Acute Toxicity Study and Faecal Dropping Capability of Ethanolic Extract of Tecoma stans in Albino Rats

Pharmacologia ◽  
2013 ◽  
Vol 4 (7) ◽  
pp. 464-468 ◽  
Author(s):  
S. Kameshwara ◽  
C. Jothimaniv ◽  
R. Senthilkum ◽  
S. Thenmozhi ◽  
R. Sundaragan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Toxicity Study ◽  
Albino Rats ◽  
Acute Toxicity Study

scholarly journals ANTI ARTHRITIC ACTIVITY OF HERBO MINERAL SIDDHA PREPARATION ARUMUGA CHENDURAM AGAINST TYPE II COLLAGEN INDUCED ARTHRITIS IN EXPERIMENTAL RATS

2020 ◽  
pp. 28-36
Author(s):  
M. Ramamurthy ◽  
V. Thanigavelan ◽  
S. Elansekaran ◽  
V. Srinivasan ◽  
P. Shanmugapriya ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Type Ii Collagen ◽  
Toxicity Study ◽  
Albino Rats ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Immune Disorder ◽  
Animal Products ◽  
Acute Toxicity Study ◽  
Wistar Albino Rats

Siddha system of medicine is the eternal science of life. It is a system that has its extensive bonding with Dravidian culture, language and beliefs. The system of medicine mostly prevailed and prospered in the regions of Dravidian cultures by the great Siddhars. It’s unique as one only than other AYUSH traditional systems of medicine across India with its distinctive abundant usage of medicinal plants, metals, minerals and animal products. Siddhars used the steps of Alchemy to prepare various medicines from metallic and mineral origin for attainment elixir and various rare diseases. Siddha medicine is classified into 32 types of internal and external medicine each. Among the 32 types of internal medicine Chendhuram is a medicine shelf life of 75 years usually from herbo-mineral combinations. Arumuga Chendhuram (ARC) is a herbo-mineral formulation cited in Siddha literature ‘Siddha Vaithiya Thirattu’. ARC was orally administered at higher dose 2gm/kg to the Wistar Albino rats in acute toxicity study and during 28 days of repeated (sub acute) toxicity study, at daily doses of 12, 24 & 48mg/kg of body weight to the Wistar Albino rats. Type II collagen arthritis is another model for developing autoimmune arthritis. The immune pathogenesis mediated by T cell and B cell response to collagen. By this model, nearly 100% arthritis can be achieved. In our study, ARC after 42 days treatment reduced the arthritic swelling significantly and degree of inflammation evident to act against auto immune disorder.

An experiemental study to evaluate the principle Trini Dravyani Nati Upayunjita w.s.r. to Kshara (Alkali)

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Amrita Paul ◽  
Umapati C. Baragi ◽  
Kashinath Hadimur ◽  
R. A. Deshmukh
Keyword(s):  
Acute Toxicity ◽  
Adverse Effects ◽  
Dose Level ◽  
Behavioral Changes ◽  
Toxicity Study ◽  
Fixed Dose ◽  
Albino Rats ◽  
Acute Administration ◽  
Acute Toxicity Study ◽  
Acute Study

Background: In Charaka Samhita it has been mentioned that three medicinal substances viz. Pippali (Piper longum), Kshara (alkali) and Lavana (salt) can be used as emergency medicine, but they should not be consumed in excess (Ati Upayunjita). If they are consumed in excess quantity they will cause several adverse effects in the body. Hence in the present study Kshara has been evaluated in experimental animals in two different phases viz. acute administration at graded doses as part of acute toxicity study and sub-acute administration at fixed dose level, as part of sub-acute toxicity study, to assess the possible adverse effects if any. Objectives: To evaluate the acute and sub-acute toxic effect of Kshara in albino rats to establish the principle of Trini Dravyani Nati Upayunjita. Materials and Methods: Wister strain albino rats of either sex weighing between 150 - 200g body weights were used for experimental study. The experiment was carried out as per ‘Ayush Guidelines’ after the IAEC clearance. For Acute Toxicity - 9 Albino rats were used and for Sub-Acute Toxicity - 12 Albino rats were used. The dose calculation was done on the basis of body surface area ratio using the table of ‘Paget and Barnes rule’. Results: In Acute toxicity study no mortality and behavioral changes were observed when the drug Kshara was studied after two dose level i.e. TED X 5 and TED X 10. In Sub-acute study some behavioral changes (including cage side behavior) were observed. No mortality was observed in any of the groups. Discussion: Acute toxicity study of Kshara showed no immediate and evident toxic signs and mortality within 24 hours of observation. In Sub-acute toxicity study in all four groups, no mortality or evident toxic effects were observed, however some mild histopathological changes were observed in sub-acute study.

scholarly journals Anti-diabetic and acute toxicity studies of Annona squamosa L. ethanolic leaves extract.

2017 ◽  
Vol 9 (4) ◽  
pp. 642 ◽  
Author(s):  
Farah - Saeed ◽  
Mansoor Ahmad
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Research Work ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Annona Squamosa ◽  
Standard Drug ◽  
Acute Toxicity Study ◽  
Rats And Mice ◽  
Body Weight Dose

<p><strong>Abstract </strong></p><p>Aim of this research work was to explore the anti-diabetic activity and acute toxicity of <em>Annona squamosa </em>L. leaves ethanolic extract in albino rats and mice respectively.</p><p>Diabetes was induced by Alloxan (120 mg/kg). Seven rats were taken in each group. Glibenclaimide (0.25 mg/kg) was taken as the standard drug. <em>A. squamosa</em> was administered orally in 100mg, 200mg and 400mg doses in three different groups of diabetes- induced rats. <em>A. squamosa</em> leaves extracts were found to have significant anti-diabetic activity.</p><p>Acute toxicity study was carried out on administration of 800mg/kg, 1600mg/kg and 5000 mg/kg body weight. No acute toxicity was observed at 800mg/kg and 1600mg/kg doses. At 5000mg/kg body weight dose 100% fatality was recorded within 24 hours.</p><p>Our research work revealed the safe and effective anti-diabetic activity of <em>Annona squamosa</em> ethanolic leaves extract. </p>

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