasmodial, anti-protozoan, anti-pyretic, hypoglycaemic, larvicidal, cytotoxicity, and mutagenic activities. Elaeodendron transvalense should to be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating the medicinal uses of the species with the ethnopharmacological properties of the species.

scholarly journals LANNEA SCHIMPERI: REVIEW OF ITS BOTANY, MEDICINAL USES, PHYTOCHEMISTRY, AND BIOLOGICAL ACTIVITIES

2019 ◽  
pp. 31-36
Author(s):  
ALFRED MAROYI
Keyword(s):  
Cardiac Glycosides ◽  
Web Of Science ◽  
Biological Activities ◽  
Journal Articles ◽  
Tropical Africa ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Phytochemical Compounds ◽  
Phytochemical Constituents ◽  
The University

Lannea schimperi is a well-known fruit tree and medicinal plant in tropical Africa. The current study critically reviewed the botany, medicinal uses, phytochemistry, and pharmacological activities of L. schimperi. Literature on botany, medicinal uses, phytochemical and biological activities of L. schimperi were collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, PubMed, BMC, ScienceDirect, and Scopus. Complementary information was gathered from pre-electronic sources such as books, book chapters, theses, scientific reports, and journal articles obtained from the University Library. This study revealed that the species is used as a source of fiber, edible fruits, and herbal medicine. Phytochemical compounds identified from the species include cyclohexenones, cardanols, alkaloids, anthocyanins, anthracene glycosides, carbohydrates, cardiac glycosides, carotenoids, condensed tannins, coumarins, flavonoids, phenolic glycosides, phenols, polyoses, polyuronoids, reducing sugars, saponins, steroids, tannins, triterpenoids, and volatile compounds. Pharmacological research revealed that extracts and phytochemical constituents isolated from L. schimperi have anesthetic, antibacterial, antifungal, anticoccidial, anti-inflammatory, antinociceptive, antioxidant, anti-trypanosoma, antiulcerogenic, cytotoxicity, and toxicity activities. L. schimperi should be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological activities of the species.

scholarly journals Genetic Biomarkers of Panic Disorder: A Systematic Review

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1310
Author(s):  
Artemii Tretiakov ◽  
Alena Malakhova ◽  
Elena Naumova ◽  
Olga Rudko ◽  
Eugene Klimov
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Panic Disorder ◽  
Molecular Mechanisms ◽  
Scientific Literature ◽  
Association Studies ◽  
Experimental Studies ◽  
Genetic Biomarkers ◽  
Manual Review

(1) Background: Although panic disorder (PD) is one of the most common anxiety disorders severely impacting quality of life, no effective genetic testing exists; known data on possible genetic biomarkers is often scattered and unsystematic which complicates further studies. (2) Methods: We used PathwayStudio 12.3 (Elsevier, The Netherlands) to acquire literature data for further manual review and analysis. 229 articles were extracted, 55 articles reporting associations, and 32 articles reporting no associations were finally selected. (3) Results: We provide exhaustive information on genetic biomarkers associated with PD known in the scientific literature. Data is presented in two tables. Genes COMT and SLC6A4 may be considered the most promising for PD diagnostic to date. (4) Conclusions: This review illustrates current progress in association studies of PD and may indicate possible molecular mechanisms of its pathogenesis. This is a possible basis for data analysis, novel experimental studies, or developing test systems and personalized treatment approaches.

scholarly journals The Neuroprotective Effects of Thymoquinone: A Review

Dose-Response ◽  
2018 ◽  
Vol 16 (2) ◽  
pp. 155932581876145 ◽  
Author(s):  
Tahereh Farkhondeh ◽  
Saeed Samarghandian ◽  
Ali Mohammad Pourbagher Shahri ◽  
Fariborz Samini
Keyword(s):  
Scientific Literature ◽  
Nigella Sativa ◽  
Neurological Diseases ◽  
Experimental Studies ◽  
Pharmacological Activities ◽  
Neuroprotective Effects ◽  
Beneficial Effects ◽  
Anti Inflammatory ◽  
Main Components ◽  
Apoptotic Effects

Thymoquinone (TQ), one of the main components active of Nigella sativa, exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on. In addition, TQ protected brain cells from various injuries due to its antioxidant, anti-inflammatory, and apoptotic effects in cell line and experimental animal models. The present study has been designed to review the scientific literature about the pharmacological activities of TQ to the neurological diseases. This study purposed that although experimental studies indicated the beneficial effects of TQ against nervous system problems, better designed clinical trials in humans are needed to confirm these effects.

A Phyto-pharmacological review of Blepharis maderaspatensis (L.) B. Heyne ex Roth

2021 ◽  
Vol 7 (1) ◽  
pp. 56-59
Author(s):  
Devang Y. Joshi ◽  
◽  
Mukeshkumar B. Nariya ◽  
Rajesh Barvaliya ◽  
◽  
...  
Keyword(s):  
Wound Healing ◽  
Leaf Extract ◽  
Diabetic Wound ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Seasonally Dry ◽  
Pharmacological Studies ◽  
Different Types ◽  
Phytochemical Constituents ◽  
Wound Healing Activity

The present highlight the comprehensive ethano-medicinal uses of B. maderaspatensis, to enlighten its phytochemical constituents and pharmacological uses which may useful in various types of diseases. Blepharis is a genus of plant in family Acanthaceae and it contains around 126 species found in seasonally dry to arid habitats. One of its plants, Blepharis maderaspatensis (L.) B. Heyne ex Roth has been recognized by the Utinjan, Otigan, Utagan, and Chatushpatri in Hindi, Gujarati, Marathi, and Sanskrit respectively. Leaf extract of B. maderaspatensis rich in phytoconstituents like saponins, mucilage, flavonoids like caffeic acid, rutin, quercetin and ferulic acid. It is useful in various types of diseases as proved by pharmacological studies as an anti-hyperlipidaemic, anti-atherogenic activities, anti-inflammatory, antinociceptive activity, anti-ulcer activity, wound healing activity and in diabetic wound. The review suggests the similar uses and nomenclature of B. maderaspatensis to Blepharis edulis as mentioned in Wealth of India. Blepharis maderaspatensis (L.) B. Heyne ex Roth has rich phytoconstituents and varied pharmacological activities. Further, it has similar uses as Blepharis edulis mentioned in Wealth of India. Blepharis maderaspatensis (L.) B. Heyne ex Roth is the species of original Utingan stated in Ayurveda. Likewise, it has similar properties and action to the Blepharis edulis (Forssk.) Pers. which could be useful for different types of diseases like inflammation, ulcer, wound, diabetic wound. Present review highlights the phytoconstituents and different ethanomedicinal claims and some proven pharmacological activities.

scholarly journals A Recent Review on Chemistry and Biological Activities of Bryophyllum Pinatum (Lam.) Oken Family: Crassulaceae

2021 ◽  
Vol 37 (2) ◽  
pp. 269-280
Author(s):  
Priyanka Yadav ◽  
Arun Kumar Mishra ◽  
Harpreet Singh
Keyword(s):  
Secondary Metabolites ◽  
Biological Activities ◽  
Biological Effects ◽  
Human Beings ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Herbal Formulation ◽  
The Family ◽  
Web Science ◽  
Phytochemical Constituents

Bryophyllum pinnatum (Lam.) Oken belongs to the family Crassulaceae, one of the important medicinal plants which has great significances to treat various disorders, ailments in human beings. This study tells phytochemical constituents and pharmacological activities of extracts of Bry.pin(Lam.) Oken. The aim of this review is to emphasise the recent and advanced research on different parts of plant extracts used. The forty secondary metabolites were isolated by different researchers where the most important includes flavonoids, terpenoids, glycosides, steroids and these secondary metabolites were responsible for various biological actions as antioxidant, anticancer, antidiabetic, anti-inflammatory, analgesics, wound healing and hepatoprotective actions which are incorporated. All this information gathered into this review were collected by using electronic search as PubMed, Research gate, Elsevier, Google scholar and Web science. Further studies also required on extracts for getting more information about mechanism of action, biological effects, safety, dosage required. By observing the medicinal uses and pharmacological profile of Bry.pin(Lam.) Oken might be transferred into a new various herbal formulation and can report for future.

Arthrophytum scoparium Extract Improves Memory Impairment and Affects Acetylcholinesterase Activity In Mice Brain

2020 ◽  
Vol 21 (6) ◽  
pp. 480-487
Author(s):  
Med A. Smach ◽  
Jawhar Hafsa ◽  
Bassem Charfeddine ◽  
Hedi Dridi ◽  
Khalifa Limem ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Saline Water ◽  
Experimental Studies ◽  
Chronic Administration ◽  
Acetylcholinesterase Activity ◽  
Control Group ◽  
Pharmacological Activities ◽  
Oxidative Damages ◽  
Y Maze ◽  
Mice Brain

Background: Arthrophytum scoparium (Pomel) Iljin (Amaranthaceae family) has been widely used in traditional Tunisian medicine to treat many disorders such as migraine, headache, and neurological disorders. This study investigates the effect of Arthrophytum scoparium Aqueous Extract (ASAE) on cognitive impairments and oxidative injury induced by galactose (10%) in a mouse model. Materials and Methods: The mice were divided randomly into 4 experimental groups, including the control group (saline water 9 ‰), Galactose group, Scop group (300 mg/kg/d), and Scop+Gal group (300 mg/kg/d). Mice received the corresponding solutions by intraperitoneal injection (i.p.) for 7 days before the Y-maze active tests. Galactose 10% was given to all groups except control and Scop groups, 30 min before the trial. Levels of Acetylcholinesterase Activity (AChE), Ascorbic Acid (AA), Gluthatione (GSH) and Malondialdehyde (MDA) in mice brains were examined. Results: Chronic administration of galactose significantly impaired cognitive performance in Y maze, caused marked oxidative damages and a significant increase in the acetylcholinesterase activity as compared to other groups. On the contrary, ASAE (300 mg/kg) treatment suppressed galactoseinduced oxidative damage by ameliorating the increased levels of GSH and AA. Moreover, ASAE treatment reduced brain AChE activities in the galactose-induced model. Conclusion: These findings suggest that ASAE exerts potent anti-amnesic effects via the modulation of cholinergic and antioxidant activities. The observed pharmacological activities should be further evaluated by detailed experimental studies and validated by clinical trials.

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