Penentuan Komposisi Bahan Bakar Nabati Dalam Bahan Bakar Minyak Campuran Menggunakan Metode Direct Counting C-14

ABSTRAK. Telah dilakukan penentuan komposisi bahan bakar nabati (BBN) dalam bahan bakar minyak campuran (BBMC) dengan metode direct counting C-14. Penentuan komposisi BBN dalam BBMC dilakukan dengan cara memipet 10 mL BBMC ke dalam vial gelas kemudian ditambahkan 10 mL larutan sintilator Ultima Gold F (UGF) ke dalamnya. Vial tersebut dikocok agar campuran menjadi homogen kemudian dicacah menggunakan LSC (Liquid Scintillation Counter) Elmer Perkin 2900TR selama 20 menit sebanyak 30 siklus. Hasil pencacahan ditampilkan dalam bentuk tSIE (transformed external standard spectrum) dan cpm (cacahan permenit). Hasil analisis memperlihatkan nilai cpm yang meningkat seiring kenaikan persentase BBN dalam BBMC. Nilai cpm terendah dan tertinggi untuk sampel bensin, avtur, dan solar berturut-turut adalah 14,2363 dan 62,0343, 10,664 dan 44,535, serta 9,410 dan 61,789. Terdapat korelasi kuat antara nilai tSIE dan nilai cpm pada bensin dan solar tapi tidak pada avtur. Hasil analisis terhadap sampel uji menunjukkan bahwa sampel tersebut berada di luar grafik deret sampel. Metode direct counting ini diharapkan dapat menjadi referensi dalam uji mutu BBMC.ABSTRACT. The composition of biofuel (BF) in mixed oil fuel (MOF) has been determined using the C-14 direct counting method. Determination of the composition of BF in MOF was carried out by pipetting 10 mL of BBMC into a glass vial and then adding 10 mL of Ultima Gold F (UGF) scintillator solution into it. The vial was shaken so that the mixture became homogeneous and then counted using the Elmer Perkin 2900TR LSC (Liquid Scintillation Counter) for 20 minutes for 30 cycles. The results of the counting are displayed in the form of tSIE (transformed external standard spectrum) and cpm (counts per minute). The results of the analysis show that the value of cpm increases with the increase in the percentage of BF in MOF. The lowest and highest cpm values for gasoline, avtur, and diesel samples were 14.2363 and 62.0343, 10.664 and 44.535, and 9.410 and 61.789, respectively. There is a strong correlation between tSIE and cpm values for gasoline and diesel but not for avtur. The results of the analysis of the test sample indicate that the sample is outside the sample series graph. This direct counting method is expected to be a reference in the BBMC quality test.

Formulation and In vitro Percutaneous Permeation and Skin accumulation of Voriconazole Microemulsified Hydrogel

The aim of the present study was to prepare and evaluate voriconazole microemulsified hydrogel. The voriconazole microemulsified is prepared by Water Titration Method. In which voriconazole microemulsified incorporated with hydrogel, Blank gels of different polymers were prepared by distilled water. Finally, the carbopol gel was prepared by dispersing 0.5% carbopol w/v and 0.5% aloe vera powder in 100 ml of water with stirring on mechanical stir. Additionally, for preservation of formulations 0.8% methyl paraben was mixed. Oil phase was selected by dissolving the voriconazole pure in different oils, oleic acid, castor oil, coconut oil, olive oil, cooten seed mineral oil and soya oil. Oleic acid was selected on the basis of higher solubility of voriconazole in it. Combination of surfactant and co-surfactant was selected on clear visual observation. Span - 40: propylene glycol in ratio 1:1 and 2:1 selected for further preparation of microemulsion. From the study F-8, F-9, F-10, F-14 and F-15 were selected for further studies. Though F-16, F-17, F-18, F-19 and F-20 formulations are also stable, but rejected due to high concentration of surfactant can cause skin irritation, skin burning and/or other complications. Characterization of selected voriconazole microemulsion formulations were evaluated under various parameters like Droplet size, Zeta potential, Poly Dispersity Index (PDI) and (%) Drug content all results showed.

Development, Characterization, and Stability Evaluation of the Anti-Cellulite Emgel Containing Herbal Extracts and Essential Oils

Recently, the herbal compress was successfully developed and applied for cellulite treatment. The aim of this study was to formulate a more convenient dosage form of herbal application from the original formula. In addition, we aimed to characterize and evaluate the stability of the developed dosage form. A gelled emulsion, or an “emgel,” incorporated with 0.1 wt% tea and coffee extracts (1:1 ratio) plus 5 wt% essential oils (mixed oil) was prepared. The caffeine content in the finished product obtained from tea and coffee extracts analyzed by HPLC was 48.1 ± 2.3 µg/g. The bio-active marker monoterpenes of mixed oil characterized by headspace GCMS were camphene 50.8 ± 1.8 µg/mg, camphor 251.0 ± 3.2 µg/mg, 3-carene 46.7 ± 1.8 µg/mg, α-citral 75.0 ± 2.1 µg/mg, β-citral 65.6 ± 1.3 µg/mg, limonene 36.8 ± 6.7 µg/mg, myrcene 53.3 ± 4.5 µg/mg, α-pinene 85.2 ± 0.6 µg/mg, β-pinene 88.4 ± 1.1 µg/mg, and terpinene-4-ol 104.3 ± 2.6 µg/mg. The stability study was carried out over a period of 3 months at 4, 25, and 50 °C. The caffeine content showed no significant changes and passed the acceptance criteria of ≥80% at all tested temperatures. However, monoterpenes showed their stability for only 2 months at 50 °C. Therefore, the shelf-life of the emgel was, consequently, calculated to be 31 months using the Q10 method. Thus, the anti-cellulite emgel was successfully formulated. The characterization methods and stability evaluation for caffeine and monoterpenes in an emgel matrix were also successfully developed and validated.

The issue of "oil shrinkage" during the compounding of oils in the processes of production, collection, preparation and transportation of hydrocarbon raw materials

The article discusses the issue of industrial compounding, which improves the quality of the raw materials supplied to the main pipelines. Compounding from "to compound" (English) - to mix. When mixing different types of oil obtained, "incompatibility" is possible, which is expressed in the precipitation of a solid sediment and violation of the stability of the colloidal system and due to the differing properties of oils. Attention to this problem is due to the tightening of requirements for the quality of raw materials that must comply with modern standards. The article discusses the causes of the problem of "incompatibility" of oil during compounding and effective ways of solving it, substantiates the need for a preliminary study of the properties of mixed oil in order to identify possible incompatibility of various types of oil. The standard tests for determination of incompatibility indices characterizing the ability of raw materials to mix are considered. The article substantiates the need to develop methods for diagnosing the incompatibility of oils as the most important task of modern chemical science, the solution of which will improve the quality of the raw material obtained and solve many technological problems in the compounding process.