Prevalence of Transfusion Transmissible Infections Among Blood Donors in South Khorasan Province, Iran: An 11-Year Study

Objectives: Transfusion transmissible infections are the most frequent complication of blood transfusions. This study was done to determine the prevalence of the hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and syphilis among blood donors at the South Khorasan Transfusion Center (SKBTC) in South Khorasan Province, Iran. This report is the first of its kind that has been performed in this region. Methods: A retrospective study was carried out on 165,267 blood donors at the SKBTC from 2006 to 2016. Data were analyzed on the metrics of donation status, age, gender, educational level, and serologic results for the infectious markers. Statistical analysis was performed using SPSS software (version 16.0). Results: The overall seroprevalence rates of HBV, HCV, and HIV infections per 100,000 donations were 247, 21, and 0.6, respectively. There was no positive donor for syphilis. HBV and HCV infections in first-time donors were present at significantly higher rates than in regular and repeat donors (P < 0.001 and P = 0.003, respectively). Although gender was not found to be significantly associated with HBV and HCV (P = 0.32), there was a significant relationship between younger age (P < 0.001) as well as lower educational level and hepatitis agents (P < 0.001). Moreover, being single evinced a significant association with HCV seropositivity (P = 0.001). Conclusions: This report found a decreased prevalence of TTIs relative to the most of previous reports. This decrease may have resulted from public health programs, improved donor selection, improved recruitment of repeat/regular donors, and the use of highly sensitive kits for the screening procedure.

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Transfusion-transmissible infections among blood donors in Kathmandu, Nepal

The Journal of Infection in Developing Countries ◽

10.3855/jidc.311 ◽

2009 ◽

Vol 3 (10) ◽

pp. 794-797 ◽

Cited By ~ 23

Author(s):

Ashish Chandra Shrestha ◽

Prakash Ghimire ◽

Bishnu Raj Tiwari ◽

Manita Rajkarnikar

Keyword(s):

Blood Donors ◽

Treponema Pallidum ◽

Cost Effective ◽

Age Group ◽

Cost Effective Approach ◽

Highly Sensitive ◽

B Virus ◽

Hbv Prevalence ◽

Donated Blood ◽

First Time

Background: Screening of transfusion-transmissible infections (TTIs) among blood donors can be a cost-effective approach to monitor the prevalence, distribution, and trends of the infections among healthy-looking individuals. The study aimed to determine the seroprevalence of four TTIs, human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis, among blood donors in Kathmandu, Nepal. Methodology: A total of 21,716 units of blood were tested for the presence of anti-HIV 1/2 IgG/IgM, HBsAg, anti-HCV IgG/IgM, and anti-Treponema pallidum IgG/IgM/IgA using commercial ELISA kits following standard protocols. Statistical analysis was performed using WinPepi Ver 3.8. Results: Seroprevalence of HIV, HBV (HBsAg), HCV and syphilis were observed to be 0.12% (95% CI = 0.08-0.18), 0.47% (95% CI = 0.39-0.57), 0.64% (95% CI = 0.54-0.75) and 0.48% (95% CI = 0.40-0.59) respectively. TTIs were dominant among male blood donors compared to female blood donors. Higher HCV seroprevalence among males compared to females was statistically significant. HIV prevalence was highest among blood donors in the age group 31 to 40 years (P > 0.5). HBV, HCV and syphilis prevalence was highest among blood donors 41 to 50 years age group, 21 to 30 years age group, and 51 to 60 years age group respectively (P < 0.05). HIV and HBV prevalence was relatively higher among first-time donors, whereas HCV and syphilis was relatively higher among the repeated donors (P > 0.05). Conclusions: It is of utmost importance to continue screening donated blood with highly sensitive and specific tests and to counsel donors who are positive to any of the above infections. It is absolutely necessary to avoid the transmission of infection from repeat donors.

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Epidemiology of hepatitis B virus infection in first-time blood donors in the southwestern region of Goiás, central Brazil

Revista Brasileira de Hematologia e Hemoterapia ◽

10.5581/1516-8484.20110013 ◽

2010 ◽

Vol 33 (1) ◽

pp. 38-42 ◽

Cited By ~ 3

Author(s):

Giulena Rosa Leite Cardoso dos Anjos ◽

Regina Maria Bringel Martins ◽

Megmar Aparecida dos Santos Carneiro ◽

Sandra Maria Brunini ◽

Sheila Araujo Teles

Keyword(s):

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Blood Donors ◽

Hepatitis B Virus Infection ◽

Central Brazil ◽

B Virus ◽

First Time

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Cytomegalovirus seroprevalence and ‘cytomegalovirus-safe’ seropositive blood donors

Epidemiology and Infection ◽

10.1017/s0950268809990094 ◽

2009 ◽

Vol 137 (12) ◽

pp. 1776-1780 ◽

Cited By ~ 11

Author(s):

K. G. BADAMI ◽

S. McQUILKAN-BICKERSTAFFE ◽

J. E. WELLS ◽

M. PARATA

Keyword(s):

New Zealand ◽

Confidence Interval ◽

Lower Risk ◽

Blood Donors ◽

Age Groups ◽

Pacific Islanders ◽

Cmv Infection ◽

Younger Age ◽

First Time

SUMMARYCytomegalovirus (CMV) seroprevalence was determined in 9343 first-time New Zealand blood donors between 2003 and 2006. Of 39 960 current seropositive donors the proportion testing seropositive more than 12 months previously was calculated. Overall, seroprevalence declined from 66·1% [95% confidence interval (CI) 64·1–68·1] in 2003 to 60·6% (95% CI 58·5–62·6) in 2006. Nevertheless, these rates are significantly higher than the 47% overall seroprevalence found in a 1988 study. Seroprevalence was higher in females than males and in older than in younger age groups in all four years examined. Ethnicity appeared to be related to seroprevalence with the highest rates found in Pacific Islanders (93·2%) and the lowest in Caucasians (54·8%). At least 38 242/39 960 (95·7%) seropositive donors were found to have seroconverted more than 12 months previously. Recent evidence suggests that such ‘remote’ seroconverters may pose a much lower risk of transfusion-transmitted CMV infection than recently infected seroconverting, but seronegative, blood donors.

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Epidemiology of hepatitis B virus infection in first-time blood donors in the southwestern region of Goiás, central Brazil

Revista Brasileira de Hematologia e Hemoterapia ◽

10.5581/v33n1a13 ◽

2010 ◽

Vol 33 (1) ◽

pp. 38-42

Author(s):

Giulena Rosa Leite Cardoso dos Anjos ◽

Regina Maria Bringel Martins ◽

Megmar Aparecida dos Santos Carneiro ◽

Sandra Maria Brunini ◽

Sheila Araujo Teles

Keyword(s):

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Blood Donors ◽

Hepatitis B Virus Infection ◽

Central Brazil ◽

B Virus ◽

First Time

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HTLV-1/2 seroprevalence and coinfection rate in Brazilian first-time blood donors: an 11-year follow-up

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652012000300002 ◽

2012 ◽

Vol 54 (3) ◽

pp. 123-130 ◽

Cited By ~ 20

Author(s):

Mariana Tomazini Pinto ◽

Evandra Strazza Rodrigues ◽

Tathiane Maistro Malta ◽

Rochele Azevedo ◽

Osvaldo Massaiti Takayanagui ◽

...

Keyword(s):

Blood Donors ◽

Infected Individual ◽

Epidemiological Studies ◽

Confirmatory Test ◽

Serological Tests ◽

Blood Donations ◽

B Virus ◽

Immunodeficiency Virus ◽

First Time

The seroprevalence and geographic distribution of HTLV-1/2 among blood donors are extremely important to transfusion services. We evaluated the seroprevalence of HTLV-1/2 infection among first-time blood donor candidates in Ribeirão Preto city and region. From January 2000 to December 2010, 1,038,489 blood donations were obtained and 301,470 were first-time blood donations. All samples were screened with serological tests for HTLV-1/2 using enzyme immunoassay (EIA). In addition, the frequency of coinfection with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Chagas disease (CD) and syphilis was also determined. In-house PCR was used as confirmatory test for HTLV-1/2. A total of 296 (0.1%) first-time donors were serologically reactive for HTLV-1/2. Confirmatory PCR of 63 samples showed that 28 were HTLV-1 positive, 13 HTLV-2 positive, 19 negative and three indeterminate. Regarding HTLV coinfection rates, the most prevalent was with HBV (51.3%) and HCV (35.9%), but coinfection with HIV, CD and syphilis was also detected. The real number of HTLV-infected individual and coinfection rate in the population is underestimated and epidemiological studies like ours are very informative.

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Seroprevalence of Hepatitis B virus infection among blood donors in Shia Muslims in a population of Lucknow

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v12i2.14942 ◽

2013 ◽

Vol 12 (2) ◽

pp. 146-149

Author(s):

Sharique Ahmed ◽

Himanshu Chaturvedi ◽

Syed Riaz Mehdi

Keyword(s):

Hepatitis B ◽

Blood Donors ◽

Public Awareness ◽

Medical Science ◽

Hepatitis B Infection ◽

Future Studies ◽

Medical College ◽

B Virus ◽

Awareness Programs ◽

First Time

Background: The objective of this study was to determine the prevalence and trends in hepatitis B infection among blood donors Shia Muslims attending the blood bank in Era's Lucknow Medical College lucknow. A retrospective study was carried out by reviewing the results of HBsAg among blood donors for the years 2002 to 2012. During this period,11962 blood donors were studied. Conclusion: There is a constant need to improve public awareness programs to lower the incidence of hepatitis B infection in the general population and in Shia Muslims and consequently first time blood donors. Future studies are also required to determine the trends and outcomes of these programs. Bangladesh Journal of Medical Science Vol. 12 No. 02 April13 Page 146-149 DOI: http://dx.doi.org/10.3329/bjms.v12i2.14942

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The contemporary status of the blood donorship in the Mari El Republic

Kazan medical journal ◽

10.17816/kmj1784 ◽

2013 ◽

Vol 94 (1) ◽

pp. 116-120

Author(s):

E Y Zangerova

Keyword(s):

Blood Transfusion ◽

Blood Donors ◽

Blood Components ◽

Gender Distribution ◽

Transfusion Center ◽

Blood Transfusion Center ◽

Weak Points ◽

Contemporary Status ◽

The Republic ◽

First Time

Aim. To detect the weak points of the existing system of blood donors’ draw in, to define the paths of blood donorship development in the Republic of Mari El. Methods. The analysis of the existing system of donorship at the period from 2002 to 2011 was conducted according to the data of combined yearly reports, data of united blood transfusion center of the Republic of Mari El database, data of Russia’s blood transfusion system facilities activity analysis. The changes in the number of blood donors, activity of blood donors, and detection of blood-transmitted diseases markers were evaluated. Results. No need for further significant increase in the number of active donors was detected, since the modern methods of blood and blood components preparation allows to increase the amounts of required blood components by other ways. The decrease in donors’ mean age was registered, the share of donors younger than 30 increased 2.8-fold compared to 2002 and 1.46-fold compared to 2007. The mean age of donors is 33,94±0,14 years, gender distribution (females - 39.2%, males - 60.8%) do not collide with the gender distribution of the general population. The share of plasma donors has significantly increased (4.8-fold in 2011). Since 2009 the share of first-time donors has increased to 42.9%, indicating the instability of the group of people ready to donate blood. Electronic database introduction and active use allows to exclude people with blood-transmitted diseases and other absolute contraindications from donating blood. The share of people willing to donate blood with registered blood-transmitted diseases has relatively dropped from 4.18% in 2007 to 1.42% in 2011. Conclusion. The main goal of blood transfusion services of Mari El Republic is still to increase the number of permanent donors, donating blood regularly, it will allow to increase the safety of blood components produced and provide the blood transfusion services stability.

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Hemogram abnormalities in apparently healthy first-time blood donors in Libreville, Gabon.

Sudan Journal of Medical Sciences ◽

10.18502/sjms.v14i3.5210 ◽

2019 ◽

Author(s):

Cyrille BISSEYE ◽

Jophrette Mireille Ntsame Ndong ◽

Landry Erik Mombo ◽

Hornéla Christine Minkoue Mambéri ◽

Guy Mouelet Migolet ◽

...

Keyword(s):

Blood Donors ◽

Blood Donation ◽

Complete Blood Count ◽

Selection Process ◽

Hypochromic Anemia ◽

Transfusion Center ◽

Blood Transfusion Center ◽

Normochromic Anemia ◽

First Time ◽

Apparently Healthy

Background: The objective of this study was to determine complete blood count (CBC) abnormalities in Libreville blood donors to advocate for hemoglobin pre-donation implementation and to take into account CBC results in blood donation qualification. Methods: This retrospective study was conducted with 4573 blood donors in March 2016 and from January to April 2017. CBC was performed using SysmexXP-300TM hematology analyzer (SYSMEX Corporation, Kobe, Japan). Results: Blood donors were predominantly males (83.7%) with an age ranging from 18 to 59 years. The abnormalities of leukocyte, platelet and erythrocyte counts were determined in blood donors. Leukopenia and thrombocytopenia were significantly more common in men than women (29.02% vs 24.4%, p = 0.011 and 16.2% vs 7.5%, p <0.001). Only 1.0% of women and 0.84% of men have leukocytosis, and 0.7% of women and 0.2% of men have thrombocytosis. Anemia was significantly more common in women compared to men (69.4% vs. 45.0%, P <0.001). Normocytic normochromic and normocytic hypochromic anemia were most common among Libreville blood donors with 39.4% and 23.6%; followed by microcytic normochromic (18.7%) and microcytic hypochromic (13.2%) anemia. Normocytic normochromic and normocytic hypochromic anemia were significantly more common in men than in women, whereas microcytic normochromic anemia was more prevalent among women compared to men (34.6% vs. 13.9%, p <0.001). Conclusions: The results of this study clearly show the need to perform a pre-donation hemoglobin test in blood donors and to take into account their hemogram in the blood donation selection process at the Libreville National Blood Transfusion Center. Keywords: Hemogram, Anemia, Blood Donors, Libreville, Gabon.

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