scholarly journals Thyroid-Stimulating Hormone Regulation and Transcription in Hypothyroidism

10.5772/32002 ◽  
2012 ◽  
Author(s):  
Koreaki Sugimoto ◽  
Kouki Mori
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Hormone Regulation ◽  
Stimulating Hormone

Genetic thyroid stimulating hormone regulation of atrial fibrillation risk is mediated through an effect on height

2021 ◽  
Author(s):  
Mingjian Shi ◽  
Ali M Manouchehri ◽  
Christian M Shaffer ◽  
Nataraja Sarma Vaitinadin ◽  
Jacklyn N Hellwege ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Genetic Association ◽  
Multiple Testing ◽  
Mendelian Randomization ◽  
Later Life ◽  
Thyroid Stimulating Hormone ◽  
Hormone Regulation ◽  
Nucleotide Polymorphisms ◽  
Free T4 ◽  
Stimulating Hormone

Abstract Background A genetic predisposition to lower thyroid stimulating hormone (TSH) levels associates with increased atrial fibrillation (AF) risk through undefined mechanisms. Defining the genetic mediating mechanisms could lead to improved targeted therapies to mitigate AF risk. Methods We used two-sample Mendelian randomization (MR) to test associations between TSH-associated single nucleotide polymorphisms (SNPs) and 16 candidate mediators. We then performed multivariable Mendelian randomization (MVMR) to test for a significant attenuation of the genetic association between TSH and AF, after adjusting for each mediator significantly associated with TSH. Results Four candidate mediators (free T4, systolic blood pressure, heart rate, and height) were significantly inversely associated with genetically predicted TSH after adjusting for multiple testing. In MVMR analyses, adjusting for height significantly decreased the magnitude of the association between TSH and AF from -0.12 (s.e. 0.02) occurrences of AF per standard deviation change in height to -0.06 (0.02) (p=0.005). Adjusting for the other candidate mediators did not significantly attenuate the association. Conclusions The genetic association between TSH and increased AF risk is mediated, in part, by taller stature. Thus, some genetic mechanisms underlying TSH variability may contribute to AF risk through mechanisms determining height occurring early in life that differ from those driven by thyroid hormone level elevations in later life.

Role of Thyrotropin-Releasing Hormone in Thyroid-Stimulating Hormone and Growth Hormone Regulation during Postnatal Maturation in Female Wistar Rats

Neonatology ◽  
1986 ◽  
Vol 50 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Vladimir Štrbák ◽  
Robert Angyal ◽  
Jana Jurčovičová ◽  
Anna Randušková
Keyword(s):  
Growth Hormone ◽  
Wistar Rats ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Hormone Regulation ◽  
Postnatal Maturation ◽  
Releasing Hormone ◽  
Female Wistar Rats ◽  
Stimulating Hormone

The epidemiology of iodine-deficiency disorders in relation to goitrogenic factors and thyroid-stimulating-hormone regulation

1993 ◽  
Vol 57 (2) ◽  
pp. 267S-270S ◽  
Author(s):  
C H Thilly ◽  
B Swennen ◽  
P Bourdoux ◽  
K Ntambue ◽  
R Moreno-Reyes ◽  
...  
Keyword(s):  
Iodine Deficiency ◽  
Thyroid Stimulating Hormone ◽  
Hormone Regulation ◽  
Iodine Deficiency Disorders ◽  
Stimulating Hormone

CLINICAL EVALUATION OF THE THYROID STIMULATING HORMONE ACTIVITY IN EXOPHTHALMOS

1961 ◽  
Vol 38 (4) ◽  
pp. 577-584 ◽  
Author(s):  
Sven Erik Björkman ◽  
Torsten Denneberg ◽  
Inge Hedenskog
Keyword(s):  
Clinical Evaluation ◽  
Thyroid Stimulating Hormone ◽  
Significant Rise ◽  
Hormone Activity ◽  
Control Subjects ◽  
Long Duration ◽  
Stimulating Factor ◽  
Stimulating Hormone

ABSTRACT A method for demonstrating the presence of a thyroid stimulating factor in the blood of patients with progressive exophthalmos after thyroidectomy or after treatment with radioiodine is described. The method consists of transfusing freshly drawn blood from the patients to euthyroid recipients and subsequently following the PBI level of the recipients at regular intervals. Six exophthalmic patients tested in this manner were found to have such a factor in their circulating blood. After transfusion of their blood a significant rise in the PBI level of the recipients could be demonstrated. Two other patients, one with exophthalmos of long duration did not show this response nor did it occur after transfusion of blood from two control subjects. In one case the action of this factor was compared with that of animal thyrotrophin and found to be of the same magnitude.

Sign in / Sign up

Export Citation Format

Share Document