scholarly journals Plasmodium falciparum ve Salmonella Typhi Koenfeksiyonu: Bir Olgu Sunumu

2014 ◽  
Vol 48 (1) ◽  
pp. 174-178
Author(s):  
Şua Sümer ◽  
Gaye Ural ◽  
Onur Ural
Keyword(s):  
Plasmodium Falciparum ◽  
Salmonella Typhi

Prevalence of Plasmodium falciparum and Salmonella typhi Infection and Coinfection and Their Association With Fever in Northern Tanzania

2018 ◽  
Vol 2 (2) ◽  
pp. 147-155
Author(s):  
Jaffu Chilongola ◽  
Sophia Kombe ◽  
Pius Horumpende ◽  
Rebeka Nazareth ◽  
Elias Sabuni ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Salmonella Typhi ◽  
Northern Tanzania

scholarly journals Clinico-Epidemiological Studies of Plasmodium Falciparum and Salmonella Typhi Co-Infection among Patients Attending Selected General Hospital in Northern Nigeria

2021 ◽  
pp. 133-143
Author(s):  
Umar Mustapha ◽  
Usman Jamila ◽  
Iliyasu Rabilu Yandoma ◽  
Mansur Sulaiman Aliyu ◽  
Danjuma Faiza Muhammad ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Venous Blood ◽  
Salmonella Typhi ◽  
Malarial Parasite ◽  
Diffusion Method ◽  
Northern Nigeria ◽  
Age Group ◽  
Educational Levels ◽  
Microbiological Methods ◽  
Study Participants

Study on the prevalence of co-infection between Plasmodium falciparum and Salmonella typhi among patients in Northern Nigeria was carried out. The study is cross-sectional designed to determine the socio-demographic characteristics as well as the risk factors for malaria and typhoid. A total of 100 consented patients of age group of 21-40 years were recruited for the study. A structured questionnaire was administered, and venous blood samples were collected and analyzed using standard microbiological methods. The isolated salmonella species were biochemically characterized, and subjected to antimicrobial susceptibility test using Kirby-Bauer disc diffusion method. The prevalence of malaria and typhoid was found to be 56% and 68% respectively. The prevalence of malarial parasite and Salmonella typhi infections was 40%. Females recorded low malarial infection of 56.9% compared to their male counterparts 43.1% (P= 0.510). The age group, educational levels and occupations of the study participants were not associated with the likelihood of having malarial parasite infection (P= 0.297, 0.15 and 0.503 respectively). Participants who did not sleep under the insecticide treated nets were more likely to have malaria than those who did (P ≤ 0.0001). The educational levels of the study participants were statistically associated with Salmonella typhi infection (P= 0.026). Water sources, use of pit latrine, hand washing before and after meal were significantly associated with Salmonella typhi infections (P= <0.0001 and P= 0.003 respectively). The isolates of Salmonella typhi and Salmonella paratyphi were found to be sensitive to chloramphenicol (86.8%), ciprofloxacin (80.9%) and amoxicillin (79.4%), but relatively resistant to penicillin and augmentin that recorded sensitivities of 19.1% and 35.3% respectively. The prevalence of malaria and typhoid infections as well as malarial parasite and Salmonella typhi co-infections is high among the study population. Fortunately, the isolated bacteria are highly sensitive to chloramphenicol and ciprofloxacin.

Ultrastructural observations on the in vitro cytoadherence of Plasmodium falciparum infected red blood cells

1990 ◽  
Vol 48 (3) ◽  
pp. 914-915
Author(s):  
D.J.P. Ferguson ◽  
A.R. Berendt ◽  
J. Tansey ◽  
K. Marsh ◽  
C.I. Newbold
Keyword(s):  
Plasmodium Falciparum ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Umbilical Vein ◽  
Cell Types ◽  
Amelanotic Melanoma ◽  
Cytoplasmic Process ◽  
Umbilical Vein Endothelial Cells

In human malaria, the most serious clinical manifestation is cerebral malaria (CM) due to infection with Plasmodium falciparum. The pathology of CM is thought to relate to the fact that red blood cells containing mature forms of the parasite (PRBC) cytoadhere or sequester to post capillary venules of various tissues including the brain. This in vivo phenomenon has been studied in vitro by examining the cytoadherence of PRBCs to various cell types and purified proteins. To date, three Ijiost receptor molecules have been identified; CD36, ICAM-1 and thrombospondin. The specific changes in the PRBC membrane which mediate cytoadherence are less well understood, but they include the sub-membranous deposition of electron-dense material resulting in surface deformations called knobs. Knobs were thought to be essential for cytoadherence, lput recent work has shown that certain knob-negative (K-) lines can cytoadhere. In the present study, we have used electron microscopy to re-examine the interactions between K+ PRBCs and both C32 amelanotic melanoma cells and human umbilical vein endothelial cells (HUVEC).We confirm previous data demonstrating that C32 cells possess numerous microvilli which adhere to the PRBC, mainly via the knobs (Fig. 1). In contrast, the HUVEC were relatively smooth and the PRBCs appeared partially flattened onto the cell surface (Fig. 2). Furthermore, many of the PRBCs exhibited an invagination of the limiting membrane in the attachment zone, often containing a cytoplasmic process from the endothelial cell (Fig. 2).

Platelet Hypersensitivity in Acute Malaria (Plasmodium falciparum) Infection in Man

1981 ◽  
Vol 46 (02) ◽  
pp. 547-549 ◽  
Author(s):  
E M Essien ◽  
M I Ebhota
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Infection ◽  
Light Transmission ◽  
Human Platelet ◽  
Platelet Rich Plasma ◽  
Wave Pattern ◽  
Falciparum Infection ◽  
Secondary Wave ◽  
Control Subjects ◽  
The Mean

SummaryDuring acute malaria infection, platelets in human platelet-rich plasma are hypersensitive to the addition of ADP between 1.0 uM and 5.0 uM, or adrenaline 0.11 uM as aggregating agents. The mean maximum aggregation amplitude (as % of light transmission) obtained from 8 subjects in response to added ADP (1.0 uM), 39.8 ± 27 (1SD), was significantly greater than the value in 6 controls (5.2±6.7 (1SD); t = 3, 51 P <0.005). A similar pattern of response was obtained with higher ADP concentrations (2.4,4.5 or 5.0 uM) in 22 patients and 20 control subjects (89.9±14.9% vs 77.8±16.5% (1SD) t = 2.45, P <0.02). Addition of 4.5 uM ADP to patient PRP usually evoked only a single aggregation wave (fused primary and secondary waves) while the typical primary and secondary wave pattern was usually obtained from controls.Mean plasma B-thromboglobulin (BTG) concentration in 7 patients (208.3 ± 15.6 ng/ml) was significantly higher than the value in 6 control subjects (59.2±15.7 ng/ml; t = 13.44, P <0.002).

Durch Vektoren übertragene Erkrankungen

2018 ◽  
Vol 18 (05) ◽  
pp. 332-338
Author(s):  
C. Kleine ◽  
U. Ziegler ◽  
E.-M. Schwienhorst ◽  
A. Stich
Keyword(s):  
Plasmodium Falciparum ◽  
Sich Eine ◽  
Malaria Tropica

ZusammenfassungDer folgende Artikel fokussiert auf Erkrankungen, deren Erreger von Vektoren (Insekten, Spinnentieren) aktiv auf den Menschen übertragen werden. Sie spielen in tropischen und subtropischen Regionen der Erde eine erhebliche Rolle und sind auch im Rahmen der Differenzialdiagnose bei kranken Reiserückkehrern von großer Bedeutung. Am wichtigsten ist die Malaria, insbesondere die lebensbedrohliche Malaria tropica durch Plasmodium falciparum. Jede fieberhafte Erkrankung aus den Tropen erfordert eine zeitnahe Malaria-Diagnostik. Tropische Viruserkrankungen durch Dengue-, West-Nil-, Chikungunya- oder Zika-Viren haben sich in den vergangenen Jahrzehnten massiv ausgebreitet und stellen auch eine zunehmende Bedrohung für den europäischen Raum dar. Andere Vektor-übertragene Erkrankungen sind zwar von großer lokaler Relevanz in endemischen Regionen, aber als importierte Infektionen in Deutschland relativ selten. Bei der Betreuung der Patienten empfiehlt sich eine enge Kooperation mit Tropenmedizinern.

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