scholarly journals First case of interconnected clusters of primary meningococcal arthritis and meningococcal meningitis due to Neisseria meningitidis serogroup B in Slovenia

2021 ◽  
pp. 1-9
Author(s):  
Miha Simoniti ◽  
Tanja Selič Kurinčič ◽  
Alenka Trop Skaza ◽  
Ines Kebler ◽  
Metka Paragi ◽  
...  
Keyword(s):  
Young Adults ◽  
Septic Arthritis ◽  
Neisseria Meningitidis ◽  
General Hospital ◽  
Meningococcal Disease ◽  
Meningococcal Meningitis ◽  
Invasive Meningococcal Disease ◽  
First Case ◽  
The Right

In this report, we describe a case of interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup B:P1.22,14:F5-1(ST-269) in young adults – a boyfriend and a girlfriend. The male was diagnosed with primary meningococcal septic arthritis of the right knee and the female was diagnosed with meningococcal meningitis with meningococcemia a few hours later. Both were hospitalized at the General Hospital Celje and treated with ceftriaxone, but with different outcomes; the female recovered completely, while the male will probably have long-term sequelae of septic arthritis.

Invasive meningococcal disease due to ciprofloxacin-resistant Neisseria meningitidis sequence type 4821: The first case in Japan

2018 ◽  
Vol 24 (4) ◽  
pp. 305-308 ◽  
Author(s):  
Yu Kawasaki ◽  
Kousaku Matsubara ◽  
Hideyuki Takahashi ◽  
Masatomo Morita ◽  
Makoto Ohnishi ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Sequence Type ◽  
Invasive Meningococcal Disease ◽  
First Case

scholarly journals AMEND study protocol: a case–control study to assess the long-term impact of invasive meningococcal disease in Australian adolescents and young adults

BMJ Open ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. e032583
Author(s):  
Helen Marshall ◽  
Mark McMillan ◽  
Bing Wang ◽  
Robert Booy ◽  
Hossein Afzali ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Outcome Measures ◽  
Meningococcal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Invasive Meningococcal Disease ◽  
Control Study

IntroductionInvasive meningococcal disease (IMD) primarily causes disease in young children and adolescents and can cause long-term disability. Many countries are considering implementation of meningococcal B and/or meningococcal ACWY vaccines to control meningococcal disease. Estimating the cost-effectiveness of meningococcal vaccine programme is hampered due to a lack of good quality costing and burden of disease data. This study aims to address this evidence gap by assessing the clinical, physical, neurocognitive, economic and societal impact of IMD on adolescents and young adults.Methods and analysisA case–control study of 64 participants with confirmed IMD (15–24 years 11 months at time of disease) and 64 control participants (17–34 years 11 months) will be conducted in Australia from 2016 to 2020. All participants will undergo a neurocognitive assessment, full medical examination, pure tone audiometry assessment and complete quality of life and behavioural questionnaires. Meningococcal cases will be assessed 2–10 years posthospitalisation and a subset of cases will be interviewed to explore in depth their experiences of IMD and its impact on their life. Primary outcome measures include general intellectual functioning from the Wechsler Adult Intelligence Scale and overall quality of life from the Health Utilities Index. Secondary outcome measures include academic achievement, executive functioning, behaviour, hearing, psychological and physical functioning. Outcome measures will be compared between cases and controls using independent t-tests or ORs, or if any significant confounders are identified, adjusted analyses (analysis of covariance or adjusted ORs) will be conducted. Thematic analysis will be used to analyse transcribed interviews and a costing model will be used to project lifetime costs.Ethics and disseminationThe Adolescent MENingococcal Disease (AMEND) study has been approved by the Human Research Ethics Committee of the Women’s and Children’s Health Network (HREC/14/WCHN/024). The results will be disseminated via peer-reviewed publications, conference presentations, study participants, and meningococcal and meningitis foundations.Trial registration numberNCT03798574.

Epidemiological Characteristics of Meningococcal Infection in Moscow

2020 ◽  
Vol 19 (2) ◽  
pp. 56-62
Author(s):  
M. I. Gritsay ◽  
M. A. Koroleva ◽  
N. N. Fomkina ◽  
I. S. Koroleva
Keyword(s):  
Young Adults ◽  
Mortality Rate ◽  
Incidence Rate ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Meningococcal Infection ◽  
Epidemic Process ◽  
Epidemiological Features ◽  
Teenagers And Young Adults ◽  
Epidemiological Characteristics

Aims. The purpose of this study was to identify current epidemiological features of meningococcal infection in Moscow.Materials and methods. Cases of invasive meningococcal disease in Moscow from 2014 to 2018 and the biomaterial from patients with an invasive meningococcal disease were analyzed.Results. The features of the epidemic process of meningococcal disease in Moscow were revealed: increasing in the incidence rate involving teenagers and young adults into the epidemic process; meningococcal strains of serogroups W and A increased in the etiology of the invasive meningococcal disease; high mortality rate.Conclusions. It seems reasonable to recommend vaccination against meningococcal disease by including adolescents, young adults and persons over 65 years old.

First case of invasive meningococcal disease‐induced myopericarditis in a patient with human immunodeficiency virus infection

2021 ◽  
Vol 51 (1) ◽  
pp. 136-137
Author(s):  
Alexandre Chlilek ◽  
Saber‐Davide Barbar ◽  
Robin Stephan ◽  
Claudine Barbuat ◽  
Guillaume Cayla ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Virus Infection ◽  
Human Immunodeficiency Virus Infection ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
First Case ◽  
Immunodeficiency Virus

Prevalence and genetic diversity of two adhesion-related genes, pilE and nadA, in Neisseria meningitidis in China

2013 ◽  
Vol 141 (10) ◽  
pp. 2163-2172 ◽  
Author(s):  
X. SUN ◽  
H. ZHOU ◽  
L. XU ◽  
H. YANG ◽  
Y. GAO ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Neisseria Meningitidis ◽  
Adhesion Molecules ◽  
Meningococcal Disease ◽  
Class Ii ◽  
Type Iv Pili ◽  
Invasive Meningococcal Disease ◽  
Class I ◽  
Type Iv

SUMMARYThe main Neisseria meningitidis adhesion molecules, type IV pili (Tfp) and Neisseria adhesion A (NadA), play important roles in the pathogenesis of invasive meningococcal disease. PilE is the major Tfp subunit. In this study, the prevalence and genetic diversity of pilE and nadA were investigated in the prevalent serogroups and clonal complexes (CC) of N. meningitidis isolated in China. All serogroup A strains belonging to CC1 and CC5 and all CC11 serogroup W135 strains were clustered into class II PilE clades. All serogroup C and most of serogroup B isolates except CC8 and ST5642 were class I PilE clades. Class II pilE sequences were highly conserved. All isolates belonging to class I PilE isolates were nadA negative. However, nadA-positive strains were exclusively found in CC5 and CC11 isolates (class II PilE). This study showed that PilE and NadA may be related to epidemic or endemic meningococcal disease.

scholarly journals Alternative Leprosy Treatment Using Rifampicin Ofloxacin Minocycline (ROM) Regimen – Two Case Reports

2019 ◽  
Vol 11 (3) ◽  
pp. 89-93
Author(s):  
Yohanes Widjaja ◽  
Khairuddin Djawad ◽  
Saffruddin Amin ◽  
Widyawati Djamaluddin ◽  
Dirmawati Kadir ◽  
...  
Keyword(s):  
Clinical Improvement ◽  
Alternative Treatment ◽  
Histopathological Examination ◽  
Case Reports ◽  
Erythematous Plaque ◽  
First Case ◽  
Satisfactory Outcome ◽  
Significant Clinical Improvement ◽  
The Right

Abstract Introduction. Leprosy is a disease that predominantly affects the skin and peripheral nerves, resulting in neuropathy and associated long-term consequences, including deformities and disabilities. According to the WHO classification, there are two categories of leprosy, paucibacillary (PB) and multibacillary (MB). The standard treatment for leprosy employs the use of WHO MDT (Multi Drug Treatment) regimen, despite its multiple downsides such as clofazimine-induced pigmentation, dapsone-induced haematological adverse effects, poor compliance due to long therapy duration, drug resistance, and relapse. Multiple studies and case reports using ROM regimen have reported satisfactory results. Nevertheless, there are still insufficient data to elucidate the optimum dosage and duration of ROM regimen as an alternative treatment for leprosy. Previous experience from our institution revealed that ROM regimen given three times weekly resulted in a satisfactory outcome. Case Reports. We report two cases of leprosy treated with ROM regimen from our institution. The first case was PB leprosy in a 64-year-old male who presented with a single scaly plaque with erythematous edge on the right popliteal fossa. Sensibility examination showed hypoesthesia with no peripheral nerve enlargement. Histopathological examination confirmed Borderline Tuberculoid leprosy. ROM regimen was started three times weekly for 6 weeks and the patient showed significant clinical improvement at the end of the treatment with no reaction or relapse until after 6 months after treatment. The second case was MB leprosy in a 24-year-old male patient with clawed hand on the 3rd-5th phalanges of the right hand and a hypoesthetic erythematous plaque on the forehead. Histopathology examination confirmed Borderline leprosy. The patients received ROM therapy 3 times a week with significant clinical improvement after 12 weeks. Conclusion. ROM regimen given three times weekly for 6 weeks in PB leprosy and 12 weeks in MB leprosy resulted in a significant clinical improvement. Thus, ROM regimen could be a more effective, safer, faster alternative treatment for leprosy.

scholarly journals Periocular Cutaneous Mucormycosis Caused by Saksenaea erythrospora

2017 ◽  
Vol 14 (04) ◽  
pp. 209-212
Author(s):  
Bunyada Putthirangsiwong ◽  
Pornchai Mahaisavariya ◽  
Weerawan Chokthaweesak ◽  
Dinesh Selva
Keyword(s):  
Complete Recovery ◽  
Molecular Techniques ◽  
First Case ◽  
Chronic Dacryocystitis ◽  
Oral Itraconazole ◽  
Periocular Region ◽  
Cutaneous Mucormycosis ◽  
The Right

Abstract Saksenaea erythrospora is a rare pathogen in humans. Ten adult cases have been previously reported, eight manifested with cutaneous infection, and two presented with invasive rhinosinusitis infection. The authors present a 16-month-old boy with progressive painful mass at the right medial canthus and upper cheek that was unresponsive to broad-spectrum antibiotics. He underwent an anterior orbitotomy and biopsy. Histopathology revealed broad nonseptate sterile hyphae and grew S. erythrospora, which was confirmed by molecular techniques. The patient was treated with intravenous liposomal amphotericin B and oral itraconazole combined with aggressive surgical debridement. The patient made a complete recovery without long-term complications at 4 months of follow-up. Primary cutaneous mucormycosis caused by S. erythrospora may rarely involve the periocular region and mimic chronic dacryocystitis. We report the first case of pediatric periocular cutaneous mucormycosis caused by S. erythrospora.

scholarly journals An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11

2019 ◽  
Vol 25 (1) ◽  
pp. 111.e1-111.e4 ◽  
Author(s):  
P. Stefanelli ◽  
C. Fazio ◽  
P. Vacca ◽  
A. Palmieri ◽  
L. Ambrosio ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease
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