scholarly journals The Role of Noncoding RNAs in Brain Cells during Rat Cerebral Ischemia

2020 ◽  
Author(s):  
Ivan B. Filippenkov ◽  
Lyudmila V. Dergunova ◽  
Svetlana A. Limborska
Keyword(s):  
Cerebral Ischemia ◽  
Noncoding Rnas ◽  
Brain Cells

scholarly journals A study of the expression of circular RNAs of the Ece1, Mvp, Egfem1, Cdyl and Rgs9 genes in transient cerebral ischemia model conditions

2020 ◽  
pp. 69-70
Author(s):  
Л.В. Валиева ◽  
И.Б. Филиппенков ◽  
В.В. Ставчанский ◽  
А.Е. Денисова ◽  
Л.В. Губский ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Real Time Pcr ◽  
Functional Role ◽  
Bioinformatics Analysis ◽  
Circular Rnas ◽  
Brain Cells ◽  
Ischemic Damage ◽  
Subcortical Structures ◽  
Regulatory Interactions

Методом ПЦР в реальном времени в подкорковых структурах мозга крыс, содержащих очаг ишемического повреждения, показано активирующее влияние ишемии на экспрессию циклических РНК (циклоРНК) генов Ece1, Mvp, Egfem1 и Cdyl, а также репрессирующее влияние на экспрессию циклоРНК гена Rgs9. Биоинформатический анализ выявил возможные цис-регуляторные взаимодействия между микроРНК, а также циклоРНК и мРНК исследуемых генов, что указывает на функциональную роль данных циклоРНК в ответе клеток мозга на ишемию. Using real-time PCR, the activating effect of ischemia on the expression of circular RNAs (circRNAs) of Ece1, Mvp, Egfem1 and Cdyl genes, as well as the repressing effect on the expression of circRNA of the Rgs9 gene, is shown in the subcortical structures of the rat brain containing the focus of ischemic damage. Bioinformatics analysis revealed possible cis-regulatory interactions between miRNAs, as well as circRNAs and mRNAs of the studied genes. The result indicates the functional role of these circRNAs in the response of brain cells to ischemia.

scholarly journals Role of microRNAs in Stroke and Poststroke Depression

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Han Yan ◽  
Min Fang ◽  
Xue-Yuan Liu
Keyword(s):  
Cerebral Ischemia ◽  
Noncoding Rnas ◽  
Cerebrovascular Diseases ◽  
Eukaryotic Cells ◽  
Poststroke Depression ◽  
Regulate Gene Expression ◽  
Diagnosis And Prognosis ◽  
Ischemic Cerebrovascular Diseases ◽  
Growth Development

microRNAs (miRNA), a sort of noncoding RNAs widely distributed in eukaryotic cells, could regulate gene expression by inhibiting transcription or translation. They were involved in important physiological and pathological processes including growth, development, and occurrence and progression of diseases. miRNAs are crucial for the development of the nervous system. Recent studies have demonstrated that some miRNAs play important roles in the occurrence and development of ischemic cerebrovascular diseases such as stroke and were also involved in the occurrence and development of poststroke depression (PSD). Herein, studies on the role of miRNAs in the cerebral ischemia and PSD were reviewed, and results may be helpful for the diagnosis and prognosis of cerebral ischemia and PSD with miRNAs in clinical practice.

scholarly journals The Role of Post-Translational Acetylation and Deacetylation of Signaling Proteins and Transcription Factors after Cerebral Ischemia: Facts and Hypotheses

2021 ◽  
Vol 22 (15) ◽  
pp. 7947
Author(s):  
Svetlana Demyanenko ◽  
Svetlana Sharifulina
Keyword(s):  
Transcription Factors ◽  
Cerebral Ischemia ◽  
Cell Fate ◽  
Hdac Inhibitors ◽  
Brain Cells ◽  
Signaling Proteins ◽  
Cell Fate Decisions ◽  
Cell Responses ◽  
Acetylation Site

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) regulate transcription and the most important functions of cells by acetylating/deacetylating histones and non-histone proteins. These proteins are involved in cell survival and death, replication, DNA repair, the cell cycle, and cell responses to stress and aging. HDAC/HAT balance in cells affects gene expression and cell signaling. There are very few studies on the effects of stroke on non-histone protein acetylation/deacetylation in brain cells. HDAC inhibitors have been shown to be effective in protecting the brain from ischemic damage. However, the role of different HDAC isoforms in the survival and death of brain cells after stroke is still controversial. HAT/HDAC activity depends on the acetylation site and the acetylation/deacetylation of the main proteins (c-Myc, E2F1, p53, ERK1/2, Akt) considered in this review, that are involved in the regulation of cell fate decisions. Our review aims to analyze the possible role of the acetylation/deacetylation of transcription factors and signaling proteins involved in the regulation of survival and death in cerebral ischemia.

Central role of neuronal IkappaBalpha kinase (IKK) in cerebral ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S458-S458
Author(s):  
Oliver Herrmann ◽  
Rossanna de Lorenzi ◽  
Sajjad Muhammad ◽  
Wen Zhang ◽  
Martin Koehrmann ◽  
...  
Keyword(s):  
Cerebral Ischemia

The Role of Melatonin in Multiple Sclerosis, Huntington's Disease and Cerebral Ischemia

2014 ◽  
Vol 13 (6) ◽  
pp. 1096-1119 ◽  
Author(s):  
Begona Escribano ◽  
Ana Colin-Gonzalez ◽  
Abel Santamaria ◽  
Isaac Tunez
Keyword(s):  
Multiple Sclerosis ◽  
Cerebral Ischemia ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals The Role of lncRNA in the Development of Tumors, Including Breast Cancer

2021 ◽  
Vol 22 (16) ◽  
pp. 8427
Author(s):  
Beata Smolarz ◽  
Anna Zadrożna-Nowak ◽  
Hanna Romanowicz
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Present Article ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Regulation Of Transcription ◽  
Ribonucleic Acids ◽  
Detailed Review ◽  
Cellular Processes

Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules seems to be of great importance for the proper functioning of the organism. Studies have shown a relationship between disturbed lncRNA expression and the pathogenesis of many diseases, including cancer. The present article presents a detailed review of the latest reports and data regarding the importance of lncRNA in the development of cancers, including breast carcinoma.

scholarly journals Genome-Wide Identification and Characterization of Long Noncoding RNAs Involved in Chinese Wheat Mosaic Virus Infection of Nicotiana benthamiana

Biology ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 232
Author(s):  
Weiran Zheng ◽  
Haichao Hu ◽  
Qisen Lu ◽  
Peng Jin ◽  
Linna Cai ◽  
...  
Keyword(s):  
Virus Infection ◽  
Mosaic Virus ◽  
Nicotiana Benthamiana ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Differentially Expressed ◽  
Genome Wide ◽  
Chinese Wheat

Recent studies have shown that a large number of long noncoding RNAs (lncRNAs) can regulate various biological processes in animals and plants. Although lncRNAs have been identified in many plants, they have not been reported in the model plant Nicotiana benthamiana. Particularly, the role of lncRNAs in plant virus infection remains unknown. In this study, we identified lncRNAs in N. benthamiana response to Chinese wheat mosaic virus (CWMV) infection by RNA sequencing. A total of 1175 lncRNAs, including 65 differentially expressed lncRNAs, were identified during CWMV infection. We then analyzed the functions of some of these differentially expressed lncRNAs. Interestingly, one differentially expressed lncRNA, XLOC_006393, was found to participate in CWMV infection as a precursor to microRNAs in N. benthamiana. These results suggest that lncRNAs play an important role in the regulatory network of N. benthamiana in response to CWMV infection.

scholarly journals LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
You-hong Wang ◽  
Zhen Guo ◽  
Liang An ◽  
Yong Zhou ◽  
Heng Xu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Nasopharyngeal Cancer ◽  
Noncoding Rnas ◽  
Dependent Protein Kinase ◽  
Damage Repair ◽  
Dependent Protein ◽  
Cancer Tissues

AbstractRadioresistance continues to be the leading cause of recurrence and metastasis in nasopharyngeal cancer. Long noncoding RNAs are emerging as regulators of DNA damage and radioresistance. LINC-PINT was originally identified as a tumor suppressor in various cancers. In this study, LINC-PINT was significantly downregulated in nasopharyngeal cancer tissues than in rhinitis tissues, and low LINC-PINT expressions showed poorer prognosis in patients who received radiotherapy. We further identified a functional role of LINC-PINT in inhibiting the malignant phenotypes and sensitizing cancer cells to irradiation in vitro and in vivo. Mechanistically, LINC-PINT was responsive to DNA damage, inhibiting DNA damage repair through ATM/ATR-Chk1/Chk2 signaling pathways. Moreover, LINC-PINT increased radiosensitivity by interacting with DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and negatively regulated the expression and recruitment of DNA-PKcs. Therefore, these findings collectively support the possibility that LINC-PINT serves as an attractive target to overcome radioresistance in NPC.

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