Evaluation of antiulcer activity of ethanolic extract ofMomordica dioicaon pylorus ligature induced and ibuprofen induced ulcer in albino rats

2013 ◽  
Vol 2 (4) ◽  
pp. 762
Author(s):  
N Raveendra Kumar ◽  
N Siva Kumar ◽  
Yakaiah Vangoori
Keyword(s):  
Ethanolic Extract ◽  
Albino Rats ◽  
Antiulcer Activity

scholarly journals EXPERIMENTAL EVALUATION OF THE ANTI-ULCER ACTIVITY OF GRAPE (VITIS VINIFERA) SEED EXTRACT IN WISTAR ALBINO RATS AGAINST HYDROCHLORIC ACID – ETHANOL INDUCED ULCER MODEL

2016 ◽  
Vol 9 (6) ◽  
pp. 346
Author(s):  
Anand M Ingale ◽  
Dr. Venkata Bharatkumar Pinnelli ◽  
Dr. Vijaya Rajendran
Keyword(s):  
Vitis Vinifera ◽  
Ethanolic Extract ◽  
Grape Seed ◽  
Gastric Volume ◽  
Seed Extract ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Free Acidity ◽  
Ulcer Model

Background:Herbal products are finding increasing demand in the treatment of Peptic ulcer, on account of their better safety and efficacy.Objectives:To evaluate the anti-ulcer activity of ethanolic extract of seeds of Vitis Vinifera in Wistar albino rats.Methods:The ethanolic extract of Vitis Vinifera was investigated for its anti-ulcer activity in rats against HCl – Ethanol induced ulcer model. The antiulcer activity was assessed by determining and comparing gastric volume, pH, free and total acidity; ulcer number and its inhibition, ulcer severity and ulcer index.Results:A significant antiulcer activity was observed. The grape seed 100mg/kg group showed significant [p < 0.05] reduction in ulcer number 30.00 ± 3.23 as compared to the control. The grape seed 200mg/kg showed significant [p < 0.05] reduction in ulcer number 27.33 ± 2.97, free acidity 20.00 ± 2.26, and gastric lesion18.00 ± 2.96 as compared to the control.Conclusion:This present study indicates that Vitis vinifera seed extract has potential anti ulcer activity in the model tested. Keywords: Vitis vinifera, Anti-ulcer, Ethanol, Free acidity, Total acidity

scholarly journals IN VITRO ANTIOXIDANT AND ANTIULCEROGENIC ACTIVITY OF CAYRATIA PEDATA VAR. GLABRA AGAINST EXPERIMENTALLY INDUCED GASTRIC LESIONS IN WISTAR STRAIN ALBINO RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 105
Author(s):  
Kalaichelvi K ◽  
Sharmila S ◽  
Dhivya Sm
Keyword(s):  
Free Radical ◽  
Plant Extracts ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenging ◽  
Gastric Ulcers ◽  
Total Phenolic ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Dependent Manner

Objective: To quantify the phytochemical constituents, scavenging different free radicals and assess the antiulcer property of aerial plant extracts of Cayratia pedata var. glabra.Methods: Quantitative analysis was performed to confirm and quantify the presence of phenolics, tannin content and total flavonoids in the aerial plant extracts of the study plant. Reducing power assay, 2, 2- diphenyl-1-picryl-hydrazyl (ABTS), ABTS•+ and metal chelating activity were used in this study. To evaluate the anti-ulcerogenic activity of ethanolic extract of C. pedata var. glabra, against indomethacin-induced gastric ulcers in rats.Results: The results of quantification of phytoconstituents showed that the total phenolic and total flavonoid content were maximum in the ethanolic extract. The results of the antioxidant property of C. pedata var. glabra showed that all the extracts possess a different range of free radical scavenging activities, which is in dose-dependent manner. The ethanolic extract of the study plant produced gastroprotective effect in indomethacin-induced rats showed the decreased level of ulcer index, gastric volume, free acidity, total acidity, total protein and increased level of percentage of protection, and pH were calculated from the effective concentrations of plant sample (400 mg/kg) compared with Omeprazole (10 mg/kg).Conclusions: It is concluded that, the C. pedata var. glabra contains strong secondary metabolites; natural source of antioxidants and different extracts of this plant possesses good free radical scavenging activity. This present study indicates that ethanolic extract of C. pedata var. glabra has potential antiulcer activity in this tested model. In future, it can be used as a bioactive source of natural antioxidants and are potential natural resources for pharmacology of functional foods.

scholarly journals IN VITRO ANTIOXIDANT AND ANTIULCEROGENIC ACTIVITY OF CAYRATIA PEDATA VAR. GLABRA AGAINST EXPERIMENTALLY INDUCED GASTRIC LESIONS IN WISTAR STRAIN ALBINO RATS.

2018 ◽  
Vol 11 (1) ◽  
pp. 105
Author(s):  
Kalaichelvi K ◽  
Sharmila S ◽  
Dhivya Sm
Keyword(s):  
Free Radical ◽  
Plant Extracts ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Free Radical Scavenging ◽  
Gastric Ulcers ◽  
Total Phenolic ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Dependent Manner

Objective: To quantify the phytochemical constituents, scavenging different free radicals and assess the antiulcer property of aerial plant extracts of Cayratia pedata var. glabra.Methods: Quantitative analysis was performed to confirm and quantify the presence of phenolics, tannin content and total flavonoids in the aerial plant extracts of the study plant. Reducing power assay, 2, 2- diphenyl-1-picryl-hydrazyl (ABTS), ABTS•+ and metal chelating activity were used in this study. To evaluate the anti-ulcerogenic activity of ethanolic extract of C. pedata var. glabra, against indomethacin-induced gastric ulcers in rats.Results: The results of quantification of phytoconstituents showed that the total phenolic and total flavonoid content were maximum in the ethanolic extract. The results of the antioxidant property of C. pedata var. glabra showed that all the extracts possess a different range of free radical scavenging activities, which is in dose-dependent manner. The ethanolic extract of the study plant produced gastroprotective effect in indomethacin-induced rats showed the decreased level of ulcer index, gastric volume, free acidity, total acidity, total protein and increased level of percentage of protection, and pH were calculated from the effective concentrations of plant sample (400 mg/kg) compared with Omeprazole (10 mg/kg).Conclusions: It is concluded that, the C. pedata var. glabra contains strong secondary metabolites; natural source of antioxidants and different extracts of this plant possesses good free radical scavenging activity. This present study indicates that ethanolic extract of C. pedata var. glabra has potential antiulcer activity in this tested model. In future, it can be used as a bioactive source of natural antioxidants and are potential natural resources for pharmacology of functional foods.

scholarly journals ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF BAUHINIA TOMENTOSA LINN. LEAVES

YMER Digital ◽  
2022 ◽  
Vol 21 (01) ◽  
pp. 175-180
Author(s):  
M Shantha ◽  
◽  
R Senthamarai ◽  
T Shri Vijaya Kirubha ◽  
Keyword(s):  
Gastric Ulcer ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Total Acidity

The leaves of Bauhinia tomentosa Linn are used traditionally in the treatment of gastric ulcer. The present study was carried out to determine the effect of ethanolic extract of Bauhinia tomentosa Linn. Leaves for antiulcer effect in pylorus ligated rats. The extract showed antiulcer activity by pyloric ligated model in albino rats. The results revealed significant reduction is total acidity and the ulceration.

Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saraca indica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats

2020 ◽  
Vol 16 (8) ◽  
pp. 1191-1196
Author(s):  
Pritt Verma ◽  
Shravan K. Paswan ◽  
Vishal K. Vishwakarma ◽  
Priyanshi Saxena ◽  
Chandana V. Rao ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Cellulose Solution ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
High Doses

Background: To evaluate the antiulcer activity of ethanolic leaves extract of Saraca indica against ethanol, pylorus ligature and indomethacin in albino rats. Materials and Methods: Ulcer was produced by ethanol, pylorus ligature and indomethacin in albino rats. Five groups (n=6) of rats were orally pre-treated with carboxymethyl cellulose solution, and ranitidine (80 mg/kg) respectively. In ethanol induced ulcer, the animals were treated with 200 and 400 mg/kg b.w. ethanolic leave extracts of Saraca indica in 0.3% CMC solution, 60 minutes before oral administration of absolute ethanol to produce gastric mucosal injury. In indomethacin induced ulcer, the drug was administered orally at the dose of 30 mg/kg b.w. After 7-9 hours of administration of indomethacin (30 mg/kg); the animals were sacrificed with high doses of anesthesia. In the pylorus ligature method, volume of free acidity, gastric secretion, pH and total acidity were estimated. In all three models, the ulcer index and % protection were estimated. Results: The anti ulcer activity of ethanolic leave extracts of Saraca indica in ethanol, indomethacin and pylorus ligature models is evident from the significant (P<0.001) reduction in ulcer index. In pylorus ligature model, significant (P<0.001) reduction in total acidity gastric volume and increase in pH were observed when compared with the standard drug. Conclusion: Ethanolic leave extracts of Saraca indica were found to be significantly protective against ethanol, indomethacin and pylorus ligature induced gastric ulcers in the experimental albino rats. The result obtained suggest that ethanolic leave extracts of Saraca indica possesses significant anti-ulcer activity.

scholarly journals Antidiabetic and antiulcerative potential of Garcinia lanceifolia Roxb. bark

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Nilutpal Sharma Bora ◽  
Partha Sarathi Bairy ◽  
Abdus Salam ◽  
Bibhuti Bhusan Kakoti
Keyword(s):  
Body Weight ◽  
Serum Levels ◽  
Northeast India ◽  
Scientific Data ◽  
Antidiabetic Activity ◽  
Histological Evaluation ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Dose Dependent

Abstract Background Garcinia lanceifolia Roxb. has been used by many ethnic communities of Northeast India to mitigate various disorders like dyspepsia, ulcers, diabetes, etc. However, a robust scientific study on its antidiabetic and antiulcer potential is unavailable till date. The aim of this present study is to scientifically validate if the antidiabetic and antiulcer effects reported by the ethnic tribes of Assam has any scientific value or not. The effects were tested in adult Wistar albino rats using approved animal models for preclinical testing of pharmacological activities. Results The hydroalcoholic extract of the bark of Garcinia lanceifolia Roxb. was prepared and its LD50 was calculated. The LD50 was determined to be greater than 5000 mg/kg body weight. The extract at doses of 250 mg/kg body weight and 500 mg/kg body weight was found to exhibit a very potent dose-dependent antidiabetic activity. The results were backed by a battery of test including analysis of serum levels of blood glucose, lipid profiles, in vivo antioxidant enzymes, and histopathological studies. Evidence of dose-dependent antiulcer activity of the extract was backed by robust scientific data. It was found that HAEGL induced a significant dose-dependent increase in the ulcer index in both alcohol-induced and acetic acid-induced ulcer models, which was evident from the macroscopic observation of the inner lining of the gastric mucosa and the histological evaluation of the extracted stomach. Conclusion The results suggested that the bark of Garcinia lanceifolia (Roxb.) has significant antidiabetic and antiulcer potential. Further studies with respect to the development herbal dosage forms and its safety evaluation are required.

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