The effect of aqueous ethanolic extract of Stachytarpheta cayennensis on the histology of the liver and fasting blood sugar of non-diabetic and diabetic wistar rats

10.5580/60 ◽  
2010 ◽  
Vol 10 (1) ◽  
Keyword(s):  
Blood Sugar ◽  
Wistar Rats ◽  
Ethanolic Extract ◽  
Fasting Blood Sugar ◽  
Aqueous Ethanolic Extract ◽  
Stachytarpheta Cayennensis

Pharmacognostic Evaluation of Bambusa vulgaris Var. vulgaris Leaf and its Toxicity Studies in Male Wistar Rats

2015 ◽  
Vol 19 ◽  
pp. 106-114
Author(s):  
GO Alade ◽  
KK Ajibesin ◽  
OR Omobuwajo
Keyword(s):  
Wistar Rats ◽  
Histopathological Examination ◽  
Ethanolic Extract ◽  
Calcium Oxalate Crystals ◽  
Blood Cell Count ◽  
Bambusa Vulgaris ◽  
Anomocytic Stomata ◽  
Male Wistar Rats ◽  
Aqueous Ethanolic Extract ◽  
Low Toxicity

The study evaluated the pharmacognostic characters and toxicity of the aqueous ethanolic extract of Bambusa vulgaris leaf in male wistar rats. The microscopy of the leaf revealed diagnostic characters such as anomocytic stomata, sinuous epidermal cells, numerous prisms of calcium oxalate crystals and covering trichomes. Histopathological examination revealed no significant adverse effects on the lungs, kidneys and the spleens after fourteen days oral administration of the extract at 250 and 500 mg/kg doses. Haematological evaluation however revealed a significant 31% reduction (p<0.05) in packed cell volume and a significant 31% increase (p<0.05) in white blood cell count at 500 mg/kg. The results suggest that administration of B. vulgaris extract may possess low toxicity when used.Keywords: Bambusa vulgaris, Toxicity, Microscopy, Standardization, Histology

scholarly journals Acute Effect of Tobacco Snuff Consumption on Plasma Total Protein, Albumin, Globulin and Fasting Blood Sugar Level in Rats

2019 ◽  
pp. 1-6
Author(s):  
C. I. Ugbor ◽  
L. O. Okonkwo ◽  
N. L. Okonkwo ◽  
N. J. Duhu
Keyword(s):  
Blood Sample ◽  
Blood Sugar ◽  
Total Protein ◽  
Blood Sugar Level ◽  
Wistar Rats ◽  
Acute Effect ◽  
Fasting Blood Sugar ◽  
Group A ◽  
Synthetic Capacity ◽  
Dose Dependent

This study was designed to investigate the effect of tobacco snuff consumption on total protein, albumin, globulin and fasting blood sugar level. Adult Wistar rats (12) weighing 150-300g were involved. They were divided into four groups; group A serving as control, while groups B, C and D served as the test groups. The rats were fed with varying doses of tobacco dust mixed with potash (tobacco snuff). At the end of the experiment, the animals were sacrificed and blood sample collected into lithium heparin container. Total protein (24.34 ± 4.10 g/dl), albumin (13.80 ± 4.66 g/dl), and fasting blood sugar were assayed and the results obtained showed statistically significant changes. However, fasting blood sugar (117.33 ± 38.50mg/dl) showed decrease that was not statistically significant in all the groups throughout the experiment. The results of this study suggest that tobacco snuff is toxic to the synthetic capacity of the liver and the observed changes were dose dependent.

scholarly journals Effect of Methanolic Extract of Vernonia amygdalina Leaves on Glycemic and Lipidaemic Indexes of Wistar Rats

2019 ◽  
pp. 1-14
Author(s):  
Emmanuel O. Ogbuagu ◽  
Augustine I. Airaodion ◽  
Uloaku Ogbuagu ◽  
Edith O. Airaodion
Keyword(s):  
Body Weight ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Methanolic Extract ◽  
Fasting Blood Sugar ◽  
Control Group ◽  
Vernonia Amygdalina ◽  
Soxhlet Apparatus

Aim: This study sought to investigate the effect of methanolic extract of Vernonia amygdalina leaves on glycemic and lipidaemic indexes of Wistar rats. Methods: Fresh plants of V. amygdalina were harvested from the Institute of Agricultural Research and Training, Ibadan. The leaves were dried and extracted using soxhlet apparatus and methanol was used as the solvent. The solvent was recovered in a rotary evaporator at 35°C with a yield of 2.24 g which represents a percentage yield of 8.96%. Ten adult male Wistar rats with body weight between 100 and 120 g were used for this study. They were randomly divided into two groups of five rats each. Animals in group 1 were administered normal saline while those in group 2 were administered V. amygdalina extract. The animals were exposed to the extract and saline solution at a dose of 3 mL per 100 g body weight 12 hourly via oral route of administration. After fourteen days of administration, the animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture. Fasting blood sugar and lipid profile were determined using standard methods. Results: V. amygdalina  leaves was observed to significantly lower fasting blood sugar, total cholesterol, triglyceride and VLDL-cholesterol but had no significant effect on the concentrations of HDL-cholesterol, LDL-cholesterol and HDL/LDL-cholesterol ratio when compared to those of the control group at p<0.05. Conclusion: The lowering effect of V. amygdalina leaves on fasting blood sugar indicated that it has the propensity to be antidiabetic. Its effect on total cholesterol and triglyceride showed that V. amygdalina leaves could be useful in the control of obesity and hypertension.

scholarly journals Antispermatogenic effects of aqueous ethanolic extract of Hymenocardia acida stem bark in Wistar rats

2010 ◽  
Vol 4 (23) ◽  
pp. 2495-2502 ◽  
Author(s):  
A H Abu ◽  
C N Uchendu
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Aqueous Ethanolic Extract

scholarly journals Study on Synergistic Effect of Bromocriptine and Sitagliptin in Streptozotocin-induced Diabetic Rats

2021 ◽  
Author(s):  
Govindaraj Nileshraj ◽  
Chandrasekaran Swithraa ◽  
Murugesan Sakthibalan ◽  
Maruti Shripati Sawadkar
Keyword(s):  
Diabetes Mellitus ◽  
Body Weight ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Wistar Rats ◽  
Low Dose ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
Liver Parameters ◽  
Dose Combination

Introduction: Diabetes mellitus is a potentially morbid condition with high prevalence worldwide. Restoration of euglycemia in type 2 diabetes mellitus is difficult to achieve due to its multifactorial pathogenesis and frequently requires multiple anti-diabetic medications with different mechanism of action. This study is based on the possible synergistic effect of Sitagliptin and Bromocriptine in reducing blood sugar in diabetic animal models. Aim: To evaluate the effect of Sitagliptin and Bromocriptinemonotherapy and their combination in three different doses on blood sugar, Lipid profile, Liver and renal parameters in diabetic albino Wistar rats. Materials and Methods: An experimental animal study was conducted on 48 adult male albino wistar rats for a period of one month (August 2014). Streptozotocin induced (40 mg/kg IP) diabetic rats were divided into six groups of eight animals each weighing 150-200 gms. Group I- Vehicle (distilled water), Group II- Sitagliptin (100 mg/kg), Group III- Bromocriptine (10 mg/kg), Group IV- Sitagliptin (75 mg/kg) + Bromocriptine (7.5 mg/kg), Group V- Sitagliptin (100 mg/kg) + Bromocriptine (10 mg/kg), Group VI- Sitagliptin (125 mg/kg) + Bromocriptine (12.5 mg/kg). All drugs were given once daily (p.o) for four weeks. Body weight, fasting blood sugar, fasting lipid profile, liver parameters and renal parameters were estimated before and after administration of the drugs. Results were analyzed with SPSS software version 16.0 using one-way ANOVA followed by post-hoc Dunnett t test. P<0.05 was considered statistically significant. Results: The low dose combination therapy [Sitagliptin (75 mg/kg) + Bromocriptine (7.5 mg/kg)] showed a significant decrease in body weight (p<0.05), fasting blood sugar (p<0.001) compared with the vehicle group. It also showed a favorable lipid profile, renal and liver parameters compared with the vehicle, monotherapy and other combination regimens. Conclusion: The low dose combination therapy of Sitagliptin and Bromocriptine showed a better control over fasting blood sugar along with a beneficial effect on lipid profile, liver parameters and renal parameters than compared to other groups.

Toxicity study of the ethanolic extract of Moringa concanensis Nimmo leaves in wistar rats

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
BRINDHA BANU BALAKRISHNAN ◽  
KALAIVANI KRISHNASAMY
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Toxicity Study

Jumpstarting Health With a 15-Day Whole-Food Plant-Based Program

2021 ◽  
pp. 155982762110063
Author(s):  
Susan M. Friedman ◽  
Carol Hee Barnett ◽  
Robert Franki ◽  
Bruce Pollock ◽  
Beth Garver ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Food Plant ◽  
Fasting Blood Sugar ◽  
Average Weight ◽  
Low Density ◽  
Average Drop

The 15-day Jumpstart was developed as an evidence-based, affordable, standardized, replicable, and scalable program, designed to demonstrate quickly to patients that changing what they eat can improve their health. The program was designed using the principles of the self-determination theory of motivation and personality. Patients were instructed to eat an Esselstyn-compliant, whole-food plant-based diet consisting of vegetables, fruits, whole grains, and legumes. Of the 389 participants in the program from September 2018 to February 2020, average weight loss was 5.8 pounds (7.3 for those whose body mass index was >30), average systolic blood pressure drop was 6.8 points (16.8 points for those with systolic blood pressure >140), average drop in cholesterol was 26 points (44 points for those with a cholesterol >200), average drop in low-density lipoprotein was 19 points (33 points for those with a low-density lipoprotein >100), and average drop in fasting blood sugar was 5.1 points (28.4 points for those starting in the diabetic range); P value was <.005 for fasting blood sugar and <.001 for all other comparisons. A 15-day program that helps patients adopt an Esselstyn-style whole-food plant-based diet, through education, individualized medical feedback, social support, and facilitated small group work, rapidly improves health.

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