scholarly journals The model of selecting multimodal technologies for the transport of perishable products

2019 ◽  
Vol 50 (2) ◽  
pp. 17-33 ◽  
Author(s):  
Paweł Leleń ◽  
Mariusz Wasiak
Keyword(s):  
Mathematical Model ◽  
Transport Cost ◽  
Maximum Temperature ◽  
Perishable Products ◽  
Safety Criterion ◽  
Significant Group ◽  
Perishable Goods ◽  
Multimodal Transport ◽  
Efficiency Of Selection ◽  
Selection Of

The main goal of this paper is to provide an original model of selecting multimodal technologies for the transport of perishable goods. The model in particular refers to the transportability of cargoes. The features of cargoes that have the most impact on transportability were specified. Formal representations of the key elements of the model were presented and characterized, including: perishable cargoes, form of transported goods (solid, liquid, etc.), means of handling (including loading devices and transport means), transport routes, categories of human labor, multimodal technologies and transportation tasks. A formal representation of decision variables, as well as constrains and a criterion function were provided. The model bases on two main solution assessment criteria: cost criterion and cargo safety criterion. A cargo safety criterion in the model is composed of 18 partial criterion functions. Each of these functions directly affects one safety aspect of the transported cargo. The exemplary partial criteria of cargo safety included in the model are: acceptable transport time, minimum or maximum temperature in the cargo’s direct surroundings, resistance to mechanical damage. In order to present a practical application of the presented mathematical model the paper shows also an example of selecting one of the multimodal technologies for the transport of perishable goods from the set of pre-defined types of multimodal transport technologies. The developed method uses different elements of the mathematical model provided in the paper, depending on the considered problem (including characteristics of cargo and their transport forms). For a significant group of perishable cargoes, it is not required to consider all defined criteria associated with cargo safety. The developed model allows for the accurate selection of transport technology for perishable cargoes for most transportation tasks. It should help to increase the efficiency of selection of multimodal transport technology for perishable products. The selected technology will then be characterized by the lowest transport cost and will ensure the safety of transported cargoes, as well as will meet other requirements determined by the transport task. As part of further work, it is possible to develop proposed method by considering additional characteristics of perishable cargoes.

Combination of ribosome and phage display for fast selection of high affinity VHH antibody fragments

2019 ◽  
pp. 27-33
Author(s):  
YuE Kravchenko ◽  
SV Ivanov ◽  
DS Kravchenko ◽  
EI Frolova ◽  
SP Chumakov
Keyword(s):  
Phage Display ◽  
Selection Procedure ◽  
Free System ◽  
Phage Displays ◽  
High Affinity ◽  
Binding Domains ◽  
A Cell ◽  
Vhh Antibodies ◽  
Efficiency Of Selection ◽  
Selection Of

Selection of antibodies using phage display involves the preliminary cloning of the repertoire of sequences encoding antigen-binding domains into phagemid, which is considered the bottleneck of the method, limiting the resulting diversity of libraries and leading to the loss of poorly represented variants before the start of the selection procedure. Selection in cell-free conditions using a ribosomal display is devoid from this drawback, however is highly sensitive to PCR artifacts and the RNase contamination. The aim of the study was to test the efficiency of a combination of both methods, including pre-selection in a cell-free system to enrich the source library, followed by cloning and final selection using phage display. This approach may eliminate the shortcomings of each method and increase the efficiency of selection. For selection, alpaca VHH antibody sequences suitable for building an immune library were used due to the lack of VL domains. Analysis of immune libraries from the genes of the VH3, VHH3 and VH4 families showed that the VHH antibodies share in the VH3 and VH4 gene groups is insignificant, and selection from the combined library is less effective than from the VHH3 family of sequences. We found that the combination of ribosomal and phage displays leads to a higher enrichment of high-affinity fragments and avoids the loss of the original diversity during cloning. The combined method allowed us to obtain a greater number of different high-affinity sequences, and all the tested VHH fragments were able to specifically recognize the target, including the total protein extracts of cell cultures.

MODERN CONDITION AND PROSPECTS OF DEVELOPMENT OF THE UKRAINIAN WHITEHEAD BREED

2016 ◽  
Vol 52 ◽  
pp. 194-202
Author(s):  
S. L. Voitenko ◽  
L. V. Vishnevsky
Keyword(s):  
Milk Yield ◽  
Milk Fat ◽  
Objective Assessment ◽  
Live Weight ◽  
Fat Content ◽  
Early Age ◽  
Average Value ◽  
The Future ◽  
Efficiency Of Selection ◽  
Selection Of

The article shows the state of Ukrainian Whiteheaded cattle, which includes distribution of cattle, the number of animals belonging to respective bloodlines, evaluation of young animals with live weight in the process of growing and milk production of cows during the first lactation. It reflects the historic development of the breed when it was colonism whiteheaded cattle, which turned into the original breed, undergone a significant expansion in livestock and increase of productivity, decreased in the number, was as basis for creation of Ukrainian Black-and-White dairy breed and now bred only in one breeding farm. Visual estimation of animal exterior showed good development of cows and calves and their belonging to the dairy type. In the vast majority the cows of the herd have a black suit, a white head with " glasses" around the eyes, white belly, udder, lower legs and brush of the tail. The youngsters aren’t consolidated by the exterior, and among them there are animals which are not typical for Ukrainian Whiteheaded breed. The young animals have some lag in live weight behind the breed standard [12] to 7 months’ age with exceeding of this trait in certain periods quite significantly in the future. It was established that selection of heifers on live weight will be effective at the early age (1-5 months), given the coefficient of variation of live weight – 22,63-30,21% and will not have a significant influence in the future. Milk yields of first-calf heifers vary considerably depending on the origin. The milk yield of first-calf heifers in the herd was 4238,5 kg on average, the heifers belonging to Mart 171 and Ozon 417 bloodlines had the best milk performance – 4483,1 and 4254,9 kg accordingly. The most aligned milk yield during the first lactation was in the cows belonging to Ozon 417 bloodline, the limits of the trait are 4128,5-4327,4 kg with the average value by the line 4254,9 kg. In contrast, the first-calf heifers of Ryezvyi 33 bloodline with average milk yield 4048,9 kg had limits of the trait 2199,3-4736,1 kg. Even greater range in cows’ milk yield during the first lactation R= 4939 kg (limits 1687 – 6626 kg) is characterized for the herd in general, it shows, on the one hand, the possibility of qualitative improvement of cows’ productivity due to selection on the investigated trait and lack of selection in the herd on the other hand. It was established that daughters of bull Chardash belonging to Ryezvyi 33 bloodline produced 4736,1 kg of milk for 305 days of the first lactation with fat content 3,6%, whereas Zlak’s descendants of the same line were characterized by the lowest milk yield for the first completed lactation – 2199,3 kg with fat content 3,7% and the average value by the line – 4048,9 kg of milk, fat content 3,6%. Similar variability of first-calf heifers’ milk yields, depending on the origin, is typical for other bloodlines of Ukrainian Whiteheaded breed. To increase milk productivity of Ukrainian Whiteheaded cows is recommended to repeat successful combinations of parental forms, and to preserve the breed – to carry out an objective assessment of animals by a range of traits, given the efficiency of selection of heifers on live weight at early age.

scholarly journals Stochastic mathematical model for vehicle routing problem in collecting perishable products

DYNA ◽  
2015 ◽  
Vol 82 (189) ◽  
pp. 199-206 ◽  
Author(s):  
Elsa Cristina Gonzalez-L. ◽  
Wilson Adarme-Jaimes ◽  
Javier Arturo Orjuela-Castro
Keyword(s):  
Mathematical Model ◽  
Vehicle Routing ◽  
Vehicle Routing Problem ◽  
Perishable Products ◽  
Routing Problem

A multi-objective model for sustainable closed-loop supply chain of perishable products under two carbon emission regulations

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Saman Esmaeilian ◽  
Dariush Mohamadi ◽  
Majid Esmaelian ◽  
Mostafa Ebrahimpour
Keyword(s):  
Mathematical Model ◽  
Supply Chain ◽  
Life Cycle ◽  
Carbon Emission ◽  
Closed Loop ◽  
Perishable Products ◽  
Supply Chain Network ◽  
Closed Loop Supply Chain ◽  
Content Type ◽  
Trade Model

Purpose This paper aims to minimize the total carbon emissions and costs and also maximize the total social benefits. Design/methodology/approach The present study develops a mathematical model for a closed-loop supply chain network of perishable products so that considers the vital aspects of sustainability across the life cycle of the supply chain network. To evaluate carbon emissions, two different regulating policies are studied. Findings According to the obtained results, increasing the lifetime of the perishable products improves the incorporated objective function (IOF) in both the carbon cap-and-trade model and the model with a strict cap on carbon emission while the solving time increases in both models. Moreover, the computational efficiency of the carbon cap-and-trade model is higher than that of the model with a strict cap, but its value of the IOF is worse. Results indicate that efficient policies for carbon management will support planners to achieve sustainability in a cost-effectively manner. Originality/value This research proposes a mathematical model for the sustainable closed-loop supply chain of perishable products that applies the significant aspects of sustainability across the life cycle of the supply chain network. Regional economic value, regional development, unemployment rate and the number of job opportunities created in the regions are considered as the social dimension.

DIFFERENTIAL EQUATIONS FOR TRAIN STARTING WITH ELASTIC CONNECTIONS

2021 ◽  
Vol 2 ◽  
pp. 18-26
Author(s):  
I.P. POPOV
Keyword(s):  
Mathematical Model ◽  
Differential Equations ◽  
Friction Force ◽  
Static Friction ◽  
Longitudinal Vibrations ◽  
Maximum Tension ◽  
Inert Mass ◽  
The Moment ◽  
Elastic Couplings ◽  
Selection Of

The starting mode for the train is the most difficult. An effective method of pulling is the selection of coupling clearances. In this case, the cars are set in motion sequentially and the inert mass, as well as the static friction force immediately at the moment of starting, are minimal. This method has two significant drawbacks - a small fixed value of the gaps in the couplings and the shock nature of the impulse transfer. These disadvantages can be avoided by using elastically deformable couplings. The aim of this work is to construct a mathematical model of "easy" starting of a train with elastic couplings. The softening of the train start-off mode is essentially due to the replacement of the simultaneous start-off of the sections with alternate ones. To exclude longitudinal vibrations of the composition, after reaching the maximum tension of the coupling, the possibility of its harmonic compression should be mechanically blocked.

Development of metaheuristics to solve a transportation inventory location routing problem considering lost sale for perishable goods

2019 ◽  
Vol 14 (1) ◽  
pp. 175-198 ◽  
Author(s):  
S.M.T. Fatemi Ghomi ◽  
B. Asgarian
Keyword(s):  
Mathematical Model ◽  
Distribution Systems ◽  
Hybrid Approach ◽  
Rational Approach ◽  
Location Routing Problem ◽  
Routing Problem ◽  
Content Type ◽  
Location Routing ◽  
Perishable Goods ◽  
The Impact

PurposeFinding a rational approach to maintain a freshness of foods and perishable goods and saving their intrinsic attributes during a distribution of these products is one of the main issues for distribution and logistics companies. This paper aims to provide a framework for distribution of perishable goods which can be applied for real life situations.Design/methodology/approachThis paper proposes a novel mathematical model for transportation inventory location routing problem. In addition, the paper addresses the impact of perishable goods age on the demand of final customers. The model is optimally solved for small- and medium-scale problems. Moreover, regarding to NP-hard nature of the proposed model, two simple and one hybrid metaheuristic algorithms are developed to cope with the complexity of problem in large scale problems.FindingsNumerical examples with different scenarios and sensitivity analysis are conducted to investigate the performance of proposed algorithms and impacts of important parameters on optimal solutions. The results show the acceptable performance of proposed algorithms.Originality/valueThe authors formulate a novel mathematical model which can be applicable in perishable goods distribution systems In this regard, the authors consider lost sale which is proportional to age of products. A new hybrid approach is applied to tackle the problem and the results show the rational performance of the algorithm.

scholarly journals Analysis of the Modified Construction of the Column Mechanism MacPherson

2018 ◽  
Vol 19 (11) ◽  
pp. 41-44
Author(s):  
Marek Kwietniewski ◽  
Tadeusz Bil
Keyword(s):  
Mathematical Model ◽  
Steering Wheel ◽  
Passenger Cars ◽  
Proper Selection ◽  
Front Suspension ◽  
Change Of Direction ◽  
Partial Elimination ◽  
Selection Of

The McPherson column name comes from the inventor of this Earle S. MacPherson solution, which was first manufactured at the Ford plant in 1949. This is one of the most commonly used types of front suspension in popular passenger cars. The advantage of this type of suspension is a compact construction, but the disadvantage is. The influence of the damping motion on the position of the steering wheel may result in an unintentional change of direction of travel. At the same time, there is a slight additional tilt of the wheels when the "spring" movement. In the proposed solution, partial elimination of this type of incorrectness is proposed by changing the type of connection of the steering rod end to the steering wheels of the vehicle. The introduced change consists in replacing one of the spherical joints in these joints into two rotary joints. Such a change introduces a mathematical model describing the behavior of the suspension under the influence of the depreciation of additional parameters. Proper selection of these parameters allows for significant reduction of unnecessary direction changes during driving. The described model of the structure of the mechanism allows to analyze the influence of all its dimensions on the selected parameters of the behavior of the wheels during the ride, resulting from the movement of the suspension and steering.

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