scholarly journals Red Wine and Yacon as a Source of Bioactive Compounds with Antidiabetic and Antioxidant Potential

2020 ◽  
Author(s):  
Mariia Nagalievska ◽  
Mariya Sabadashka ◽  
Nataliia Sybirna
Keyword(s):  
Phenolic Compounds ◽  
Red Wine ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Low Grade ◽  
Smallanthus Sonchifolius ◽  
Grape Wine ◽  
Low Grade Inflammation ◽  
Antioxidant Effects ◽  
Active Substances

Phytochemicals derived from different plants are promising therapeutic agents. Herbal compounds can be used under diseases, etiological causes of which are alterations of carbohydrate, protein, and lipid metabolisms, along with increased oxidative stress and chronic low-grade inflammation. Potential sources of biologically active substances may be grape wine, rich in phenolic compounds. Well-studied examples of polyphenols are phenolic acids, catechins, anthocyanins, and flavonoids, etc. Another source of biologically active compounds is yacon (Smallanthus sonchifolius Poepp. & Endl.). The aboveground part of yacon is rich in phenolic compounds and terpenes. Main biologically active substances from tuberous roots of yacon are fructooligosaccharides and phenolic compounds. The section will be devoted to the analysis of hypoglycemic and antioxidant effects, and molecular targets of the complex of biologically active substances derived from red wine and yacon.

scholarly journals COMPOSITION OF BIOLOGICALLY ACTIVE SUBSTANCES OF THE HORSE CHESTNUT (AECULUS HIPPOCASTANUM L.)

ÈKOBIOTEH ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 33-39
Author(s):  
V.P. Kurchenko ◽  
◽  
N.V. Sushinskaya ◽  
K.I. Maiorava ◽  
E.I. Tarun ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Horse Chestnut ◽  
Hazard Class ◽  
Active Substances

The study of the composition of biologically active substances, alcoholic extracts from flowers of Aeculus hippocastanum L. According to the results of HPLC-MS and GC-MS analyzes, the extract contains the main amounts of phenolic compounds: quercetin, epicatechin, kaempferol. In addition, the extract contains fatty acids and their esters, alcohols, 3-deoxy-d-manno lactone, 1,2,3,5-cyclohexantethrol, α-methyl-mannofuranoside, γ sitosterol. Antioxidant activity of an extract from flowers of A. hippocastanum is associated with the peculiarities of the compositionof biologically active substances. The toxological-hygienic assessment of flowers of this species in acute and subacute experiments showed that it belongs to the 4th hazard class (low hazard).

scholarly journals Optimization of parameters of the extraction process of biologically active substances of grass Adonis vernalis

2021 ◽  
Vol 3 (3(59)) ◽  
pp. 14-18
Author(s):  
Anna Krvavych ◽  
Roksolana Konechna
Keyword(s):  
Phenolic Compounds ◽  
Extraction Method ◽  
Cardiac Glycosides ◽  
Maximum Yield ◽  
Particle Diameter ◽  
Cardiac Activity ◽  
Value Added ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Substances

The object of this research is the herb Adonis vernalis and hydroalcoholic extracts obtained on its basis. By the nature of the action, the drugs Adonis vernalis belong to the group of cardiac glycosides and occupy an intermediate place between strophanthin and digitalis. In official medicine, biologically active compounds of Adonis vernalis are included in drugs such as Cardiovalen, Adonis-bromine, Caridiolin and Cardiophyte. In the extemporal formulation, the extract is part of the Bechterew’s medicine. Until recently, scientists have made significant progress in studying the phytochemical and pharmacological action of the herb Adonis vernalis. However, one should not be limited to the use of Adonis vernalis only for stimulating cardiac activity, one should also consider the promising antioxidant effect of flavonoids and phenolic compounds that are contained in this medicinal plant. Also, studies of the extraction conditions of the herb Adonis vernalis are not described in the scientific literature. The study carried out the extraction of the grass Adonis vernalis by various methods (static and dynamic). The type of extract was chosen as the most rational, which provides the maximum yield of extractives (phenolic compounds and cardiac glycosides). For this, the optimal extraction conditions were selected, namely, the particle size, the type of extractant, the value of the hydromodule and the extraction method. Accordingly, the optimal particle diameter for maximum extraction of biologically active substances of the herb Adonis vernalis is 2.5 mm, the optimal extractant is 70 % ethyl alcohol, the ratio of raw materials: extractant is 1:10, the optimal extraction method is maceration with constant stirring. Phytochemical studies of the quantitative composition of the main groups of biologically active substances were carried out using calorimetric and spectrophotometric methods of analysis. As a result of the optimization of the process and its introduction into production on an industrial scale, the value added effect will be achieved. And also a high-quality product has been created that will compete with broad-spectrum drugs already existing on the market.

scholarly journals Research of biologically active compounds of catalpa (Catalpa bignonioides Walt.)

2020 ◽  
pp. 52-58
Author(s):  
O. V. Demeshko ◽  
S. V. Romanova ◽  
V. V. Kovalyov ◽  
I. I. Batiuchenko
Keyword(s):  
Acetic Acid ◽  
Phenolic Compounds ◽  
Chromatographic Analysis ◽  
Skin Diseases ◽  
Biologically Active Compounds ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Compounds ◽  
Chromatographic Paper ◽  
Active Substances

Catalpa bignonioides Walt. (catalpa) the family Bignoniaceae – a tree, which originates from North America. Catalpa bark contains resins and tannins. Monoterpene glycosides were found in the leaf. Catalpa seeds contain up to 30% of eleostearic acid. Decoctions are made of the bark of the tree. They serve as a gastric agent and have an anthelmintic effect. Decoction of the bark exhibits bronchodilator action, is used in the complex treatment of cancer. The leaves are used to treat skin diseases. The infusion of fruits has anti-herpetic and hypoglycemic properties. The aim of the work is to investigate biologically active compounds of the leaves of catalpa bignini. The object of the study was the leaves of common catalpa harvested in the summer of 2018 in Sevastopol. Chemical identification reactions and methods of chromatographic analysis were used to determine the major groups of biologically active substances of the leaves of the catalpa (chromatographic paper Filtrak FN No. 4, Munktell, Czech Republic). Chromatography was performed in pre-selected solvent systems: n-butanol‒acetic acid‒water (BAW) (4:1:2) ‒ I direction and 15% acetic acid ‒ II direction. Identification reactions were performed with aqueous and aqueous-alcoholic extracts of catalpa leaves. The qualitative composition of the phenolic compounds was investigated by paper chromatography. The content of the sum of phenolic compounds, hydroxycyclic acids and flavonoids was determined by the spectrophotometric method. Based on the held reactions and chromatographic analysis, by the characteristic fluorescence in the filtered UV light before and after treatment with chromogenic reagents and the values of Rf in the raw material the presence of the following groups of biologically active substances were determined: flavonoids, phenol glycosides, hydroxycoric acids. According to the chromatographic analysis, at least 9 substances of phenolic nature have been detected in the alcohol-aqueous extracts. For the first time, the presence of the following groups of biologically active substances: hydroxycoric acids, phenologic glycosides, flavonoids was determined in the leaves of catalpa. Quantitative content of natural compounds in the leaves of common catalpa: the sum of phenolic compounds (4,76 ± 0,04%), of hydroxycoric acids (3,42 ± 0,02%), of flavonoids (1,88 ± 0,02%). The results of the study will be used in the development of the draft quality control methods for medicinal plant raw materials.

Micellar-mediated extraction of green tea containing Chrysanthemum morifolium flowers

2017 ◽  
Vol 1 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Justyna Suliga ◽  
Paweł Śliwa
Keyword(s):  
Fatty Acids ◽  
Phenolic Compounds ◽  
Green Tea ◽  
Plant Material ◽  
Chrysanthemum Morifolium ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Tween 20 ◽  
Sorbitan Esters ◽  
Active Substances

Micellar mediated extraction (MME) is a new and alternative method of obtaining biologically active substances, such as flavones, flavanones, anthocyanins, triterpene from plant material. In this study a series of polyethoxylated sorbitan esters of fatty acids (Tween 20, 40, 60 and 80) have been applied for the extraction of green tea containing Chrysanthemum morifolium flowers. Results showed that all tested surfactants were effective in the solubilisation of flavonoids and phenolic compounds. Probably, because of too high hydrophilicity, Tween 20 was not sufficient to obtain antioxidants, in contrast to another Tween. It has been shown that method is economical, attractive and ecological.

scholarly journals Comparative study of phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine

2021 ◽  
pp. 66-75
Author(s):  
Iryna Sas ◽  
Andrii Hrytsyk ◽  
Taras Koliadzhyn ◽  
Oleh Koshovyi
Keyword(s):  
Phenolic Compounds ◽  
Comparative Study ◽  
Hydroxycinnamic Acids ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Drugs ◽  
Raw Material ◽  
Wide Range ◽  
Nitrogen Containing Compounds ◽  
Active Substances

Species of Betonica L. genus are widespread in Ukraine and contain different groups of biologically active substances: hydroxycinnamic acids, flavonoids, tannins, iridoids, terpenoids, steroids, essential oil, organic acids, vitamin K, nitrogen-containing compounds, phenylethanoid glycosides. Species of Betonica L. genus show a wide range of pharmacological activity (anti-inflammatory, antioxidant, choleretic, diuretic, sedative, antitumor, antihypertensive, etc.) and phenolic compounds are one of the most important and promising groups of biologically active substances of these plants. The aim. The aim of the work was to conduct a comparative study of the phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine. Materials and methods. The object of the study was the herb of Betonica peraucta and Betonica brachydonta harvested in the phase of mass flowering of the plant in Ivano-Frankivsk region. The study of phenolic compounds was carried out by paper chromatography, HPLC and spectrophotometry. Results. 7 components of tannins, 4 flavonoids, 5 hydroxycinnamic acids, 2 coumarins were identified and quantified by HPLC in the studied raw material. The quantitative content of the main groups of phenolic compounds in the herb of Betonica peraucta and Betonica brachydonta was determined by the method of absorption spectrophotometry: polyphenols – 5.96 % and 4.82 %, tannins – 1.62 % and 0.68 %, flavonoids – 2.07 % and 1.13 %, hydroxycinnamic acids – 7.01 % and 3.58 %, respectively. Conclusions. As a result of the conducted studies it was found that the content of phenolic compounds in the herb of Betonica peraucta is significantly higher than in the herb of Betonica brachydonta. Therefore, this species is promising for further research and creation of new drugs

scholarly journals EDIBLE ONION FLOWERS (ALLIUM L.) AS A SOURCE OF BIOLOGICALLY ACTIVE SUBSTANCES

2021 ◽  
pp. 291-297
Author(s):  
Tat'yana Ivanovna Fomina ◽  
Tat'yana Abdulkhailovna Kukushkina
Keyword(s):  
Phenolic Compounds ◽  
Raw Materials ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Raw Material ◽  
Forest Steppe ◽  
Dry Matter Content ◽  
Total Sugars ◽  
Active Substances ◽  
Pectin Substances

The results of comparative study of the content of biologically active substances in the flowers of 10 species of perennial onions Allium aflatunense B. Fedtsch., A. altaicum Pall., A. flavum L., A. microdictyon Prokh., A. nutans L., A. obliquum L., A. ramosum L., A. rosenbachianum Regel, A. schoenoprasum L., A. senescens L. var. glaucum Regel (A. senescens ssp. glaucum (Schrad.) N. Friesen) are presented. The freshly collected raw materials in the phase of mass flowering were analyzed. The dry matter content was determined by drying 1 g of raw material at 100–105 °C to a constant mass. The amount of phenolic compounds, pectin substances, total sugars, and carotenoids was determined spectrophotometrically using SF-56 (Russia) and SF "Agilent" 8453 (USA). For the first time, data on the quantitative content of the main groups of secondary metabolites in onion flowers were obtained. It has been established that in the forest-steppe of Western Siberia, flowers of Allium species contain: 10.7-22.5% dry substances, 6.6-26.2% total sugars, 3.3–18.6% pectin substances, 3.6–10.6% phenolic compounds, 3.0–23.4  mg% carotenoids (per mass of absolutely dry materials) and 35.4–157.8 mg% ascorbic acid (per mass of raw materials). The highest values were found for A. rosenbachianum, A. flavum, and A. aflatunense. The high variability of the accumulation of biologically active substances is due to the species and the influence of weather conditions during the growing season. The study showed the prospects for using onion flowers as a source of various bioactive compounds, including when added to food.

scholarly journals INFLUENCE OF DIFFERENT TECHNOLOGICAL PROCESSES ON THE CONTENT OF BIOLOGICALLY ACTIVE SUBSTANCES AT THE PRODUCTION OF DRY RED WINE FROM THE CABERNET SAUVIGNON VARIETY

Akademos ◽  
2021 ◽  
Vol 60 (1) ◽  
pp. 63-67
Author(s):  
Nicolae Taran ◽  
◽  
Boris Morari ◽  
Olga Soldatenco ◽  
◽  
...  
Keyword(s):  
Red Wine ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Cabernet Sauvignon ◽  
Red Wines ◽  
Wine Production ◽  
Technological Processes ◽  
Active Substances

This research was focused on the influence of different fermentation-maceration processes for the optimization of the extraction of anthocyanins, tannins and biologically active substances from grapes of the Cabernet Sauvignon variety and their impact on the quality during dry red wine production. It was determined that increasing the duration of the fermentation-maceration process and extracting 20 % of the juice from the must allow the production of dry red wines with high proanthocyanidin content.

scholarly journals New Biotechnology for the Production of Phytocompounds from Secondary Products of Grain Processing

2019 ◽  
Vol 49 (1) ◽  
pp. 5-13
Author(s):  
Анна Битюкова ◽  
Anna Bityukova ◽  
Александра Амелькина ◽  
Alexandra Amelkina ◽  
Александр Евтеев ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Antioxidant Properties ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Secondary Products ◽  
Functional Ingredients ◽  
Biotechnological Approach ◽  
Oat Bran ◽  
Active Substances

The present research features a new biotechnological approach for complex processing of secondary cereal products. The approach makes it possible to obtain new functional foods and ingredients, such as carbohydrate-protein concentrate, dietary fiber concentrates, biologically active substances, polyphenols, and xylo-oligosaccharides. The complex biotechnology involves oat bran biotransformation and includes chemical, hydrothermal, and enzymatic methods of extraction, which allows manufacturers to obtain functional ingredients with antioxidant and prebiotic properties. The concentrates obtained as a result of the study contained a significant amount of protein, hydrolysis products of polysaccharides (glucose, maltodextrins), and free polyphenols. The experiment produced concentrates of biologically active substances containing xylo-oligosaccharides and phenolic compounds. The content of polyphenols was 67% of the total amount in oat bran, protein – 6.9%, carbohydrates – 80.7% xylo-oligosaccharides whith prebiotic properties 35.3%–71.5%, and ash 11.3%. The obtained data indicated a high antioxidant activity of polyphenol extracts. The differences in antioxidant activity between various methods of extraction are associated primarily with the completeness of extraction and the stability of the extracted phenolic compounds. Ultrasonic treatment proved beneficial for the extraction kinetics and the polyphenol yield at the initial stage, with an increase in antioxidant properties. As for the antioxidant activity of polyphenol concentrate during storage, the research did not reveal changes for 8 months at a temperature of 20 ± 1°C and a relative humidity of 70 ± 5%. The study of the growth dynamics of Lactobacillus acidophilus and Bifi obacterium bifi um in media containing xylo-oligosaccharide concentrate confirmed the presence of prebiotic properties and their selectivity. The accumulation of biomass of prebiotic cultures occurred faster with the use of nutrient media with the use of xylo-oligosaccharide concentrate and lactulose, as compared with milk. Thus, the research confirmed the feasibility of biotechnology for transforming oat bran into functional ingredients, which makes it possible to use them in new technological solutions for products with bifidogenic properties.

scholarly journals THE STUDY OF ANTIOXIDANT ACTIVITY OF THE HERB ASTRAGALUS GLYCYPHYLLUS L

2019 ◽  
Vol 19 (1-2) ◽  
pp. 27-32
Author(s):  
T. A Pozdnyakova ◽  
R. A Bubenchikov
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Phenolic Compounds ◽  
Raw Materials ◽  
Natural Antioxidants ◽  
Hydroxycinnamic Acids ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Chain Reactions ◽  
Active Substances

Topicality. In the process of originating and development of many diseases, an important role belongs to free radicals, which trigger chain reactions leading to damage of cells and tissues. The natural antioxidants can help to neutralize free radicals, among which phenolic compounds are the most active. The presence of these groups of biologically active substances in the herb Astragalus glycyphyllus L. suggests the presence of antioxidant activity in the phyto-complexes of the studied plant. The purpose of this research was to study the antioxidant activity of extracts from the herb Astragalus glycyphyllus L. Materials and methods. The object of the study was the air-dry herb Astragalus glycyphyllus L. harvested in the period of mass flowering. To obtain the most reliable results of the study, the investugation of the antioxidant activity of extracts from the herb Astragalus glycyphyllus L. was carried out by two met hods: by the method based on the chemical reaction between potassium permanganate and regenerating biologically active substances contained in extracts from the studied plant and by spectrophotometry of free radicals based on the reaction interactions of 2,2-diphenyl-1-picrylhydrazyl with antioxidants contained in plant raw materials. To establish the dependence between the antioxidant activity and the presence of phenolic compounds in the plant, the content of flavonoids and hydroxycinnamic acids in Astragalus glycyphyllus L. was determined. Results. It was found that all the studied extracts from the herb Astragalus glycyphyllus L. have antioxidant activity, but their values are different depending on the used extractant. In this case, a consistent pattern is observed between the content in the extraction of phenolic compounds (hydroxycinnamic acids and flavonoids) and the magnitude of antioxidant activity. Conclusions. As a result of the conducted research, the total antioxidant activity of extracts from the herb Astragalus glycyphyllus L. was established. Its value was found to be related to the content of phenolic compounds in the plant by a positive correlation. The obtained data indicate the promising use of the herb Astragalus glycyphyllus L. as a source of natural antioxidants. · Keywords: Astragalus glycyphyllus L.; antioxidant activity; flavonoids; hydroxycinnamic acids; free radicals.

scholarly journals Innovative Method for Obtaining Biologically Active Compounds from Brewery Mash

2021 ◽  
Vol 51 (1) ◽  
pp. 113-124
Author(s):  
Konstantin Kobelev ◽  
Marina Gernet ◽  
Irina Gribkova
Keyword(s):  
Phenolic Compounds ◽  
Phenolic Acids ◽  
Raw Materials ◽  
Ethanol Solution ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Cellulolytic Enzyme ◽  
Enzyme Preparations ◽  
Naoh Solution ◽  
Active Substances

Introduction. Brewery mash, or brewer’s spent grain (BSG), is a by-product of brewing industry. It is known to contain valuable biologically active substances. However, their extraction is complicated by the presence of various polymers. The research featured various physicochemical methods for obtaining valuable biological compounds from brewery waste. The new method modified complex non-starch polysaccharides, lignin, arabinoxylans, and other high-molecular compounds associated with phenolic compounds. The research objective was to solve the problem of recycling industrial by-products that accumulate in large quantities and require expensive processing or disposal. The paper introduces new technological approaches for deep processing of BSG as a source of secondary raw materials in order to obtain extracts fortified with polyphenolic compounds. Study objects and methods. The research featured BSG from malt subjected to treatment with ECA-activated water (catholyte with pH 9.6 ± 0.1), followed by enzymatic hydrolysis of cellulolytic enzyme preparations and extraction with a polar solvent of the resulting free polyphenolic substances. The experiments were based on standard methods for assessing the content of various biologically active substances. Results and discussion. A 70% water-ethanol solution proved to be optimal at the BSG:extractant ratio of 2:1, process temperature = 50 ± 2°C, and extraction time = 60 ± 5 min. Under the same conditions, 70 %vol. of beer distillate made it possible to extract phenolic acids, flavonoid rutin, irreplaceable and nonessential amino acids, and non-starch polysaccharide β-glucan from the BSG matrix. The BSG treatment with 1M NaOH solution delivered viscous hydrolysates fortified with flavonoids rutin and quercetin, which did not happen when acid hydrolysis was used. The combined use of ECA-treated water (catholyte with pH 9.6 ± 0.1) for 24 ± 0.05 h, combined with biocatalysis with the enzyme preparation Viskoflo MG for 2 ± 0.05 h, made it possible to obtain BSG extracts with a high content of phenolic acids and aldehydes, as well as flavonoid rutin. Conclusion. The study revealed the mechanism of hydrolytic decomposition of BSG non-starch polysaccharides, considering the compounds contained in the extracts. The BSG hydrolysates fortified with various phenolic compounds can be used in various food technologies, e.g., in fermented drinks.

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