scholarly journals Fibrinogen-to-albumin ratio predicts mortality in COVID-19 patients admitted to the intensive care unit

2021 ◽  
Vol 89 (6) ◽  
pp. 557-564
Author(s):  
Abdulmecit Afşin ◽  
Hakan Tibilli ◽  
Yusuf Hoşoğlu ◽  
Ramazan Asoğlu ◽  
Ahmet Süsenbük ◽  
...  
2018 ◽  
Vol 55 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Isabela Bernasconi JOSÉ ◽  
Vânia Aparecida LEANDRO-MERHI ◽  
José Luis Braga de AQUINO

ABSTRACT BACKGROUND: Enteral nutritional therapy (ENT) is the best route for the nutrition of critically ill patients with improved impact on the clinical treatment of such patients. OBJECTIVE: To investigate the energy and protein supply of ENT in critically ill in-patients of an Intensive Care Unit (ICU). METHODS: Prospective longitudinal study conducted with 82 critically ill in-patients of an ICU, receiving ENT. Anthropometric variables, laboratory tests (albumin, CRP, CRP/albumin ratio), NUTRIC-score and Nutritional Risk Screening (NRS-2002), energy and protein goals, and the inadequacies and complications of ENT were assessed. Statistical analysis was performed using the Chi-square or Fischer tests and the Wilcoxon test. RESULTS: A total of 48.78% patients were at high nutritional risk based on NUTRIC score. In the CRP/albumin ratio, 85.37% patients presented with a high risk of complications. There was a statistically significant difference (P<0.0001) for all comparisons made between the target, prescription and ENT infusion, and 72% of the quantities prescribed for both calories and proteins was infused. It was observed that the difference between the prescription and the infusion was 14.63% (±10.81) for calories and 14.21% (±10.5) for proteins, with statistically significant difference (P<0.0001). In the relationship between prescription and infusion of calories and proteins, the only significant association was that of patients at high risk of CRP/albumin ratio, of which almost 94% received less than 80% of the energy and protein volume prescribed (P=0.0111). CONCLUSION: The administration of ENT in severely ill patients does not meet their actual energy and protein needs. The high occurrence of infusion inadequacies, compared to prescription and to the goals set can generate a negative nutritional balance.


2021 ◽  
Vol Volume 14 ◽  
pp. 7349-7359
Author(s):  
Xiulan Peng ◽  
Yali Huang ◽  
Haifeng Fu ◽  
Zhi Zhang ◽  
Anbing He ◽  
...  

2018 ◽  
Vol 7 (3) ◽  
pp. 39 ◽  
Author(s):  
Tak Oh ◽  
Eunjeong Ji ◽  
Hyo-seok Na ◽  
Byunghun Min ◽  
Young-Tae Jeon ◽  
...  

2020 ◽  
Vol 10 (01) ◽  
pp. e1-e11
Author(s):  
Shereen A. Mohamed ◽  
Rabab ElHawary

AbstractIt is necessary to stratify the risk of pediatric patients at the time of intensive care unit (ICU) admission and to predict their outcomes. This helps to allocate the scarce ICU resources to start the appropriate treatment. The objective of this study was to evaluate the prognostic value of C-reactive protein/albumin ratio on admission to pediatric intensive care unit (PICU) in predicting mortality, PICU length of stay, the need for mechanical ventilation, and the use of inotropic drugs. This cohort study was conducted at Pediatric Cairo University Hospital. The study included 178 critically ill children. Pediatric Risk of Mortality–III (PRISM-III) score was calculated; CRP and serum albumin levels were assessed within 24 hours from admission. The median CRP/albumin ratio was significantly higher in nonsurvivors than survivors (18.60 and 4.65, respectively). The CRP/albumin ratio at a cutoff of ≥25.83 had significant discriminatory power in predicting mortality (area under the curve [AUC] = 0.795 and p < 0.001) with 85.4% accuracy. Furthermore, CRP/albumin ratio alone showed a comparable discriminatory power to that of PRISM-III score (AUCs = 0.795 and 0.793, respectively). A multivariable logistic regression analysis revealed that each unit of increase in the CRP/albumin ratio increased the risk of mortality by 1.075 (odds ratio [OR] = 1.075). CRP/albumin ratio showed a significantly higher median in ventilated (6.86) compared with non-ventilated (5.22) patients. Patients supported with inotropes showed significantly higher median CRP/albumin ratio (11.70 and 3.68, respectively). CRP/albumin ratio at admission to PICU was a good independent predictor of mortality.


2021 ◽  
Vol 59 (244) ◽  
pp. 1247-1251
Author(s):  
Pratiksha Gyawali ◽  
Himal Shrestha ◽  
Vivek Pant ◽  
Prabodh Risal ◽  
Sharad Gautam

Introduction: Sepsis is the most common cause of mortality among patients admitted to intensive care unit. There is emerging evidence on the role of C-reactive protein to albumin ratio (C-reactive protein/Albumin) in predicting outcomes in patients with critical illness and sepsis, admitted to intensive care unit. We aimed to find out the median value of C-reactive protein/Albumin ratio among patients admitted to intensive care unit of a tertiary care hospital. Methods: We conducted a descriptive cross-sectional study of 110 critically ill patients (>18 years old) admitted to intensive care unit of Dhulikhel Hospital from April, 2014 to June, 2016. The ethical approval (Reference number.51/16) was obtained from Institutional Review Committee at Kathmandu University School of Medical Sciences. C-reactive protein/albumin ratio was calculated from records of patients admitted to the intensive care unit. Convenience sampling was done. Data were entered into Microsoft Excel and analysed using Statistical Package for Social Sciences version 20. Point estimate at 95% Confidence Interval was calculated along with frequencies and percentages for binary data. Results: Among 110 patients admitted to the intensive care unit, the median value of C-reactive protein/Albumin ratio was found to be 3.4 (Interquartile range: 3.1-4.5). Conclusions: Our study showed higher median C-reactive protein /Albumin similar to toher studies. Sepsis is a common finding among patients admitted to intensive care unit. Monitoring of C-reactive protein/albumin level in a patient admitted to intensive care unit could be useful for stratifying patients with a high risk of developing sepsis.


2019 ◽  
Vol 28 (3) ◽  
pp. 160-167
Author(s):  
Hacı Hasan Yeter ◽  
◽  
Damla Eyupoglu ◽  
Tural Pasayev ◽  
Sila Cetik ◽  
...  

2020 ◽  
Vol 35 (3) ◽  
pp. 222-229
Author(s):  
Neyla Edelwais Silva ◽  
Cervantes Caporossi ◽  
Alberto Bicudo Salomão ◽  
Diana Borges Dock Nascimento ◽  
Daniela Alencar Moreira

Introduction: The ability of selenium to reduce free radicals, associated with its performance as an essential cofactor for glutathione peroxidase, confers a potential role for patients in the intensive care unit. The aim of this study was to evaluate the plasma levels of selenium and glutathione peroxidase at admission and for the period of 7 days of evolution in hospitalized patients. Methods: Observational study with adult patients (n = 22) admitted to the intensive care unit. Three blood samples were taken, on days 1, 3 and 7, to assess selenium, and two for glutathione peroxidase, on days 1 and 7. There was no type of intervention. Results: Selenium levels at admission were below the reference values in half of the patients. When stratifying patients (n = 22) according to the risk of infectious and inflammatory complications (C-reactive protein / albumin ratio), patients classified as high risk had selenium dosage at admission below those of moderate risk (p = 0.032). Among patients with complete follow-up (all dosages were performed), 66.7% were at high risk and among them 75% had selenium below the reference values and below the moderate risk group (p = 0.014). Glutathione peroxidase dosages were normal in all patients, regardless of classification. Conclusion: Approximately 50% of critically ill patients were admitted to the intensive care unit with selenium below the reference values. On admission and progression to the seventh day, patients classified as high risk had selenium dosage below the reference value and below that of patients at moderate risk.


Sign in / Sign up

Export Citation Format

Share Document