scholarly journals Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake

2021 ◽  
Vol 30 (6) ◽  
pp. 375-386
Author(s):  
Go Eun Ha ◽  
Eunji Cheong
Keyword(s):  
Food Intake ◽  
Restraint Stress ◽  
Chronic Restraint Stress

scholarly journals PO-281 Vibration Training Restores Food Intake and Body Weight in a Rat Model of Depression

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Guangcong Peng ◽  
Luodan Yang ◽  
Chongyun Wu ◽  
Jun Hou ◽  
Limei Zhang ◽  
...  
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Food Intake ◽  
Depressive Disorder ◽  
Rat Model ◽  
Restraint Stress ◽  
Mental Condition ◽  
Control Group ◽  
Chronic Restraint Stress ◽  
Vibration Training

Objective Stress is well known to negatively affect body weight and food intake in animal models, but the underlying mechanisms have not yet been well elucidated and effective treatment is lacking. This project was initiated to study the potential beneficial effect of vibration training, a novel neuromuscular training method, in the treatment of depression. Methods Adult Sprague-Dawley male rats were randomly divided into the following three groups: 1) naïve control group, 2) depressive disorder group, and 3) depression with vibration training treatment group. To develop a depression phenotype, rats were individually and gently restricted in a modified, well-ventilated tube for 4 h every day for 21 days. Animals in vibration training treatment group were subjected to 30 min of vibration training (30 Hz, 5 days / week) for continuous 5 weeks. Body weight, physical and mental condition, and food intake were recorded daily and the data were statistically analyzed and compared between groups. Results 1. Daily body weight and food intake measurements revealed that both parameters decreased rapidly after the initiating daily restraint stress, compared with control group.  Intriguingly, both body weight and food intake of the depressive disorder group with 5-week vibration training were significantly improved. 2. The secretion of serotonin and dopamine in animals with chronic restraint stress were decreased compared with normal animals, and this attenuation was significantly prevented by vibration training. Conclusions The present study demonstrates that vibration training is capable of restoring food intake and body weight in a rat model of chronic restraint stress-induced depression.

scholarly journals Chronic restraint stress impairs cognition via modulating HDAC2 expression

2021 ◽  
Vol 12 (1) ◽  
pp. 154-163
Author(s):  
Jie Wu ◽  
Cui Liu ◽  
Ling Zhang ◽  
Bing He ◽  
Wei-Ping Shi ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Hippocampal Neurons ◽  
Restraint Stress ◽  
Glucocorticoid Receptors ◽  
Chronic Restraint Stress ◽  
Akt Signaling Pathway ◽  
Object Recognition Test ◽  
Protein Levels ◽  
Synaptic Functions ◽  
Plus Maze

Abstract Background To investigate the effects of chronic restraint stress on cognition and the probable molecular mechanism in mice. Methods In the current work, a restraining tube was used as a way to induce chronic stress in mice. The protein levels were determined with ELISA and western blot. A series of behavior tests, including the Morris water maze, elevated plus maze, open field test, and novel object recognition test, were also performed to examine the anxiety and the ability of learning and memory. Moreover, murine neuroblastoma N2a cells were used to confirm the findings from mice under chronic stress. Results Decreased synaptic functions were impaired in chronic stress with the downregulation of PSD95, GluR-1, the neurotrophic factor BDNF, and immediate-onset genes Arc and Egr. Chronic restraint decreased the histone acetylation level in hippocampal neurons while HDAC2 was increased and was co-localized with glucocorticoid receptors. Moreover, chronic stress inhibited the PI3K/AKT signaling pathway and induced energy metabolism dysfunctions. Conclusion This work examining the elevated levels of HDAC2 in the hippocampus may provide new insights and targets for drug development for treating many neurodegenerative diseases.

Antidepressant-like effects of albiflorin involved the NO signaling pathway in rats model of chronic restraint stress

2020 ◽  
Vol 18 (11) ◽  
pp. 872-880
Author(s):  
Ying-Li ZHU ◽  
Lin-Yuan WANG ◽  
Dan-Ping ZHAO ◽  
Cheng-Long WANG ◽  
Rui ZHANG ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Restraint Stress ◽  
Chronic Restraint Stress ◽  
No Signaling

Effects of acute and chronic restraint stress on nitroglycerin-induced hyperalgesia in rats

2005 ◽  
Vol 383 (1-2) ◽  
pp. 7-11 ◽  
Author(s):  
A. Costa ◽  
A. Smeraldi ◽  
C. Tassorelli ◽  
R. Greco ◽  
G. Nappi
Keyword(s):  
Restraint Stress ◽  
Chronic Restraint Stress

scholarly journals Chronic restraint stress decreases the repair potential from mesenchymal stem cells on liver injury by inhibiting TGF- β 1 generation

2014 ◽  
Vol 5 (6) ◽  
pp. e1308-e1308 ◽  
Author(s):  
X Yang ◽  
Z-P Han ◽  
S-S Zhang ◽  
P-X Zhu ◽  
C Hao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Injury ◽  
Restraint Stress ◽  
Chronic Restraint Stress
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