Treatment modalities and relative survival in patients with brain metastasis from colorectal cancer

204 Background: More than 50% of colorectal cancer (CRC) patients will develop metastatic disease. Brain metastasis (BM) from colorectal cancer is uncommon (0.6-1.36%). This study aims to investigate the patient characteristics, treatment modalities and prognostic factors in this rare population. Methods: 104 patients with brain metastasis disease from CRC were identified from over 30,000 colorectal cancer patients at the Mayo Clinic Rochester between 1/1994 and 6/2019. A retrospective review was conducted by using data from electronic medical records (EMR). Statistical analysis utilized the Kaplan-Meier method, Log-rank test, and Cox proportional hazards models. Results: Among the 104 patients, 62 were male (59.6%) and 42 were female (40.4%). Median age at CRC diagnosis was 58.4 and at BM diagnosis was 61. Thirty-three patients had right-sided colon cancers, 27 patients had left-sided colon cancers and 39 patients had rectal cancer. Median time from CRC diagnosis to BM was 30.7 months. The majority of patients (58.7%) presented with a solitary brain lesion. Eighty-six patients (82.7%) had extracranial metastatic disease at BM diagnosis. Median survival was 7.0 months (95% CI 2.6-16.9) from BM diagnosis. Age <70, solitary BM, surgery, radiation, and chemotherapy were associated with statistically significant improved survival on univariate and multivariate analysis. Multi-modality treatment including surgical brain lesion resection, postoperative stereotactic radiation (SRS) with/without whole brain radiation (WBRT), and chemotherapy significantly improved median overall survival (Table). Conclusions: Although BM from CRC carries poor prognosis, multi-modality treatment (surgery, radiation and systemic chemotherapy) for patients with limited BM improves clinical outcome. [Table: see text]

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German oncology certification system for colorectal cancer – relative survival rates of a single certified centre vs. national and international registry data

Innovative Surgical Sciences ◽

10.1515/iss-2021-0002 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Maximilian Richter ◽

Lena Sonnow ◽

Amir Mehdizadeh-Shrifi ◽

Axel Richter ◽

Rainer Koch ◽

...

Keyword(s):

Colorectal Cancer ◽

Rectal Cancer ◽

International Comparison ◽

Cancer Registry ◽

Survival Data ◽

Survival Rates ◽

Relative Survival ◽

Registry Data ◽

Cancer Registry Data ◽

Colon And Rectal Cancer

Abstract Objectives To evaluate how the certification of specialised Oncology Centres in Germany affects the relative survival of patients with colorectal cancer (CRC) by means of national and international comparison. Methods Between 2007 and 2013, 675 patients with colorectal cancer, treated at the Hildesheim Hospital, an academic teaching hospital of the Hannover Medical School (MHH), were included. A follow-up of the entire patient group was performed until 2014. To obtain international data, a SEER-database search was done. The relative survival of 148,957 patients was compared to our data after 12, 36 and 60 months. For national survival data, we compared our rates with 41,988 patients of the Munich Cancer Registry (MCR). Results Relative survival at our institution tends to be higher in advanced tumour stages compared to national and international cancer registry data. Nationally we found only little variation in survival rates for low stages CRC (UICC I and II), colon, and rectal cancer. There were notable variations regarding relative survival rates for advanced CRC tumour stages (UICC IV). These variations were even more distinct for rectal cancer after 12, 36 and 60 months (Hildesheim Hospital: 89.9, 40.3, 30.1%; Munich Cancer Registry (MCR): 65.4, 28.7, 16.6%). The international comparison of CRC showed significantly higher relative survival rates for patients with advanced tumour stages after 12 months at our institution (77 vs. 54.9% for UICC IV; raw p<0.001). Conclusions Our findings suggest that patients with advanced tumour stages of CRC and especially rectal cancer benefit most from a multidisciplinary and guidelines-oriented treatment at Certified Oncology Centres. For a better evaluation of cancer treatment and improved national and international comparison, the creation of a centralised national cancer registry is necessary.

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A Comparative Study of Epidemiology, Clinicopathologic Features and Outcome of Colorectal Cancer Patients between Ain Shams University Hospitals and Luxor International Hospital

QJM ◽

10.1093/qjmed/hcab103.005 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Tarek Hussein Kamel ◽

Amr Lotfy Farag ◽

Dr/Sherif Hassanin Ahmed ◽

Chresteen Talaat Samy Hanna

Keyword(s):

Colorectal Cancer ◽

Comparative Study ◽

Disease Free Survival ◽

University Hospital ◽

Treatment Modalities ◽

Clinicopathologic Features ◽

Free Survival ◽

Significant Difference ◽

Group A ◽

Group B

Abstract Background Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world. It is the third most common malignancy after lung & breast and the fourth leading cause of cancer-related deaths worldwide, accounting for approximately 1,400,000 new cases and about 700,000 deaths worldwide. Objectives The aim of this retrospective study is to compare the epidemiology, clinicopathologic features, different treatment modalities and outcomes regarding disease free survival (DFS), progression free survival (PFS) & overall survival (OS) of colorectal cancer disease between cases presented to Ain shams university hospital & to Luxor international hospital in 3 consecutive years. Patients and Methods The study is retrospective comparative study. Clinical oncology department in Ain Shams University Hospital and Luxor International Hospital. The data Collected from January 2013 to December 2015. This study analyzed hospital records of patients who diagnosed with colorectal cancer (CRC) and allocated into two groups: Group A: CRC patients presented to Ain-Shams University Hospital from January 2013 to December 2015, group B: CRC patients presented to Luxor International Hospital from January 2013 to December 2015. Results There was no statistically significant difference regarding age parameter in LIH when compared to ASU, but the study was consistent with higher incidence in patients who were aged more than forty- accounted about 70.5% in all CRC cases. Cases less than 40 years old, in group A were 35.2%, while in Group B were 23.5%. Even there was no statistically significant difference but it may be attributable to more westernization in Lower Egypt. Other explanation may be due to decreased low socioeconomic status and different lifestyle factors in more developing region what increase risk of colorectal cancer. Among our cases, there is no statistically significant difference regarding gender between the two hospitals. Both sexes almost were affected equally, females appeared to be at a slightly higher risk of developing CRC cancer with current prevalence 1.3:1 in ASU group, and 1.1:1 in LIH group. Conclusion The need to increase awareness about CRC in Egypt especially upper Egypt, is recommended. An awareness campaign should be performed to promote detection of CRC at its earliest and most curable stage by recognizing early symptoms and enabling early referrals for colonoscopy. Those at higher risk should be offered more intensive surveillance. Similarity of the data from different centers suggests that this is the picture of colorectal cancer typical of Egypt.

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Brain metastasis in advanced colorectal cancer: results from the South Australian metastatic colorectal cancer (SAmCRC) registry

Cancer Biology and Medicine ◽

10.20892/j.issn.2095-3941.2017.0068 ◽

2017 ◽

Vol 14 (4) ◽

pp. 371 ◽

Cited By ~ 4

Author(s):

Tapia Rico Gonzalo ◽

J. Price Timothy ◽

Karapetis Christos ◽

Piantadosi Cynthia ◽

Padbury Rob ◽

...

Keyword(s):

Colorectal Cancer ◽

Brain Metastasis ◽

Metastatic Colorectal Cancer ◽

Advanced Colorectal Cancer ◽

The South

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FIRST BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 1: PRE-TREATMENT EVALUATION

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/s0102-6720201500040002 ◽

2015 ◽

Vol 28 (4) ◽

pp. 222-230 ◽

Cited By ~ 6

Author(s):

Felipe José Fernandez COIMBRA ◽

Heber Salvador de Castro RIBEIRO ◽

Márcio Carmona MARQUES ◽

Paulo HERMAN ◽

Rubens CHOJNIAK ◽

...

Keyword(s):

Colorectal Cancer ◽

Liver Metastases ◽

Multimodal Treatment ◽

Colorectal Liver Metastases ◽

Epidemiological Data ◽

Treatment Modalities ◽

Established Method ◽

Curative Intent ◽

Pre Treatment ◽

Definition Of

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients with these tumors. Aim : In this module, was contextualized the clinical situations and parameterized epidemiological data and results of the various treatment modalities established. Method: Was realized deep discussion on detecting and staging metastatic colorectal cancer, as well as employment of imaging methods in the evaluation of response to instituted systemic therapy. Results : The next step was based on the definition of which patients would have their metastases considered resectable and how to expand the amount of patients elegible for modalities with curative intent. Conclusion : Were presented clinical, pathological and molecular prognostic factors, validated to be taken into account in clinical practice.

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Treatment Modalities in Colorectal Cancer

The Role of Laser in Gastroenterology ◽

10.1007/978-94-009-2454-3_10 ◽

1989 ◽

pp. 120-130

Author(s):

Elisabeth M. H. Mathus-Vliegen

Keyword(s):

Colorectal Cancer ◽

Treatment Modalities

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Brain Metastasis of Colorectal Cancer: Microenvironment and Molecular Mechanism

Brain Metastases from Primary Tumors ◽

10.1016/b978-0-12-801419-6.00016-1 ◽

2015 ◽

pp. 191-202

Author(s):

Zong-You Chen ◽

Xiao-Dong Gu ◽

Yi-Wen Zang

Keyword(s):

Colorectal Cancer ◽

Brain Metastasis ◽

Molecular Mechanism ◽

Cancer Microenvironment

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A practical approach to the management of colorectal cancer during the COVID-19 crisis in the reference cancer treatment center in Tunisia

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155220961139 ◽

2020 ◽

Vol 26 (8) ◽

pp. 1931-1933

Author(s):

Feriel Letaief ◽

Imen Gharbi ◽

Adel Hamdi ◽

Yosra Yahyaoui ◽

Mona Ayadi ◽

...

Keyword(s):

Colorectal Cancer ◽

Immune System ◽

Digestive Tract ◽

Targeted Therapies ◽

Malignant Tumors ◽

Multidisciplinary Care ◽

Treatment Modalities ◽

Treatment Center ◽

Public Healthcare ◽

International Phenomenon

COVID-19 is an exceptional public healthcare emergency that affected all countries. The corona virus pandemic has made the treatment of all cancers difficult. This international phenomenon represents an outbreak in medicine and this situation is a major issue for all patients, whether they are infected with the virus or not. Colorectal cancer is one of the most common malignant tumors of the digestive tract which needs special multidisciplinary care. Treatment modalities including chemotherapy and targeted therapies can weaken the immune system and then cause serious or lethal coronavirus infections. This document gives an idea about how we dealt to protect patients with colorectal cancer at Salah Azaiez Institute during COVID 19 pandemic.

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