scholarly journals Flaky Tail Mouse as a Novel Animal Model of Atopic Dermatitis: Possible Roles of Filaggrin in the Development of Atopic Dermatitis

10.5772/25609 ◽  
2012 ◽  
Author(s):  
Catharina Sagita ◽  
Kenji Kabashim
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis

scholarly journals Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ik Jun Moon ◽  
Mi Ra Yun ◽  
Hae Kyeong Yoon ◽  
Keon Hee Lee ◽  
Sun Young Choi ◽  
...  
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Skin Barrier ◽  
Treated Group ◽  
Transepidermal Water Loss ◽  
Atmospheric Plasma ◽  
Therapeutic Modality ◽  
Skin Barrier Function ◽  
Control Group ◽  
Epidermal Thickness

AbstractCold atmospheric plasma (CAP) has been incorporated into various fields, including promotion of cutaneous wound healing. Atopic dermatitis (AD) is a chronic cutaneous condition characterized by inflammation-induced skin wounds and impaired skin barrier function. To investigate whether CAP may improve AD using an animal model. Dermatophagoides farinae extracts (DFE)-induced murine models of AD were used in this study. The plasma-treated group received a total of 6 CAP treatments during 2 weeks, while the control group did not receive any treatment. Differences in dermatitis severity, transepidermal water loss (TEWL), serum level of immunoglobulin (Ig) E and epidermal thickness were evaluated in both groups. The dermatitis severity was significantly improved by CAP treatment. TEWL was lower in the plasma-treated group compared with the non-treated control group. Serum Ig E dropped significantly after treatment with CAP. Difference in epidermal thickness of the ear skin was not significant between the plasma-treated and non-treated groups. Localized treatment of AD with CAP decreases dermatitis severity, TEWL, and serum Ig E level. These results show CAP’s potentials as a novel therapeutic modality for AD.

scholarly journals Inhibitory Effect of Angelica keiskei Extract in an Atopic Dermatitis Animal Model

2012 ◽  
Vol 19 (5) ◽  
pp. 792-798 ◽  
Author(s):  
Min-A Kim ◽  
Hyeong-U Son ◽  
Dong-Yoon Nam ◽  
Yong-Su Cha ◽  
Yong-Kyu Shin ◽  
...  
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Inhibitory Effect ◽  
Angelica Keiskei

Altered mRNA and protein expression of filaggrin in the skin of a canine animal model for atopic dermatitis

2013 ◽  
Vol 24 (3) ◽  
pp. 329-e73 ◽  
Author(s):  
Domenico Santoro ◽  
Rosanna Marsella ◽  
Kim Ahrens ◽  
Thomas K. Graves ◽  
David Bunick
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Protein Expression ◽  
Mrna And Protein Expression

scholarly journals Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin

2005 ◽  
Vol 202 (4) ◽  
pp. 541-549 ◽  
Author(s):  
Jane Yoo ◽  
Miyuki Omori ◽  
Dora Gyarmati ◽  
Baohua Zhou ◽  
Theingi Aye ◽  
...  
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Elevated Serum ◽  
Allergic Inflammation ◽  
Disease Process ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Thymic Stromal Lymphopoietin ◽  
Common Disease

The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans. To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene. Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease.

scholarly journals Mouse model of DNCB-induced atopic dermatitis

2017 ◽  
Vol 12 (2) ◽  
pp. 30
Author(s):  
Alshammari Fanar Hamad ◽  
Jong-Hun Han ◽  
Irfan Ahmad Rather
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Video Clip ◽  
Skin Inflammation ◽  
New Drugs ◽  
Dorsal Skin ◽  
Reference Drug ◽  
Allergic Skin ◽  
Full Screen ◽  
Selection Of

<p>Atopic dermatitis is a skin disease characterized by allergic skin inflammation, redness and itching. The animal model is necessary to find out new drugs. The DNCB-induced animal model of atopic dermatitis includes the following steps: 1) Selection of animals; 2) Shaving of dorsal skin; 3) Applying DNCB once in 24 hours for three days; 4) Monitoring the development of atopy on day 4 post DNCB application. Further, the efficacy of reference drug can be determined by applying on the atopy skin, depends on the nature and aim of the work.</p><p><strong>Video Clip of Methodology</strong>: 8 min   <a href="https://www.youtube.com/v/XbFt1bOnulc">Full Screen</a>   <a href="https://www.youtube.com/watch?v=XbFt1bOnulc">If Failed</a></p>

scholarly journals Review : Clinical application and efficacy of herbal medicines by modulating cytokines in atopic dermatitis-induced animal model

2012 ◽  
Vol 27 (4) ◽  
pp. 33-44 ◽  
Author(s):  
Yeong-Chul Park ◽  
Jung-Dae Lim ◽  
Yong-Ki Park ◽  
Mi-Sook Yoon ◽  
Sun-Dong Lee
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Clinical Application ◽  
Herbal Medicines

scholarly journals Evaluation of Itch by Using NC/NgaTnd Mice: A Model of Human Atopic Dermatitis

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Akane Tanaka ◽  
Hiroshi Matsuda
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Clinical Symptoms ◽  
Skin Barrier ◽  
Sensory Nerves ◽  
Laboratory Animals ◽  
Skin Barrier Function ◽  
The Novel ◽  
Suitable Animal Model ◽  
Spontaneous Animal Model

Atopic dermatitis (AD) is the extremely complicated syndrome that various abnormalities develop in a heap. There are various factors in patients for the onset and exacerbation of AD, including genetic cofactors of individuals, environmental factors, the failure of the skin barrier function, unfavorable regulation of the immune system, and the hypersensitivity of sensory nerves. In recent years, there have been many trials of the drug discovery that targets itch, because itch is one of the most serious clinical symptoms of AD. The selection of the suitable animal model that represents the condition of patients, as well as innovative analyzing protocols that can precisely evaluate itch, is indispensable for investigation of an effective drug for AD. In the paper, the unique spontaneous animal model for AD (NC/NgaTnd mice) and the novel quantification system of the laboratory animals that may bring a great progress in the future study of itch are outlined.

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