Recent progress in development of transgenic silkworms overexpressing recombinant human proteins with therapeutic potential in silk glands

Reactive oxygen species (ROS) are important in normal cellular function and physiology. However, oxidative stress resulting from an accumulation of ROS has a detrimental impact on cellular function, and ROS has been implicated in the pathogenesis of a number of diseases, including cardiovascular diseases. This review provides a summary of the impact of ROS on cardiovascular health and diseases, highlighting the therapeutic use of antioxidants. In addition, this review summarizes the health benefits of polyphenols, and the recent progress on understanding the cellular and physiological actions by which polyphenols may impart their beneficial properties on cardiovascular health.

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High-efficiency production of human serum albumin in the posterior silk glands of transgenic silkworms, Bombyx mori L

PLoS ONE ◽

10.1371/journal.pone.0191507 ◽

2018 ◽

Vol 13 (1) ◽

pp. e0191507 ◽

Cited By ~ 2

Author(s):

Qiujie Qian ◽

Zhengying You ◽

Lupeng Ye ◽

Jiaqian Che ◽

Yiran Wang ◽

...

Keyword(s):

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Bombyx Mori ◽

High Efficiency ◽

Silk Glands ◽

Transgenic Silkworms ◽

Bombyx Mori L

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Molecular Mechanisms Underlying Cancer Preventive and Therapeutic Potential of Algal Polysaccharides

Current Pharmaceutical Design ◽

10.2174/1381612825666190425155126 ◽

2019 ◽

Vol 25 (11) ◽

pp. 1210-1235 ◽

Cited By ~ 3

Author(s):

Soraya Sajadimajd ◽

Saeideh Momtaz ◽

Pouya Haratipour ◽

Fardous F. El-Senduny ◽

Amin Iran Panah ◽

...

Keyword(s):

Signaling Pathways ◽

Anticancer Agents ◽

Recent Progress ◽

Molecular Mechanisms ◽

Therapeutic Potential ◽

Sulfated Polysaccharides ◽

Cochrane Library ◽

Therapeutic Effects ◽

Cancer Management ◽

Algal Polysaccharides

Background: Algal polysaccharide and oligosaccharide derivatives have been shown to possess a variety of therapeutic potentials and drug delivery applications. Algal polysaccharides contain sulfated sugar monomers derived from seaweed including brown, red, and green microalgae. Here, in this review, the recent progress of algal polysaccharides’ therapeutic applications as anticancer agents, as well as underlying cellular and molecular mechanisms was investigated. Moreover, recent progress in the structural chemistry of important polysaccharides with anticancer activities were illustrated. Methods: Electronic databases including “Scopus”, “PubMed”, and “Cochrane library” were searched using the keywords “cancer”, or “tumor”, or “malignancy” in title/abstract, along with “algae”, or “algal” in the whole text until July 2018. Only English language papers were included. Results: The most common polysaccharides involved in cancer management were sulfated polysaccharides, Fucoidans, Carageenans, and Ulvan from different species of algae that have been recognized in vitro and in vivo. The underlying anticancer mechanisms of algal polysaccharides included induction of apoptosis, cell cycle arrest, modulation of transduction signaling pathways, suppression of migration and angiogenesis, as well as activation of immune responses and antioxidant system. VEGF/VEGFR2, TGFR/Smad/Snail, TLR4/ROS/ER, CXCL12/ CXCR4, TGFR/Smad7/Smurf2, PI3K/AKT/mTOR, PBK/TOPK, and β-catenin/Wnt are among the main cellular signaling pathways which have a key role in the preventive and therapeutic effects of algal polysaccharides against oncogenesis. Conclusion: Algal polysaccharides play a crucial role in the management of cancer and may be considered the next frontier in pharmaceutical research. Further well-designed clinical trials are mandatory to evaluate the efficacy and safety of algal polysaccharides in patients with cancer.

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An optimized sericin-1 expression system for mass-producing recombinant proteins in the middle silk glands of transgenic silkworms

Transgenic Research ◽

10.1007/s11248-013-9695-6 ◽

2013 ◽

Vol 22 (5) ◽

pp. 925-938 ◽

Cited By ~ 46

Author(s):

Feng Wang ◽

Hanfu Xu ◽

Lin Yuan ◽

Sanyuan Ma ◽

Yuancheng Wang ◽

...

Keyword(s):

Recombinant Proteins ◽

Expression System ◽

Silk Glands ◽

Transgenic Silkworms

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Expression of hIGF-I in the silk glands of transgenic silkworms and in transformed silkworm cells

Science in China Series C Life Sciences ◽

10.1007/s11427-009-0148-7 ◽

2009 ◽

Vol 52 (12) ◽

pp. 1131-1139 ◽

Cited By ~ 21

Author(s):

Yue Zhao ◽

Xi Li ◽

GuangLi Cao ◽

RenYu Xue ◽

ChengLiang Gong

Keyword(s):

Silk Glands ◽

Transgenic Silkworms

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Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/7277966 ◽

2021 ◽

Vol 2021 ◽

pp. 1-11

Author(s):

Lihua Ni ◽

Cheng Yuan ◽

Xiaoyan Wu

Keyword(s):

Endoplasmic Reticulum ◽

Er Stress ◽

Renal Damage ◽

Recent Progress ◽

Therapeutic Potential ◽

Experimental Treatment ◽

Renal Cells ◽

Pharmacological Agents ◽

Current Article ◽

Made In

Recent progress has been made in understanding the roles and mechanisms of endoplasmic reticulum (ER) stress in the development and pathogenesis of diabetic nephropathy (DN). Hyperglycemia induces ER stress and apoptosis in renal cells. The induction of ER stress can be cytoprotective or cytotoxic. Experimental treatment of animals with ER stress inhibitors alleviated renal damage. Considering these findings, the normalization of ER stress by pharmacological agents is a promising approach to prevent or arrest DN progression. The current article reviews the mechanisms, roles, and therapeutic aspects of these findings.

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Recent progress on the discovery of NLRP3 inhibitors and their therapeutic potential

Current Medicinal Chemistry ◽

10.2174/0929867327666200123093544 ◽

2020 ◽

Vol 27 ◽

Author(s):

Ma Su ◽

Weiwei Wang ◽

Feng Liu ◽

Huanqiu Li

Keyword(s):

Immune System ◽

Nlrp3 Inflammasome ◽

Radiation Effects ◽

Recent Progress ◽

Therapeutic Potential ◽

Inflammatory Diseases ◽

Full Range ◽

Pyrin Domain ◽

Inhibitory Agents ◽

Inflammasome Inhibitors

Background: Inflammation is the fast coordinating response of body’s immune system to irritants caused by pathogens, external injuries and chemical or radiation effects. The NLRP3 (nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3) inflammasome is a critical component of the innate immune system. Malfunction of NLRP3 inflammasome will contribute to various pathogenesis of complex diseases, such as uncontrolled infection, autoimmune diseases, neurodegenerative diseases, and metabolic disorders. This review aims to describe recent progress on discovery of NLRP3 inflammasome inhibitors and their therapeutic potential. Methods: Based on the mechanism of NLRP3 activation, several types of NLRP3 inhibitors were described and summarized according to their origins, structures, bioactivity and mechanism of action. Structure-activity-relationship (SAR) was also listed for different scaffolds, as well as effective pharmacophore. Results: Over one-hundred papers were included in the review. The development of NLRP3 inhibitors was described from the earliest glyburide in 2001 to the latest progress in 2019. Several series of inhibitors were categorized, such as JC-series based on glyburide and BC-series based on 2APB. Many other small molecules as NLRP3 inhibitors were also listed. SAR, application in related therapeutic models and five different action mechanisms were described. Conclusion: The findings of this review confirmed the importance of developing NLRP3 inflammasome inhibitors. Various NLRP3 inhibitors have been discovered as effective therapeutic treatments to multiples diseases such as type II diabetes, experimental autoimmune encephalomyelitis, stress-related mood disorders, etc. The development of a full range of NLRP3 inflammasome inhibitors is still at its foundational phase. We are looking forward to identification of inhibitory agents which provide the most potent therapeutic strategies and efficiently treat NLRP3 inflammasome-related inflammatory diseases.

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