scholarly journals A Survey on the Prevalence of Chlamydia Trachomatis and Mycoplasma Genitalium Infections in Symptomatic and Asymptomatic Men Referring to Urology Clinic of Labbafinejad Hospital, Tehran, Iran

2013 ◽  
Vol 15 (4) ◽  
pp. 340-4 ◽  
Author(s):  
Omid Yeganeh ◽  
Mahmood Jeddi-Tehrani ◽  
Farhad Yaghmaie ◽  
Kourosh Kamali ◽  
Hamed Heidari-Vala ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Mycoplasma Genitalium ◽  
Urology Clinic ◽  
Asymptomatic Men

scholarly journals Prevalence of urogenital, anal, and pharyngeal infections with Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium: a cross-sectional study in Reunion island

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
A. Calas ◽  
N. Zemali ◽  
G. Camuset ◽  
J. Jaubert ◽  
R. Manaquin ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Neisseria Gonorrhoeae ◽  
Mycoplasma Genitalium ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Transmitted Infection ◽  
Cross Sectional ◽  
Sexually Transmitted ◽  
Urogenital Infection ◽  
High Prevalence

Abstract Background Recommendations for sexually transmitted infection (STI) screening vary significantly across countries. This study evaluated the prevalence of urogenital and extragenital infections with Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Mycoplasma genitalium (MG) in patients visiting a French STI clinic in the Indian Ocean region to determine whether current STI screening practices should be updated. Methods This cross-sectional study examined all patients who visited the STI clinic between 2014 and 2015. Triplex polymerase chain reaction screening for CT, NG, and MG was performed on urine, vaginal, pharyngeal, and anal specimens (FTD Urethritis Basic Kit, Fast Track Diagnostics, Luxembourg). Results Of the 851 patients enrolled in the study, 367 were women (367/851, 43.2%) and 484 were men (484/851, 56.0%). Overall, 826 urogenital specimens (826/851, 97.1%), 606 pharyngeal specimens (606/851, 71.2%), and 127 anal specimens (127/851, 14.9%) were taken from enrolled patients. The prevalence of urogenital CT and MG was high in women ≤25 years (19/186, 10.21%; 5/186, 2.69%) and in men who have sex with women ≤30 years (16/212, 7.54%; 5/212, 2.36%). Among patients with urogenital CT infection, 13.7% (7/51) had urethritis. All patients with urogenital MG infection were asymptomatic. Men who have sex with men had a high prevalence of pharyngeal CT (2/45, 4.44%) and NG (3/44, 6.81%) and a high prevalence of anal CT (2/27, 7.41%), NG (2/27, 7.40%), and MG (1/27, 3.70%). After excluding patients with concomitant urogenital infection, extragenital infections with at least 1 of the 3 pathogens were found in 20 swabs (20/91, 21.9%) taken from 16 patients (16/81, 19.7%), all of them asymptomatic. Conclusions Routine multisite screening for CT, NG, and MG should be performed to mitigate the transmission of STIs in high-risk sexually active populations.

scholarly journals Mycoplasma Genitalium Among Women With Nongonococcal, Nonchlamydial Pelvic Inflammatory Disease

2006 ◽  
Vol 2006 ◽  
pp. 1-5 ◽  
Author(s):  
Catherine L. Haggerty ◽  
Patricia A. Totten ◽  
Sabina G. Astete ◽  
Roberta B. Ness
Keyword(s):  
Chlamydia Trachomatis ◽  
Pelvic Inflammatory Disease ◽  
Young Women ◽  
Inflammatory Disease ◽  
Plasma Cells ◽  
Mycoplasma Genitalium ◽  
Pelvic Organ ◽  
Etiologic Agent ◽  
Surface Epithelium ◽  
Pilot Sample

Pelvic inflammatory disease (PID) is a frequent condition of young women, often resulting in reproductive morbidity. Although Neisseria gonorrhoeae and/or Chlamydia trachomatis are/is recovered from approximately a third to a half of women with PID, the etiologic agent is often unidentified. We need PCR to test for M genitalium among a pilot sample of 50 women with nongonococcal, nonchlamydial endometritis enrolled in the PID evaluation and clinical health (PEACH) study. All participants had pelvic pain, pelvic organ tenderness, and leukorrhea, mucopurulent cervicitis, or untreated cervicitis. Endometritis was defined as≥5 surface epithelium neutrophils per×400field absent of menstrual endometrium and/or≥2 stromal plasma cells per×120field. We detected M genitalium in 7 (14%) of the women tested: 6 (12%) in cervical specimens and 4 (8%) in endometrial specimens. We conclude that M genitalium is prevalent in the endometrium of women with nongonococcal, nonchlamydial PID.

Urethral inflammatory response to ureaplasma is significantly lower than to Mycoplasma genitalium and Chlamydia trachomatis

2016 ◽  
Vol 28 (8) ◽  
pp. 773-780 ◽  
Author(s):  
Harald Moi ◽  
Nils Reinton ◽  
Ivana Randjelovic ◽  
Elina J Reponen ◽  
Line Syvertsen ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Inflammatory Response ◽  
Ureaplasma Urealyticum ◽  
Mycoplasma Genitalium ◽  
Nucleic Acid Amplification ◽  
Rrna Gene ◽  
Polymorphonuclear Leucocytes ◽  
Male Patients ◽  
Micro Organisms

A non-syndromic approach to treatment of people with non-gonococcal urethritis (NGU) requires identification of pathogens and understanding of the role of those pathogens in causing disease. The most commonly detected and isolated micro-organisms in the male urethral tract are bacteria belonging to the family of Mycoplasmataceae, in particular Ureaplasma urealyticum and Ureaplasma parvum. To better understand the role of these Ureaplasma species in NGU, we have performed a prospective analysis of male patients voluntarily attending a drop in STI clinic in Oslo. Of 362 male patients who were tested for NGU using microscopy of urethral smears, we found the following sexually transmissible micro-organisms: 16% Chlamydia trachomatis, 5% Mycoplasma genitalium, 14% U. urealyticum, 14% U. parvum and 5% Mycoplasma hominis. We found a high concordance in detecting in turn U. urealyticum and U. parvum using 16s rRNA gene and ureD gene as targets for nucleic acid amplification testing (NAAT). Whilst there was a strong association between microscopic signs of NGU and C. trachomatis infection, association of M. genitalium and U. urealyticum infections in turn were found only in patients with severe NGU (>30 polymorphonuclear leucocytes, PMNL/high powered fields, HPF). U. parvum was found to colonise a high percentage of patients with no or mild signs of NGU (0–9 PMNL/HPF). We conclude that urethral inflammatory response to ureaplasmas is less severe than to C. trachomatis and M. genitalium in most patients and that testing and treatment of ureaplasma-positive patients should only be considered when other STIs have been ruled out.

scholarly journals In Vitro Activity of Lefamulin against Sexually Transmitted Bacterial Pathogens

2018 ◽  
Vol 62 (5) ◽  
Author(s):  
Susanne Paukner ◽  
Astrid Gruss ◽  
Jørgen Skov Jensen
Keyword(s):  
Chlamydia Trachomatis ◽  
Bacterial Pathogens ◽  
Mycoplasma Genitalium ◽  
Standard Of Care ◽  
Multidrug Resistant ◽  
In Vitro Activity ◽  
First Line ◽  
Content Type ◽  
Sexually Transmitted

ABSTRACT The pleuromutilin antibiotic lefamulin demonstrated in vitro activity against the most relevant bacterial pathogens causing sexually transmitted infections (STI), including Chlamydia trachomatis (MIC 50/90 , 0.02/0.04 mg/liter; n = 15), susceptible and multidrug-resistant Mycoplasma genitalium (MIC range, 0.002 to 0.063 mg/liter; n = 6), and susceptible and resistant Neisseria gonorrhoeae (MIC 50/90 , 0.12/0.5 mg/liter; n = 25). The results suggest that lefamulin could be a promising first-line antibiotic for the treatment of STI, particularly in populations with high rates of resistance to standard-of-care antibiotics.

Negonorėjiniai uretritai: etiopatogenezė, klinikos, diagnostikos ir gydymo savitumai

2021 ◽  
Vol 25 (4) ◽  
pp. 259-264
Author(s):  
Simona Žilinskienė ◽  
Arūnas Petkevičius
Keyword(s):  
Chlamydia Trachomatis ◽  
Ureaplasma Urealyticum ◽  
Mycoplasma Hominis ◽  
Mycoplasma Genitalium ◽  
Gardnerella Vaginalis ◽  
Ureaplasma Parvum

Negonorėjinis uretritas (NGU) yra dažniausia vyrų lytinių takų liga. Mokslinių tyrimų rezultatais pagrįsta, kad pagrindiniai sukėlėjai yra Chlamydia trachomatis, Mycoplasma genitalium, Ureaplasma urealyticum. Įdiegus pažangius molekulinės diagnostikos metodus, dažnai šlaplės mikrofloroje randama Mycoplasma hominis, Ureaplasma parvum, Gardnerella vaginalis ir kitų saprofitinių mikroorganizmų, kurių svarba uretritų etiopatogenezėje yra prieštaringa ir iki galo neišaiškinta. Negydytas vyrų uretritas gali sukelti sutrikimų, susijusių su reprodukcine bei lytine funkcija, ir yra viena iš pagrindinių nevaisingumo priežasčių. Šio straipsnio tikslas yra, apžvelgus mokslinę literatūrą, išanalizuoti vyrų NGU epidemiologiją, priežastis, diagnostikos ir gydymo galimybes.

Non-gonococcal urethritis and mucopurulent cervicitis

2019 ◽  
pp. 161-168
Keyword(s):  
Antibiotic Resistance ◽  
Chlamydia Trachomatis ◽  
Clinical Features ◽  
Mycoplasma Genitalium ◽  
Common Cause ◽  
Urethral Discharge ◽  
Separate Section ◽  
Diagnosis And Management ◽  
Gonococcal Urethritis

Non-gonococcal urethritis (NGU) is caused by Chlamydia trachomatis in 11–50% of cases, but Mycoplasma genitalium is being increasingly recognized as a common cause. Mycoplasma genitalium is not as well understood, and experience with treatment is limited; however, antibiotic resistance is already a problem. Asymptomatic in up to 20% of men, symptoms include dysuria and urethral discharge. Mucopurulent cervicitis is the female equivalent, but is less well defined. This chapter describes the aetiology, clinical features, complications, and investigations and management of NGU, and mucopurulent cervicitis. Management of recurrent and persistent urethritis is also covered, including a separate section for diagnosis and management of Mycoplasma genitalium.

Urethritis

2020 ◽  
pp. 1606-1609
Author(s):  
Patrick Horner
Keyword(s):  
Chlamydia Trachomatis ◽  
Neisseria Gonorrhoeae ◽  
Partner Notification ◽  
Mycoplasma Genitalium ◽  
Urethral Discharge ◽  
Gonococcal Urethritis

Urethritis is defined as detectable urethral inflammation in the presence of symptoms or an observable urethral discharge. It is conventionally classified into gonococcal urethritis (GU, caused by Neisseria gonorrhoeae) and non-gonococcal urethritis (NGU, caused by Chlamydia trachomatis, Mycoplasma genitalium, and other causes, but with no known pathogen detected in over 30% of cases). Diagnosis is by urethral smear and microbiological investigations. Treatment with appropriate antibiotics should be given only to those with proven urethritis, and the diagnosis and its implications should be discussed with the patient. Partner notification is essential, not only to prevent re-infection but also to prevent onward transmission from partner(s) and the development of complications if left untreated.

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