scholarly journals Spermatogenic and Histologic Evaluation of Imiprothrin in Male Reproductive System of Adult Wistar Rats

Pharmacologia ◽  
2017 ◽  
Vol 8 (2) ◽  
pp. 52-58
Author(s):  
Ojewale Abdulfatai Olakunle ◽  
Akingbade Adebanji Modupe ◽  
Onyekuru Gift Uzochukwu ◽  
Olasehinde Oluwaseun Ruth ◽  
Ibitoye babatunde oluwaseun ◽  
...  
Author(s):  
Aderemi Kehinde ◽  
Adedoyin Adefisan ◽  
Olayinka Adebayo ◽  
Oluwatosin Adaramoye

AbstractTuberculosis (TB) is a global health problem. The effects of anti-TB drugs on male reproductive system have not been properly evaluated. We investigated the effects of anti-TB drugs on testicular antioxidant indices, sperm characteristics and hormonal levels in rats, and the protective role of kolaviron (KV), a biflavonoid fromTwenty-eight male Wistar rats were assigned into four groups and orally treated with corn oil (control), anti-TB drugs [4-Tabs=isoniazid (5 mg/kg), rifampicin (10 mg/kg), pyrazinamide (15 mg/kg) and ethambutol (15 mg/kg) in combination], anti-TB drugs +KV and KV alone (200 mg/kg). Anti-TB drugs and KV were given three times per week for 8 weeks. In vitro, reducing power, inhibition of lipid peroxidation (LPO), diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical scavenging effects of KV were examined.KV at 10, 20, 50 and 100 μg/mL showed strong reducing potential and effectively scavenged DPPH and OH radicals in a concentration-dependent manner. Furthermore, KV significantly inhibited LPO in rats’ liver homogenate. In vivo, administration of 4-Tabs caused a significant (p<0.05) decrease in body weight gain and weight of testis of rats. Body weight gain and weight of testis decreased by 45% and 36%, respectively, in the 4-Tabs-treated rats. Also, 4-Tabs increased testicular lipid peroxidation by 82%, with a concomitant decrease in antioxidant indices. Testicular reduced glutathione, superoxide dismutase and glutathione peroxidase decreased by 2.2-, 1.9- and 1.6-folds, respectively. Likewise, 4-Tabs markedly decreased sperm count, motility, luteinizing hormone and testosterone. Co-administration of KV with 4-Tabs normalized body weight, enhanced antioxidant system and improved sperm characteristics.Kolaviron protects male reproductive system from oxidative damage by anti-tuberculosis drugs via the antioxidative mechanism.


2017 ◽  
pp. 66-69
Author(s):  
K. A. Kidun ◽  
E. K. Solodova ◽  
T. S. Ugolnik

Stress has an unfavorable effect on male reproductive system. The aim of the work was to study the morphological changes in testicular tissues of Wistar rats in chronic stress according to Ortiz. We detected hyperemia of vessels, reduction of the diameter of seminiferous tubules, exfoliation of the seminiferous epithelium from the basement membrane, and also destructive changes in the seminiferous epithelium including development of necrosis in the testis of the rats after stress.


Sign in / Sign up

Export Citation Format

Share Document