Bridging Indigenous Knowledge and Scientific Evidence for Pharmacological Studies of Phaleria macrocarpa: A Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Md. Abdur Rashd Mia ◽  
Sahena Ferdosh ◽  
Qamar Uddin Ahmed ◽  
Abul Bashar Mohammed Helaluddin ◽  
Md. Zaidul Islam Sarker
Keyword(s):  
Systematic Review ◽  
Skin Diseases ◽  
Scientific Evidence ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Related Data ◽  
Online Databases ◽  
Phaleria Macrocarpa ◽  
Online Library ◽  
Identification Techniques

Background: Phaleria macrocarpa (Scheff.) Boerl. (Thymelaeaceae), usually referred to as God’s crown, Mahkota dewa, Pau, grows all the year in tropical countries including Malaysia, Indonesia, Papua New Guinea and Australia. It is traditionally used to treat haemorrhoids, stroke, heart disease, tumour, impotence, diabetes, allergies, kidney and liver disorders, migraine, acne and skin ailments. Objective: The purpose of this systematic review is to provide important insight on P. macrocarpa’s traditional use, toxicity, classification of compounds, and pharmacological activities thus identifying the gap in scientific analysis and potential analytical opportunities for future directions on this herb. Method: The related data for this systematic review were collected from renowned online databases, namely Wiley Online Library, Web of Science, Springer Link, PubMed, Science Direct, Scopus, and Google scholar. Results: Around 48 compounds, including benzophenone, xanthonoids, norcucurbitacin derivatives, flavonoids, lignans, fatty acids and esters, phytosterols, aromatic acids and so on were identified from different parts. These constituents and different solvent extracts using various identification techniques have been reported to show a broad range of pharmacological activities. Besides various traditional claims and pharmacological functions, scientific evidence on its ethnopharmacological aspects has been well-documented. Studies found that the plant demonstrates antidiabetic, antioxidant, antimicrobial, anticancer, anti-hypercholesterolemia and antihypertensive. Conclusion: Despite various claims, there is still inadequate scientific evidence particularly on P. macrocarpa’s benefit in the management of dysentery, asthma, skin diseases and rheumatoid arthritis, necessitates future studies. There is also a need to test its pharmacokinetics and toxicological data on humans to verify its potential bioactive properties.

scholarly journals Primary neural leprosy: systematic review

2013 ◽  
Vol 71 (6) ◽  
pp. 397-404 ◽  
Author(s):  
Jose Antonio Garbino ◽  
Wilson Marques Jr ◽  
Jaison Antonio Barreto ◽  
Carlos Otto Heise ◽  
Marcia Maria Jardim Rodrigues ◽  
...  
Keyword(s):  
Systematic Review ◽  
Scientific Evidence ◽  
Specific Treatment ◽  
Nerve Biopsy ◽  
Molecular Testing ◽  
Chain Reaction ◽  
Online Databases ◽  
Polymerase Chain ◽  
Definition Of ◽  
Based Medicine

The authors proposed a systematic review on the current concepts of primary neural leprosy by consulting the following online databases: MEDLINE, Lilacs/SciELO, and Embase. Selected studies were classified based on the degree of recommendation and levels of scientific evidence according to the “Oxford Centre for Evidence-based Medicine”. The following aspects were reviewed: cutaneous clinical and laboratorial investigations, i.e. skin clinical exam, smears, and biopsy, and Mitsuda's reaction; neurological investigation (anamnesis, electromyography and nerve biopsy); serological investigation and molecular testing, i.e. serological testing for the detection of the phenolic glycolipid 1 (PGL-I) and the polymerase chain reaction (PCR); and treatment (classification criteria for the definition of specific treatment, steroid treatment, and cure criteria).

scholarly journals A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata

2017 ◽  
Vol 6 (1) ◽  
pp. 53-58
Author(s):  
Vikas Chander ◽  
◽  
J.S. Aswal ◽  
Rajendra Dobhal ◽  
D.P. Uniyal ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Scientific Evidence ◽  
Active Constituent ◽  
Traditional Use ◽  
Traditional Medicines ◽  
Benzylisoquinoline Alkaloid ◽  
Ameliorative Effect ◽  
Pharmacological Potential ◽  
Phytochemical Studies ◽  
Protoberberine Alkaloid

Plants have been the basis of many traditional medicines throughout the world for thousands of years and continue to provide new remedies to mankind. They are one of the richest sources of compounds. Berberis aristata is one of the major plants used in Ayurveda for several remedies. It is used as a tonic, alternative, demulscent, diaphoretic and diuretic, and in the treatment of diarrhoea, jaundice, skin diseases, syphilis, chronic rheumatism and urinary disorders. Scientific evidence suggests its versatile biological functions that support its traditional use in the orient. Phytochemical studies shows that plant Berberis aristata contains mainly yellow colored alkaloids Berberine, oxyberberine, berbamine, aromoline, a protoberberine alkaloid karachine, palmatine, oxycanthine and taxilamine and tannins, sugar, starch. Among the several compounds Berberine is main constitute having various pharmacological actions. It is, a benzylisoquinoline alkaloid, occurs as an active constituent in numerous medicinal plants and has an array of pharmacological properties. It has been used in Ayurvedic and Chinese medicine for its antimicrobial, antiprotozoal, antidiarrheal and antitrachoma activity. Moreover, several clinical and preclinical studies demonstrate ameliorative effect of berberine against several disorders including metabolic, neurological and cardiological problems. This review provides a summary regarding the pharmacokinetic and pharmacodynamic features of berberine, with a focus on the different mechanisms underlying its multispectrum activity..

scholarly journals Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4294 ◽  
Author(s):  
Jianmei Zhang ◽  
Stephanie Triseptya Hunto ◽  
Yoonyong Yang ◽  
Jongsung Lee ◽  
Jae Youl Cho
Keyword(s):  
Skin Diseases ◽  
Fungal Infections ◽  
Scientific Evidence ◽  
Inflammatory Activity ◽  
Future Research ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
New Strategy ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive search of the published literature was conducted to locate original publications pertaining to T. impetiginosa up to June 2020. The main inquiry used the following keywords in various combinations in titles and abstracts: T. impetiginosa, Taheebo, traditional uses, phytochemistry, immunopharmacological, anti-inflammatory activity. Immunopharmacological activity described in this paper includes its anti-inflammatory, anti-allergic, anti-autoimmune, and anti-cancer properties. Particularly, T. impetiginosa has a strong effect on anti-inflammatory activity. This paper also describes the target pathway underlying how T. impetiginosa inhibits the inflammatory response. The need for further investigation to identify other pharmacological activities as well as the exact target proteins of T. impetiginosa was also highlighted. T. impetiginosa may provide a new strategy for prevention and treatment of many immunological disorders that foster extensive research to identify potential anti-inflammatory and immunomodulatory compounds and fractions as well as to explore the underlying mechanisms of this herb. Further scientific evidence is required for clinical trials on its immunopharmacological effects and safety.

Current issues in Employee Commitment: A Systematic Review

2019 ◽  
Vol 2 (4) ◽  
pp. 77-89
Author(s):  
Washington Machokoto
Keyword(s):  
Systematic Review ◽  
Language Proficiency ◽  
Employee Commitment ◽  
Quality Service ◽  
Open Access Journals ◽  
Online Databases ◽  
Business Source Premier ◽  
Online Library ◽  
Leadership Dimensions ◽  
Academic Search

Employee commitment (EC) literature has grown very broad, and there is a need to understand the current issues in this body of literature. This systematic review aimed to examine current issues in EC. The research search in several databases, including EBSCO Business Source Premier (BSP), Business Source Complete (BSC), Directory of Open Access Journals (DOAJ), Academic Search Complete (ASC), Science Direct (SD), Sage Journals (SJ), Taylor and Francis Online (T&FO), Emerald Insight (EI), Wiley Online Library (WOL) and ProQuest. The search in online databases found 86 studies and through vigorous eight studies was selected for review. After analysing the material, “human resource (HR) policies”, “wages/salaries”, “management/supervisory and subordinates relationships”, “language proficiency”, “quality service and units’ delivery”, “continuous improvement organisations”, “emotional empowerment”, “job satisfaction” and “leadership dimensions” emerged as important current issues. Also, the review found that there is no relationship between EC and the economic crisis. The researcher concludes that the literature on EC has grown very broad, and the researcher should conduct regular reviews to update future researchers. However, besides the limitation of a systematic process, the current reviewer recommends that more studies should be done to establish the results of this review.

scholarly journals Mandibular advancement devices: a real alternative to CPAP therapy?

2020 ◽  
Vol 4 (1) ◽  
pp. 128-136
Author(s):  
Helena Patrícia Campos da Silva ◽  
Francisco Maligno ◽  
João Carlos Pinho ◽  
Olívia Pinho
Keyword(s):  
Systematic Review ◽  
Scientific Evidence ◽  
Sleep Apnea Syndrome ◽  
Mandibular Advancement ◽  
Synthesis Methods ◽  
Cpap Therapy ◽  
Obstructive Sleep ◽  
Mandibular Advancement Devices ◽  
Online Library

Background: Obstructive sleep apnea syndrome (OSAS) is characterized by interruption of breath during sleep. OSAS is related to hypertension, type II diabetes and obesity. This disease has various implications on patient’s quality of life. The gold standard for OSAS treatment is continuous positive airway pressure (CPAP). Due to the high level of patients that complain about CPAP therapy, mandibular advancement devices could play an important role in OSAS treatment. Objectives: The purpose of this review is to appraise scientific evidence concerning the effectiveness of Mandibular Advancement Devices (MADs) for OSAS treatment and look over MADs designs that are currently being used scanning for its efficacy. Data sources: Five databases will be accessed (SCOPUS, PubMed, Web of Science, Science Direct and Wiley Online Library) and 6 keywords will be combined. Study eligibility and criteria: This systematic review will only include study’s developed with humans diagnosed with OSAS and with more than eighteen years old. English is the only language accepted. Study appraisal and synthesis methods: Studies assessment will be made by two authors (HCS and FM) and organized in three different parts: screen all articles; screen all abstracts, screen all full texts. In all phases articles that don’t have interest for this systematic review will be excluded. Two review authors (HCS and FM) will also assess the risk of bias and the quality of evidence, taking as a reference the Cochrane Collaboration’s Tool.

scholarly journals A NARRATIVE REVIEW OF ZINGIBERACEAE FAMILY AS ANTIBACTERIAL AGENT FOR TRADITIONAL MEDICATION BASED ON BALINESE LOCAL WISDOM

2020 ◽  
Vol 2 (2) ◽  
pp. 66
Author(s):  
Ayu Irayanti ◽  
A.A Gede Rai Yadnya Putra
Keyword(s):  
Antibacterial Activity ◽  
Literature Review ◽  
Antibacterial Agent ◽  
Native Plants ◽  
Skin Diseases ◽  
Scientific Evidence ◽  
Narrative Review ◽  
Scientific Publications ◽  
Traditional Use ◽  
Family Based

Background: One of the native plants from Indonesia that have been widely used for traditional medication as an antibacterial comes from the Zingiberaceae family. Based on Usada Bali, the Zingiberaceae family used to treat digestive, respiratory, and skin diseases. Objective: This literature review aimed to discuss antibacterial activity from the Zingiberaceae family and see its validity as a traditional use as antibacterial based on Balinese local wisdom medication method (Usada) with its scientific evidence. Methods: The method of this literature review is the study of literature from several scientific publications in national and international journals about the antibacterial activity of the Zingiberaceae family. Results: Several studies showed that the Zingiberaceae family has an antibacterial activity with various inhibitions depended on the type of bacteria. Conclusion: The Zingiberaceae family mentioned in Usada Bali has been scientifically proved to have antibacterial activity, so it shows the validity as a traditional use as antibacterial based on Usada with its scientific evidence. Keywords: Zingiberaceae, antibacterial, Usada

scholarly journals Impact of Psoriasis and Hidradenitis Suppurativa in Pregnancy, a Systematic Review

2021 ◽  
Vol 10 (24) ◽  
pp. 5894
Author(s):  
Maria-Angeles Ferrer-Alcala ◽  
Manuel Sánchez-Díaz ◽  
Salvador Arias-Santiago ◽  
Alejandro Molina-Leyva
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Hidradenitis Suppurativa ◽  
Skin Diseases ◽  
Case Reports ◽  
Scientific Evidence ◽  
Acne Inversa ◽  
Inflammatory Skin Diseases ◽  
Search Terms ◽  
The Impact

Psoriasis and hidradenitis suppurativa (HS) are chronic inflammatory skin diseases that frequently develop in young women. The aim of this study is to evaluate how hidradenitis suppurativa and psoriasis impact women desiring to conceive, and their influence on fertility and gestation. A systematic review of articles dating from January 2015 to April 2021 was performed using the Scopus (Elsevier) database. The search terms were (psoriasis and (birth or pregnancy or fertility)) and ((hidradenitis suppurativa or acne inversa) and (birth or pregnancy or fertility)). The search was limited to human data. Systematic reviews, case reports, clinical practice guidelines, expert consensus and conference papers were excluded. The impact of HS on pregnancy includes an impaired desire for pregnancy, a decrease in fertility, the worsening of the disease during pregnancy and potential adverse events during pregnancy. Moreover, the pregnancy might imply a change on the treatment of HS. The impact of psoriasis on pregnancy includes a decrease in fertility, potential adverse events during pregnancy and an unpredictable evolution of the disease. Moreover, the pregnancy might imply a change on the treatment of psoriasis, although biologic therapies do not appear to increase the risk of adverse events. In conclusion, both HS and psoriasis have an impact on pregnancy. A decrease of fertility has been reported. Moreover, both diseases have an unpredictable evolution during pregnancy. Pregnant women who are under biologic therapy do not seem to have a higher rate of adverse events. Treatment of both conditions is usually halted during pregnancy since scientific evidence about their safety is not conclusive, or teratogenic risk has been proven.

scholarly journals Treatment of urinary tract infections with medicinal plants: Monographs of some plants species revealed by traditherapists

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Victorien Dougnon ◽  
Phénix Assogba ◽  
Hornel Koudokpon ◽  
Césaire Ayena ◽  
Sosthéne Vissoh ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Urinary Tract Infections ◽  
Viral Infections ◽  
Skin Diseases ◽  
Scientific Evidence ◽  
Traditional Use ◽  
Suitable Alternative ◽  
The World ◽  
Tract Infections

Medicinal plants are a precious heritage for humanity and especially for the majority of poor communities in developing countries who depend on them for primary health care and livelihoods. They are used in traditional practices against urinary tract infections without any scientific evidence for most of the species used. This work aims to have a summary of the literature on some medicinal plants used in the treatment of urinary tract infections. To do this, this study was carried out based on the different medicinal plants cited by herbalists in southern Togo against urinary tract infections. The names of these different plants have each been the subject of research with keywords in search engines such as Google Scholar, PubMed, FreefullPdf, and others to bring out the traditional use of these plants in the world. From all of the above, it appears that the medicinal plant species cited by actors of the Togolese pharmacopoeia are used to treat several diseases in the world. The organs of these plants, such as leaves, bark, and roots are used in the treatment of common illnesses such as typhoid fever, diarrhea, malaria, bronchitis, and hypofertility. Coughs, colds, skin diseases, toothache, gonorrhoea, viral infections, and many other diseases are treated with these plants. The plants are often combined with other plants in traditional medicine. They are used in the form of decoction, fumigation, herbal tea, and others. The type of disease treated by the plants changes from region to region and is also dependent on the culture of the region in the world. The use of medicinal plants is a very ancient practice. It is a very suitable alternative to modern medicine. However, there is a need to have more detailed studies on these plants, such as their toxicological effects.

A Systematic Review of User Expectations and Outcomes of Crisis Support Services

Crisis ◽  
2020 ◽  
pp. 1-9
Author(s):  
Kelly Mazzer ◽  
Megan O'Riordan ◽  
Alan Woodward ◽  
Debra Rickwood
Keyword(s):  
Systematic Review ◽  
Support Services ◽  
Text Message ◽  
Positive Outcomes ◽  
Online Chat ◽  
Online Databases ◽  
Personal Crisis ◽  
Crisis Support ◽  
User Expectations ◽  
Behavioural Sciences

Abstract. Background: Crisis support services play an important role in providing free, immediate access to support people in the community experiencing a personal crisis. Recently, services have expanded from telephone to digital modalities including online chat and text message services. This raises the question of what outcomes are being achieved for increasingly diverse service users across different modalities. Aims: This systematic review aimed to determine the expectations and outcomes of users of crisis support services across three modalities (telephone, online chat, and text message/SMS). Method: Online databases (CINAHL, MEDLINE, PsycARTICLES, PsycINFO, Psychological and Behavioural Sciences Collection) and gray literature were searched for studies measuring expectations and outcomes of crisis support services. Results: A total of 31 studies were included in the review, the majority of which were telephone-based. Similar expectations were found for telephone and online chat modalities, as well as consistently positive outcomes, measured by changes in emotional state, satisfaction, and referral plans. Limitations/Conclusion: There is a paucity of consistent outcome measures across and within modalities and limited research about users of text message/SMS services.

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

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