Retrospective Evalution of Pediatric Brucella Patients Followed and Family Screening with Household Members for Brucella Infection

Abstract Background: Brucellosis is a zoonotic infectious disease caused by brucella, patients often show obvious clinical manifestation, however, many cases of asymptomatic brucella infection were reported. Previous scholars have described or screened the asymptomatic infection, but little attention has been paid to the results. This research focused on the short-term results in patients with asymptomatic brucella infectionMethods: 595 household members of shepherds in brucellosis endemic areas were included, all of them have questionnaires and laboratory tests. Based on inclusion and exclusion criteria for the cohort, 15 asymptomatic infections were included and followed-up for 18months.Results: Among 595 subjects, 34(5.7%) were asymptomatic infections, 460(77.3%) were healthy, 58patients (9.7%) were diagnosed as brucellosis, 13(2.2%) suspected cases, 19(3.2%) cured cases and 11(1.8%) unclear diagnosis. Among 15 asymptomatic infections, the median age was 34 [12, 50] years, there were 40%cases <18 years old and the male-female ratio was 1.5:1, 60% cases were farmers and herdsmen, 11(73.3%) cases had a history of possible exposure to brucella. Average follow-up time was 10.47 ± 8.47 months. A total of 7 asymptomatic infections developed into brucellosis, of which five patients turned in the first month of follow-up, one patient in the second month, and one minor case turned in the seventh month. Remaining asymptomatic infections showed negative outcomes after 7 months of follow-up, among them, SAT titer decreased in two cases, no changes in SAT titer and clinical manifestations in six cases.Conclusions: Continued exposure to brucella may be a major risk factor for asymptomatic infection turn to brucellosis.

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Prevalence of mental disorders in household-members of patients with inflammatory bowel disease

Gastroenterology ◽

10.1016/s0016-5085(01)82021-7 ◽

2001 ◽

Vol 120 (5) ◽

pp. A407-A407

Author(s):

M VERGARA ◽

F CASELLAS ◽

X BADIA ◽

J MALAGELADA

Keyword(s):

Inflammatory Bowel Disease ◽

Mental Disorders ◽

Bowel Disease ◽

Inflammatory Bowel ◽

Household Members

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Prevalence of paraganglioma at first screen in SDH mutation carriers identified through family screening

Endocrine Abstracts ◽

10.1530/endoabs.50.p285 ◽

2017 ◽

Author(s):

Isra Ahmed Mohamed ◽

Anand Velusamy ◽

Louise Izatt ◽

Adrian Li ◽

Mamta Joshi ◽

...

Keyword(s):

Family Screening ◽

Mutation Carriers ◽

Sdh Mutation

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A novel IGSF1 mutation in a large Irish kindred highlights the need for family screening in the IGSF1 deficiency syndrome

Endocrine Abstracts ◽

10.1530/endoabs.51.p060 ◽

2017 ◽

Author(s):

Edna Roche ◽

Anne McGowan ◽

Olympia Koulouri ◽

Marc-Olivier Turgeon ◽

Adeline K Nicholas ◽

...

Keyword(s):

Deficiency Syndrome ◽

Family Screening

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Community based design approach as initial stage to promote urban composting from a Hill Station of the Philippines

10.31124/advance.9642488 ◽

2019 ◽

Author(s):

Marcelino Jr Lunag ◽

Jessie C. Elauria ◽

Juanito D. Burguillos

Keyword(s):

Population Density ◽

Community Involvement ◽

The Philippines ◽

Design Stage ◽

High Population Density ◽

Community Based ◽

Hill Station ◽

Initial Stage ◽

Household Members ◽

Community Based Design

This study confirms that lack of space due to high population density restricts household members and the barangay to comply with the existing law regarding composting. With these, community involvement in the design stage of compost bin as initial stage was done accordingly. The participants were voluntarily interviewed and were given questionnaires, which was endorsed and approved by barangay committee.

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Multiple Myeloma or Brucellosis: A Case Report

Infectious Disorders - Drug Targets ◽

10.2174/1871526519666190307123047 ◽

2020 ◽

Vol 20 (1) ◽

pp. 102-105 ◽

Cited By ~ 1

Author(s):

Hossein A. Rahdar ◽

Mansoor Kodori ◽

Mohamad R. Salehi ◽

Mahsa Doomanlou ◽

Morteza Karami-Zarandi ◽

...

Keyword(s):

Multiple Myeloma ◽

Brucella Melitensis ◽

Severe Disease ◽

Correct Diagnosis ◽

Clinical Manifestations ◽

Bone Marrow Aspiration ◽

Major Health Problem ◽

Brucella Infection ◽

Wide Range ◽

Parental Treatment

Background: Brucellosis, a major health problem in developing countries, is a multisystem infection with a broad spectrum of clinical manifestations. Hematological complications, ranging from an intravascular coagulopathy to mild homeostasis disorders (such as gammopathy), have been reported in brucella infection. These signs and symptoms may lead to misdiagnosis of brucellosis with other hematological diseases. Case: A 65-year-old male whose occupation was shepherding was referred to our hospital as a known case of multiple myeloma with continuous fever, muscle weakness, and night sweating after taking 2 courses of chemotherapy. The laboratory diagnosis of multiple myeloma had been based on the observation of a high percent of plasma cells in the bone marrow aspiration. At follow- up, the result of patient's fever workup, with 2 sets of blood cultures, was positive for Brucella melitensis. Isolated brucella was confirmed as B. melitensis by 16S rRNA sequencing. Brucellosis serologic test was performed by agglutination test and positive results were obtained. The patient was discharged with the cessation of fever and general improvement after the end of the parental treatment phase of brucella bacteremia. Conclusions: Brucella infection may cause a severe disease, mimicking a primary hematological disease, which could complicate the correct diagnosis. In brucellosis cases, due to the wide range of symptoms, in addition to cultivation and serological methods, molecular methods should also be used to prevent inappropriate diagnosis and additional costs.

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P4521Comparative prevalence and diagnostic yield of family screening in inherited cardiac diseases. 10K single centre registry

European Heart Journal ◽

10.1093/eurheartj/ehx504.p4521 ◽

2017 ◽

Vol 38 (suppl_1) ◽

Author(s):

D. Lopez Cuenca ◽

M.C. Olmo ◽

F. Castro ◽

J.P. Hernandez Del Rincon ◽

F. Pastor ◽

...

Keyword(s):

Diagnostic Yield ◽

Cardiac Diseases ◽

Single Centre ◽

Family Screening

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Seroprevalence of SARS-CoV-2, Symptom Profiles and Sero-Neutralization in a Suburban Area, France

Viruses ◽

10.3390/v13061076 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1076

Author(s):

Anne Gégout Petit ◽

Hélène Jeulin ◽

Karine Legrand ◽

Nicolas Jay ◽

Agathe Bochnakian ◽

...

Keyword(s):

Odds Ratio ◽

World Health Organisation ◽

World Health ◽

Preventive Effect ◽

Neutralization Activity ◽

Symptom Profiles ◽

The World ◽

Household Members ◽

Total Immunoglobulin

The World Health Organisation recommends monitoring the circulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated anti–SARS-CoV-2 total immunoglobulin (IgT) antibody seroprevalence and in vitro sero-neutralization in Nancy, France, in spring 2020. Individuals were randomly sampled from electoral lists and invited with household members over 5 years old to be tested for anti–SARS-CoV-2 (IgT, i.e., IgA/IgG/IgM) antibodies by ELISA (Bio-rad); the sero-neutralization activity was evaluated on Vero CCL-81 cells. Among 2006 individuals, the raw seroprevalence was 2.1% (95% confidence interval 1.5 to 2.9), was highest for 20- to 34-year-old participants (4.7% (2.3 to 8.4)), within than out of socially deprived area (2.5% vs. 1%, p = 0.02) and with than without intra-family infection (p < 10−6). Moreover, 25% of participants presented at least one COVID-19 symptom associated with SARS-CoV-2 positivity (p < 10−13), with highly discriminant anosmia or ageusia (odds ratio 27.8 [13.9 to 54.5]); 16.3% (6.8 to 30.7) of seropositive individuals were asymptomatic. Positive sero-neutralization was demonstrated in vitro for 31/43 seropositive subjects. Regarding the very low seroprevalence, a preventive effect of the lockdown in March 2020 can be assumed for the summer, but a second COVID-19 wave, as expected, could be subsequently observed in this poorly immunized population.

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The number of household members as a risk factor for peptic ulcer disease

Scientific Reports ◽

10.1038/s41598-021-84892-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mi Hong Yim ◽

Keun Ho Kim ◽

Bum Ju Lee

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Binary Logistic Regression ◽

Cross Sectional Study ◽

Living Alone ◽

Cross Sectional ◽

Ulcer Disease ◽

Logistic Regression Models ◽

Household Members ◽

H Pylori

AbstractPeptic ulcer disease (PUD) is caused by many sociodemographic and economic risk factors other than H. pylori infection. However, no studies reported an association between PUD and the number of household members. We showed the number of family members affected by PUD based on sex in a Korean population. This cross-sectional study used 1998–2009 data from the Korea National Health and Nutrition Examination Survey of the Korea Centers for Disease Control and Prevention. Multiple binary logistic regression models adjusted for confounders were constructed to analyze the association of PUD with the number of household members. The number of household members was associated with PUD, age, body mass index (BMI), waist circumference, systolic blood pressure, hemoglobin, glucose, location (urban/rural), income, education level, stress, current drinking, and smoking in both sexes. Men with other household members had a higher PUD risk compared to men or women living alone (reference), and the opposite was observed for women. Men with 4 household members had a higher PUD risk than men living alone in the model adjusted for age, BMI, income, location, education, and stress (OR = 2.04 [95% CI 1.28–3.27], p value = .003). Women with more than 6 household members had a lower PUD risk than women living alone in the adjusted model (OR = 0.50 [0.33–0.75], p value = .001). Women with more household members had a lower PUD risk. However, more men had PUD than women regardless of the number of household members.

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