Anti-epileptic Activity of Carica papaya seed extract in Experimental Animals

2019 ◽  
Vol 12 (12) ◽  
pp. 6007
Author(s):  
Divya ◽  
Prasanna Shama Khandige ◽  
Ullas Prakash D’ Souza ◽  
Himanshu Joshi ◽  
Zeena Fernandes ◽  
...  
Keyword(s):  
Carica Papaya ◽  
Epileptic Activity ◽  
Seed Extract ◽  
Experimental Animals ◽  
Carica Papaya Seed ◽  
Papaya Seed

scholarly journals Narrative Review: Nano Kapsul Ekstrak Biji papaya (Carica Papaya L.) sebagai Antifertilitas

2021 ◽  
Vol 6 (2) ◽  
pp. 10-24
Author(s):  
Shinta Nur Fajriyah ◽  
Yuliana Eka Lestari ◽  
Nadiatul Istiqamah Suaka ◽  
Endang Darmawan
Keyword(s):  
Carica Papaya ◽  
Skin Diseases ◽  
Diarrheal Disease ◽  
Seed Extract ◽  
Narrative Review ◽  
Human Needs ◽  
Digestive Disorders ◽  
Carica Papaya Seed ◽  
Papaya Seed ◽  
Research Show

Papaya (Carica Papaya L.) is a plant commonly found in Indonesia. Interestingly, its seeds traditionally used as antifertility. All parts of the Carica Papaya tree can be used for human needs from the fruit, leaves, seeds, sap, and stems. Carica Papaya seed extract contains secondary metabolite compounds in class Triterpenoids, flavonoids, alkaloids, saponins, and tannins which have functioned as antifertility. Nanocapsule is an innovation of nanoparticle dosage form with small particle size, that can accelerate the drug to the target. This Narrative Review purposed to determine the usefulness of the nanocapsules of Carica Papaya seed extract as antifertility. This research is a Narrative Review. A total of 36 articles that met the inclusion and exclusion criteria were analyzed descriptively, which include the efficacy of Carica Papaya, nanocapsules, and antifertility. The articles used include articles published in national journals and international journals. The result of the Narrative Review is presented in descriptive form. The results of the research show that Carica Papaya can be used traditionally to treat skin diseases, diarrheal disease, overcoming digestive disorders, and by research can be used as antifertility, The size of the nanoparticles obtained in the study ranged from 76.47 nm to 693.8 nm, and Carica Papaya seed extract is used as an antifertility by reducing sperm quantity, semen pH, spermatogenesis process, interfering the action of pituitary gonads, by preclinical reducing the number of ovum quality and the number of de Graff Follicles in female mice. Overall, it can be concluded that Carica Papaya nanocapsules in particle sizes between 76.46 nm to 693.8 nm can be used as antifertility that preclinically can affect the reproduction of female and male mice.

scholarly journals Carica papaya seed extract slows human sperm

2019 ◽  
Vol 241 ◽  
pp. 111972 ◽  
Author(s):  
V. Ghaffarilaleh ◽  
D. Fisher ◽  
R. Henkel
Keyword(s):  
Carica Papaya ◽  
Human Sperm ◽  
Seed Extract ◽  
Carica Papaya Seed ◽  
Papaya Seed

Efficacy of Carica papaya seed extract on periodontitis: A clinico-microbiological study

2019 ◽  
Vol 7 (2) ◽  
pp. 35
Author(s):  
VivekanandaMarenahally Rangaraju ◽  
Shamna Mousin ◽  
HarshaM Babu ◽  
Shivaprasad Dasappa
Keyword(s):  
Carica Papaya ◽  
Seed Extract ◽  
Microbiological Study ◽  
Carica Papaya Seed ◽  
Papaya Seed

scholarly journals Dose-Dependent Chemopreventive Effect of Methanol Extract of Carica papaya Seed on Potassium Bromate- Induced Nephrotoxicity in Rats

2019 ◽  
pp. 1-12
Author(s):  
M. A. Kanadi ◽  
A. M. Wudil ◽  
A. J. Alhassan ◽  
A. L. Ngwen ◽  
A. I. Yaradua ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Uric Acid ◽  
Carica Papaya ◽  
Renal Toxicity ◽  
Seed Extract ◽  
Albino Rats ◽  
Carica Papaya Seed ◽  
Dose Dependent ◽  
Papaya Seed

Aim: To investigate the effect of Carica papaya seed extract on KBrO3 - induced nephrotoxicity in rats. Renal toxicity was induced by a single oral dose of 100 mg/kg body weight of KBrO3. Study Design: Thirty (30) male albino rats were divided into six groups, five rats per group; normal control, KBrO3 control, papaya control and KBrO3 group administered with methanol seed extract of 200 mg/kg, 400 mg/kg and 600 mg/kg body weight for 48 hours. Place and Duration of Study: Department of Biochemistry Laboratory, Faculty of Basic Medical Sciences, Bayero University Kano, Nigeria, from April 2018 to August 2018. Methodology: Serum urea, creatinine, uric acid and electrolytes were determined using kits from randox laboratories. Furthermore, activities of renal brush border membrane marker enzymes namely γ-glutamyltransferase (GGT), alkaline phosphatase (ALP), maltase (Mal) and leucine aminopeptidase (LAP) and some parameters of oxidative stress including catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA) were determined in homogenates prepared from renal cortex and medulla of the kidney of rats using colorimetric methods. Results: Administration of KBrO3 significantly (P<0.05) increases the serum levels of urea, creatinine, uric acid and all electrolytes studied in a dose-dependent fashion from 200mg/kg to 400mg/kg and 600mg/kg in that order. Furthermore, the activities of GGT, ALP, Mal and LAP decrease in renal homogenates with KBrO3 administration. Also the activities of CAT, SOD, GPx and level of GSH decreases while the level of MDA significantly (P<0.05) increases however concurrent administration of Carica papaya seed extract prevented all the KBrO3- induced changes in the biochemical parameters studied . Conclusion: It was suggested that methanol seed extract of Carica papaya possess nephroprotective effect against KBrO3 –induced renal toxicity and oxidative stress, and the most effective dose was 600 mg/kg body weight.

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